Cytochrome P450 eicosanoids and cerebral vascular function

Expert Reviews in Molecular Medicine

Volumn 13, Issue , 2011, Pages

  Imig, John D ^a   Simpkins, Alexis N ^b   Renic, Marija ^a   Harder, David R ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

20 HYDROXYEICOSA 6,15 DIENOIC ACID; 20 HYDROXYICOSATETRAENOIC ACID; CENTRAL NERVOUS SYSTEM AGENTS; CYTOCHROME P450; EPOXIDE HYDROLASE; EPOXYICOSATRIENOIC ACID; HET 0016; ICOSANOID; NITRIC OXIDE; TS 011; UNCLASSIFIED DRUG; 20 HYDROXY 5,8,11,14 EICOSATETRAENOIC ACID; 20-HYDROXY-5,8,11,14-EICOSATETRAENOIC ACID; DIHOMO GAMMA LINOLENIC ACID; HYDROXYICOSATETRAENOIC ACID;

ARACHIDONIC ACID METABOLISM; ARTICLE; AUTOREGULATION; BRAIN ATHEROSCLEROSIS; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN VASOSPASM; CEREBROVASCULAR DISEASE; ENDOTHELIAL DYSFUNCTION; EPHX2 GENE; GENE; GENETIC POLYMORPHISM; GENETIC RISK; HUMAN; HYPERTENSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SUBARACHNOID HEMORRHAGE; BRAIN CIRCULATION; METABOLISM; PHYSIOLOGY; REVIEW;

8,11,14-EICOSATRIENOIC ACID; CEREBROVASCULAR CIRCULATION; CYTOCHROME P-450 ENZYME SYSTEM; EICOSANOIDS; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS;

EID: 79956129813     PISSN: 14623994     EISSN: 14623994     Source Type: Journal    
DOI: 10.1017/S1462399411001773     Document Type: Article

References (91)

