-
1
-
-
14844351853
-
Genetics of type 2 diabetes mellitus: Status and perspectives
-
Hansen L, Pedersen O 2005 Genetics of type 2 diabetes mellitus: status and perspectives. Diabetes Obes Metab 7:122-135
-
(2005)
Diabetes Obes Metab
, vol.7
, pp. 122-135
-
-
Hansen, L.1
Pedersen, O.2
-
2
-
-
34548032087
-
Genome-wide association studies provide new insights into type 2 diabetes aetiology
-
Frayling TM 2007 Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 8:657-662
-
(2007)
Nat Rev Genet
, vol.8
, pp. 657-662
-
-
Frayling, T.M.1
-
3
-
-
1842537887
-
Type 2 diabetes in the young: The evolving epidemic
-
Bloomgarden ZT 2004 Type 2 diabetes in the young: the evolving epidemic. Diabetes Care 27:998-1010
-
(2004)
Diabetes Care
, vol.27
, pp. 998-1010
-
-
Bloomgarden, Z.T.1
-
4
-
-
0035464799
-
Characteristics of an adult population with newly diagnosed type 2 diabetes: The relation of obesity and age of onset
-
Hillier TA, Pedula KL 2001 Characteristics of an adult population with newly diagnosed type 2 diabetes: the relation of obesity and age of onset. Diabetes Care 24:1522-1527
-
(2001)
Diabetes Care
, vol.24
, pp. 1522-1527
-
-
Hillier, T.A.1
Pedula, K.L.2
-
5
-
-
0242365592
-
Complications in young adults with early-onset type 2 diabetes: Losing the relative protection of youth
-
Hillier TA, Pedula KL 2003 Complications in young adults with early-onset type 2 diabetes: losing the relative protection of youth. Diabetes Care 26:2999-3005
-
(2003)
Diabetes Care
, vol.26
, pp. 2999-3005
-
-
Hillier, T.A.1
Pedula, K.L.2
-
6
-
-
0036166596
-
Risk of diabetes in siblings of index cases with type 2 diabetes: Implications for genetic studies
-
Weijnen CF, Rich SS, Meigs JB, Krolewski AS, Warram JH 2002 Risk of diabetes in siblings of index cases with type 2 diabetes: implications for genetic studies. Diabet Med 19:41-50
-
(2002)
Diabet Med
, vol.19
, pp. 41-50
-
-
Weijnen, C.F.1
Rich, S.S.2
Meigs, J.B.3
Krolewski, A.S.4
Warram, J.H.5
-
8
-
-
0037677524
-
Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11
-
Frayling TM, Wiltshire S, Hitman GA, Walker M, Levy JC, Sampson M, Groves CJ, Menzel S, McCarthy MI, Hattersley AT 2003 Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11. Diabetes 52:1857-1863
-
(2003)
Diabetes
, vol.52
, pp. 1857-1863
-
-
Frayling, T.M.1
Wiltshire, S.2
Hitman, G.A.3
Walker, M.4
Levy, J.C.5
Sampson, M.6
Groves, C.J.7
Menzel, S.8
McCarthy, M.I.9
Hattersley, A.T.10
-
9
-
-
0026793446
-
Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study
-
Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR 1992 Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 17:925-929
-
(1992)
Lancet
, vol.17
, pp. 925-929
-
-
Martin, B.C.1
Warram, J.H.2
Krolewski, A.S.3
Bergman, R.N.4
Soeldner, J.S.5
Kahn, C.R.6
-
10
-
-
0038242819
-
TRB3: A tribbles homolog that inhibits Akt/PKB activation by insulin in liver
-
Du K, Herzig S, Kulkarni RN, Montminy M 2003 TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 6:1574-1577
-
(2003)
Science
, vol.6
, pp. 1574-1577
-
-
Du, K.1
Herzig, S.2
Kulkarni, R.N.3
Montminy, M.4
-
11
-
-
24144466446
-
The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy
-
Prudente S, Hribal ML, Flex E, Turchi F, Morini E, De Cosmo S, Bacci S, Tassi V, Cardellini M, Lauro R, Sesti G, Dallapiccola B, Trischitta V 2005 The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy. Diabetes 54:2807-2811
-
(2005)
Diabetes
, vol.54
, pp. 2807-2811
-
-
