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Volumn 6, Issue 5, 2011, Pages

ENPP1 affects insulin action and secretion: Evidences from in vitro studies

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; COMPLEMENTARY DNA; DEOXYGLUCOSE; ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1; GLIBENCLAMIDE; GLUCOSE TRANSPORTER 4; GLUTAMINE; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; INSULIN RECEPTOR; LYSINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHODIESTERASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN KINASE B; SERINE; THREONINE; TYROSINE; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; GLUCOSE; INORGANIC PYROPHOSPHATASE;

EID: 79955872917     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019462     Document Type: Article
Times cited : (39)

References (54)
  • 1
    • 0024026298 scopus 로고
    • Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM
    • DeFronzo RA, (1988) Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37: 667-687.
    • (1988) Diabetes , vol.37 , pp. 667-687
    • DeFronzo, R.A.1
  • 2
    • 0025663581 scopus 로고
    • Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents
    • Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR, (1990) Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med 113: 909-915.
    • (1990) Ann Intern Med , vol.113 , pp. 909-915
    • Warram, J.H.1    Martin, B.C.2    Krolewski, A.S.3    Soeldner, J.S.4    Kahn, C.R.5
  • 3
    • 0027762766 scopus 로고
    • Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians
    • Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, et al. (1993) Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med 329: 1988-1992.
    • (1993) N Engl J Med , vol.329 , pp. 1988-1992
    • Lillioja, S.1    Mott, D.M.2    Spraul, M.3    Ferraro, R.4    Foley, J.E.5
  • 4
    • 0042570843 scopus 로고    scopus 로고
    • Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
    • Virkamaki A, Ueki K, Kahn CR, (1999) Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103: 931-943.
    • (1999) J Clin Invest , vol.103 , pp. 931-943
    • Virkamaki, A.1    Ueki, K.2    Kahn, C.R.3
  • 5
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
    • Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, et al. (1999) Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96: 329-339.
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1    Brüning, J.C.2    Winnay, J.N.3    Postic, C.4    Magnuson, M.A.5
  • 6
    • 0348048485 scopus 로고    scopus 로고
    • Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice
    • Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, et al. (2004) Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab 286: E41-E49.
    • (2004) Am J Physiol Endocrinol Metab , vol.286
    • Otani, K.1    Kulkarni, R.N.2    Baldwin, A.C.3    Krutzfeldt, J.4    Ueki, K.5
  • 7
    • 34547482573 scopus 로고    scopus 로고
    • Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance
    • Okada T, Liew CW, Hu J, Hinault C, Michael MD, et al. (2007) Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A 104: 8977-8982.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 8977-8982
    • Okada, T.1    Liew, C.W.2    Hu, J.3    Hinault, C.4    Michael, M.D.5
  • 8
    • 77955284657 scopus 로고    scopus 로고
    • The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells
    • Liew CW, Bochenski J, Kawamori D, Hu J, Leech CA, et al. (2010) The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. J Clin Invest 120: 2876-2888.
    • (2010) J Clin Invest , vol.120 , pp. 2876-2888
    • Liew, C.W.1    Bochenski, J.2    Kawamori, D.3    Hu, J.4    Leech, C.A.5
  • 9
    • 0029893417 scopus 로고    scopus 로고
    • A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies
    • Almind K, Inoue G, Pedersen O, Kahn CR, (1996) A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies. J Clin Invest 97: 2569-2575.
    • (1996) J Clin Invest , vol.97 , pp. 2569-2575
    • Almind, K.1    Inoue, G.2    Pedersen, O.3    Kahn, C.R.4
  • 10
    • 0034351407 scopus 로고    scopus 로고
    • The Gly→Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells
    • Hribal ML, Federici M, Porzio O, Lauro D, Borboni P, et al. (2000) The Gly→Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells. J Clin Endocrinol Metab 85: 2004-2013.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2004-2013
    • Hribal, M.L.1    Federici, M.2    Porzio, O.3    Lauro, D.4    Borboni, P.5
  • 11
    • 24144466446 scopus 로고    scopus 로고
    • The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy
    • Prudente S, Hribal ML, Flex E, Turchi F, Morini E, et al. (2005) The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy. Diabetes 54: 2807-2811.
