Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 26, Issue 12, 2006, Pages 1551-1561

  Poloyac, Samuel M ^a   Zhang, Yuqing ^b   Bies, Robert R ^a   Kochanek, Patrick M ^b   Graham, Steven H ^b,c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Arachidonic acid; Cytochrome P450; Hydroxyeicosatetraenoic acid; Middle cerebral artery occlusion; N hydroxy N 4 butyl 2 methylphenylformamidine; Stroke

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; ARACHIDONIC ACID; CYTOCHROME P450; HET 0016; NEUROPROTECTIVE AGENT; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG; VASOCONSTRICTOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN DAMAGE; BRAIN ISCHEMIA; BRAIN MICROSOME; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DISTRIBUTION; DRUG EFFECT; DRUG HALF LIFE; DRUG TISSUE LEVEL; HEMISPHERE; LASER DOPPLER FLOWMETRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; STROKE;

AMIDINES; ANIMALS; BRAIN INJURIES; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR CIRCULATION; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYEICOSATETRAENOIC ACIDS; MALE; MICROSOMES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; VASOCONSTRICTION;

EID: 33751336305     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600309     Document Type: Article

References (45)

1. Amaral SL, Maier KG, Schippers DN, Roman RJ, Greene AS (2003) CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis. Am J Physiol Heart Circ Physiol 284:H1528-35
2. Anandatheerthavarada HK, Addya S, Dwivedi RS, Biswas G, Mullick J, Avadhani NG (1997) Localization of multiple forms of inducible cytochromes P450 in rat liver mitochondria-immunological characteristics and patterns of xenobiotic substrate metabolism. Arch Biochem Biophys 339:136-50
3. Ayata C, Dunn AK, Gursoy OY, Huang Z, Boas DA, Moskowitz MA (2004) Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex. J Cereb Blood Flow Metab 24: 744-55
4. Bolcato CA, Frye RF, Zemaitis MA, Poloyac SM (2003) Determination of 20-hydroxyeicosatetraenoic acid in microsomal incubates using high-performance liquid chromatography-mass spectrometry (HPLC-MS). J Chromatogr B 794:363-72
5. Cambj-Sapunar L, Yu M, Harder DR, Roman RJ (2003) Contribution of 5-hydroxytryptamine1B receptors and 20-hydroxyeiscosatetraenoic acid to fall in cerebral blood flow after subarachnoid hemorrhage. Stroke 34: 1269-75
6. Carroll MA, Balazy M, Huang DD, Rybalova S, Falck JR, McGiff JC (1997) Cytochrome P450-derived renal HETEs-storage and release. Kidney Int 51:1696-702
7. Chen P, Guo M, Wygle D, Edwards PA, Falck JR, Roman RJ et al. (2005) Inhibitors of cytochrome P450 4A suppress angiogenic responses. Am J Pathol 166:615-24
8. Coyle P (1987) Dorsal cerebral collaterals of stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar Kyoto rats (WKY). Anat Rec 218:40-4
9. Cui X, Kawashima H, Barclay TB, Peters JM, Gonzalez FJ, Morgan ET et al. (2001) Molecular cloning and regulation of expression of two novel mouse CYP4F genes-expression in peroxisome proliferator-activated receptor alpha-deficient mice upon lipopolysaccharide and clofibrate challenges. J Pharmacol Exp Ther 296: 542-50
10. Dawson DA, Furuya K, Gotoh J, Nakao Y, Hallenbeck JM (1999) Cerebrovascular hemodynamics and ischemic tolerance-lipopolysaccharide-induced resistance to focal cerebral ischemia is not due to changes in severity of the initial ischemic insult, but is associated with preservation of microvascular perfusion. J Cereb Blood Flow Metab 19:616-23
11. Fischer EG, Ames III A, Hedley-Whyte ET, O'Gorman S (1977) Reassessment of cerebral capillary changes in acute global ischemia and their relationship to the 'noreflow phenomenon'. Stroke 8:36-9
12. Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C et al. (1999) Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study-a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 282:2003-11
13. Gebremedhin D, Lange AR, Lowry TF, Taheri MR, Birks EK, Hudetz AG et al. (2000) Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circ Res 87:60-5
14. 2+ current. J Physiol 507 (Pt 3):771-81
15. Guengerich FP (1984) Microsomal enzymes involved in toxicology-analysis and separation. In: Principles and methods of toxicology (Hayes AW, ed), New York: Raven Press, 609-34
16. Harder DR, Gebremedhin D, Narayanan J, Jefcoat C, Falck JR, Campbell WB et al. (1994) Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels. Am J Physiol 266:H2098-107
17. Hayashi T, Abe K, Suzuki H, Itoyama Y (1997) Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats. Stroke 28:2039-44
