-
1
-
-
13644253448
-
Nucleic acid purification by Fast Protein liquid chromatography
-
Rahman, K., U. Voss, P. J. Nicholls, and A. D. B. Malcolm. 1988. Nucleic acid purification by Fast Protein liquid chromatography. Biochemical Society Transactions 16: 368.
-
(1988)
Biochemical Society Transactions
, vol.16
, pp. 368
-
-
Rahman, K.1
Voss, U.2
Nicholls, P.J.3
Malcolm, A.D.B.4
-
2
-
-
0025216544
-
A general method of optimizing automated DNA synthesis to decrease chemical consumption to less than half
-
Yeung, A. T., and C. G. Miller. 1990. A general method of optimizing automated DNA synthesis to decrease chemical consumption to less than half. Analytical Biochemistry 187: 66-75.
-
(1990)
Analytical Biochemistry
, vol.187
, pp. 66-75
-
-
Yeung, A.T.1
Miller, C.G.2
-
3
-
-
0025979162
-
High-performance liquid chromatography of oligoguanylates at high pH
-
Stribling, R. 1991. High-performance liquid chromatography of oligoguanylates at high pH. Journal of Chromatography 538: 474-479.
-
(1991)
Journal of Chromatography
, vol.538
, pp. 474-479
-
-
Stribling, R.1
-
4
-
-
0026506242
-
Separation of synthetic phosphorothioate oligodeoxynucleotides from their oxygenated (phosphodiester) defect species by strong-anion-exchange high-performance liquid chromatography
-
Bergot, B. J., and W. Egan. 1992. Separation of synthetic phosphorothioate oligodeoxynucleotides from their oxygenated (phosphodiester) defect species by strong-anion-exchange high-performance liquid chromatography. Journal of Chromatography 599: 35-42.
-
(1992)
Journal of Chromatography
, vol.599
, pp. 35-42
-
-
Bergot, B.J.1
Egan, W.2
-
5
-
-
0028006673
-
Quantitative analysis of phosphorothioate oligonucleotides in biological fluids using direct injection fast anion-exchange chromatography and capillary gel electrophoresis
-
Bourque, A. J., and A. S. Cohen. 1994. Quantitative analysis of phosphorothioate oligonucleotides in biological fluids using direct injection fast anion-exchange chromatography and capillary gel electrophoresis. Journal of Chromatography B 662: 343-349.
-
(1994)
Journal of Chromatography B
, vol.662
, pp. 343-349
-
-
Bourque, A.J.1
Cohen, A.S.2
-
6
-
-
0028567241
-
Combined pH gradient and anion-exchange high performance liquid chromatographic separation of oligodeoxyribonucleotides
-
Lu, T., and H. B. Gray, Jr. 1994. Combined pH gradient and anion-exchange high performance liquid chromatographic separation of oligodeoxyribonucleotides. Journal of Chromatography A 686: 339-343.
-
(1994)
Journal of Chromatography A
, vol.686
, pp. 339-343
-
-
Lu, T.1
Gray, H.B.2
-
7
-
-
0029831960
-
High resolution nucleic acid separations by high performance liquid chromatography
-
ed. B. Karger and B. Hancock, New York: Academic Press
-
Thayer, J. R., R. M. McCormick, and N. Avdalovic. 1996. High resolution nucleic acid separations by high performance liquid chromatography. In Methods in Enzymol, ed. B. Karger and B. Hancock, 271, 147-174. New York: Academic Press.
-
(1996)
Methods in Enzymol
, vol.271
, pp. 147-174
-
-
Thayer, J.R.1
McCormick, R.M.2
Avdalovic, N.3
-
8
-
-
0030010222
-
Isolation of oligodeoxynucleoside phosphorothioate diastereomers by the combination of DEAE ion-exchange and reversed-phase chromatography
-
Kanehara, H., M. Mizuguchi, and K. Makino. 1996. Isolation of oligodeoxynucleoside phosphorothioate diastereomers by the combination of DEAE ion-exchange and reversed-phase chromatography. Nucleosides and Nucleotides 15: 399-406.
-
(1996)
Nucleosides and Nucleotides
, vol.15
, pp. 399-406
-
-
Kanehara, H.1
Mizuguchi, M.2
Makino, K.3
-
9
-
-
0036629203
-
Separation of synthetic oligonucleotide dithioates from monothiophosphate impurities by anion-exchange chromatography on a mono-q column
-
Yang, X., R. P. Hodge, B. A. Luxon, R. Shope, and D. G. Gorenstein. 2002. Separation of synthetic oligonucleotide dithioates from monothiophosphate impurities by anion-exchange chromatography on a mono-q column. Analytical Biochemistry 306: 92-99.
-
(2002)
Analytical Biochemistry
, vol.306
, pp. 92-99
-
-
Yang, X.1
Hodge, R.P.2
Luxon, B.A.3
Shope, R.4
Gorenstein, D.G.5
-
11
-
-
85137874558
-
-
Strategies for large scale purification of synthetic oligonucleotides, and GE Healthcare Application Note 18-1111-25, Automated pilot scale purification of synthetic phosphorothioate oligonucleotides
-
GE Healthcare Application Note 18-1116-00, Strategies for large scale purification of synthetic oligonucleotides: http://www1.gelifesciences.com/aptrix/upp00919.nsf/Content/D14A5305E5FA4C74C1257628001CC150/$file/18111600AA.pdf, and GE Healthcare Application Note 18-1111-25, Automated pilot scale purification of synthetic phosphorothioate oligonucleotides http://www1.gelifesciences.com/aptrix/upp00919.nsf/Content/7B387A892A39BACCC1257628001CCB09/$file/18111125AC.pdf.
-
GE Healthcare Application Note 18-1116-00
-
-
-
12
-
-
0029993626
-
Use of 1, 2, 4-dithiazolidine-3, 5-dione (DtsNH) and 3-ethoxy-1, 2, 4-dithiazoline-5-one (EDITH) for synthesis of phosphorothioate-containing oligodeoxyribonucleotides
-
Xu, Q., K. Musier-Forsyth, R. P. Hammer, and G. Barany. 1996. Use of 1, 2, 4-dithiazolidine-3, 5-dione (DtsNH) and 3-ethoxy-1, 2, 4-dithiazoline-5-one (EDITH) for synthesis of phosphorothioate-containing oligodeoxyribonucleotides. Nucleic Acids Research 24: 1602-1607.
-
(1996)
Nucleic Acids Research
, vol.24
, pp. 1602-1607
-
-
Xu, Q.1
Musier-Forsyth, K.2
Hammer, R.P.3
Barany, G.4
-
13
-
-
0031579953
-
Phosphorothioate oligonucleotide metabolism: Characterization of the “N+"-mer by CE and HPLC-ESI/MS
-
Cummins, L. L., M. Winniman, and H. J. Gaus. 1997. Phosphorothioate oligonucleotide metabolism: characterization of the “N+"-mer by CE and HPLC-ESI/MS. Bioorganic and Medicinal Chemistry Letters 7: 1225-1230.
-
(1997)
Bioorganic and Medicinal Chemistry Letters
, vol.7
, pp. 1225-1230
-
-
Cummins, L.L.1
Winniman, M.2
Gaus, H.J.3
-
14
-
-
85137871285
-
Polymerase-endonuclease amplification reaction for large-scale enzymatic production on antisense oligonucleotides
-
hdl:10101/npre.2009.3711.1, posted 2 Sept. 2009
-
Wang, X. D., and P. R. Gou. 2009. Polymerase-endonuclease amplification reaction for large-scale enzymatic production on antisense oligonucleotides. Nature Proceedings (hdl:10101/npre.2009.3711.1, posted 2 Sept. 2009).
