An aptamer that neutralizes R5 strains of HIV-1 binds to core residues of gp120 in the CCR5 binding site

Virology

Volumn 381, Issue 1, 2008, Pages 46-54

  Cohen, Carla ^a   Forzan, Mario ^a   Sproat, Brian ^b   Pantophlet, Ralph ^c   McGowan, Ian ^d   Burton, Dennis ^c   James, William ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b INTEGRATED DNA TECHNOLOGIES   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Aptamer; Coreceptor; gp120; HIV 1; Microbicide; Neutralization

Indexed keywords

ALANINE; APTAMER; APTAMER B40; CD4 ANTIBODY; CHEMOKINE RECEPTOR CCR5; GLYCOPROTEIN GP 120; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEIC ACID STRUCTURE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; VIRUS ISOLATION; VIRUS NEUTRALIZATION; VIRUS STRAIN;

ANTI-HIV AGENTS; BINDING SITES; CELLS, CULTURED; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; RECEPTORS, CCR5; RNA;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 54049134705     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2008.08.025     Document Type: Article

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