18. Hendrich KS, Kochanek PM, Melick JA, Schiding JK, Statler KD, Williams DS et al. (2001) Cerebral perfusion during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats studied by arterial spin-labeled MRI. Magn Reson Med 46:202-6
19. Hercule HC, Wang MH, Oyekan AO (2003) Contribution of cytochrome P450 4A isoforms to renal functional response to inhibition of nitric oxide production in the rat. J Physiol 551:971-9
20. Hevner RF, Liu S, Wong-Riley MT (1993) An optimized method for determining cytochrome oxidase activity in brain tissue homogenates. J Neurosci Methods 50: 309-19
21. Hossmann KA (1997) Reperfusion of the brain after global ischemia-hemodynamic disturbances. Shock 8:95-101 (discussion 102-103)
22. 2+ efflux by 20-hydroxyeicosatetraenoic acid in rat renal epithelial cells. Jpn J Physiol 54:415-9
23. 2+ of N-methyl-D-aspartate-activated channels. Biophys J 57:1085-90
24. Josko J (2003) Cerebral angiogenesis and expression of VEGF after subarachnoid hemorrhage (SAH) in rats. Brain Res 981:58-69
25. Kaduce TL, Fang X, Harmon SD, Oltman CL, Dellsperger KC, Teesch LM et al. (2004) 20-Hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells. J Biol Chem 279:2648-56
26. Kalsotra A, Turman CM, Dash PK, Strobel HW (2003) Differential effects of traumatic brain injury on the cytochrome P450 system-a perspective into hepatic and renal drug metabolism. J Neurotrauma 20:1339-50
27. Karibe H, Zarow GJ, Graham SH, Weinstein PR (1994) Mild intraischemic hypothermia reduces postischemic hyperperfusion, delayed postischemic hypoperfusion, blood-brain barrier disruption, brain edema, and neuronal damage volume after temporary focal cerebral ischemia in rats. J Cereb Blood Flow Metab 14:620-7
28. Kaya D, Gursoy-Ozdemir Y, Yemisci M, Tuncer N, Aktan S, Dalkara T (2005) VEGF protects brain against focal ischemia without increasing blood-brain permeability when administered intracerebroventricularly. J Cereb Blood Flow Metab 25(9):1111-8
29. Kehl F, Cambj-Sapunar L, Maier KG, Miyata N, Kametani S, Okamoto H et al. (2002) 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat. Am J Physiol Heart Circ Physiol 282:H1556-65
30. McHedlishvili G, Varazashvili M, Mamaladze A, Momtselidze N (1997) Blood flow structuring and its alterations in capillaries of the cerebral cortex. Microvasc Res 53: 201-10
31. 31P magnetic resonance spectroscopy and behavioral studies. J Neurotrauma 5:17-31
32. Miyata N, Seki T, Tanaka Y, Omura T, Taniguchi K, Doi M et al. (2005) Beneficial effects of a new 20-HETE synthesis inhibitor, TS-011, on hemorrhagic and ischemic stroke. J Pharmacol Exp Ther 314:77-85
33. Miyata N, Taniguchi K, Seki T, Ishimoto T, Sato-Watanabe M, Yasuda Y et al. (2001) HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme. Br J Pharmacol 133:325-9
34. Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A (1984) Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307:462-5
35. Poloyac SM, Perez A, Blouin RA (2000) Tissue specific alterations in the 6-hydroxylation of chlorzoxazone following traumatic brain injury in the rat. Drug Metab Dispos 29:296-8
36. Poloyac SM, Reynolds RB, Yonas H, Kerr ME (2005) Identification and quantification of the hydroxyeicosatetraenoic acids, 20-HETE and 12-HETE, in the cerebrospinal fluid after subarachnoid hemorrhage. J Neurosci Methods 144:257-63
37. Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF et al. (2004) The effect of isoniazid on CYP2E1 and CYP4A mediated hydroxylation of arachidonic acid in the rat liver and kidney. Drug Metab Dispos 32:727-33
38. Shimizu S, Nagayama T, Jin KL, Zhu L, Loeffert JE, Watkins SC et al. (2001) bcl-2 Antisense treatment prevents induction of tolerance to focal ischemia in the rat brain. J Cereb Blood Flow Metab 21:233-43
39. Sun CW, Falck JR, Okamoto H, Harder DR, Roman RJ (2000) Role of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries. Am J Physiol Heart Circ Physiol 279:H339-50
40. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR (1990) A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab 10:290-3
41. Symon L, Branston NM, Strong AJ (1976) Autoregulation in acute focal ischemia. An experimental study. Stroke 7:547-54
42. Tindberg N, Baldwin HA, Cross AJ, Ingelman-Sundberg M (1996) Induction of cytochrome P450 2E1 expression in rat and gerbil astrocytes by inflammatory factors and ischemic injury. Mol Pharmacol 50: 1065-72
43. Yu M, Cambj-Sapunar L, Kehl F, Maier KG, Takeuchi K, Miyata N et al. (2004) Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. Eur J Pharmacol 486:297-306
44. Zhang Z, Chopp M (2002) Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia. Trends Cardiovasc Med 12:62-6
45. + channel in renal arterioles. Am J Physiol 270:R228-37