-
(2009)
Nature Proceedings
-
-
Wang, X.D.1
Gou, P.R.2
-
15
-
-
8944231156
-
Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of protein kinase C-α expression
-
Dean, N., R. McKay, L. Miraglia, et al. 1996. Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of protein kinase C-α expression. Cancer Research 56: 3499-3507.
-
(1996)
Cancer Research
, vol.56
, pp. 3499-3507
-
-
Dean, N.1
McKay, R.2
Miraglia, L.3
-
16
-
-
0029129615
-
Investigation of the ʼn-1' impurity in phosphorothioate oligodeoxynucleotides synthesized by the solid-phase β-cyanoethyl phosphoramidite method using stepwise sulfurization
-
Fearon, K. L., J. T. Stults, B. J. Bergot, L. M. Christensen, and A. M. Raible. 1995. Investigation of the ʼn-1' impurity in phosphorothioate oligodeoxynucleotides synthesized by the solid-phase β-cyanoethyl phosphoramidite method using stepwise sulfurization. Nucleic Acids Research 23: 2754-2761.
-
(1995)
Nucleic Acids Research
, vol.23
, pp. 2754-2761
-
-
Fearon, K.L.1
Stults, J.T.2
Bergot, B.J.3
Christensen, L.M.4
Raible, A.M.5
-
17
-
-
0034837564
-
Stereochemistry of cleavage of internucleotide bonds by Serratia marcescens endonuclease
-
Koziolkiewicz, M., A. Owczarek, K. Domañski, M. Nowak, P. Guga, and W. J. Stec. 2001. Stereochemistry of cleavage of internucleotide bonds by Serratia marcescens endonuclease. Bioorganic and Medicinal Chemistry 9: 2403-2409.
-
(2001)
Bioorganic and Medicinal Chemistry
, vol.9
, pp. 2403-2409
-
-
Koziolkiewicz, M.1
Owczarek, A.2
Domañski, K.3
Nowak, M.4
Guga, P.5
Stec, W.J.6
-
18
-
-
0030963933
-
Determination of antisense phosphorothioate oligonucleotides and catabolites in biological fluids and tissue extracts using anion-exchange high-performance liquid chromatography and capillary gel electrophoresis
-
Chen, S.-H., M. Qian, J. M. Brennan, and J. M. Gallo. 1997. Determination of antisense phosphorothioate oligonucleotides and catabolites in biological fluids and tissue extracts using anion-exchange high-performance liquid chromatography and capillary gel electrophoresis. Journal of Chromatography B 692: 43-51.
-
(1997)
Journal of Chromatography B
, vol.692
, pp. 43-51
-
-
Chen, S.-H.1
Qian, M.2
Brennan, J.M.3
Gallo, J.M.4
-
19
-
-
0029156023
-
Synthesis of oligodeoxyribonucleotide N3′-P5′ phosphoramidates
-
Chen, J.-K., R. G. Schultz, D. H. Lloyd, and S. Gryaznov. 1995. Synthesis of oligodeoxyribonucleotide N3′-P5′ phosphoramidates. Nucleic Acids Research 23: 2661-2668.
-
(1995)
Nucleic Acids Research
, vol.23
, pp. 2661-2668
-
-
Chen, J.-K.1
Schultz, R.G.2
Lloyd, D.H.3
Gryaznov, S.4
-
20
-
-
0038487839
-
Synthesis and properties of oligo-2′-deoxyribonucleotides containing internucleotidic phosphoramidate linkages modified with pendant groups ending with either two amino or two hydroxyl functions
-
Asseline, U., M. Chassignol, J. Draus, M. Durand, and J-C. Maurizot. 2003. Synthesis and properties of oligo-2′-deoxyribonucleotides containing internucleotidic phosphoramidate linkages modified with pendant groups ending with either two amino or two hydroxyl functions. Bioorganic and Medicinal Chemistry 11: 3499-3511.
-
(2003)
Bioorganic and Medicinal Chemistry
, vol.11
, pp. 3499-3511
-
-
Asseline, U.1
Chassignol, M.2
Draus, J.3
Durand, M.4
Maurizot, J.-C.5
-
21
-
-
34948854919
-
Excision of 5-halogenated uracils by human thymine DNA glycosylase
-
Morgan, M. T., M. T. Bennet, and A. C. Drohat. 2007. Excision of 5-halogenated uracils by human thymine DNA glycosylase. Journal of Biological Chemistry 282: 27578-27586.
-
(2007)
Journal of Biological Chemistry
, vol.282
, pp. 27578-27586
-
-
Morgan, M.T.1
Bennet, M.T.2
Drohat, A.C.3
-
22
-
-
0033944163
-
Synthesis and characterization of oligonucleotides containing 2′-deoxyxanthosine using phosphoramidite chemistry
-
Jurczyk, S. C., J. Horlacher, K. G. Devined, S. A. Benner, and T. R. Battersby. 2000. Synthesis and characterization of oligonucleotides containing 2′-deoxyxanthosine using phosphoramidite chemistry. Helvetica Chimica Acta 83: 1517-1524.
-
(2000)
Helvetica Chimica Acta
, vol.83
, pp. 1517-1524
-
-
Jurczyk, S.C.1
Horlacher, J.2
Devined, K.G.3
Benner, S.A.4
Battersby, T.R.5
-
23
-
-
0029151591
-
Synthesis, deprotection, analysis and purification of RNA and ribozymes
-
Wincott, F., A. DiRenzo, C. Shaffer, S. Grimm, D. Tracz, C. Workman, D. Sweedler, C. Gonzalez, S. Scaringe, and N. Usman. 1995. Synthesis, deprotection, analysis and purification of RNA and ribozymes. Nucleic Acids Research 23: 2677-2684.
-
(1995)
Nucleic Acids Research
, vol.23
, pp. 2677-2684
-
-
Wincott, F.1
DiRenzo, A.2
Shaffer, C.3
Grimm, S.4
Tracz, D.5
Workman, C.6
Sweedler, D.7
Gonzalez, C.8
Scaringe, S.9
Usman, N.10
-
24
-
-
38049051153
-
RNA as scaffold for pyrene excited complexes
-
Grünewald, C., T. Kwon, N. Piton, U. Förster, J. Wachtveitl, and J. W. Engels. 2008. RNA as scaffold for pyrene excited complexes. Bioorganics and Medicinal Chemistry 16: 19-26.
-
(2008)
Bioorganics and Medicinal Chemistry
, vol.16
, pp. 19-26
-
-
Grünewald, C.1
Kwon, T.2
Piton, N.3
Förster, U.4
Wachtveitl, J.5
Engels, J.W.6
-
25
-
-
0033570216
-
Synthesis and properties of RNA analogs oligoribonucleotide N3′-P5′ phosphoramidates
-
Matray, T. J., and S. M. Gryaznov. 1999. Synthesis and properties of RNA analogs oligoribonucleotide N3′-P5′ phosphoramidates. Nucleic Acids Research 27: 3976-3985.
-
(1999)
Nucleic Acids Research
, vol.27
, pp. 3976-3985
-
-
Matray, T.J.1
Gryaznov, S.M.2
-
26
-
-
0029091063
-
Large scale synthesis of oligoribonucleotides on a high-loaded polystyrene (HLP) support
-
Tsou, D., A. Hampel, A. Andrus, and R. Vinayak. 1995. Large scale synthesis of oligoribonucleotides on a high-loaded polystyrene (HLP) support. Nucleosides and Nucleotides 14: 1481-1492.
-
(1995)
Nucleosides and Nucleotides
, vol.14
, pp. 1481-1492
-
-
Tsou, D.1
Hampel, A.2
Andrus, A.3
Vinayak, R.4
-
27
-
-
0029560403
-
Assay of ribozyme-substrate cleavage by anion-exchange high-performance, liquid chromatography
-
Vinayak, R., A. Andrus, N. D. Sinha, and A. Hampel. 1995. Assay of ribozyme-substrate cleavage by anion-exchange high-performance, liquid chromatography. Analytical Biochemistry 232: 204-209.
