Tribbles-2 is a novel regulator of inflammatory activation of monocytes

International Immunology

Volumn 20, Issue 12, 2008, Pages 1543-1550

  Eder, Katalin ^a   Guan, Hongtao ^a   Sung, Hye Y ^a   Ward, Jon ^a   Angyal, Adrienn ^b   Janas, Michelle ^c   Sarmay, Gabriella ^b   Duda, Erno ^d   Turner, Martin ^c   Dower, Steven K ^a   Francis, Sheila E ^a   Crossman, David C ^a   Kiss Toth, Endre ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^c BABRAHAM INSTITUTE   (United Kingdom)

^d INSTITUTE OF BIOCHEMISTRY   (Hungary)

Author keywords

IL 8; Inflammation; MAP kinases; Tribbles

Indexed keywords

CELL PROTEIN; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; TRIBBLES 2 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLOGY; DOWN REGULATION; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MONOCYTE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION;

ATHEROSCLEROSIS; CELL LINE; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-8; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPROTEINS, LDL; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MONOCYTES; PROTEIN BINDING; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 57049148987     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxn116     Document Type: Article

References (35)

1. Wilkin, F., Suarez-Huerta, N., Robaye, B. et al. 1997. Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells. Eur. J. Biochem. 248:660.
2. Wilkin, F., Savonet, V., Radulescu, A., Petermans, J., Dumont, J. E. and Maenhaut, C. 1996. Identification and characterization of novel genes modulated in the thyroid of dogs treated with methimazole and propylthiouracil. J. Biol. Chem. 271:28451.
3. Bisoffi, M., Klima, I., Gresko, E. et al. 2004. Expression profiles of androgen independent bone metastatic prostate cancer cells indicate up-regulation of the putative serine-threonine kinase GS3955. J. Urol. 172:1145.
4. Zhang, Y., Davis, J. L. and Li, W. 2005. Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display. Mol. Immunol. 42:1275.
5. Sung, H. Y., Francis, S. E., Crossman, D. C. and Kiss-Toth, E. 2006. Regulation of expression and signalling modulator function of mammalian tribbles is cell-type specific. Immunol. Lett. 104:171.
6. Saka, Y. and Smith, J. C. 2004. A Xenopus tribbles orthologue is required for the progression of mitosis and for development of the nervous system. Dev. Biol. 273:210.
7. Keeshan, K., He, Y., Wouters, B. J. et al. 2006. Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell 10:401.
8. Keeshan, K., Shestova, O., Ussin, L. and Pear, W. S. 2008. Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia. Blood Cells Mol. Dis. 40:119.
9. Rorth, P., Szabo, K. and Texido, G. 2000. The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation. Mol. Cell 6:23.
10. Iynedjian, P. B. 2004. Lack of evidence for a role of TRB3/NIPK as inhibitor of PKB-mediated insulin signaling in primary hepatocytes. Biochem. J. 386:113.
11. Du, K., Herzig, S., Kulkarni, R. N. and Montminy, M. 2003. TRB3: A tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300:1574.
12. Kiss-Toth, E., Bagstaff, S. M., Sung, H. Y. et al. 2004. Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. J. Biol. Chem. 279:42703.
13. Kiss-Toth, E., Wyllie, D. H., Holland, K. et al. 2006. Functional mapping and identification of novel regulators for the Toll/ interleukin-1 signalling network by transcription expression cloning. Cell. Signal. 18:202.
14. Naiki, T., Saijou, E., Miyaoka, Y., Sekine, K. and Miyajima, A. 2007. TRB2, a mouse tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKTand C/EBPbeta. J. Biol. Chem. 282:24075.
15. Sung, H. Y., Guan, H., Czibula, A. et al. 2007. Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways. J. Biol. Chem. 282:18379.