    • (2005) Diabetes , vol.54 , pp. 2807-2811
    • Prudente, S.1    Hribal, M.L.2    Flex, E.3    Turchi, F.4    Morini, E.5
  • 12
    • 46249084940 scopus 로고    scopus 로고
    • TRIB3 R84 variant is associated with impaired insulin-mediated nitric oxide production in human endothelial cells
    • Andreozzi F, Formoso G, Prudente S, Hribal ML, Pandolfi A, et al. (2008) TRIB3 R84 variant is associated with impaired insulin-mediated nitric oxide production in human endothelial cells. Arterioscler Thromb Vasc Biol 28: 1355-1360.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1355-1360
    • Andreozzi, F.1    Formoso, G.2    Prudente, S.3    Hribal, M.L.4    Pandolfi, A.5
  • 13
    • 77955657265 scopus 로고    scopus 로고
    • TRIB3 R84 variant affects glucose homeostasis by altering the interplay between insulin sensitivity and secretion
    • Prudente S, Baratta R, Andreozzi F, Morini E, Farina MG, et al. (2010) TRIB3 R84 variant affects glucose homeostasis by altering the interplay between insulin sensitivity and secretion. Diabetologia 53: 1354-1361.
    • (2010) Diabetologia , vol.53 , pp. 1354-1361
    • Prudente, S.1    Baratta, R.2    Andreozzi, F.3    Morini, E.4    Farina, M.G.5
  • 14
    • 0029118510 scopus 로고
    • Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1
    • Clausen JO, Hansen T, Bjørbaek C, Echwald SM, Urhammer SA, et al. (1995) Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1. Lancet 346: 397-402.
    • (1995) Lancet , vol.346 , pp. 397-402
    • Clausen, J.O.1    Hansen, T.2    Bjørbaek, C.3    Echwald, S.M.4    Urhammer, S.A.5
  • 15
    • 0035078748 scopus 로고    scopus 로고
    • The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans
    • Stumvoll M, Fritsche A, Volk A, Stefan N, Madaus A, et al. (2001) The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans. Diabetes 50: 882-885.
    • (2001) Diabetes , vol.50 , pp. 882-885
    • Stumvoll, M.1    Fritsche, A.2    Volk, A.3    Stefan, N.4    Madaus, A.5
  • 17
    • 0036319044 scopus 로고    scopus 로고
    • Insulin secretory function is impaired in isolated human islets carrying the Gly(972)→Arg IRS-1 polymorphism
    • Marchetti P, Lupi R, Federici M, Marselli L, Masini M, et al. (2002) Insulin secretory function is impaired in isolated human islets carrying the Gly(972)→Arg IRS-1 polymorphism. Diabetes 51: 1419-1424.
    • (2002) Diabetes , vol.51 , pp. 1419-1424
    • Marchetti, P.1    Lupi, R.2    Federici, M.3    Marselli, L.4    Masini, M.5
  • 18
    • 0032587076 scopus 로고    scopus 로고
    • The Gly972→Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells
    • Porzio O, Federici M, Hribal ML, Lauro D, Accili D, et al. (1999) The Gly972→Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells. J Clin Invest 104: 357-364.
    • (1999) J Clin Invest , vol.104 , pp. 357-364
    • Porzio, O.1    Federici, M.2    Hribal, M.L.3    Lauro, D.4    Accili, D.5
  • 19
    • 0345328687 scopus 로고    scopus 로고
    • Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes
    • Kahn CR, (2003) Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes. Exp Diabesity Res 4: 169-182.
    • (2003) Exp Diabesity Res , vol.4 , pp. 169-182
    • Kahn, C.R.1
  • 20
    • 70749139756 scopus 로고    scopus 로고
    • Insulin signaling regulating genes: effect on T2DM and cardiovascular risk
    • Prudente S, Morini E, Trischitta V, (2009) Insulin signaling regulating genes: effect on T2DM and cardiovascular risk. Nat Rev Endocrinol 5: 682-693.
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 682-693
    • Prudente, S.1    Morini, E.2    Trischitta, V.3
  • 21
    • 39149099952 scopus 로고    scopus 로고
    • The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities
    • Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, et al. (2008) The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities. Endocr Rev 29: 62-75.
    • (2008) Endocr Rev , vol.29 , pp. 62-75
    • Goldfine, I.D.1    Maddux, B.A.2    Youngren, J.F.3    Reaven, G.4    Accili, D.5
  • 22
    • 0028795761 scopus 로고
    • Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus
    • Maddux BA, Sbraccia P, Kumakura S, Sasson S, Youngren J, et al. (1995) Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus. Nature 373: 448-451.