-
(1995)
Analytical Biochemistry
, vol.232
, pp. 204-209
-
-
Vinayak, R.1
Andrus, A.2
Sinha, N.D.3
Hampel, A.4
-
28
-
-
0033560683
-
Fast and simple purification of chemically modified hammerhead ribozymes using a lipophilic capture tag
-
Sproat, B. S., T. Rupp, N. Menhardt, D. Keane, and B. Beijer. 1999. Fast and simple purification of chemically modified hammerhead ribozymes using a lipophilic capture tag. Nucleic Acids Research 27: 1950-1955.
-
(1999)
Nucleic Acids Research
, vol.27
, pp. 1950-1955
-
-
Sproat, B.S.1
Rupp, T.2
Menhardt, N.3
Keane, D.4
Beijer, B.5
-
29
-
-
0036293201
-
A pH-dependent conformational change, rather than the chemical step, appears to be rate-limiting in the hammerhead ribozyme cleavage reaction
-
Murray, J. B., C. M. Dunham, and W. G. Scott. 2002. A pH-dependent conformational change, rather than the chemical step, appears to be rate-limiting in the hammerhead ribozyme cleavage reaction. Journal of Molecular Biology 315: 121-130.
-
(2002)
Journal of Molecular Biology
, vol.315
, pp. 121-130
-
-
Murray, J.B.1
Dunham, C.M.2
Scott, W.G.3
-
30
-
-
0030726554
-
Inter-domain cross-linking and molecular modeling of the hairpin ribozyme
-
Earnshaw, D. J., B. Masquida, S. Müller, S. Th. Sigurdsson, F. Eckstein, E. Westhof, and M. J. Gait. 1997. Inter-domain cross-linking and molecular modeling of the hairpin ribozyme. Journal of Molecular Biology 274: 197-212.
-
(1997)
Journal of Molecular Biology
, vol.274
, pp. 197-212
-
-
Earnshaw, D.J.1
Masquida, B.2
Müller, S.3
Sigurdsson, S.T.4
Eckstein, F.5
Westhof, E.6
Gait, M.J.7
-
31
-
-
0035476599
-
Methylation of the nucleobases in RNA oligonucleotides mediates duplex-hairpin conversion
-
Micura, R., W. Pils, C. Höbartner, K. Grubmayr, M-O. Ebert, and B. Jaun. 2001. Methylation of the nucleobases in RNA oligonucleotides mediates duplex-hairpin conversion. Nucleic Acids Research. 29: 3997-4005.
-
(2001)
Nucleic Acids Research
, vol.29
, pp. 3997-4005
-
-
Micura, R.1
Pils, W.2
Höbartner, C.3
Grubmayr, K.4
Ebert, M.-O.5
Jaun, B.6
-
32
-
-
3042559668
-
Chemical syntheses of inhibitory substrates of the RNA-RNA ligation reaction catalyzed by the hairpin ribozyme
-
Massey, A. P., and S. Th. Sigurdsson. 2004. Chemical syntheses of inhibitory substrates of the RNA-RNA ligation reaction catalyzed by the hairpin ribozyme. Nucleic Acids Research 32: 2017-2022.
-
(2004)
Nucleic Acids Research
, vol.32
, pp. 2017-2022
-
-
Massey, A.P.1
Sigurdsson, S.T.2
-
33
-
-
34250724493
-
Chimeric RNAse H-competent oligonucleotides directed to the HIV-1 Rev response element
-
Prater, C. E., A. D. Saleh, M. P. Wear, and P. S. Miller. 2007. Chimeric RNAse H-competent oligonucleotides directed to the HIV-1 Rev response element. Bioorganic and Medicinal Chemistry 15: 5386-5395.
-
(2007)
Bioorganic and Medicinal Chemistry
, vol.15
, pp. 5386-5395
-
-
Prater, C.E.1
Saleh, A.D.2
Wear, M.P.3
Miller, P.S.4
-
34
-
-
54049134705
-
An aptamer that neutralizes R5 strains of HIV-1 binds to core residues of gp120 in the CCR5 binding site
-
Cohen, C., M. Forzan, B. Sproat, R. Pantophlet, I. McGowan, D. Burton, and W. James. 2008. An aptamer that neutralizes R5 strains of HIV-1 binds to core residues of gp120 in the CCR5 binding site. Virology 381: 46-54.
-
(2008)
Virology
, vol.381
, pp. 46-54
-
-
Cohen, C.1
Forzan, M.2
Sproat, B.3
Pantophlet, R.4
McGowan, I.5
Burton, D.6
James, W.7
-
35
-
-
34250789334
-
Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs
-
Mackman, R. L., L. Zhang, V. Prasad, et al. 2007. Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs. Bioorganic and Medicinal Chemistry 15: 5519-5528.
-
(2007)
Bioorganic and Medicinal Chemistry
, vol.15
, pp. 5519-5528
-
-
Mackman, R.L.1
Zhang, L.2
Prasad, V.3
-
36
-
-
0034192170
-
Surface plasmon resonance kinetic studies of the HIV TAR RNA kissing hairpin complex and its stabilization by 2-thiouridine modification
-
Nair, T. M., D. G. Myszka, and D. R. Davis. 2000. Surface plasmon resonance kinetic studies of the HIV TAR RNA kissing hairpin complex and its stabilization by 2-thiouridine modification. Nucleic Acids Research 28: 1935-1940.
-
(2000)
Nucleic Acids Research
, vol.28
, pp. 1935-1940
-
-
Nair, T.M.1
Myszka, D.G.2
Davis, D.R.3
-
37
-
-
0028877084
-
Phosphoryl migration during the chemical synthesis of RNA
-
M. A. Morgan, S. A. Kazakov, and S. M. Hecht. 1995. Phosphoryl migration during the chemical synthesis of RNA, Nucleic Acids Research 23: 3949-3953.
-
(1995)
Nucleic Acids Research
, vol.23
, pp. 3949-3953
-
-
Morgan, M.A.1
Kazakov, S.A.2
Hecht, S.M.3
-
38
-
-
33846011902
-
Identification of aberrant 2′-5′ RNA link age isomers by pellicular anion-exchange chromatography
-
Thayer, J. R., S. Rao, N. Puri, C. A. Burnett, and M. Young. 2007. Identification of aberrant 2′-5′ RNA link age isomers by pellicular anion-exchange chromatography. Analytical Biochemistry 361: 132-139.
-
(2007)
Analytical Biochemistry
, vol.361
, pp. 132-139
-
-
Thayer, J.R.1
Rao, S.2
Puri, N.3
Burnett, C.A.4
Young, M.5
-
39
-
-
33646199862
-
RNA interference by 2′, 5′-linked nucleic acid duplexes in mammalian cells
-
T. P. Prakash, B. Kraynack, B. F. Baker, E. E. Swayze, and B. Bhat. 2006. RNA interference by 2′, 5′-linked nucleic acid duplexes in mammalian cells. Bioorganic and Medicinal Chemistry Letters 16: 3238-3240.
-
(2006)
Bioorganic and Medicinal Chemistry Letters
, vol.16
, pp. 3238-3240
-
-
Prakash, T.P.1
Kraynack, B.2
Baker, B.F.3
Swayze, E.E.4
Bhat, B.5
-
40
-
-
34347206680
-
The human 2′-5′ oligoadenylate synthetase family: Unique interferon-inducible enzymes catalyzing 2′-5′ instead of 3′-5′ phosphodiester bond formation
-
Hovanessian, A. G., and J. Justesen. 2007. The human 2′-5′ oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2′-5′ instead of 3′-5′ phosphodiester bond formation. Biochemie 89: 779-788.