Prudente, S.1
Hribal, M.L.2
Flex, E.3
Turchi, F.4
Morini, E.5
De Cosmo, S.6
Bacci, S.7
Tassi, V.8
Cardellini, M.9
Lauro, R.10
Sesti, G.11
Dallapiccola, B.12
Trischitta, V.13
-
12
-
-
46249084940
-
TRIB3 R84 variant is associated with impaired insulin mediated nitric oxide production in human endothelial cells
-
Andreozzi F, Formoso G, Prudente S, Hribal ML, Pandolfi A, Bellacchio E, Di Silvestre S, Trischitta V, Consoli A, Sesti G 2008 TRIB3 R84 variant is associated with impaired insulin mediated nitric oxide production in human endothelial cells. Arterioscler Thromb Vasc Biol 28:1355-1360
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 1355-1360
-
-
Andreozzi, F.1
Formoso, G.2
Prudente, S.3
Hribal, M.L.4
Pandolfi, A.5
Bellacchio, E.6
Di Silvestre, S.7
Trischitta, V.8
Consoli, A.9
Sesti, G.10
-
13
-
-
34248146520
-
Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis
-
Okamoto H, Latres E, Liu R, Thabet K, Murphy A, Valenzeula D, Yancopoulos GD, Stitt TN, Glass DJ, Sleeman MW 2007 Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis. Diabetes 56:1350-1356
-
(2007)
Diabetes
, vol.56
, pp. 1350-1356
-
-
Okamoto, H.1
Latres, E.2
Liu, R.3
Thabet, K.4
Murphy, A.5
Valenzeula, D.6
Yancopoulos, G.D.7
Stitt, T.N.8
Glass, D.J.9
Sleeman, M.W.10
-
14
-
-
34548862332
-
Glutamine to arginine substitution at amino acid 84 of mammalian tribbles homolog TRIB3 and CKD in whites with type 2 diabetes
-
De Cosmo S, Prudente S, Andreozzi F, Morini E, Rauseo A, Scarpelli D, Zhang YY, Xu R, Perticone F, Dallapiccola B, Sesti G, Doria A, Trischitta V 2007 Glutamine to arginine substitution at amino acid 84 of mammalian tribbles homolog TRIB3 and CKD in whites with type 2 diabetes. Am J Kidney Dis 50:688-689
-
(2007)
Am J Kidney Dis
, vol.50
, pp. 688-689
-
-
De Cosmo, S.1
Prudente, S.2
Andreozzi, F.3
Morini, E.4
Rauseo, A.5
Scarpelli, D.6
Zhang, Y.Y.7
Xu, R.8
Perticone, F.9
Dallapiccola, B.10
Sesti, G.11
Doria, A.12
Trischitta, V.13
-
15
-
-
85031355481
-
-
Wee Liew C, Bochenski J, Hu J, Krowleski AS, Kulkarni RN Effects of TRB3 on β-cell insulin exocytosis. Proc 68th Scientific Sessions of the American Diabetes Association, San Francisco, CA, 2008, 186-OR (Abstract)
-
Wee Liew C, Bochenski J, Hu J, Krowleski AS, Kulkarni RN Effects of TRB3 on β-cell insulin exocytosis. Proc 68th Scientific Sessions of the American Diabetes Association, San Francisco, CA, 2008, 186-OR (Abstract)
-
-
-
-
16
-
-
42349106044
-
-
Zeggini E, Scott LJ, Saxena R, Voight BF, for the Diabetes Genetics Replication and Meta-analysis DIAGRAM Consortium 2008 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40:638-645
-
Zeggini E, Scott LJ, Saxena R, Voight BF, for the Diabetes Genetics Replication and Meta-analysis DIAGRAM Consortium 2008 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40:638-645
-
-
-
-
17
-
-
1042268060
-
-
American Diabetes Associations 2004 Screening for diabetes. Diabetes Care 27(Suppl 1):S11-S14
-
American Diabetes Associations 2004 Screening for diabetes. Diabetes Care 27(Suppl 1):S11-S14
-
-
-
-
19
-
-
0032821965
-
Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp
-
Matsuda M, DeFronzo RA 1999 Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 9:1462-1470
-
(1999)
Diabetes Care
, vol.9
, pp. 1462-1470
-
-
Matsuda, M.1
DeFronzo, R.A.2
-
20
-
-
0036319044
-
Insulin secretory function is impaired in isolated human islets carrying the Gly(972)->Arg IRS-1 polymorphism
-