    • (1995) Nature , vol.373 , pp. 448-451
    • Maddux, B.A.1    Sbraccia, P.2    Kumakura, S.3    Sasson, S.4    Youngren, J.5
  • 23
    • 0030444778 scopus 로고    scopus 로고
    • Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity
    • Belfiore A, Costantino A, Frasca F, Pandini G, Mineo R, et al. (1996) Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity. Mol Endocrinol 10: 1318-1326.
    • (1996) Mol Endocrinol , vol.10 , pp. 1318-1326
    • Belfiore, A.1    Costantino, A.2    Frasca, F.3    Pandini, G.4    Mineo, R.5
  • 24
    • 0033957339 scopus 로고    scopus 로고
    • Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit
    • Maddux BA, Goldfine ID, (2000) Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit. Diabetes 49: 13-19.
    • (2000) Diabetes , vol.49 , pp. 13-19
    • Maddux, B.A.1    Goldfine, I.D.2
  • 25
    • 0035080028 scopus 로고    scopus 로고
    • The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)
    • Costanzo BV, Trischitta V, Di Paola R, Spampinato D, Pizzuti A, et al. (2001) The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121). Diabetes 50: 831-836.
    • (2001) Diabetes , vol.50 , pp. 831-836
    • Costanzo, B.V.1    Trischitta, V.2    Di Paola, R.3    Spampinato, D.4    Pizzuti, A.5
  • 27
    • 60949083043 scopus 로고    scopus 로고
    • Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity
    • Chin CN, Dallas-Yang Q, Liu F, Ho T, Ellsworth K, et al. (2009) Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity. Eur J Pharmacol 606: 17-24.
    • (2009) Eur J Pharmacol , vol.606 , pp. 17-24
    • Chin, C.N.1    Dallas-Yang, Q.2    Liu, F.3    Ho, T.4    Ellsworth, K.5
  • 28
    • 12744274524 scopus 로고    scopus 로고
    • Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance
    • Dong H, Maddux BA, Altomonte J, Meseck M, Accili D, et al. (2005) Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance. Diabetes 54: 367-372.
    • (2005) Diabetes , vol.54 , pp. 367-372
    • Dong, H.1    Maddux, B.A.2    Altomonte, J.3    Meseck, M.4    Accili, D.5
  • 30
    • 0031026510 scopus 로고    scopus 로고
    • Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-alpha gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity
    • Frittitta L, Youngren JF, Sbraccia P, D'Adamo M, Buongiorno A, et al. (1997) Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-alpha gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity. Diabetologia 40: 282-289.
    • (1997) Diabetologia , vol.40 , pp. 282-289
    • Frittitta, L.1    Youngren, J.F.2    Sbraccia, P.3    D'Adamo, M.4    Buongiorno, A.5
  • 31
    • 0031747108 scopus 로고    scopus 로고
    • Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling
    • Frittitta L, Spampinato D, Solini A, Nosadini R, Goldfine ID, et al. (1998) Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling. Diabetes 47: 1095-1100.
    • (1998) Diabetes , vol.47 , pp. 1095-1100
    • Frittitta, L.1    Spampinato, D.2    Solini, A.3    Nosadini, R.4    Goldfine, I.D.5
  • 32
    • 0032799097 scopus 로고    scopus 로고
    • Increased activity of membrane glycoprotein PC-1 in the fibroblasts from non-insulin-dependent diabetes mellitus patients with insulin resistance
    • Teno S, Kanno H, Oga S, Kumakura S, Kanamuro R, et al. (1999) Increased activity of membrane glycoprotein PC-1 in the fibroblasts from non-insulin-dependent diabetes mellitus patients with insulin resistance. Diabetes Res Clin Pract 45: 25-30.
    • (1999) Diabetes Res Clin Pract , vol.45 , pp. 25-30
    • Teno, S.1    Kanno, H.2    Oga, S.3    Kumakura, S.4    Kanamuro, R.5
  • 33
    • 38949109352 scopus 로고    scopus 로고
    • Transcriptome and proteome expressions involved in insulin resistance in muscle and activated T-lymphocytes of patients with type 2 diabetes
    • Stentz FB, Kitabchi AE, (2007) Transcriptome and proteome expressions involved in insulin resistance in muscle and activated T-lymphocytes of patients with type 2 diabetes. Genomics Proteomics Bioinformatics 5: 216-235.
