Association of common variants of CYP4A11 and CYP4F2 with stroke in the Han Chinese population

Pharmacogenetics and Genomics

Volumn 20, Issue 3, 2010, Pages 187-194

  Ding, Hu ^a   Cui, Guanglin ^a   Zhang, Lan ^a   Xu, Yujun ^a   Bao, Xunna ^a   Tu, Yuanchao ^b   Wu, Bin ^a   Wang, Qi ^a   Hui, Rutai ^c   Wang, Wei ^a   Dackor, Ryan T ^d   Kissling, Grace E ^d   Zeldin, Darryl C ^d   Wang, Dao Wen ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Xin Hua Hospital   (China)

^c FUWAI HOSPITAL   (China)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Genetics; Han Chinese population; Haplotypes; Ischemic stroke

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; CYTOCHROME P450; CYTOCHROME P450 4A11; CYTOCHROME P450 4F2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CEREBROVASCULAR ACCIDENT; CHINESE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; STROKE;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHINA; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENETIC VARIATION; HUMANS; MALE; MIDDLE AGED; SEX FACTORS; STROKE;

EID: 76749107061     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e328336eefe     Document Type: Article

References (34)

1. Powell PK, Wolf I, Jin R, Lasker JM. Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11. J Pharmacol Exp Ther 1998; 285:1327-1336.
2. Lasker JM, Chen WB, Wolf I, Bloswick BP, Wilson PD, Powell PK. Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11. J Biol Chem 2000; 275:4118-4126.
3. Alonso-Galicia M, Drummond HA, Reddy KK, Falck JR, Roman RJ. Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide. Hypertension 1997; 29:320-325.
4. Gladden MH, Jankowska E, Czarkowska-Bauch J. New observations on coupling between group II muscle afferents and feline gamma-motoneurones. J Physiol 1998; 512:507-520.
5. Harder DR, Gebremedhin D, Narayanan J, Jefcoat C, Falck JR, Campbell WB, Roman R. Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels. Am J Physiol 1994; 266:H2098-H2107.
6. Harder DR, Lange AR, Gebremedhin D, Birks EK, Roman RJ. Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue. J Vasc Res 1997; 34:237-243.
7. Lange A, Gebremedhin D, Narayanan J, Harder D. 20-Hydroxyeicosatetraenoic acid-induced vasoconstriction and inhibition of potassium current in cerebral vascular smooth muscle is dependent on activation of protein kinase C. J Biol Chem 1997; 272:27345-27352.
8. Ma YH, Gebremedhin D, Schwartzman ML, Falck JR, Clark JE, Masters BS, et al. 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. Circ Res 1993; 72:126-136.
9. Gebremedhin D, Lange AR, Lowry TF, Taheri MR, Birks EK, Hudetz AG, et al. Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circ Res 2000; 87:60-65.
10. Kehl F, Cambj-Sapunar L, Maier KG, Miyata N, Kametani S, Okamoto H, et al. 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat. Am J Physiol Heart Circ Physiol 2002; 282:H1556-H1565.
11. Yu M, Cambj-Sapunar L, Kehl F, Maier KG, Takeuchi K, Miyata N, et al. Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. Eur J Pharmacol 2004; 486:297-306.
12. Miyata N, Seki T, Tanaka Y, Omura T, Taniguchi K, Doi M, et al. Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke. J Pharmacol Exp Ther 2005; 314:77-85.
13. Omura T,Tanaka Y, Miyata N, Koizumi C, Sakurai T, Fukasawa M, et al. Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury. Stroke 2006; 37:1307-1313.
14. Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, et al. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation 2005; 111:63-69.
15. Stec DE, Roman RJ, Flasch A, Rieder MJ. Functional polymorphism in human CYP4F2 decreases 20-HETE production. Physiol Genomics 2007; 30:74-81.
16. Liu H, Zhao Y, Nie D, Shi J, Fu L, Li Y, et al. Association of a functional cytochrome P450 4F2 haplotype with urinary 20-HETE and hypertension. J Am Soc Nephrol 2008; 19:714-721.
17. Mayer B, Lieb W, Gotz A, Konig IR, Aherrahrou Z, Thiemig A, et al. Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy. Hypertension 2005; 46:766-771.
18. Ward NC, Tsai IJ, Barden A, Van Bockxmeer FM, Puddey IB, Hodgson JM, Croft KD. A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. Hypertension 2008; 51:1393-1398.
19. Ward NC, Rivera J, Hodgson J, Puddey IB, Beilin LJ, Falck JR, Croft KD. Urinary 20-hydroxyeicosatetraenoic acid is associated with endothelial dysfunction in humans. Circulation 2004; 110:438-443.
20. Wang JS, Singh H, Zhang F, Ishizuka T, Deng H, Kemp R, et al. Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus. Circ Res 2006; 98:962-969.
21. Ishizuka T, Cheng J, Singh H, Vitto MD, Manthati VL, Falck JR, Laniado-Schwartzman M. 20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappa B activation and the production of inflammatory cytokines in human endothelial cells. J Pharmacol Exp Ther 2008; 324:103-110.
22. Cheng J, Ou JS, Singh H, Falck JR, Narsimhaswamy D, Pritchard KA Jr, Schwartzman ML. 20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling. Am J Physiol Heart Circ Physiol 2008; 294:H1018-H1026.
23. Benter IF, Francis I, Cojocel C, Juggi JS, Yousif MH, Canatan H. Contribution of cytochrome P450 metabolites of arachidonic acid to hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME. Auton Autacoid Pharmacol 2005; 25:143-154.
24. Giannotti G, Landmesser U. Endothelial dysfunction as an early sign of atherosclerosis. Herz 2007; 32:568-572.
25. Corrado E, Rizzo M, Coppola G, Muratori I, Carella M, Novo S. Endothelial dysfunction and carotid lesions are strong predictors of clinical events in patients with early stages of atherosclerosis: a 24-month follow-up study. Coron Artery Dis 2008; 19:139-144.
26. Fava C, Montagnana M, Almgren P, Rosberg L, Lippi G, Hedblad B, et al. The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure. Hypertension 2008; 52:373-380.
27. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE 3rd. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24:35-41.
28. Pritchard JK, Rosenberg NA. Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet 1999; 65:220-228.
29. Reich DE, Goldstein DB. Detecting association in a case-control study while correcting for population stratification. Genet Epidemiol 2001; 20:4-16.
30. Gonzalez JR, Armengol L, Sole X, Guino E, Mercader JM, Estivill X, Moreno V. SNPassoc: an R package to perform whole genome association studies. Bioinformatics 2007; 23:644-645.
31. Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002; 70:425-434.
32. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21:263-265.
33. Gauderman W, Morrison J. QUANTO 1.1: A computer program for power and sample size calculations for genetic-epidemiology studies, http:// hydra.usc.edu/gxe; 2006.
34. Cho BH, Park BL, Kim LH, Chung HS, Shin HD. Highly polymorphic human CYP4A11 gene. J Hum Genet 2005; 50:259-263.