Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation

Cancer Science

Volumn 102, Issue 6, 2011, Pages 1115-1122

  Yokoyama, Takashi ^a   Nakamura, Takuro ^a  

^a CANCER INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ADAPTOR PROTEIN; CCAAT ENHANCER BINDING PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN TRIBBLES; UNCLASSIFIED DRUG;

CELL FUNCTION; CELL TRANSFORMATION; HOMEOSTASIS; LEUKEMIA; LEUKEMOGENESIS; METABOLIC DISORDER; NEUROLOGIC DISEASE; ONCOGENE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; TRIB 1 GENE; TRIB 2 GENE;

ANIMALS; CARDIOVASCULAR DISEASES; CCAAT-ENHANCER-BINDING PROTEINS; CELL CYCLE PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; DROSOPHILA; DROSOPHILA PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; METABOLIC DISEASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 79956220948     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2011.01914.x     Document Type: Review

References (75)

1. Braun BS, Shannon K. Targeting Ras in myeloid leukemias. Clin Cancer Res 2008; 8: 2249-52.
2. Johnson PF. Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors. J Cell Sci 2005; 118: 2545-55.
3. Nerlov C. C/EBPα mutations in acute myeloid leukaemias. Nat Rev Cancer 2004; 4: 394-400.
4. Grosshans J, Wieschaus E. A genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila. Cell 2000; 101: 523-31.
5. Mata J, Curado S, Ephrussi A, Rorth P. Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating String/CDC25 proteolysis. Cell 2000; 101: 511-22.
6. Seher TC, Leptin M. Tribbles, a cell-cycle brake that coordinates proliferation and morphogenesis during Drosophila gastrulation. Curr Biol 2000; 10: 623-9.
7. Nabel-Rosen H, Toledano-Katchalski H, Volohonsky G, Volk T. Cell divisions of the Drosophila embryonic mesoderm are repressed via posttranscriptional regulation of string/cdc25 by HOW. Curr Biol 2005; 15: 295-302.
8. Wilkin F, Suarez-Huerta N, Robaye B et al. Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells. Eur J Biochem 1997; 248: 660-8.
9. Mayumi-Matsuda K, Kojima S, Suzuki H, Sakata T. Identification of a novel kinase-like gene induced during neuronal cell death. Biochem Biophys Res Commun 1999; 258: 260-4.
10. Tang K, Finley RL, Nie D, Honn KV. Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening. Biochemistry 2000; 39: 3185-91.
11. Hanks SK, Hunter T. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J 1995; 9: 576-96.
12. Hegedus Z, Czibula A, Kiss-Toth E. Tribbles: a family of kinase-like proteins with potent signaling regulatory function. Cell Signal 2007; 19: 238-50.
13. Qi L, Heredia JE, Altarejoz JY et al. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 2006; 312: 1763-6.
14. Yokoyama T, Kanno Y, Yamazaki Y et al. Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis. Blood, 2010; 116: 2768-75.
15. Imajo M, Nishida E. Human tribbles homolog 1 functions as a negative regulator of retinoic acid receptor. Genes Cells 2010; 15: 1089-97.
16. Rorth P, Szabo K, Texido G. The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation. Mol Cell 2000; 6: 23-30.
17. Keeshan K, He Y, Wouters BJ et al. Tribbles homolog 2 inactivates C/EBPα and causes acute myelogenous leukemia. Cancer Cell 2006; 10: 401-11.
18. Naiki T, Saijou E, Miyaoka Y, Sekine K, Miyajima A. TRB2, a mouse tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPβ. J Biol Chem 2007; 282: 24075-82.
19. Yamamoto M, Uematsu S, Okamoto T et al. Enhancer TLR-mediated NF-IL6-dependent gene expression by Trib1 deficiency. J Exp Med 2007; 204: 2233-9.
20. Selim E, Frkanec JT, Cunard R. Fibrates upregulate TRB3 in lymphocytes independent of PPARα by augmenting CCAAT/enhancer-binding proteinβ (C/EBPβ) expression. Mol Immunol 2007; 44: 1218-29.
21. Ord D, Ord T. Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions. Biochem Biophys Res Commun 2005; 330: 210-8.
22. Ohoka N, Yoshii S, Hattori T, Onozaki K, Hayashi H. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J 2005; 24: 1243-55.