-
(2007)
Biochemie
, vol.89
, pp. 779-788
-
-
Hovanessian, A.G.1
Justesen, J.2
-
41
-
-
9144247189
-
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
-
Soutschek, J., A. Akinc, B. Bramlage, et al. 2004. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432: 173-178.
-
(2004)
Nature
, vol.432
, pp. 173-178
-
-
Soutschek, J.1
Akinc, A.2
Bramlage, B.3
-
42
-
-
3142779038
-
Thermodynamic and structural characterization of 2′-nitrogen-modified RNA duplexes
-
Pham, J. W., I. Radhakrishnan, and E. J. Sontheimer. 2004. Thermodynamic and structural characterization of 2′-nitrogen-modified RNA duplexes. Nucleic Acids Research 32: 3446-3455.
-
(2004)
Nucleic Acids Research
, vol.32
, pp. 3446-3455
-
-
Pham, J.W.1
Radhakrishnan, I.2
Sontheimer, E.J.3
-
43
-
-
50149101511
-
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
-
Frank-Kamentetsy, M., A. Grefhorst, N. N. Anderson, et al. 2008. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proceedings of the National Academy of Sciences United States of America 105, 11915-11920.
-
(2008)
Proceedings of the National Academy of Sciences United States of America
, vol.105
, pp. 11915-11920
-
-
Frank-Kamentetsy, M.1
Grefhorst, A.2
Anderson, N.N.3
-
44
-
-
0041331496
-
siRNA function in RNAi: A chemical modification analysis
-
Chiu, Y.-L., and T. M. Rana. 2003. siRNA function in RNAi: a chemical modification analysis. RNA 9, 1034-1048.
-
(2003)
RNA
, vol.9
, pp. 1034-1048
-
-
Chiu, Y.-L.1
Rana, T.M.2
-
45
-
-
36148961231
-
Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: Insights into substrate requirements by the human RISC Ago2 enzyme
-
Li, F., P. S. Pallan, M. A. Maier, et al. 2007. Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: Insights into substrate requirements by the human RISC Ago2 enzyme. Nucleic Acids Research. 35: 6424-6438.
-
(2007)
Nucleic Acids Research
, vol.35
, pp. 6424-6438
-
-
Li, F.1
Pallan, P.S.2
Maier, M.A.3
-
46
-
-
36248965157
-
Light-dependent RNA interference with nucleobase-caged siRNAs
-
Mikat, V., and A. Heckel. 2007. Light-dependent RNA interference with nucleobase-caged siRNAs. RNA 13: 2341-2347.
-
(2007)
RNA
, vol.13
, pp. 2341-2347
-
-
Mikat, V.1
Heckel, A.2
-
47
-
-
0034666308
-
The generation and characterization of antagonist RNA Aptamers to human oncostatin M
-
Rhodes, A., A. Deakin, J. Spaull, B. Coomber, A. Aitken, P. Life, and S. Rees. 2000. The generation and characterization of antagonist RNA Aptamers to human oncostatin M. Journal of Biological Chemistry 275, 28555-28561.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 28555-28561
-
-
Rhodes, A.1
Deakin, A.2
Spaull, J.3
Coomber, B.4
Aitken, A.5
Life, P.6
Rees, S.7
-
48
-
-
0032896149
-
Novel approach to specific growth factor inhibition in vivo: Antagonism of platelet-derived growth factor in glomerulonephritis by aptamers
-
Floege, J., T. Ostendorf, U. Janssen, M. Burg, H. H. Radeke, C. Vargeese, S. C. Gill, L. S. Green, and N. Janjic. 1999. Novel approach to specific growth factor inhibition in vivo: antagonism of platelet-derived growth factor in glomerulonephritis by aptamers. American Journal of Pathology 154: 169-179.
-
(1999)
American Journal of Pathology
, vol.154
, pp. 169-179
-
-
Floege, J.1
Ostendorf, T.2
Janssen, U.3
Burg, M.4
Radeke, H.H.5
Vargeese, C.6
Gill, S.C.7
Green, L.S.8
Janjic, N.9
-
49
-
-
37349040378
-
First-in-human evaluation of anti von Willebrand Factor therapeutic aptamer ARC1779 in healthy volunteers
-
Gilbert, J. C., T. DeFeo-Fraulini, R. M. Hutabarat, C. J. Horvath, P. G. Merlino, H. N. Marsh, J. M. Healy, S. BouFakhreddine, T.V. Holohan, and R. G. Schaub. 2009. First-in-human evaluation of anti von Willebrand Factor therapeutic aptamer ARC1779 in healthy volunteers. Circulation 116: 2678-2686.
-
(2009)
Circulation
, vol.116
, pp. 2678-2686
-
-
Gilbert, J.C.1
DeFeo-Fraulini, T.2
Hutabarat, R.M.3
Horvath, C.J.4
Merlino, P.G.5
Marsh, H.N.6
Healy, J.M.7
BouFakhreddine, S.8
Holohan, T.V.9
Schaub, R.G.10
-
50
-
-
33847636806
-
Thioaptamer decoy targeting of AP-1 proteins influences cytokine expression and the outcome of arenavirus infections
-
Fennewald, S. M., E. P. Scott, L. Zhang, et al. 2007. Thioaptamer decoy targeting of AP-1 proteins influences cytokine expression and the outcome of arenavirus infections. Journal of General Virology 88: 981-990.
-
(2007)
Journal of General Virology
, vol.88
, pp. 981-990
-
-
Fennewald, S.M.1
Scott, E.P.2
Zhang, L.3
-
51
-
-
33846833901
-
Toxicological overview of impurities in pharmaceutical products
-
Jackson-Kram, D., and T. McGovern. 2007. Toxicological overview of impurities in pharmaceutical products. Advanced Drug Delivery Reviews, 59: 38-42.
-
(2007)
Advanced Drug Delivery Reviews
, vol.59
, pp. 38-42
-
-
Jackson-Kram, D.1
McGovern, T.2
-
52
-
-
33747890096
-
Regulation of genotoxic and carcinogenic impurities in drug substances and products
-
McGovern, T., and D. Jackson-Kram. 2006. Regulation of genotoxic and carcinogenic impurities in drug substances and products. Trends in Analytical Chemistry 25: 790-795.
-
(2006)
Trends in Analytical Chemistry
, vol.25
, pp. 790-795
-
-
McGovern, T.1
Jackson-Kram, D.2
-
53
-
-
33644827201
-
-
Pharmacology and Toxicology
-
U.S. DeparTment of Health and Human Services, FDA (CDER). 2006. Guidance for Industry, Investigators and Reviewers: Exploratory IND Studies, Pharmacology and Toxicology. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM078933.pdf.
-
(2006)
Guidance for Industry, Investigators and Reviewers: Exploratory IND Studies
-
-
-
54
-
-
39449113045
-
2′-Methylseleno-modified oligoribonucleotides for X-ray crystallography synthesized by the ACE RNA solid-phase approach
-
Puffer, B., H. Moroder, M. Aigner, and R. Micura. 2008. 2′-Methylseleno-modified oligoribonucleotides for X-ray crystallography synthesized by the ACE RNA solid-phase approach. Nucleic Acids Research 36: 970-983.
-
(2008)
Nucleic Acids Research
, vol.36
, pp. 970-983
-
-
Puffer, B.1
Moroder, H.2
Aigner, M.3
Micura, R.4
-
55
-
-
0033860560
-
Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction
-
Murray, J. B., H. Szöke, A. Szöke, and W. G. Scott. 2000. Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction. Molecular Cell 5: 279-287.
-
(2000)
Molecular Cell
, vol.5
, pp. 279-287
-
-
Murray, J.B.1
Szöke, H.2
Szöke, A.3
Scott, W.G.4
-
56
-
-
0346158948
-
Why does TNA cross-pair more strongly with RNA than with DNA? An answer from X-ray analysis
-
Pallan, P. S., C. H. Wilds, Z. Wawrzak, R. Krishnamurthy, A. Eschenmoser, and M. Egli. 2003. Why does TNA cross-pair more strongly with RNA than with DNA? An answer from X-ray analysis. Angewandte Chemie (International Edition in English) 42: 5893-5895.
