TRB3 suppresses adipocyte differentiation by negatively regulating PPARγ transcriptional activity

Journal of Lipid Research

Volumn 49, Issue 4, 2008, Pages 880-892

  Takahashi, Yu ^a   Ohoka, Nobumichi ^a,b   Hayashi, Hidetoshi ^c   Sato, Ryuichiro ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b Basic Research Activities for Innovative Biosciences   (Japan)

^c NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Perilipin; Peroxisome proliferator activated receptor ; Tribbles homolog 3; Triglyceride 3T3 L1

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN HOMOLOGOUS PROTEIN; LENTIVIRUS VECTOR; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; REGULATOR PROTEIN; TRIACYLGLYCEROL; TRIBBLES HOMOLOG 3 PROTEIN; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; PROTEIN SERINE THREONINE KINASE; REPRESSOR PROTEIN; TRB3 PROTEIN, MOUSE; TRIB3 PROTEIN, HUMAN;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; TRANSCRIPTION REGULATION; TRIBBLES HOMOLOG 3 GENE; ANIMAL; CELL LINE; CYTOLOGY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM;

ADIPOCYTES; ANIMALS; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL LINE; HUMANS; MICE; PPAR GAMMA; PROTEIN-SERINE-THREONINE KINASES; REPRESSOR PROTEINS; RNA INTERFERENCE; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 44949098710     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M700545-JLR200     Document Type: Article

References (36)