1. Faraci, F.M. and Heistad, D.D. (1998) Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiological Reviews 78, 53-97 (Pubitemid 28070975)
2. Harder, D.R. et al. (1997) Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue. Journal of Vascular Research 34, 237-243 (Pubitemid 27281699)
3. Girouard, H. and Iadecola, C. (2006) Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. Journal of Applied Physiology 100, 328-335 (Pubitemid 43671125)
4. Krizanac-Bengez, L., Mayberg, M.R. and Janigro, D. (2004) The cerebral vasculature as a therapeutic target for neurological disorders and the role of shear stress in vascular homeostatis and pathophysiology. Neurological Research 26, 846-853 (Pubitemid 39628562)
5. Filosa, J.A. and Blanco, V.M. (2007) Neurovascular coupling in the mammalian brain. Experimental Physiology 92, 641-646 (Pubitemid 47024943)
6. Koehler, R.C., Gebremedhin, D. and Harder, D.R. (2006) Role of astrocytes in cerebrovascular regulation. Journal of Applied Physiology 100, 307-317 (Pubitemid 43671123)
7. Koehler, R.C., Roman, R.J. and Harder, D.R. (2009) Astrocytes and the regulation of cerebral blood flow. Trends in Neurosciences 32, 160-169
8. Strandgaard, S. and Paulson, O.B. (1984) Cerebral autoregulation. Stroke 15, 413-416 (Pubitemid 14105951)
9. Johnson, P.C. (1991) The myogenic response. News in Physiological Sciences 6, 41-42
10. Roman, R.J. (2003) Autoregulation of blood flow. In Hypertension Primer (Izzo J.L. and Black H.R., eds), pp. 114-117, Lippincott Williams & Wilkins, Philadelphia, PA, Chapter 39
11. Dunn, K.M. and Nelson, M.T. (2010) Potassium channels and neurovascular coupling. Circulation Journal 74, 608-616
12. Dunn, K.M. et al. (2008) Elevated production of 20- HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. American Journal of Physiology. Heart and Circulatory Physiology 295, H2455-H2465
13. Harder, D.R. et al. (1994) Formation and action of a P- 450 4A metabolite of arachidonic acid in cat cerebral microvessels. American Journal of Physiology 266, H2098-H2107
14. Roman, R.J. (2002) P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiological Reviews 82, 131-185 (Pubitemid 34654217)
15. Iliff, J.J. et al. (2010) Epoxyeicosanoid signaling in CNSfunction and disease. Prostaglandins and Other Lipid Mediators 91, 68-84
16. Liu, X. et al. (2008) Interaction of nitric oxide, 20- HETE, and EETs during functional hyperemia in whisker barrel cortex. American Journal of Physiology. Heart and Circulatory Physiology 295, H619-H631
17. Imig, J.D., Falck, J.R. and Inscho, E.W. (1999) Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness. British Journal of Pharmacology 127, 1399-1405 (Pubitemid 29358940)
18. Gebremedhin, D. et al. (2000) Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circulation Research 87, 60-65 (Pubitemid 30456936)
19. Dickinson, C.J. (2001) Why are strokes related to hypertension? Classic studies and hypotheses revisited. Journal of Hypertension 19, 1515-1521 (Pubitemid 32783767)
20. Jennings, J.R. et al. (2005) Reduced cerebral blood flow response and compensation among patients with untreated hypertension. Neurology 64, 1358-1365 (Pubitemid 40570501)
21. Niwa, K. et al. (2002) Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein. American Journal of Physiology. Heart and Circulatory Physiology 283, H315-H323 (Pubitemid 34705353)
22. Niwa, K. et al. (2000) Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. Proceedings of the National Academy of Sciences of the United States of America 97, 9735-9740 (Pubitemid 30650845)
23. Dietrich, H.H., Kajita, Y. and Dacey, R.G., Jr. (1996) Local and conducted vasomotor responses in isolated rat cerebral arterioles. American Journal of Physiology. Heart and Circulatory Physiology 271, H1109-H1116
24. Iadecola, C. (2004) Neurovascular regulation in the normal brain and in Alzheimer's disease. Nature Reviews. Neuroscience 5, 347-360 (Pubitemid 38568496)
25. Goldstein, L.B. et al. (2001) Primary prevention of ischemic stroke: a statement for healthcare professionals from the stroke council of the American Heart Association. Circulation 103, 163-182 (Pubitemid 32050453)
26. Zweifler, R.M. (2003) Management of acute stroke. Southern Medical Journal 96, 380-385 (Pubitemid 37127524)
27. Alberts, M.J. (2003) Update on the treatment and prevention of ischaemic stroke. Current Medical Research and Opinion 19, 438-441 (Pubitemid 36994448)
28. Sudhahar, V., Shaw, S. and Imig, J.D. (2010) Epoxyeicosatrienoic acid analogs and vascular function. Current Medical Chemistry 17, 1181-1190
29. Imig, J.D. (2010) Targeting epoxides for organ damage in hypertension. Journal of Cardiovascular Pharmacology 56, 329-335
30. Sodhi, K. et al. (2009) Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-null mice. Journal of Pharmacology and Experimental Therapeutics 331, 906-916
31. Imig, J.D. et al. (2010) Development of epoxyeicosatrienoic acid analogs with in vivo anti-hypertensive actions. Frontiers in Vascular Physiology 1, 157
32. Imig, J.D. and Hammock, B.D. (2009) Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases. Nature Reviews. Drug Discovery 8, 794-805