Marchetti P, Lupi R, Federici M, Marselli L, Masini M, Boggi U, Del Guerra S, Patane G, Piro S, Anello M, Bergamini E, Purrello F, Lauro R, Mosca F, Sesti G, Del Prato S 2002 Insulin secretory function is impaired in isolated human islets carrying the Gly(972)->Arg IRS-1 polymorphism. Diabetes 51:1419-1424
-
(2002)
Diabetes
, vol.51
, pp. 1419-1424
-
-
Marchetti, P.1
Lupi, R.2
Federici, M.3
Marselli, L.4
Masini, M.5
Boggi, U.6
Del Guerra, S.7
Patane, G.8
Piro, S.9
Anello, M.10
Bergamini, E.11
Purrello, F.12
Lauro, R.13
Mosca, F.14
Sesti, G.15
Del Prato, S.16
-
21
-
-
38949212271
-
Analysis and application of European genetic substructure using 300KSNP information
-
Tian C, Plenge RM, Ransom M, Lee A, Villoslada P, Selmi C, Klareskog L, Pulver AE, Qi L, Gregersen PK, Seldin MF 2008 Analysis and application of European genetic substructure using 300KSNP information. PLoS Genet 1:e4
-
(2008)
PLoS Genet
, vol.1
-
-
Tian, C.1
Plenge, R.M.2
Ransom, M.3
Lee, A.4
Villoslada, P.5
Selmi, C.6
Klareskog, L.7
Pulver, A.E.8
Qi, L.9
Gregersen, P.K.10
Seldin, M.F.11
-
22
-
-
38949104183
-
Discerning the ancestry of European Americans in genetic association studies
-
Price AL, Butler J, Patterson N, Capelli C, Pascali VL, Scarnicci F, Ruiz-Linares A, Groop L, Saetta AA, Korkolopoulou P, Seligsohn U, Waliszewska A, Schirmer C, Ardlie K, Ramos A, Nemesh J, Arbeitman L, Goldstein DB, Reich D, Hirschhorn JN 2008 Discerning the ancestry of European Americans in genetic association studies. PLoS Genet 1:e236
-
(2008)
PLoS Genet
, vol.1
-
-
Price, A.L.1
Butler, J.2
Patterson, N.3
Capelli, C.4
Pascali, V.L.5
Scarnicci, F.6
Ruiz-Linares, A.7
Groop, L.8
Saetta, A.A.9
Korkolopoulou, P.10
Seligsohn, U.11
Waliszewska, A.12
Schirmer, C.13
Ardlie, K.14
Ramos, A.15
Nemesh, J.16
Arbeitman, L.17
Goldstein, D.B.18
Reich, D.19
Hirschhorn, J.N.20
more..
-
23
-
-
19944426903
-
-
Lyssenko V, Almgren P, Anevski D, Perfekt R, Lahti K, Nissén M, Isomaa B, Forsen B, Homström N, Saloranta C, Taskinen MR, Groop L, Tuomi T; Botnia Study Group 2005 Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes. Diabetes 54:166-174
-
Lyssenko V, Almgren P, Anevski D, Perfekt R, Lahti K, Nissén M, Isomaa B, Forsen B, Homström N, Saloranta C, Taskinen MR, Groop L, Tuomi T; Botnia Study Group 2005 Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes. Diabetes 54:166-174
-
-
-
-
24
-
-
0035078748
-
The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans
-
Stumvoll M, Fritsche A, Volk A, Stefan N, Madaus A, Maerker E, Teigeler A, Koch M, Machicao F, Haring H 2001 The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans. Diabetes 50:882-885
-
(2001)
Diabetes
, vol.50
, pp. 882-885
-
-
Stumvoll, M.1
Fritsche, A.2
Volk, A.3
Stefan, N.4
Madaus, A.5
Maerker, E.6
Teigeler, A.7
Koch, M.8
Machicao, F.9
Haring, H.10
-
25
-
-
0029118510
-
Insulin resistance: Interactions between obesity and a common variant of insulin receptor substrate-1
-
Clausen JO, Hansen T, Bjorbaek C, Echwald SM, Urhammer SA, Rasmussen S, Andersen CB, Hansen L, Almind K, Pedersen O 1995 Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1. Lancet 346:397-402
-
(1995)
Lancet
, vol.346
, pp. 397-402
-
-
Clausen, J.O.1
Hansen, T.2
Bjorbaek, C.3
Echwald, S.M.4
Urhammer, S.A.5
Rasmussen, S.6
Andersen, C.B.7
Hansen, L.8
Almind, K.9
Pedersen, O.10
-
26
-
-
0037622751
-
The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients
-
