20-HETE can act as a nonhypoxic regulator of HIF-1α in human microvascular endothelial cells

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 2, 2009, Pages

  Guo, Austin M ^a   Scicli, Gloria ^a   Sheng, Ju ^a   Falck, John C ^c   Edwards, Paul A ^a   Scicli, A Guillermo ^a,b,d  

^a HENRY FORD HOSPITAL   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d HENRY FORD HEALTH SYSTEM   (United States)

Author keywords

20 hydroxyeicosatrienoic acid; Cytochrome P 4504A; Hypoxia inducible factor; Nitric oxide synthase; Superoxide; Vascular endothelial growth factor

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 20 HYDROXYEICOSA 5,14 DIENOIC ACID; 20 HYDROXYICOSATETRAENOIC ACID; APOCYNIN; DIPHENYLIODONIUM SALT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MACROGOL; NEUTRALIZING ANTIBODY; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MICROVASCULATURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

BUTADIENES; CAPILLARIES; CELLS, CULTURED; DERMIS; ENDOTHELIAL CELLS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NADPH OXIDASE; NITRIC OXIDE SYNTHASE; NITRILES; RNA, SMALL INTERFERING; SUPEROXIDES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 68049101447     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00874.2008     Document Type: Article

References (51)

1. Alom-Ruiz SP, Anilkumar N, Shah AM. Reactive oxygen species and endothelial activation. Antioxid Redox Signal 10: 1089-1100, 2008.
2. Anagnostou A, Liu Z, Steiner M, Chin K, Lee ES, Kessimian N, Noguchi CT. Erythropoietin receptor mRNA expression in human endothelial cells. Proc Natl Acad Sci USA 91: 3974-3978, 1994. (Pubitemid 24139555)
3. Biswas S, Gupta MK, Chattopadhyay D, Mukhopadhyay CK. Insulin-induced activation of hypoxia-inducible factor-1 requires generation of reactive oxygen species by NADPH oxidase. Am J Physiol Heart Circ Physiol 292: H758-H766, 2007. (Pubitemid 46246923)
4. Brahimi-Horn MC, Chiche J, Pouyssegur J. Hypoxia signalling controls metabolic demand. Curr Opin Cell Biol 19: 223-229, 2007. (Pubitemid 46386401)
5. Brahimi-Horn MC, Pouyssegur J. Harnessing the hypoxia-inducible factor in cancer and ischemic disease. Biochem Pharmacol 73: 450-457, 2007. (Pubitemid 44958373)
6. Brune B, Zhou J. The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1alpha (HIF-1alpha). Curr Med Chem 10: 845-855, 2003. (Pubitemid 36443239)
7. Capdevila JH, Falck JR, Imig JD. Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension. Kidney Int 72: 683-689, 2007.
8. Chen P, Guo M, Wygle D, Edwards PA, Falck JR, Roman RJ, Scicli AG. Inhibitors of cytochrome P450 4A suppress angiogenic responses. Am J Pathol 166: 615-624, 2005. (Pubitemid 40189056)
9. Chen P, Scicli GM, Guo M, Fenstermacher JD, Dahl D, Edwards PA, Scicli AG. Role of angiotensin II in retinal leukostasis in the diabetic rat. Exp Eye Res 83: 1041-1051, 2006. (Pubitemid 44397025)
10. Chen Y, Medhora M, Falck JR, Pritchard KA Jr, Jacobs ER. Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 291: L378-L385, 2006. (Pubitemid 44343713)
11. Cheng J, Ou JS, Singh H, Falck JR, Narsimhaswamy D, Pritchard KA Jr, Schwartzman ML. 20-Hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling. Am J Physiol Heart Circ Physiol 294: H1018-H1026, 2008. (Pubitemid 351253316)
12. Chowdhury R, Hardy A, Schofield CJ. The human oxygen sensing machinery and its manipulation. Chem Soc Rev 37: 1308-1319, 2008.