23. Ohoka N, Hattori T, Kitagawa M, Onozaki K, Hayashi H. Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. J Biol Chem 2007; 282: 35687-94.
24. Rutkowski DT, Kaufman RJ. A trip to the ER: coping with stress. Trends Cell Biol 2004; 14: 20-8.
25. Bowers AJ, Scully S, Boylan JF. SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia. Oncogene 2003; 22: 2823-35.
26. He L, Marecki JC, Serrero G, Simmen FA, Ronis MJJ, Badger TM. Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health. Mol Endocrinol 2007; 21: 2541-50.
27. Ord D, Ord T. Mouse NIPK interacts with ATF4 and affects its transcriptional activity. Exp Cell Res 2003; 286: 308-20.
28. Jousse C, Deval C, Maurin AC et al. TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feed back on the ATF4 pathway. J Biol Chem 2007; 282: 15851-61.
29. Kiss-Toth E, Bagstaff SM, Sung HY et al. Human Tribbles, a protein family controlling mitogen-activated protein kinase cascades. J Biol Chem 2004; 279: 42703-8.
30. Jin G, Yamazaki Y, Takuwa M et al. Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis. Blood 2007; 109: 3998-4005.
31. Kiss-Toth E, Wyllie DH, Holland K et al. Functional mapping and identification of novel regulators for the Toll/Interleukin-1 signalling network by transcription expression cloning. Cell Signal 2006; 18: 202-14.
32. Sung HY, Guan H, Czibula A et al. Human Tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways. J Biol Chem 2007; 282: 18379-87.
33. Sung HY, Francis SE, Crossman DC, Kiss-Toth E. Regulation of expression and signaling modulator function of mammalian tribbles is cell-type specific. Immunol Lett 2006; 104: 171-7.
34. Eder K, Guan H, Sung HY et al. Tribbles-2 is a novel regulator of inflammatory activation of monocytes. Int Immunol 2008; 20: 1543-50.
35. Pujol N, Cypowyj S, Ziegler K et al. Distinct innate immune responses to infection and wounding in the C. elegans epidermis. Curr Biol 2008; 18: 481-9.
36. Chan MC, Nguyen PH, Davis BN et al. A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor. Mol Cell Biol 2007; 27: 5776-89.
37. Wu M, Xu LG, Zhai Z, Shu HB. SINK is a p65-interacting negative regulator of NF-κB-dependent transcription. J Biol Chem 2003; 278: 27072-9.
38. Xu J, Lv S, Qin Y et al. TRB3 interacts with CtIP and is overexpressed in certain cancers. Biochim Biophys Acta 2007; 1770: 273-8.
39. Nakamura T. Retroviral insertional mutagenesis identifies oncogene cooperation. Cancer Sci 2005; 96: 7-12.
40. Keeshan K, Shestova O, Ussin L, Pear WS. Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia. Blood Cells Mol Dis 2008; 40: 119-21.
41. Argiropoulos B, Palmqvist L, Yung E et al. Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3. Exp Hematol 2008; 36: 845-59.
42. Keeshan K, Dedhia PH, Vega ME et al. Transformation by Tribbles homologue 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood 2010; 116: 4948-57.
43. Dedhia PH, Keeshan K, Uljon S et al. Differential ability of Tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemia. Blood 2010; 116: 1321-8.
44. Eiring AM, Harb JG, Neviani P et al. miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell 2010; 140: 652-65.
45. Radomska HS, Basseres DS, Zheng R et al. Block of C/EBPα function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations. J Exp Med 2006; 203: 371-81.
46. Storlazzi CT, Fioretos T, Surace C et al. MYC-containing double minutes in hematologic malignancies: evidence in favor of the episome model and exclusion of MYC as the target gene. Hum Mol Genet 2006; 15: 933-42.
47. Rothlisberger B, Heizmann M, Bargetzi MJ, Huber AR. TRIB1 overexpression in acute myeloid leukemia. Cancer Genet Cytogenet 2007; 176: 58-60.
48. Jones L, Wei G, Sevcikova S et al. Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia. J Exp Med 2010; 207: 2581-94.
49. Kanezaki R, Toki T, Terui K et al. Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia. Blood 2010; 116: 4631-8.
