The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice

British Journal of Pharmacology

Volumn 161, Issue 6, 2010, Pages 1391-1402

  Marumo, Toshiyuki ^a   Eto, Kei ^b,c   Wake, Hiroaki ^b,c   Omura, Tomohiro ^a   Nabekura, Junichi ^b,c,d  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

Author keywords

20 HETE; Ischaemia; Microcirculation; Peri infarct; Two photon microscopy

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; FATTY ACID SYNTHASE INHIBITOR; N(3 CHLORO 4 MORPHOLIN 4 YL)PHENYL N' HYDROXYIMIDO FORMAMIDE; TS 011; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOREGULATION; BLOOD FLOW VELOCITY; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN MICROCIRCULATION; BRAIN PERFUSION; CONTROLLED STUDY; DRUG EFFECT; FATTY ACID SYNTHESIS; MALE; MICROVASCULATURE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION; STROKE; THROMBOSIS;

ANIMALS; BLOOD FLOW VELOCITY; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; FORMAMIDES; HOMEOSTASIS; HYDROXYEICOSATETRAENOIC ACIDS; INFARCTION, MIDDLE CEREBRAL ARTERY; INFUSIONS, INTRAVENOUS; MALE; MICE; MICE, INBRED C57BL; MICROCIRCULATION; MORPHOLINES;

EID: 78049403602     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00973.x     Document Type: Article

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