13. Daly C, Pasnikowski E, Burova E, Wong V, Aldrich TH, Griffiths J, Ioffe E, Daly TJ, Fandl JP, Papadopoulos N, McDonald DM, Thurston G, Yancopoulos GD, Rudge JS. Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proc Natl Acad Sci USA 103: 15491-15496, 2006. (Pubitemid 44625619)
14. Deudero JJ, Caramelo C, Castellanos MC, Neria F, Fernandez-Sanchez R, Calabia O, Penate S, Gonzalez-Pacheco FR. Induction of hypoxia-inducible factor 1alpha gene expression by vascular endothelial growth factor. J Biol Chem 283: 11435-11444, 2008.
15. Dhanasekaran A, Bodiga S, Gruenloh SK, Gao Y, Dunn LK, Falck JR, Buonaccorsi JN, Medhora MM, Jacobs ER. 20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells. Am J Physiol Heart Circ Physiol 296: H777-H786, 2009.
16. Dworakowski R, Alom-Ruiz SP, Shah AM. NADPH oxidase-derived reactive oxygen species in the regulation of endothelial phenotype. Pharmacol Rep 60: 21-28, 2008. (Pubitemid 351586539)
17. Elson DA, Thurston G, Huang LE, Ginzinger DG, McDonald DM, Johnson RS, Arbeit JM. Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha. Genes Dev 15: 2520-2532, 2001. (Pubitemid 32937863)
18. Ferrara N. The role of VEGF in the regulation of physiological and pathological angiogenesis. EXS 209-231, 2005.
19. Fong GH. Mechanisms of adaptive angiogenesis to tissue hypoxia. Angiogenesis 11: 121-140, 2008.
20. Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 277: 38205-38211, 2002. (Pubitemid 35154674)
21. Gorlach A, Kietzmann T. Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors. Methods Enzymol 435: 421-446, 2007.
22. Gort EH, Groot AJ, Derks van de Ven TL, van der Groep P, Verlaan I, van Laar T, van Diest PJ, van der Wall E, Shvarts A. Hypoxia-inducible factor-1alpha expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas. Oncogene 25: 6123-6127, 2006. (Pubitemid 44562410)
23. Guo AM, Arbab AS, Falck JR, Chen P, Edwards PA, Roman RJ, Scicli AG. Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation. J Pharmacol Exp Ther 321: 18-27, 2007. (Pubitemid 46456964)
24. Guo AM, Sheng J, Scicli GM, Arbab AS, Lehman NL, Edwrads PA, Falck JR, Roman RJ, Scicli AG. Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo. J Pharmacol Exp Ther 327: 10-19, 2008.
25. Kasuno K, Takabuchi S, Fukuda K, Kizaka-Kondoh S, Yodoi J, Adachi T, Semenza GL, Hirota K. Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. J Biol Chem 279: 2550-2558, 2004. (Pubitemid 38114240)
26. Kelly BD, Hackett SF, Hirota K, Oshima Y, Cai Z, Berg-Dixon S, Rowan A, Yan Z, Campochiaro PA, Semenza GL. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ Res 93: 1074-1081, 2003. (Pubitemid 37485038)
27. Kilic M, Kasperczyk H, Fulda S, Debatin KM. Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance. Oncogene 26: 2027-2038, 2007. (Pubitemid 46514744)
28. Kohl R, Zhou J, Brune B. Reactive oxygen species attenuate nitricoxide-mediated hypoxia-inducible factor-1alpha stabilization. Free Radic Biol Med 40: 1430-1442, 2006.
29. Lee S, Chen TT, Barber CL, Jordan MC, Murdock J, Desai S, Ferrara N, Nagy A, Roos KP, Iruela-Arispe ML. Autocrine VEGF signaling is required for vascular homeostasis. Cell 130: 691-703, 2007. (Pubitemid 47268059)
30. Lopez-Lazaro M. HIF-1: hypoxia-inducible factor or dysoxia-inducible factor? FASEB J 20: 828-832, 2006. (Pubitemid 44943940)
31. Manalo DJ, Rowan A, Lavoie T, Natarajan L, Kelly BD, Ye SQ, Garcia JG, Semenza GL. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105: 659-669, 2005. (Pubitemid 40070750)
