The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)

Diabetes

Volumn 50, Issue 4, 2001, Pages 831-836

  Costanzo, Benedetta V ^a   Trischitta, Vincenzo ^b   Di Paola, Rosa ^b   Spampinato, Daniela ^a   Pizzuti, Antonio ^b,c   Vigneri, Riccardo ^a   Frittitta, Lucia ^a,d  

^a UNIVERSITY OF CATANIA   (Italy)

^b CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^d GARIBALDI HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR; MEMBRANE PROTEIN;

ARTICLE; CELL PROLIFERATION; DIABETES MELLITUS; GLYCOGEN SYNTHESIS; HUMAN; HUMAN CELL; INSULIN RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0035080028     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.4.831     Document Type: Article

References (36)

1. Banting lecture 1988: Role of insulin resistance in human disease
2. Insulin resistance in the pathogenesis of NIDDM in Pima Indians (Review)
3. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study
4. Metabolic and genetic characterization of prediabetic states
5. Banting lecture: Insulin action, diabetogenes, and the cause of type II diabetes
6. The genetics of non insulin-dependent diabetes mellitus: Tools and aims
7. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
8. Strategies and prospect for finding insulin resistance genes
9. Ecto-phosphodiesterase/pyrophosphatase of lymphocytes and non-lymphoid cells: Structure and function of the PC-1 family
10. Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus
11. Overexpression of membrane glycoprotein PC-1 can influence insulin action at a postreceptor site
12. Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity
13. Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor α-subunit
14. No correlation of plasma cell 1 overexpression with insulin resistance in diabetic rats and 3T3-L1 adipocytes
15. PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: Relationship to insulin receptor tyrosine-kinase and whole body insulin sensitivity
16. Skeletal muscle content of membrane glycoprotein PC-1 in obesity: Relationship to muscle glucose transport
17. Increased adipose tissue PC-1 protein content, but not tumor necrosis factor-a gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity
18. Elevated PC-1 content in cultured fibroblasts correlates with decreased in vivo and in vitro insulin action in non diabetic subjects: Evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling
19. Increased activity of membrane glycoprotein PC-1 in the fibroblasts from non-insulin-dependent diabetes mellitus patients with insulin resistance
20. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance
21. Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis
22. The K121Q variant of human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish caucasians
23. Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells
24. High efficiency transformation of mammalian cells by plasmid DNA
25. Inhibition of insulin receptor phosphorylation by PC-1 is not mediated by the hydrolysis of adenosine triphosphate or the generation of adenosine
26. Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation
27. Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrids receptor overexpression: Evidence for a second mechanism of IGF-1 signaling
28. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
29. Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and downregulation
30. Molecular antibody to receptor for insulin somatomedin-C
31. A simple, rapid and sensitive DNA assay procedure
32. Abnormal activation of glycogen synthesis in fibroblasts from NIDDM subjects: Evidence for an abnormality specific to glucose metabolism
33. Decreased insulin receptor tyrosine kinase activity and plasma cell membrane glycoprotein-1 overexpression in skeletal muscle from obese women with gestational diabetes mellitus (GDM): Evidence for increased serine/threonine phosphorylation in pregnancy and GDM
34. A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria
35. Deletion of residues 485-599 from the human insulin receptor abolishes antireceptor antibody binding and influences tyrosine kinase activation
36. The somatomedin B domain of vitronectin: Structural requirements for the binding and stabilization of active type 1 plasminogen activator inhibitor