    • (2007) Genomics Proteomics Bioinformatics , vol.5 , pp. 216-235
    • Stentz, F.B.1    Kitabchi, A.E.2
  • 34
    • 0032857338 scopus 로고    scopus 로고
    • A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance
    • Pizzuti A, Frittitta L, Argiolas A, Baratta R, Goldfine ID, et al. (1999) A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. Diabetes 48: 1881-1884.
    • (1999) Diabetes , vol.48 , pp. 1881-1884
    • Pizzuti, A.1    Frittitta, L.2    Argiolas, A.3    Baratta, R.4    Goldfine, I.D.5
  • 36
    • 48249098981 scopus 로고    scopus 로고
    • Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study
    • Stolerman ES, Manning AK, McAteer JB, Dupuis J, Fox CS, et al. (2008) Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study. Diabetes 57: 1971-1977.
    • (2008) Diabetes , vol.57 , pp. 1971-1977
    • Stolerman, E.S.1    Manning, A.K.2    McAteer, J.B.3    Dupuis, J.4    Fox, C.S.5
  • 37
    • 58149354288 scopus 로고    scopus 로고
    • Role of the ENPP1 K121Q polymorphism in glucose homeostasis
    • Baratta R, Rossetti P, Prudente S, Barbetti F, Sudano D, et al. (2008) Role of the ENPP1 K121Q polymorphism in glucose homeostasis. Diabetes 57: 3360-3364.
    • (2008) Diabetes , vol.57 , pp. 3360-3364
    • Baratta, R.1    Rossetti, P.2    Prudente, S.3    Barbetti, F.4    Sudano, D.5
  • 38
    • 33746726490 scopus 로고    scopus 로고
    • Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects
    • Grarup N, Urhammer SA, Ek J, Albrechtsen A, Glumer C, et al. (2006) Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects. Diabetologia 49: 2097-2104.
    • (2006) Diabetologia , vol.49 , pp. 2097-2104
    • Grarup, N.1    Urhammer, S.A.2    Ek, J.3    Albrechtsen, A.4    Glumer, C.5
  • 39
    • 79952392468 scopus 로고    scopus 로고
    • The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients
    • Bacci S, Rizza S, Prudente S, Spoto B, Powers C, et al. (2011) The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients. Diabetes 60: 1000-1007.
    • (2011) Diabetes , vol.60 , pp. 1000-1007
    • Bacci, S.1    Rizza, S.2    Prudente, S.3    Spoto, B.4    Powers, C.5
  • 40
    • 70349574150 scopus 로고    scopus 로고
    • ENPP1 Q121 variant, increased pulse pressure and reduced insulin signaling, and nitric oxide synthase activity in endothelial cells
    • Bacci S, Di Paola R, Menzaghi C, Di Fulvio P, Di Silvestre S, et al. (2009) ENPP1 Q121 variant, increased pulse pressure and reduced insulin signaling, and nitric oxide synthase activity in endothelial cells. Arterioscler Thromb Vasc Biol 29: 1678-1683.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1678-1683
    • Bacci, S.1    Di Paola, R.2    Menzaghi, C.3    Di Fulvio, P.4    Di Silvestre, S.5
  • 41
    • 67651085620 scopus 로고    scopus 로고
    • Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo
    • Zhou HH, Chin CN, Wu M, Ni W, Quan S, et al. (2009) Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo. Eur J Pharmacol 616: 346-352.
    • (2009) Eur J Pharmacol , vol.616 , pp. 346-352
    • Zhou, H.H.1    Chin, C.N.2    Wu, M.3    Ni, W.4    Quan, S.5
  • 42
    • 0034698052 scopus 로고    scopus 로고
    • Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells
    • Aspinwall CA, Qian WJ, Roper MG, Kulkarni RN, Kahn CR, et al. (2000) Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta-cells. J Biol Chem 275: 22331-22338.
    • (2000) J Biol Chem , vol.275 , pp. 22331-22338
    • Aspinwall, C.A.1    Qian, W.J.2    Roper, M.G.3    Kulkarni, R.N.4    Kahn, C.R.5
  • 43
    • 9644270397 scopus 로고    scopus 로고
    • Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells
    • Bernal-Mizrachi E, Fatrai S, Johnson JD, Ohsugi M, Otani K, et al. (2004) Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells. J Clin Invest 114: 928-936.