1. Matsuzawa, Y., T. Funahashi, and T. Nakamura. 1999. Molecular mechanism of metabolic syndrome X: contribution of adipocytokines, adipocytes-derived bioactive substances. Ann. N. Y. Acad. Sci. 892: 146-154.
2. Wajchenberg, B. L. 2000. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr. Rev. 21: 697-738.
3. Hotamisligil, G. S., N. S. Shargill, and B. M. Spiegelman. 1993. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 259: 87-91.
4. Lin, F. T., and M. D. Lane. 1994. CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc. Natl. Acad. Sci. USA. 91: 8757-8761.
5. Tontonoz, P., E. Hu, and B. M. Spiegelman. 1994. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 79: 1147-1156.
6. Tontonoz, P., R. A. Graves, A. I. Budavari, H. Erdjument-Bromage, M. Lui, E. Hu, P. Tempst, and B. M. Spiegelman. 1994. Adipocyte- specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha. Nucleic Acids Res. 22: 5628-5634.
7. Mukherjee, R., L. Jow, G. E. Croston, and J. R. Paterniti, Jr. 1997. Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPAR- gamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists. J. Biol. Chem. 272: 8071-8076.
8. Chawla, A., J. J. Repa, R. M. Evans, and D. J. Mangelsdorf. 2001. Nuclear receptors and lipid physiology: opening the X-files. Science. 294: 1866-1870.
9. Gregoire, F. M., C. M. Smas, and H. S. Sul. 1998. Understanding adipocyte differentiation. Physiol. Rev. 78: 783-809.
10. Kim, J. B., and B. M. Spiegelman. 1996. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev. 10: 1096-1107.
11. Tontonoz, P., J. B. Kim, R. A. Graves, and B. M. Spiegelman. 1993. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol. Cell. Biol. 13: 4753-4759.
12. Foretz, M., C. Pacot, I. Dugail, P. Lemarchand, C. Guichard, X. Le Liepvre, C. Berthelier-Lubrano, B. Spiegelman, J. B. Kim, P. Ferre, et al. 1999. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Mol. Cell. Biol. 19: 3760-3768.
13. Kim, J. B., P. Sarraf, M. Wright, K. M. Yao, E. Mueller, G. Solanes, B. B. Lowell, and B. M. Spiegelman. 1998. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J. Clin. Invest. 101: 1-9.
14. Fajas, L., K. Schoonjans, L. Gelman, J. B. Kim, J. Najib, G. Martin, J. C. Fruchart, M. Briggs, B. M. Spiegelman, and J. Auwerx. 1999. Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol. Cell. Biol. 19: 5495-5503.
15. Kim, J. B., H. M. Wright, M. Wright, and B. M. Spiegelman. 1998. ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand. Proc. Natl. Acad. Sci. USA. 95: 4333-4337.
16. Du, K., S. Herzig, R. N. Kulkarni, and M. Montminy. 2003. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science. 300: 1574-1577.
17. Kato, S., and K. Du. 2007. TRB3 modulates C2C12 differentiation by interfering with Akt activation. Biochem. Biophys. Res. Commun. 353: 933-938.
18. Ohoka, N., S. Yoshii, T. Hattori, K. Onozaki, and H. Hayashi. 2005. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J. 24: 1243-1255.
19. Schwarzer, R., S. Dames, D. Tondera, A. Klippel, and J. Kaufmann. 2006. TRB3 is a PI 3-kinase dependent indicator for nutrient starvation. Cell. Signal. 18: 899-909.
20. Qi, L., J. E. Heredia, J. Y. Altarejos, R. Screaton, N. Goebel, S. Niessen, I. X. Macleod, C. W. Liew, R. N. Kulkarni, J. Bain, et al. 2006. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science. 312: 1763-1766.
21. Arimura, N., T. Horiba, M. Imagawa, M. Shimizu, and R. Sato. 2004. The peroxisome proliferator-activated receptor gamma regulates expression of the perilipin gene in adipocytes. J. Biol. Chem. 279: 10070-10076.
22. Morita, S., T. Kojima, and T. Kitamura. 2000. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther. 7: 1063-1066.
23. Kitamura, T., Y. Koshino, F. Shibata, T. Oki, H. Nakajima, T. Nosaka, and H. Kumagai. 2003. Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics. Exp. Hematol. 31: 1007-1014.
24. Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7: 2745-2752.
25. Nakahara, M., N. Furuya, K. Takagaki, T. Sugaya, K. Hirota, A. Fukamizu, T. Kanda, H. Fujii, and R. Sato. 2005. Ileal bile acid- binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine. J. Biol. Chem. 280: 42283-42289.
26. Kanayama, T., M. Arito, K. So, S. Hachimura, J. Inoue, and R. Sato. 2007. Interaction between sterol regulatory element-binding proteins and liver receptor homolog-1 reciprocally suppresses their transcriptional activities. J. Biol. Chem. 282: 10290-10298.
27. Hirokane, H., M. Nakahara, S. Tachibana, M. Shimizu, and R. Sato. 2004. Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4. J. Biol. Chem. 279: 45685-45692.
28. Tontonoz, P., E. Hu, R. A. Graves, A. I. Budavari, and B. M. Spiegelman. 1994. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8: 1224-1234.
29. Koo, S. H., H. Satoh, S. Herzig, C. H. Lee, S. Hedrick, R. Kulkarni, R. M. Evans, J. Olefsky, and M. Montminy. 2004. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat. Med. 10: 530-534.
30. Iwaki, M., M. Matsuda, N. Maeda, T. Funahashi, Y. Matsuzawa, M. Makishima, and I. Shimomura. 2003. Induction of adiponec- tin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes. 52: 1655-1663.
31. Rosen, E. D., C. J. Walkey, P. Puigserver, and B. M. Spiegelman. 2000. Transcriptional regulation of adipogenesis. Genes Dev. 14: 1293-1307.
32. Rosen, E. D., and O. A. MacDougald. 2006. Adipocyte differentiation from the inside out. Nat. Rev. Mol. Cell Biol. 7: 885-896.
33. Bezy, O., C. Vernochet, S. Gesta, S. R. Farmer, and C. R. Kahn. 2007. TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity. Mol. Cell. Biol. 27: 6818-6831.
34. Ozcan, U., Q. Cao, E. Yilmaz, A. H. Lee, N. N. Iwakoshi, E. Ozdelen, G. Tuncman, C. Gorgun, L. H. Glimcher, and G. S. Hotamisligil. 2004. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science. 306: 457-461.
35. Ozcan, U., E. Yilmaz, L. Ozcan, M. Furuhashi, E. Vaillancourt, R. O. Smith, C. Z. Gorgun, and G. S. Hotamisligil. 2006. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science. 313: 1137-1140.
36. Okamoto,H., E.Latres,R.Liu, K. Thabet,A.Murphy, D. Valenzeula, G. D. Yancopoulos, T. N. Stitt, D. J. Glass, and M. W. Sleeman. 2007. Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis. Diabetes. 56: 1350-1356.