16. Giri, R. K., Selvaraj, S. K. and Kalra, V. K. 2003. Amyloid peptide-induced cytokine and chemokine expression in THP-1 monocytes is blocked by small inhibitory RNA duplexes for early growth response-1 messenger RNA. J. Immunol. 170:5281.
17. Hoffmann, E., Dittrich-Breiholz, O., Holtmann, H. and Kracht, M. 2002. Multiple control of interleukin-8 gene expression. J. Leukoc. Biol. 72:847.
18. Marie, C., Roman-Roman, S. and Rawadi, G. 1999. Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Infect. Immun. 67:688.
19. Ohoka, N., Yoshii, S., Hattori, T., Onozaki, K. and Hayashi, H. 2005. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J. 24:1243.
20. Corcoran, C. A., Luo, X., He, Q., Jiang, C., Huang, Y. and Sheikh, M. S. 2005. Genotoxic and endoplasmic reticulum stresses differentially regulate TRB3 expression. Cancer Biol. Ther. 4: 1063.
21. Schwarzer, R., Dames, S., Tondera, D., Klippel, A. and Kaufmann, J. 2005. TRB3 is a PI 3-kinase dependent indicator for nutrient starvation. Cell. Signal. 18:899.
22. Nyfeler, B., Michnick, S. W. and Hauri, H. P. 2005. Capturing protein interactions in the secretory pathway of living cells. Proc. Natl Acad. Sci. USA 102:6350.
23. Remy, I. and Michnick, S. W. 2004. Mapping biochemical networks with protein-fragment complementation assays. Methods Mol. Biol. 261:411.
24. Remy, I. and Michnick, S. W. 2004. A cDNA library functional screening strategy based on fluorescent protein complementation assays to identify novel components of signaling pathways. Methods 32:381.
25. Argiropoulos, B., Palmqvist, L., Yung, E. et al. 2008. Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3. Exp. Hematol. 36:845.
26. Van Berkel, T. J., De Rijke, Y. B. and Kruijt, J. K. 1991. Different fate in vivo of oxidatively modified low density lipoprotein and acetylated low density lipoprotein in rats. Recognition by various scavenger receptors on Kupffer and endothelial liver cells. J. Biol. Chem. 266:2282.
27. Kamps, J. A., Kruijt, J. K., Kuiper, J. and van Berkel, T. J. 1992. Characterization of the interaction of acetylated LDL and oxidatively modified LDL with human liver parenchymal and Kupffer cells in culture. Arterioscler. Thromb. 12:1079.
28. Yancey, P. G., Miles, S., Schwegel, J. and Jerome, W. G. 2002. Uptake and trafficking of mildly oxidized LDL and acetylated LDL in THP-1 cells does not explain the differences in lysosomal metabolism of these two lipoproteins. Microsc. Microanal. 8:81.
29. Bhattacharyya, A., Pathak, S., Datta, S., Chattopadhyay, S., Basu, J. and Kundu, M. 2002. Mitogen-activated protein kinases and nuclear factor-kappaB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages. Biochem. J. 368:121.
30. Dobreva, I., Waeber, G., James, R. W. and Widmann, C. 2006. Interleukin-8 secretion by fibroblasts induced by low density lipoproteins is p38 MAPK-dependent and leads to cell spreading and wound closure. J. Biol. Chem. 281:199.
31. Fu, Y., Luo, N. and Lopes-Virella, M. F. 2002. Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages. Atherosclerosis 160:11.
32. Kibayashi, E., Urakaze, M., Kobashi, C. et al. 2005. Inhibitory effect of pitavastatin (NK-104) on the C-reactive-protein-induced interleukin-8 production in human aortic endothelial cells. Clin. Sci. (Lond). 108:515.
33. Scholz, H., Yndestad, A., Damas, J. K. et al. 2003. 8-Isoprostane increases expression of interleukin-8 in human macrophages through activation of mitogen-activated protein kinases. Cardiovasc. Res. 59:945.
34. Hegedus, Z., Czibula, A. and Kiss-Toth, E. 2007. Tribbles: A family of kinase-like proteins with potent signalling regulatory function. Cell. Signal. 19:238.
35. Hegedus, Z., Czibula, A. and Kiss-Toth, E. 2006. Tribbles: Novel regulators of cell function; evolutionary aspects. Cell. Mol. Life Sci. 63:1632.