Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness

British Journal of Pharmacology

Volumn 127, Issue 6, 1999, Pages 1399-1405

  Imig, John D ^a   Falck, John R ^b   Inscho, Edward W ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Autoregulation; Endothelium derived hyperpolarizing factor (EDHF); Epoxyeicosatrienoic acids (EETs); Kidney; Microcirculation; Renal blood flow

Indexed keywords

CYTOCHROME P450; ENZYME INHIBITOR; HEXANOIC ACID DERIVATIVE; OXYGENASE; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; AUTOREGULATION; BLOOD VESSEL DIAMETER; CONTROLLED STUDY; KIDNEY BLOOD FLOW; KIDNEY PERFUSION; MALE; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; RAT;

AMIDES; ANIMALS; ARTERIOLES; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HEXANOIC ACIDS; HOMEOSTASIS; KIDNEY; MALE; MIXED FUNCTION OXYGENASES; OXYGENASES; PERFUSION; PRESSURE; RATS; RATS, SPRAGUE-DAWLEY; RENAL ARTERY; SIGNAL TRANSDUCTION; SULFONES;

EID: 0032784521     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702662     Document Type: Article

References (24)

1. Alonso-Galicia, M., Sun, C.W., Falck, J.R., Harder, D.R. & Roman, R.J. (1998). Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries. Am. J. Physiol., 275, F370-F378.
2. Campbell, W.B., Gebremedhin, D., Pratt, P.F. & Harder, D.R. (1996). Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ. Res., 78, 415-423.
3. Carmines, P.K., Mitchell, K.D. & Navar, L.G. (1992). Effects of calcium antagonists on renal hemodynamics and glomerular function. Kid. Int., 41, S43-S48.
4. Casellas, D., Carmines, P.K. & Navar, L.G. (1995). Microvascular reactivity of in vitro blood perfused juxtamedullary nephrons from rats. Kid. Int., 28, 752-759.
5. Gebremedhin, D., Lange, A.R., Narayanan, J., Aebly, M.R., Jacobs, E.R. & Harder, D.R. (1998). Cat cerebral arterial smooth muscle cells express cytochrome P450 4A2 enzyme and produce the vasoconstrictor 20-HETE which enhances L-type Ca current. J. Physiol., 507, 771-781.
6. Imig, J.D., Navar, L.G., Roman, R.J., Reddy, K.K. & Falck, J.R. (1996a). Actions of epoxygenase metabolites on the preglomerular vasculature. J. Am. Soc. Nephrol., 7, 2364-2370.
7. Imig, J.D. & Roman, R.J. (1992). Nitric oxide modulates vascular tone in preglomerular arterioles. Hypertension, 19, 770-774.
8. Imig, J.D., Zou, A.P., Ortiz De Montellano, P.R., Sui, Z. & Roman, R.J. (1994). Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure. Am. J. Physiol., 266, H1879-H1885.
9. Imig, J.D., Zou, A.P., Stec, D.E., Harder, D.R., F alck, J.R. & Roman, R.J. (1996b). Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. Am. J. Physiol., 270, R217-R227.
10. Inscho, E.W., Cook, A.K. & Navar, L.G. (1996). Pressure-mediated vasoconstriction of juxtamedullary afferent arterioles involves P2-purinoceptor activation. Am. J. Physiol., 271, F1077-F1085.
11. Kauser, K., Clark, J.E., Masters, B.S., Ortiz De Montellano, P.R., Ma, Y.H., Harder, D.R. & Roman, R.J. (1991). Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries. Circ. Res., 68, 1154-1163.
12. Kramp, R.A., Genard, J., Fourmanoir, P., Caron, N., Laekeman, G. & Herman, A. (1995). Renal hemodynamics and blood flow autoregulation during acute cyclooxygenase inhibition in male rats. Am. J. Physiol., 268, F468-F479.
13. Ma, Y.H., Gebremedhin, D., Schwartzman, M.L., Falck, J.R., Clark, J.E., Masters, B.S., Harder, D.R. & Roman, R.J. (1993). 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. Circ. Res., 72, 126-136.
14. Mombouli, J.V., Bissiriou, I., Agboton, V.D. & Vanhoutte, P.M. (1996). Bioassay of endothelium-derived hyperpolarizing factor. Biochem. Biophys. Res. Commun., 221, 484-488.
15. Navar, L.G., Bell, P.D. & Burke, T.J. (1982). Role of a macula densa feedback mechanism as a mediator of renal autoregulation. Kid. Int., 22, S157-S164.
16. Navar, L.G., Inscho, E.W., Majid, D.S.A., Imig, J.D., Harrison-Bernard, L.M. & Mitchell, K.D. (1996). Paracrine regulation of the renal microcirculation. Physiol. Rev., 76, 425-536.
17. Pfeilschifter, J. (1990). Extracellular ATP stimulates polyphosphoinoiside hydrolysis and prostaglandin synthesis in rat renal mesangial cells. Cell. Signal., 2, 129-138.
18. Sarubbi, D. & Quilley, J. (1991). Evidence against a role of arachidonic acid metabolites in autoregulatory responses of the isolated perfused rat kidney. Eur. J. Pharmacol., 197, 27-31.
19. Takenaka, T., Harrison-Bernard, L.H., Inshco, E.W., Carmines, P.K. & Navar, L.G. (1994). Autoregulation of afferent arteriolar blood flow in juxtamedullary nephrons. Am. J. Physiol., 267, F879-F887.
20. Wang, M.H., Brand-Schieber, E., Zand, B.A., Nguyen, X., Falck, J.R., Balu, N. & Schwartzman. (1998). Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors. J. Pharmacol. Exp. Ther., 284, 966-973.
21. Ca-channel blockade prevents sustained pressure-induced depolarization in rat mesenteric small arteries. Am. J. Physiol., 272, H2241-H2249.
22. Zou, A.P., Imig, J.D., Kaldunski, M.L., Ortiz De Montellano, P.R., Sui, Z. & Roman, R.J. (1994a). Inhibition of renal vascular 20-HETE production impairs autoregulation of renal blood flow. Am. J. Physiol., 266, F275-F282.
23. Zou, A.P., Imig, J.D., Ortiz De Montellano, P.R., Sui, Z., Falck, J.R. & Roman, R.J. (1994b). Effect of P-450 ω-hydroxylase metabolites of arachidonic acid on tubuloglomerular feedback. Am. J. Physiol., 266, F934-F941.
24. Zou, A.P., Ma, Y.H., Sui, Z.H., Ortiz De Montellano, P.R., Clark, J.E., Masters, B.S. & Roman, R.J. (1994c). Effect of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid ω-hydroxylase, on renal function. J. Pharmacol. Exp. Ther., 268, 474-481.