33. Fornage, M. et al. (2005) The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke.HumanMolecular Genetics 14, 2829-2837 (Pubitemid 41418788)
34. Koerner, I.P. et al. (2007) Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury. Journal of Neuroscience 27, 4642-4649 (Pubitemid 46663588)
35. Zhang, L. et al. (2008) genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in Chinese population. Pharmacogenetics and Genomics 18, 45-51 (Pubitemid 351161647)
36. Fava, C. et al. (2010) Homozygosity for the EPHX2 K55R polymorphism increases the long-term risk of ischemic stroke in men: a study in Swedes. Pharmacogenetics and Genomics 20, 94-103
37. Gschwendtner, A. et al. (2008) Genetic variation in soluble epoxide hyrolase (EPHX2) is associated with an increased risk of ischemic stroke in white Europeans. Stroke 39, 1593-1596
38. Lee, J. et al. (2010) genetically reduced soluble epoxide hydrolase activity and risk of stroke and other cardiovascular disease. Stroke 41, 27-33
39. Dorrance, A.M. et al. (2005) An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology 46, 842-848 (Pubitemid 44378259)
40. Simpkins, A.N. et al. (2009) Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural rotection. American Journal of Pathology 174, 2086-2095
41. Zhang, W. et al. (2007) Soluble epoxide hydrolase: a novel therapeutic target in stroke. Journal of Cerebral Blood Flow and Metabolism 27, 1931-1940 (Pubitemid 350129162)
42. Zhang, W. et al. (2008) Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia. Stroke 39, 2073-2078
43. Yamori, Y. (1984) Development of the spontantaneously hypertensive rat (SHR) and of various spontaneous rat models, and their implications. In Handbook of Hypertension, Vol. 4. Experimental and Genetic Models of Hypertension (de JongW., ed.), pp. 224-239, Elsevier, Amsterdam, New York, Oxford.
44. Alkayed, N.J. et al. (2002) Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack. Stroke 33, 1677-1684 (Pubitemid 34619978)
45. Liu, M. and Alkayed, N.J. (2005) Hypoxic preconditioning and tolerance via hypoxia inducible factor (HIF) 1alpha-linked induction of P450 2C11 epoxygenase in astrocytes. Journal of Cerebral Blood Flow and Metabolism 25, 939-948 (Pubitemid 41061709)
46. Fleming, I. (2007) Epoxyeicosatrienoic acids, cell signaling and angiogenesis. Prostaglandins and Other Lipid Mediators 82, 60-67 (Pubitemid 44880162)
47. Yang, B. et al. (2001) Overexpression of cytochrome P450 CYP2J2 protects against hypoxiareoxygenation injury in cultured bovine aortic endothelial cells. Molecular Pharmacology 60, 310-320 (Pubitemid 32678296)
48. Dickens, M. et al. (1997) A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277, 693-696 (Pubitemid 27373916)
49. Kim, I.J. et al. (1999) Molecular cloning of multiple splicing variants of JIP-1 preferentially expressed in brain. Journal of Neurochemistry 72, 1335-1343
50. Whitmarsh, A.J. et al. (1998) A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 281, 1671-1674 (Pubitemid 28435582)
51. Becker, A.J. et al. (1999) Differential regulation of apoptosis-related genes in resistant and vulnerable subfields of the rat epileptic hippocampus. Brain Research. Molecular Brain Research 67, 172-176 (Pubitemid 29170080)
52. Fu, Z. et al. (2008) Haplotype-based case study of human CYP4A11 gene and cerebral infarction in Japanese subject. Endocrine 33, 215-222
53. Fu, Z. et al. (2008) A haplotype of the CYP4F2 gene is associated with cerebral infarction in Japanese men. American Journal of Hypertension 21, 1216-1223
54. Ding, H. et al. (2010) Association ofcommonvariants of CYP4A11 and CYP4F2 with stroke in the Han Chinese population. Pharmacogenetics and Genomics 20, 187-194
55. Miyata, N. et al. (2005) Beneficial effects of a new 20- hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4- morpholin-4-yl) phenyl-N'- hydroxyimido formamide], on hemorrhagic and ischemic stroke. Journal of Pharmacology and Experimental Therapeutics 314, 77-85 (Pubitemid 41058243)
56. Renic, M. et al. (2009) Effect of 20-HETE inhibition on infarct volume and cerebral blood flow after transient middle cerebral artery occlusion. Journal of Cerebral Blood Flow and Metabolism 29, 629-639
57. Marumo, T. et al. (2010) The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice. British Journal of Pharmacology 161, 1391-1402
58. Tanaka, Y. et al. (2007) Continuous inhibition of 20- HETE synthesis by TS-011 improves neurological and functional outcomes after transient focal cerebral ischemia in rats. Neuroscience Research 59, 475-480 (Pubitemid 350007819)
59. Poloyac, S.M. et al. (2006) Protective effect of the 20- HETE inhibitor HET0016 on brain damage after temporary focal ischemia. Journal of Cerebral Blood Flow and Metabolism 26, 1551-1561 (Pubitemid 44809084)
60. De Mey, J.G. et al. (2005) Toward functional genomics of flow-induced outward remodeling of resistance arteries. American Journal of Physiology. Heart and Circulatory Physiology 288, H1022-H1027 (Pubitemid 40270002)
61. Berk, B.C. (2001) Vascular smooth muscle growth: autocrine growth mechanisms. Physiological Reviews 81, 999-1030 (Pubitemid 32606665)
62. Glasglov, S. et al. (1987) Compensatory enlargement of human atherosclerotic coronary arteries. New England Journal of Medicine 316, 1371-1375