-
(2003)
Angewandte Chemie (International Edition in English)
, vol.42
, pp. 5893-5895
-
-
Pallan, P.S.1
Wilds, C.H.2
Wawrzak, Z.3
Krishnamurthy, R.4
Eschenmoser, A.5
Egli, M.6
-
57
-
-
67349164013
-
Effect of 1-methyladenine on the thermodynamic stabilities of double-helical DNA structures
-
Yang, H., and S. L. Lam. 2009. Effect of 1-methyladenine on the thermodynamic stabilities of double-helical DNA structures. FEBS Letters 583: 1548-1553.
-
(2009)
FEBS Letters
, vol.583
, pp. 1548-1553
-
-
Yang, H.1
Lam, S.L.2
-
58
-
-
0004136246
-
-
2nd ed., Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press
-
Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
-
(1989)
Molecular Cloning: A Laboratory Manual
-
-
Sambrook, J.1
Fritsch, E.F.2
Maniatis, T.3
-
59
-
-
18244414259
-
An improved synthesis of oligodeoxynucleotide N3′-P5′ phosphoramidates and their chimera using hindered phosphoramidite monomers and a novel handle for reverse phase purification
-
Fearon, K. L., B. L. Hirschbein, J. S. Nelson, et al. 1998. An improved synthesis of oligodeoxynucleotide N3′-P5′ phosphoramidates and their chimera using hindered phosphoramidite monomers and a novel handle for reverse phase purification. Nucleic Acids Research 26: 3813-3824.
-
(1998)
Nucleic Acids Research
, vol.26
, pp. 3813-3824
-
-
Fearon, K.L.1
Hirschbein, B.L.2
Nelson, J.S.3
-
60
-
-
85137927287
-
Detection and plasma pharmacokinetics of an anti-vascular endothelial growth factor oligonucleotide-aptamer (NX1838) in rhesus monkeys. Journal of Chromatography B 732: 203-212. Also Bouchard, P. R., R. M. Hutabarat, and K. M. Thompson. 2010. Discovery and development of therapeutic aptamers
-
Tucker, C. E., L.-S. Chen, M. B. Judkins, J. A. Farmer, S. C. Gill, and D. W. Drolet. 1999. Detection and plasma pharmacokinetics of an anti-vascular endothelial growth factor oligonucleotide-aptamer (NX1838) in rhesus monkeys. Journal of Chromatography B 732: 203-212. Also Bouchard, P. R., R. M. Hutabarat, and K. M. Thompson. 2010. Discovery and development of therapeutic aptamers. Annual Review of Pharmacology and Toxicology 50: 237-257.
-
(1999)
Annual Review of Pharmacology and Toxicology
, vol.50
, pp. 237-257
-
-
Tucker, C.E.1
Chen, L.-S.2
Judkins, M.B.3
Farmer, J.A.4
Gill, S.C.5
Drolet, D.W.6
-
61
-
-
33748955961
-
Characterization and sequence verification of thiolated deoxyoligonucleotides used for microarray construction
-
Van Aerschot, A., and J. Rozenski. 2006. Characterization and sequence verification of thiolated deoxyoligonucleotides used for microarray construction. Journal of the American Society for Mass Spectrometry 17: 1396-1400.
-
(2006)
Journal of the American Society for Mass Spectrometry
, vol.17
, pp. 1396-1400
-
-
Van Aerschot, A.1
Rozenski, J.2
-
62
-
-
0037402412
-
A highly efficient and automated method of purifying and desalting PCR products for analysis by electrospray ionization mass spectrometry
-
Jiang, Y., and S. A. Hofstadler. 2003. A highly efficient and automated method of purifying and desalting PCR products for analysis by electrospray ionization mass spectrometry. Analytical Biochemistry 316: 50-57.
-
(2003)
Analytical Biochemistry
, vol.316
, pp. 50-57
-
-
Jiang, Y.1
Hofstadler, S.A.2
-
63
-
-
0034731349
-
A general approach for identification of RNA-protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs)
-
Urlaub, H., K. HarTmuth, S. Kostka, G. Grelle, and R. Lührmann. 2000. A general approach for identification of RNA-protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs). Journal of Biological Chemistry 52: 41458-41468.
-
(2000)
Journal of Biological Chemistry
, vol.52
, pp. 41458-41468
-
-
Urlaub, H.1
HarTmuth, K.2
Kostka, S.3
Grelle, G.4
Lührmann, R.5
-
64
-
-
33644754087
-
Induced fit and “lock and key” recognition of 5S RNA by zinc fingers of transcription factor IIIA
-
Lee, B. M., J. Xu, B. K. Clarkson, M. A. Martinez-Yamout, H. J. Dyson, D. A. Case, J. M. Gottesfeld, and P. E. Wright. 2006. Induced fit and “lock and key” recognition of 5S RNA by zinc fingers of transcription factor IIIA. Journal of Molecular Biology 357: 275-291.
-
(2006)
Journal of Molecular Biology
, vol.357
, pp. 275-291
-
-
Lee, B.M.1
Xu, J.2
Clarkson, B.K.3
Martinez-Yamout, M.A.4
Dyson, H.J.5
Case, D.A.6
Gottesfeld, J.M.7
Wright, P.E.8
-
65
-
-
1842787939
-
Purification of pharmaceutical-grade plasmid DNA by anion-exchange chromatography in and RNAse-free process
-
Eon-Duval, A., and G. Burke. 2004. Purification of pharmaceutical-grade plasmid DNA by anion-exchange chromatography in and RNAse-free process. Journal of Chromatography B 804: 327-335.
-
(2004)
Journal of Chromatography B
, vol.804
, pp. 327-335
-
-
Eon-Duval, A.1
Burke, G.2
-
66
-
-
0036071392
-
Specific phosphorothioate substitutions probe the active site of Bacillus subtilis Ribonuclease P
-
Crary, S. M., J. C. Kurz, and C. A. Fierke. 2002. Specific phosphorothioate substitutions probe the active site of Bacillus subtilis Ribonuclease P. RNA 8: 933-947.
-
(2002)
RNA
, vol.8
, pp. 933-947
-
-
Crary, S.M.1
Kurz, J.C.2
Fierke, C.A.3
-
67
-
-
10744226820
-
Cleavage of DNA without loss of genetic information by incorporation on a disaccharide nucleoside
-
Nauwelaerts, K., K.VasTmans, M. Froeyen, et al. 2003. Cleavage of DNA without loss of genetic information by incorporation on a disaccharide nucleoside. Nucleic Acids Research 31: 6758-6769.
-
(2003)
Nucleic Acids Research
, vol.31
, pp. 6758-6769
-
-
Nauwelaerts, K.1
VasTmans, K.2
Froeyen, M.3
-
68
-
-
0030831236
-
Synthesis and evaluation of oligodeoxyribonucleotides containing an aryl(trifluoromethyl) diazirine moiety as the cross-linking probe: Photoaffinity labeling of mammalian DNA polymerase β
-
Yamaguchi, T., K. Suyama, K. Narita, S. Kohgo, A. Tomikawa, and M. Saneyoshi. 1997. Synthesis and evaluation of oligodeoxyribonucleotides containing an aryl(trifluoromethyl) diazirine moiety as the cross-linking probe: Photoaffinity labeling of mammalian DNA polymerase β. Nucleic Acids Research 25: 2352-2358.
