Design, synthesis, and anti-HIV activity of 4′-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 4, 2009, Pages 1739-1746

  Boojamra, Constantine G ^a   Parrish, Jay P ^a   Sperandio, David ^a   Gao, Ying ^a   Petrakovsky, Oleg V ^a   Lee, Sharon K ^a   Markevitch, David Y ^a   Vela, Jennifer E ^a   Laflamme, Genevieve ^a   Chen, James M ^a   Ray, Adrian S ^a   Barron, Abraham C ^a   Sparacino, Mark L ^a   Desai, Manoj C ^a   Kim, Choung U ^a   Cihlar, Tomas ^a   Mackman, Richard L ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

Antiviral; Antiviral therapy; Carbocyclic nucleosides; Diphosphophosphonate; HIV treatment; Nucleosides; Nucleotides; Phosphorylation; Reverse transcriptase; Reverse transcriptase inhibitors

Indexed keywords

2',3' DIDEHYDRO 2',3' DIDEOXY 2' FLUORO 5' O PHOSPHONOMETHYLADENOSINE; 4 (6 AMINO 9H PURIN 9 YL) 1 ETHYNYLCYCLOPENT 2 ENYLOXY)METHYLPHOSPHONIC ACID; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CARBOCYCLIC NUCLEOSIDE; CARBOCYCLIC NUCLEOSIDE PHOSPHONATE DERIVATIVE; DRUG METABOLITE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TENOFOVIR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; NONHUMAN; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANTI-HIV AGENTS; CELL LINE, TUMOR; DRUG DESIGN; HIV REVERSE TRANSCRIPTASE; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEOSIDES; PHOSPHONIC ACIDS; PRODRUGS; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 60049093573     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.12.028     Document Type: Article

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