63. Korshunov, V.A., Schwartz, S.M. and Berk, B.C. (2007) Vascular remodeling: hemodynamic and biochemical mechanisms underlying Glagov's phenomenon. Arteriosclerosis, Thrombosis, and Vascular Biology 27, 1772-1728
64. Integan, H.D. and Schiffrin, E.L. (2001) Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis. Hypertension 38, 581-587
65. Toda, N., Okunishi, H. and Miyazaki, M. (1982) Length-passive tension relationships in cerebral and peripheral arteies isolated from spontaneously hypertensive and normotensive rats. Japanese Circulation Journal 46, 1088-1094 (Pubitemid 13213555)
66. Buus, C.L. et al. (2001) Smooth muscle cell changes during flow-related remodeling of rat mesenteric resistance arteries. Circulation Research 89, 180-186 (Pubitemid 34135827)
67. Zargham, R. (2008) Preventing restenosis after angioplasty: a multistage approach. Clinical Science 114, 257-264 (Pubitemid 351294001)
68. Przybyla-Zawislak, B.D. et al. (2003) Polymorphisms in human soluble epoxide hydrolase. Molecular Pharmacology 64, 482-490 (Pubitemid 36910013)
69. Srivastava, P.K. et al. (2004) Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quaternary structure. Archives of Biochemistry and Biophysics. 427, 164-169 (Pubitemid 38757765)
70. Lee, C.R. et al. (2006) Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Human Molecular Genetics 15, 1640-1649 (Pubitemid 43904830)
71. Fornage, M. et al. (2004) Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Circulation 109, 335-339 (Pubitemid 38133900)
72. Ng, V.Y. et al. (2006) Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1. Arteriosclerosis, Thrombosis, and Vascular Biology 26, 2462-2468 (Pubitemid 44607466)
73. Davis, B.B. et al. (2002) Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proceedings of the National Academy of Sciences of the United States of America 99, 2222-2227 (Pubitemid 34169042)
74. Nieves,D. andMoreno, J.J. (2007)Epoxyeicosatrienoic acids induce growth inhibition and calpain/caspase- 12 dependent apoptosis in PDGF cultured 3T6 fibroblast. Apoptosis 12, 1979-1988 (Pubitemid 47498231)
75. Sun, J. et al. (2002) Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids. Circulation Research 90, 1020-1027 (Pubitemid 34633869)
76. Zhao, X. et al. (2004) Soluble epoxide hydrolase inhibition protects the kidney from hypertensioninduced damage. Journal of the American Society of Nephrology 15, 1244-1253 (Pubitemid 38526005)
77. Coyle, P. and Jokelainen, P.T. (1983) Differential outcome to middle cerebral artery occlusion in spontaneously hypertensive stroke-prone rats (SHRSP) and Wistar Kyoto (WKY) rats. Stroke 14, 605-611 (Pubitemid 13036791)
78. Carswell, H.V. et al. (1999) Genetic and gender influences on sensitivity to focal cerebral ischemia in the stroke-prone spontaneously hypertensive rat. Hypertension 33, 681-685 (Pubitemid 29091647)
79. Jesmin, S. et al. (2004) Characterization of regional cerebral blood flow and expression of angiogenic growth factors in the frontal cortex of juvenile male SHRSP and SHR. Brain Research 1030, 72-82
80. Coyle, P. and Heistad, D.D. (1991) Development of collaterals in the cerebral circulation. Blood Vessels 28, 183-189
81. Zhang, C. and Harder, D.R. (2002) Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic acid. Stroke 33, 2957-2964 (Pubitemid 35462872)
82. Munzenmaier, D.H. and Harder, D.R. (2000) Cerebral microvascular endothelial cell tube formation: role of astrocytic epoxyeicosatrienoic acid release. American Journal of Physiology. Heart and Circulatory Physiology. 278, H1163-H1167 (Pubitemid 30235492)
83. Simpkins, A.N. et al. (2010) Soluble epoxide hydrolase inhibition modulates vascular remodeling. American Journal of Physiology. Heart and Circulatory Physiology 298, H795-H806
84. Stec, D.E. et al. (2007) 20-Hydroxyeicosatetraenoic acid (20-HETE) stimulates migration of vascular smooth muscle cells. Cell Physiology and Biochemistry 19, 121-128
85. Ljuca, F. and Drevensek, G. (2010) Endothelin-1 induced vascular smooth muscle cell proliferation is mediated by cytochrome P-450 arachidonic acid metabolites. Bosnian Journal of Basic Medical Sciences 10, 223-226
86. Liang, C.J. et al. (2008) 20-HETE inhibits the proliferation of vascular smooth muscle cells via transforming growth factor-beta. Journal of Lipid Research 49, 66-73
87. Guo, A.M. et al. (2009) 20-HETE can act as a nonhypoxic regulator of HIF-1alpha in human microvascular endothelial cells. American Journal of Physiology. Heart and Circulatory Physiology 297, H602-H613
88. Guo, A.M. et al. (2007) Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acidinduced endothelial cell proliferation. Journal of Pharmacology and Experimental Therapeutics 321, 18-27 (Pubitemid 46456964)
89. Kozak, W. et al. (2000) Role of cytochrome P-450 in endogenous antipyresis. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 279, R455-R460
90. Terashvili, M. et al. (2008) Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray. Journal of Pharmacology and Experimental Therapeutics 326, 614-622
91. Inceoglu, B. et al. (2008) Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways. Proceedings of the National Academy of Sciences of the United States of America 105, 18901-18906