-
(1997)
Nucleic Acids Research
, vol.25
, pp. 2352-2358
-
-
Yamaguchi, T.1
Suyama, K.2
Narita, K.3
Kohgo, S.4
Tomikawa, A.5
Saneyoshi, M.6
-
69
-
-
0034193124
-
Accurate and rapid modeling of iron-bleomycin-induced DNA damage using tethered duplex oligonucleotides and electrospray ionization ion trap mass spectrometric analysis
-
Harsch, A., L. A. Marzill, R. C. Bunt, J. Stubbe, and P. Vouros. 2000. Accurate and rapid modeling of iron-bleomycin-induced DNA damage using tethered duplex oligonucleotides and electrospray ionization ion trap mass spectrometric analysis. Nucleic Acids Research 28: 1978-1995.
-
(2000)
Nucleic Acids Research
, vol.28
, pp. 1978-1995
-
-
Harsch, A.1
Marzill, L.A.2
Bunt, R.C.3
Stubbe, J.4
Vouros, P.5
-
70
-
-
59649090385
-
Structure and dynamics of a DNA-based model system for the study of electron spin-spin interactions
-
Biczo, R., and D. J. Hirsh. 2009. Structure and dynamics of a DNA-based model system for the study of electron spin-spin interactions. Journal of Inorganic Biochemistry 103: 362-372.
-
(2009)
Journal of Inorganic Biochemistry
, vol.103
, pp. 362-372
-
-
Biczo, R.1
Hirsh, D.J.2
-
71
-
-
11444270384
-
Time gating improves sensitivity in energy transfer assays with terbium chelate/dark quencher oligonucleotide probes
-
Johansson, M. K., R. M. Cook, J. Xu, and K. N. Raymond. 2004. Time gating improves sensitivity in energy transfer assays with terbium chelate/dark quencher oligonucleotide probes. Journal of the American Chemical Society 126: 16451-16455.
-
(2004)
Journal of the American Chemical Society
, vol.126
, pp. 16451-16455
-
-
Johansson, M.K.1
Cook, R.M.2
Xu, J.3
Raymond, K.N.4
-
72
-
-
70349388223
-
Versatile synthesis and rational design of caged morpholinos
-
Ouyang, X., I. A. Shestopalov, S. Sinha, G. Zheng, C. L. W. Pitt, W-H. Li, A. J. Olson, and J. K. Chen. 2009. Versatile synthesis and rational design of caged morpholinos. Journal of the American Chemical Society 131: 13255-13269.
-
(2009)
Journal of the American Chemical Society
, vol.131
, pp. 13255-13269
-
-
Ouyang, X.1
Shestopalov, I.A.2
Sinha, S.3
Zheng, G.4
Pitt, C.L.W.5
Li, W.-H.6
Olson, A.J.7
Chen, J.K.8
-
73
-
-
33747194676
-
Cartridge-based high-throughput purification of oligonucleotides for reliable oligonucleotide arrays
-
Semenyuk, A., M. Ahnfelt, C. EsTmer, X. Yong-Hao, A. Földesi, Y.-S. Kao, H.-H. Chen, W.-C. Kao, K. Peck, and M. Kwiatkowski. 2006. Cartridge-based high-throughput purification of oligonucleotides for reliable oligonucleotide arrays. Analytical Biochemistry 356: 132-141.
-
(2006)
Analytical Biochemistry
, vol.356
, pp. 132-141
-
-
Semenyuk, A.1
Ahnfelt, M.2
EsTmer, C.3
Yong-Hao, X.4
Földesi, A.5
Kao, Y.-S.6
Chen, H.-H.7
Kao, W.-C.8
Peck, K.9
Kwiatkowski, M.10
-
74
-
-
0037115879
-
Synthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3′-phosphoglycolate, 5′-phosphate gapped lesion
-
Junker, H-D., S. T. Hoehn, R. C. Bunt, V. Marathius, J. Chen, C. J. Turner, and J. Stubbe. 2002. Synthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3′-phosphoglycolate, 5′-phosphate gapped lesion. Nucleic Acids Research 30: 5497-5508.
-
(2002)
Nucleic Acids Research
, vol.30
, pp. 5497-5508
-
-
Junker, H.-D.1
Hoehn, S.T.2
Bunt, R.C.3
Marathius, V.4
Chen, J.5
Turner, C.J.6
Stubbe, J.7
-
75
-
-
34548426097
-
Interaction of the Family-B DNA polymerase from the archaeon Pyrococcus furiosus with deaminated bases
-
Gill, S., R. O’Neill, R. J. Lewis, and B. A. Connolly. 2007. Interaction of the Family-B DNA polymerase from the archaeon Pyrococcus furiosus with deaminated bases. Journal of Molecular Biology 372: 855-863.
-
(2007)
Journal of Molecular Biology
, vol.372
, pp. 855-863
-
-
Gill, S.1
O’Neill, R.2
Lewis, R.J.3
Connolly, B.A.4
-
76
-
-
65949108217
-
Mechanistic aspects of the formation of guanidinohydantoin from spiroiminodihydantoin under acidic conditions
-
Ye, Y., B. H. Munk, J. G. Muller, A. Cogbill, C. J. Burrows, and B. Schlegel. 2009. Mechanistic aspects of the formation of guanidinohydantoin from spiroiminodihydantoin under acidic conditions. Chemical Research Toxicology 22: 526-535.
-
(2009)
Chemical Research Toxicology
, vol.22
, pp. 526-535
-
-
Ye, Y.1
Munk, B.H.2
Muller, J.G.3
Cogbill, A.4
Burrows, C.J.5
Schlegel, B.6
-
77
-
-
14844286411
-
Combination reactions of superoxide with 8-oxo-7, 8-dihydroguanine radicals in DNA
-
Misiaszek, R., Y. Uvaydov, C. Crean, N. E. Geacintov, and V. Shafirovich. 2005. Combination reactions of superoxide with 8-oxo-7, 8-dihydroguanine radicals in DNA. Journal of Biological Chemistry 280: 6293-6300.
-
(2005)
Journal of Biological Chemistry
, vol.280
, pp. 6293-6300
-
-
Misiaszek, R.1
Uvaydov, Y.2
Crean, C.3
Geacintov, N.E.4
Shafirovich, V.5
-
78
-
-
60049093573
-
Design synthesis and anti-HIC activity of 4′-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors
-
Boojamra, C. G., J. P. Parrish, D. Sperandio, et al. 2009. Design synthesis and anti-HIC activity of 4′-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors. Bioorganic and Medicinal Chemistry 17: 1739-1746.
-
(2009)
Bioorganic and Medicinal Chemistry
, vol.17
, pp. 1739-1746
-
-
Boojamra, C.G.1
Parrish, J.P.2
Sperandio, D.3
-
79
-
-
0033556120
-
The crystal structure of the RNA/DNA hybrid rGAAGAGAAGC.d(GCTTCTCTTC) shows significant differences to that found in solution
-
Conn, G. L., T. Brown, and G. A. Leonard. 1999. The crystal structure of the RNA/DNA hybrid rGAAGAGAAGC.d(GCTTCTCTTC) shows significant differences to that found in solution. Nucleic Acids Research 27: 555-561.
-
(1999)
Nucleic Acids Research
, vol.27
, pp. 555-561
-
-
Conn, G.L.1
Brown, T.2
Leonard, G.A.3
-
80
-
-
0037036357
-
Plasticity of recognition of the 3′-end of mischarged tRNA by class-I aminoacyl-tRNA synthetases
-
Nordin, B. E., and P. Schimmel. 2002. Plasticity of recognition of the 3′-end of mischarged tRNA by class-I aminoacyl-tRNA synthetases. Journal of Biological Chemistry 277: 20510-20517.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 20510-20517
-
-
Nordin, B.E.1
Schimmel, P.2
-
81
-
-
63249135046
-
Aminoacyl-tRNA recognition by the FemXWv transferase for bacterial cell wall synthesis
-
Fonvielle, M., M. Chemama, R. Villet, M. Lecerf, A. Bouhss, J-M. Valéry, M. Ethève-Quelquejeu, and M. Arthur. 2009. Aminoacyl-tRNA recognition by the FemXWv transferase for bacterial cell wall synthesis. Nucleic Acids Research 37: 1589-1601.