50. Huang Z, Dore LC, Li Z et al. GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Mol Cell Biol 2009; 29: 5168-80.
51. Yin B, Delwel R, Valk PJ et al. A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene. Blood 2009; 113: 1075-85.
52. Zhou Y, Li L, Liu Q et al. E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3. Cell Signal 2008; 20: 942-8.
53. Miyoshi N, Ishii H, Mimori K et al. Abnormal expression of TRIB3 in colorectal cancer: a novel marker for prognosis. Br J Cancer 2009; 10: 1664-70.
54. Zanella F, Renner O, Garcia B et al. Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells. Oncogene 2010; 29: 2973-82.
55. Du K, Herzig S, Kulkarni RN, Montminy M. TRB3: a tribbles homolog that inhibits AKT/PKB activation by insulin in liver. Science 2003; 300: 1574-7.
56. Humphrey RK, Newcomb CJ, Yu SMA et al. Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells. J Biol Chem 2010; 285: 22426-36.
57. Koo SH, Satoh H, Herzig S et al. PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3. Nat Med 2004; 10: 530-4.
58. Takahashi Y, Ohoka N, Hayashi H, Sato R. TRB3 suppresses adipocyte differentiation by negatively regulating PPARγ transcriptional activity. J Lipid Res 2008; 49: 880-92.
59. Prudente S, Hribal ML, Flex E et al. The functional Q84R polymorphism of mammalian tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy. Diabetes 2005; 54: 2807-11.
60. De Cosmo S, Prudente S, Andreozzi F et al. Glutamine to arginine substitution at amino acid 84 of mammalian Tribbles homolog TRIB3 and CKD in whites with type 2 diabetes. Am J Kidney Dis 2007; 50: 688-9.
61. Liew CW, Bochenski J, Kawamori D et al. The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse β cells. J Clin Invest 2010; 120: 2876-88.
62. Formoso G, Di Tomo P, Andreozzi F et al. The TRIB3 R84 variant is associated with increased carotid intima-media thickness in vivo and with enhanced MAPK signalling in human endothelial cells. Cardiovasc Res 2011; 89: 184-92.
63. Deng J, James CH, Patel L et al. Human tribbles homologue 2 is expressed in unstable regions of carotid plaques and regulates macrophage IL-10 in vitro. Clin Sci 2009; 116: 241-8.
64. Eder K, Guan H, Sung HY, Francis SE, Crossman DC, Kiss-Toth E. LDL uptake by monocytes in response to inflammation is MAPK dependent but independent of tribbles protein expression. Immunol Lett 2008; 116: 178-83.
65. Ostertag A, Jones A, Rose AJ et al. Control of adipose tissue inflammation through TRB1. Diabetes 2010; 59: 1991-2000.
66. Burkhardt R, Toh SA, Lagor WR et al. Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. J Clin Invest 2010; 120: 4410-4.
67. Tang M, Zhong M, Shang Y et al. Differential regulation of collagen types I and III expression in cardiac fibroblasts by AGEs through TRB3/MAPK signaling pathway. Cell Mol Life Sci 2008; 65: 2924-32.
68. Okamoto H, Latres E, Liu R et al. Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis. Diabetes 2007; 56: 1350-6.
69. Avery J, Etzion S, DeBosch BJ et al. TRB3 function in cardiac endoplasmic reticulum stress. Circ Res 2010; 106: 1516-23.
70. Park KW, Waki H, Kim WK et al. The small molecule phenamil induces osteoblast differentiation and mineralization. Mol Cell Biol 2009; 29: 3905-14.
71. Chan MC, Weisman AS, Kang H et al. The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the BMP signaling pathway. Mol Cell Biol 2011; 31: 517-30.
72. Zhang Y, Davis JL, Li W. Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display. Mol Immunol 2005; 42: 1275-81.
73. Cvetkovic-Lopes V, Bayer L, Dorsaz S et al. Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. J Clin Invest 2010; 120: 713-9.
74. Cravero JD, Carlson CS, Im HJ, Yammani RR, Long D, Loeser RF. Increased expression of the AKT/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Arthritis Rheum 2009; 60: 492-500.
75. Takasato M, Kobayashi C, Okabayashi K et al. Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development. Biochem Biophys Res Commun 2008; 373: 648-52.