32. Maxwell PH. Hypoxia-inducible factor as a physiological regulator. Exp Physiol 90: 791-797, 2005.
33. Medhora M, Chen Y, Gruenloh S, Harland D, Bodiga S, Zielonka J, Gebremedhin D, Gao Y, Falck JR, Anjaiah S, Jacobs ER. 20-HETE increases superoxide production and activates NADPH oxidase in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 294: L902-L911, 2008.
34. Miyata N, Roman RJ. Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system. J Smooth Muscle Res 41: 175-193, 2005. (Pubitemid 41596358)
35. Page EL, Chan DA, Giaccia AJ, Levine M, Richard DE. Hypoxiainducible factor-1α stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Mol Biol Cell 19: 86-94, 2008.
36. Pages G, Pouyssegur J. Transcriptional regulation of the vascular endothelial growth factor gene-a concert of activating factors. Cardiovasc Res 65: 564-573, 2005. (Pubitemid 40138977)
37. Platt DH, Bartoli M, El-Remessy AB, Al-Shabrawey M, Lemtalsi T, Fulton D, Caldwell RB. Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3. Free Radic Biol Med 39: 1353-1361, 2005. (Pubitemid 41540090)
38. Pouyssegur J, Mechta-Grigoriou F. Redox regulation of the hypoxia-inducible factor. Biol Chem 387: 1337-1346, 2006.
39. Richard DE, Berra E, Pouyssegur J. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. J Biol Chem 275: 26765-26771, 2000. (Pubitemid 30688019)
40. Roman RJ. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 82: 131-185, 2002.
41. Semenza GL. Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE 2007: cm8, 2007.
42. Semenza GL. Life with oxygen. Science 318: 62-64, 2007.
43. Semenza GL. Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1. Exp Physiol 92: 988-991, 2007. (Pubitemid 47568844)
44. Singh H, Schwartzman ML. Renal vascular cytochrome P450-derived eicosanoids in androgen-induced hypertension. Pharmacol Rep 60: 29-37, 2008. (Pubitemid 351586540)
45. Stec DE, Gannon KP, Beaird JS, Drummond HA. 20-Hydroxyeicosatetraenoic acid (20-HETE) stimulates migration of vascular smooth muscle cells. Cell Physiol Biochem 19: 121-128, 2007. (Pubitemid 46270895)
46. Tanaka Y, Omura T, Fukasawa M, Horiuchi N, Miyata N, Minagawa T, Yoshida S, Nakaike S. Continuous inhibition of 20-HETE synthesis by TS-011 improves neurological and functional outcomes after transient focal cerebral ischemia in rats. Neurosci Res 59: 475-480, 2007. (Pubitemid 350007819)
47. Ushio-Fukai M. VEGF signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal 9: 731-739, 2007. (Pubitemid 46799105)
48. Wang JS, Singh H, Zhang F, Ishizuka T, Deng H, Kemp R, Wolin MS, Hintze TH, Abraham NG, Nasjletti A, Laniado-Schwartzman M. Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus. Circ Res 98: 962-969, 2006. (Pubitemid 43755250)
49. Yamakawa M, Liu LX, Date T, Belanger AJ, Vincent KA, Akita GY, Kuriyama T, Cheng SH, Gregory RJ, Jiang C. Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors. Circ Res 93: 664-673, 2003. (Pubitemid 37222163)
50. Ye C, Sweeny D, Sukbuntherng J, Zhang Q, Tan W, Wong S, Madan A, Ogilvie B, Parkinson A, Antonian L. Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416. Toxicol In Vitro 20: 154-162, 2006. (Pubitemid 43087699)
51. Zacchigna S, Tasciotti E, Kusmic C, Arsic N, Sorace O, Marini C, Marzullo P, Pardini S, Petroni D, Pattarini L, Moimas S, Giacca M, Sambuceti G. In vivo imaging shows abnormal function of vascular endothelial growth factor-induced vasculature. Hum Gene Ther 18: 515-524, 2007. (Pubitemid 47036045)