-
(2009)
Nucleic Acids Research
, vol.37
, pp. 1589-1601
-
-
Fonvielle, M.1
Chemama, M.2
Villet, R.3
Lecerf, M.4
Bouhss, A.5
Valéry, J.-M.6
Ethève-Quelquejeu, M.7
Arthur, M.8
-
83
-
-
33746410027
-
Structural basis for specificity in the Poxvirus topoisomerase
-
Perry, K., Y. Hwang, F. D. Bushman, and G. D. Van Duyne. 2006. Structural basis for specificity in the Poxvirus topoisomerase. Molecular Cell 213: 343-354.
-
(2006)
Molecular Cell
, vol.213
, pp. 343-354
-
-
Perry, K.1
Hwang, Y.2
Bushman, F.D.3
Van Duyne, G.D.4
-
84
-
-
14844300910
-
Albumin-protamine-oligonucleotide nanoparticles as a new antisense delivery system. Part 1: Physicochemical characterization
-
Lochmann, D., J. Weyermann, C. Georgens, R. Prassl, and A. Zimmer. 2005. Albumin-protamine-oligonucleotide nanoparticles as a new antisense delivery system. Part 1: Physicochemical characterization. European Journal of Pharmaceuticals and Biopharmaceuticals 59: 419-429.
-
(2005)
European Journal of Pharmaceuticals and Biopharmaceuticals
, vol.59
, pp. 419-429
-
-
Lochmann, D.1
Weyermann, J.2
Georgens, C.3
Prassl, R.4
Zimmer, A.5
-
85
-
-
0025859180
-
Identification of amino acids in lac repressor protein cross-linked to operator DNA specifically substituted with bromodeoxyuridine
-
Allen T. D., K. L. Wick, and K. S. Matthews. 1991. Identification of amino acids in lac repressor protein cross-linked to operator DNA specifically substituted with bromodeoxyuridine. Journal of Biological Chemistry 266: 6113-6119.
-
(1991)
Journal of Biological Chemistry
, vol.266
, pp. 6113-6119
-
-
Allen, T.D.1
Wick, K.L.2
Matthews, K.S.3
-
86
-
-
55849140201
-
A molecular ruler for measuring quantitative distance distributions
-
Matthew-Fenn, R. S., R. Das, J. A. Silverman, P. A. Walker, and P. A. B. Harbury. 2008. A molecular ruler for measuring quantitative distance distributions. PLoS ONE 3(10): e3229. doi:10.1371/journal.pone.0003229.
-
(2008)
PLoS ONE
, vol.3
, Issue.10
-
-
Matthew-Fenn, R.S.1
Das, R.2
Silverman, J.A.3
Walker, P.A.4
Harbury, P.A.B.5
-
87
-
-
84859338859
-
Continuous rods of macroporous polymer as high-performance liquid chromatography separation media
-
Svec, F., and J. M. J. Frechet. 1992. Continuous rods of macroporous polymer as high-performance liquid chromatography separation media. Analytical Chemistry 64: 820-822.
-
(1992)
Analytical Chemistry
, vol.64
, pp. 820-822
-
-
Svec, F.1
Frechet, J.M.J.2
-
88
-
-
0032081289
-
Molded rigid polymer monoliths as separation media for capillary electrochromatography. 2. Effect of chromatographic conditions on the separation
-
Peters, E. C., M. Petro, F. Svec, and J. M. J. Frechet. 1998. Molded rigid polymer monoliths as separation media for capillary electrochromatography. 2. Effect of chromatographic conditions on the separation. Analytical Chemistry 70: 2296-2302.
-
(1998)
Analytical Chemistry
, vol.70
, pp. 2296-2302
-
-
Peters, E.C.1
Petro, M.2
Svec, F.3
Frechet, J.M.J.4
-
89
-
-
33645656958
-
Monolithic materials: Promises, challenges, achievements
-
Svec, F., and C. G. Huber. 2006. Monolithic materials: promises, challenges, achievements. Analytical Chemistry 78: 2100-2107.
-
(2006)
Analytical Chemistry
, vol.78
, pp. 2100-2107
-
-
Svec, F.1
Huber, C.G.2
-
90
-
-
61449251703
-
Separation of hypoviral double-stranded RNA on monolithic chromatographic supports
-
Perica, M. C., I. Sola, L. Urbas, F. Smrekar, and M. Krajacic. 2009. Separation of hypoviral double-stranded RNA on monolithic chromatographic supports. Journal of Chromatography A 1216: 2712-2716.
-
(2009)
Journal of Chromatography A
, vol.1216
, pp. 2712-2716
-
-
Perica, M.C.1
Sola, I.2
Urbas, L.3
Smrekar, F.4
Krajacic, M.5
-
91
-
-
77950299213
-
New monolith technology for automated anion-exchange purification of nucleic acids
-
Thayer, J. R., K. J. Flook, A. Woodruff, S. Rao, and C. A. Pohl. 2010. New monolith technology for automated anion-exchange purification of nucleic acids. Journal of Chromatography B, 878: 933-941, doi:10.1016/j.jchromb.2010.01.030.
-
(2010)
Journal of Chromatography B
, vol.878
, pp. 933-941
-
-
Thayer, J.R.1
Flook, K.J.2
Woodruff, A.3
Rao, S.4
Pohl, C.A.5
-
93
-
-
13644252225
-
Control of oligonucleotide retention on a pH-stabilized strong anion exchange column
-
Thayer, J. R., V. Barreto, S. Rao, and C. Pohl. 2005. Control of oligonucleotide retention on a pH-stabilized strong anion exchange column. Analytical Biochemistry 338: 39-47.
-
(2005)
Analytical Biochemistry
, vol.338
, pp. 39-47
-
-
Thayer, J.R.1
Barreto, V.2
Rao, S.3
Pohl, C.4
-
94
-
-
0027973464
-
Separation and characterization of diastereoisomers of antisense oligodeoxyribonucleoside phosphorothioates
-
Murakami, A., Y. Tamura, H. Wada, and K. Makino. 1994. Separation and characterization of diastereoisomers of antisense oligodeoxyribonucleoside phosphorothioates. Analytical Biochemistry 223: 285-290.
-
(1994)
Analytical Biochemistry
, vol.223
, pp. 285-290
-
-
Murakami, A.1
Tamura, Y.2
Wada, H.3
Makino, K.4
-
95
-
-
0028109614
-
Synthesis and properties of oligothymidylate analogs containing stereoregulated phosphorothioate and phosphodiester linkages in an alternating manner
-
Patil, S. V., B. Mane, and M. M. Salunkhe. 1994. Synthesis and properties of oligothymidylate analogs containing stereoregulated phosphorothioate and phosphodiester linkages in an alternating manner. Bioorganic and Medicinal Chemistry Letters 4: 2663-2666.
-
(1994)
Bioorganic and Medicinal Chemistry Letters
, vol.4
, pp. 2663-2666
-
-
Patil, S.V.1
Mane, B.2
Salunkhe, M.M.3
-
96
-
-
0032559980
-
Solid phase stereoselective synthesis of oligonucleoside phosphorothioates: The nucleoside bicyclic oxazaphospholidines as novel synthons
-
Iyer, R. P., M.-J. Guo, D. Yu, and S. Agrawal. 1998. Solid phase stereoselective synthesis of oligonucleoside phosphorothioates: The nucleoside bicyclic oxazaphospholidines as novel synthons. Tetrahedron Letters 39: 2491-2494.