    • (2004) J Clin Invest , vol.114 , pp. 928-936
    • Bernal-Mizrachi, E.1    Fatrai, S.2    Johnson, J.D.3    Ohsugi, M.4    Otani, K.5
  • 44
    • 77954143522 scopus 로고    scopus 로고
    • Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
    • Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, et al. (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 42: 579-589.
    • (2010) Nat Genet , vol.42 , pp. 579-589
    • Voight, B.F.1    Scott, L.J.2    Steinthorsdottir, V.3    Morris, A.P.4    Dina, C.5
  • 45
  • 46
    • 78751474014 scopus 로고    scopus 로고
    • Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase
    • Oriente F, Iovino S, Cabaro S, Cassese A, Longobardi E, et al. (2011) Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase. Diabetes 60: 138-147.
    • (2011) Diabetes , vol.60 , pp. 138-147
    • Oriente, F.1    Iovino, S.2    Cabaro, S.3    Cassese, A.4    Longobardi, E.5
  • 47
    • 0346850870 scopus 로고    scopus 로고
    • Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism
    • Miele C, Riboulet A, Maitan MA, Oriente F, Romano C, et al. (2003) Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism. J Biol Chem 278: 47376-47387.
    • (2003) J Biol Chem , vol.278 , pp. 47376-47387
    • Miele, C.1    Riboulet, A.2    Maitan, M.A.3    Oriente, F.4    Romano, C.5
  • 48
    • 77952091923 scopus 로고    scopus 로고
    • Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells
    • Raciti GA, Iadicicco C, Ulianich L, Vind BF, Gaster M, et al. (2010) Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. Diabetologia 53: 955-965.
    • (2010) Diabetologia , vol.53 , pp. 955-965
    • Raciti, G.A.1    Iadicicco, C.2    Ulianich, L.3    Vind, B.F.4    Gaster, M.5
  • 49
    • 4544349092 scopus 로고    scopus 로고
    • Glucosamine-induced alterations of mitochondrial function in pancreatic B-cells: possible role of protein glycosilation
    • Anello M, Spampinato D, Piro S, Purrello F, Rabuazzo AM, (2004) Glucosamine-induced alterations of mitochondrial function in pancreatic B-cells: possible role of protein glycosilation. Am J Physiol Endocrinol Metab 287: E602-E608.
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Anello, M.1    Spampinato, D.2    Piro, S.3    Purrello, F.4    Rabuazzo, A.M.5
  • 50
    • 3042781662 scopus 로고    scopus 로고
    • Synergistic effect on insulin secretion from INS-1 cells of a sulfonylurea and a phosphodiesterase 3 inhibitor
    • Parker JC, VanVolkenburg MA, Gao F, (2004) Synergistic effect on insulin secretion from INS-1 cells of a sulfonylurea and a phosphodiesterase 3 inhibitor. Life Sci 75: 1479-1490.
    • (2004) Life Sci , vol.75 , pp. 1479-1490
    • Parker, J.C.1    VanVolkenburg, M.A.2    Gao, F.3
  • 51
    • 77955261951 scopus 로고    scopus 로고
    • Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors
    • Clare L, Kirkpatrick CL, Marchetti P, Purrello F, Piro S, et al. (2010) Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors. PLoS One 5: e11053.
    • (2010) PLoS One , vol.5
    • Clare, L.1    Kirkpatrick, C.L.2    Marchetti, P.3    Purrello, F.4    Piro, S.5
  • 52
    • 35848963392 scopus 로고    scopus 로고
    • The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients
    • Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, et al. (2007) The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia 50: 2486-2494.
    • (2007) Diabetologia , vol.50 , pp. 2486-2494
    • Marchetti, P.1    Bugliani, M.2    Lupi, R.3    Marselli, L.4    Masini, M.5
  • 53
    • 20044390365 scopus 로고    scopus 로고
    • Functional and molecular defects of pancreatic islets in human type 2 diabetes
    • Del Guerra S, Lupi R, Marselli L, Masini M, Bugliani M, et al. (2005) Functional and molecular defects of pancreatic islets in human type 2 diabetes. Diabetes 54: 727-735.
    • (2005) Diabetes , vol.54 , pp. 727-735
    • Del Guerra, S.1    Lupi, R.2    Marselli, L.3    Masini, M.4    Bugliani, M.5


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