Marini MA, Frontoni S, Mineo D, Bracaglia D, Cardellini M, De Nicolais P, Baroni A, D'Alfonso R, Perna M, Lauro D, Federici M, Gambardella S, Lauro R, Sesti G 2003 The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients. J Clin Endocrinol Metab 88:3368-3371
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 3368-3371
-
-
Marini, M.A.1
Frontoni, S.2
Mineo, D.3
Bracaglia, D.4
Cardellini, M.5
De Nicolais, P.6
Baroni, A.7
D'Alfonso, R.8
Perna, M.9
Lauro, D.10
Federici, M.11
Gambardella, S.12
Lauro, R.13
Sesti, G.14
-
27
-
-
0029893417
-
A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies
-
Almind K, Inoue G, Pedersen O, Kahn CR 1996 A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies. J Clin Invest 11:2569-2575
-
(1996)
J Clin Invest
, vol.11
, pp. 2569-2575
-
-
Almind, K.1
Inoue, G.2
Pedersen, O.3
Kahn, C.R.4
-
28
-
-
9444276572
-
Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset
-
Zeggini E, Parkinson J, Halford S, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, Sampson MJ, Feskens EJ, Hattersley AT, McCarthy MI 2004 Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset. Diabetes 53:3319-3322
-
(2004)
Diabetes
, vol.53
, pp. 3319-3322
-
-
Zeggini, E.1
Parkinson, J.2
Halford, S.3
Owen, K.R.4
Frayling, T.M.5
Walker, M.6
Hitman, G.A.7
Levy, J.C.8
Sampson, M.J.9
Feskens, E.J.10
Hattersley, A.T.11
McCarthy, M.I.12
-
29
-
-
9444289880
-
Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes
-
Florez JC, Sjögren M, Burtt N, Orho-Melander M, Schayer S, Sun M, Almgren P, Lindblad U, Tuomi T, Gaudet D, Hudson TJ, Daly MJ, Ardlie KG, Hirschhorn JN, Altshuler D, Groop L 2004 Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes. Diabetes 53:3313-3318
-
(2004)
Diabetes
, vol.53
, pp. 3313-3318
-
-
Florez, J.C.1
Sjögren, M.2
Burtt, N.3
Orho-Melander, M.4
Schayer, S.5
Sun, M.6
Almgren, P.7
Lindblad, U.8
Tuomi, T.9
Gaudet, D.10
Hudson, T.J.11
Daly, M.J.12
Ardlie, K.G.13
Hirschhorn, J.N.14
Altshuler, D.15
Groop, L.16
-
30
-
-
58149354288
-
Role of the ENPP1 K121Q polymorphism on glucose homeostasis
-
Baratta R, Rossetti P, Prudente S, Barbetti F, Sudano D, Nigro A, Farina MG, Pellegrini F, Trischitta V, Frittitta L 2008 Role of the ENPP1 K121Q polymorphism on glucose homeostasis. Diabetes 57:3360-3364
-
(2008)
Diabetes
, vol.57
, pp. 3360-3364
-
-
Baratta, R.1
Rossetti, P.2
Prudente, S.3
Barbetti, F.4
Sudano, D.5
Nigro, A.6
Farina, M.G.7
Pellegrini, F.8
Trischitta, V.9
Frittitta, L.10
-
31
-
-
34250627956
-
ENPP1 gene, insulin resistance and related clinical outcomes
-
Bacci S, De Cosmo S, Prudente S, Trischitta V 2007 ENPP1 gene, insulin resistance and related clinical outcomes. Curr Opin Clin Nutr Metab Care 4:403-409
-
(2007)
Curr Opin Clin Nutr Metab Care
, vol.4
, pp. 403-409
-
-
Bacci, S.1
De Cosmo, S.2
Prudente, S.3
Trischitta, V.4
-
32
-
-
42449116149
-
-
McAteer JB, Prudente S, Bacci S, Lyon HN, Hirschhorn JN, Trischitta V, Florez JC; ENPP1 Consortium 2008 The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects. Diabetes 4:1125-1130
-
McAteer JB, Prudente S, Bacci S, Lyon HN, Hirschhorn JN, Trischitta V, Florez JC; ENPP1 Consortium 2008 The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects. Diabetes 4:1125-1130
-
-
-
-
33
-
-
33645982255
-
From mice to men: Insights into the insulin resistance syndromes
-
Biddinger SB, Kahn CR 2006 From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol 68:123-158
-
(2006)
Annu Rev Physiol
, vol.68
, pp. 123-158
-
-
Biddinger, S.B.1
Kahn, C.R.2
|