-
(1998)
Tetrahedron Letters
, vol.39
, pp. 2491-2494
-
-
Iyer, R.P.1
Guo, M.-J.2
Yu, D.3
Agrawal, S.4
-
97
-
-
85137919108
-
Separation of oligonucleotide phosphorothioate diastereoisomers by anion-exchange chromatography
-
preparation
-
J. R. Thayer, Y. Wu, E. Hansen, M. D. Angelino, and S. Rao. 2010. Separation of oligonucleotide phosphorothioate diastereoisomers by anion-exchange chromatography. Analytical Chemistry. In preparation.
-
(2010)
Analytical Chemistry
-
-
Thayer, J.R.1
Wu, Y.2
Hansen, E.3
Angelino, M.D.4
Rao, S.5
-
98
-
-
55549089296
-
Selectivity and affinity of DNA triplex forming oligonucleotides containing the nucleoside analogues 2′-O-methyl-5-(3-amino-1-propynyl)uridine and 2′-O-methyl-5-propynyluridine
-
Li, H., P. S. Miller, and M. M. Seidman. 2008. Selectivity and affinity of DNA triplex forming oligonucleotides containing the nucleoside analogues 2′-O-methyl-5-(3-amino-1-propynyl)uridine and 2′-O-methyl-5-propynyluridine. Organic and Biomolecular Chemistry 6: 4212-4217.
-
(2008)
Organic and Biomolecular Chemistry
, vol.6
, pp. 4212-4217
-
-
Li, H.1
Miller, P.S.2
Seidman, M.M.3
-
99
-
-
34547638949
-
Synthesis and investigation of deoxyribonucleic acid/locked nucleic acid chimeric molecular beacons
-
Yang, C. J., L. Wang, Y. Wu, Y. Kim, C. D. Medley, H. Lin, and W. Tan. 2007. Synthesis and investigation of deoxyribonucleic acid/locked nucleic acid chimeric molecular beacons. Nucleic Acids Research 35: 4030-4041.
-
(2007)
Nucleic Acids Research
, vol.35
, pp. 4030-4041
-
-
Yang, C.J.1
Wang, L.2
Wu, Y.3
Kim, Y.4
Medley, C.D.5
Lin, H.6
Tan, W.7
-
100
-
-
65349089004
-
2′-Deoxy-1-methylpseudocytidine, a stable analog of 2′-deoxy-5-methylisocytidine
-
Kim, H.-J., N. A. Leal, and S. A. Benner. 2009. 2′-Deoxy-1-methylpseudocytidine, a stable analog of 2′-deoxy-5-methylisocytidine. Bioorganic and Medicinal Chemistry 17: 3728-3732.
-
(2009)
Bioorganic and Medicinal Chemistry
, vol.17
, pp. 3728-3732
-
-
Kim, H.-J.1
Leal, N.A.2
Benner, S.A.3
-
101
-
-
0024213241
-
Computer-assisted retention prediction system for oligonucleotides in gradient anion-exchange chromatography
-
Baba, Y., M. Fukuda, and N. Yoza. 1988. Computer-assisted retention prediction system for oligonucleotides in gradient anion-exchange chromatography. Journal of Chromatography 458: 385-394.
-
(1988)
Journal of Chromatography
, vol.458
, pp. 385-394
-
-
Baba, Y.1
Fukuda, M.2
Yoza, N.3
-
102
-
-
70349147840
-
RNA interference-mediated silencing of the respiratory syncytial virus nucleocapsid defines a potent antiviral strategy
-
Alvarez, R., S. Elbashir, T. Borland, et al. 2009. RNA interference-mediated silencing of the respiratory syncytial virus nucleocapsid defines a potent antiviral strategy. Antimicrobial Agents and Chemotherapy 53: 3952-3962.
-
(2009)
Antimicrobial Agents and Chemotherapy
, vol.53
, pp. 3952-3962
-
-
Alvarez, R.1
Elbashir, S.2
Borland, T.3
-
104
-
-
67349183756
-
Development of lipidoid-siRNA formulations for systemic delivery to the liver
-
Akinc, A., M. Goldberg, J. Qin, et al. 2009. Development of lipidoid-siRNA formulations for systemic delivery to the liver. Molecular Therapy 17: 872-879.
-
(2009)
Molecular Therapy
, vol.17
, pp. 872-879
-
-
Akinc, A.1
Goldberg, M.2
Qin, J.3
-
105
-
-
41849149676
-
RNAi therapeutics: An update on delivery
-
Nguyen, T., E. M. Menocal, J. Harborth, and J. H. Fruehauf. 2008. RNAi therapeutics: an update on delivery. Current Opinions in Molecular Therapeutics 10: 158-167.
-
(2008)
Current Opinions in Molecular Therapeutics
, vol.10
, pp. 158-167
-
-
Nguyen, T.1
Menocal, E.M.2
Harborth, J.3
Fruehauf, J.H.4
-
106
-
-
0032578383
-
Moieties in an RNA promoter specifically recognized by a viral RNA-dependent RNA polymerase
-
Siegel, R. W., L. Bellon, L. Beigelman, and C. C. Kao. 1998. Moieties in an RNA promoter specifically recognized by a viral RNA-dependent RNA polymerase. Proceedings of the National Academy of Sciences of the United States of America 95: 11613-11618.
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, pp. 11613-11618
-
-
Siegel, R.W.1
Bellon, L.2
Beigelman, L.3
Kao, C.C.4
-
107
-
-
2942512191
-
High-throughput analysis of oligonucleotides using automated electrospray ionization mass spectrometry
-
Hail, M., B. Elliot, and K. Anderson. 2004. High-throughput analysis of oligonucleotides using automated electrospray ionization mass spectrometry. American Biotechnology Laboratory 22:12-14.
-
(2004)
American Biotechnology Laboratory
, vol.22
, pp. 12-14
-
-
Hail, M.1
Elliot, B.2
Anderson, K.3
-
108
-
-
77649188794
-
Identification of RNA linkage isomers by anion-exchange purification with ESI-MS of automatically desalted phosphodiesterase-II digests
-
Thayer, J. R., N. Puri, C. Burnett, M. E. Hail, and S. Rao. 2010. Identification of RNA linkage isomers by anion-exchange purification with ESI-MS of automatically desalted phosphodiesterase-II digests. Analytical Biochemistry 399: 110-117.
-
(2010)
Analytical Biochemistry
, vol.399
, pp. 110-117
-
-
Thayer, J.R.1
Puri, N.2
Burnett, C.3
Hail, M.E.4
Rao, S.5
-
109
-
-
0017280605
-
A conformational study of adenylyl-(3′, 5′)-adenosine and adenylyl-(2′, 5′)-adenosine in aqueous solution by carbon-13 magnetic resonance spectroscopy
-
Schleich, T., B. P. Cross, and I. C. P. Smith. 1976. A conformational study of adenylyl-(3′, 5′)-adenosine and adenylyl-(2′, 5′)-adenosine in aqueous solution by carbon-13 magnetic resonance spectroscopy. Nucleic Acids Research 3: 355-370.
-
(1976)
Nucleic Acids Research
, vol.3
, pp. 355-370
-
-
Schleich, T.1
Cross, B.P.2
Smith, I.C.P.3
-
110
-
-
58849147582
-
Detection of aberrant 2′-5′ linkages in RNA by anion exchange
-
ed. S. Beaucage, 10.13.1-11. New York: Wiley Interscience
-
Thayer, J. R., S. Rao, and N. Puri. 2008. Detection of aberrant 2′-5′ linkages in RNA by anion exchange. In Current Protocols in Nucleic Acid Chemistry, ed. S. Beaucage, 10.13.1-11. New York: Wiley Interscience.
-
(2008)
Current Protocols in Nucleic Acid Chemistry
-
-
Thayer, J.R.1
Rao, S.2
Puri, N.3
|