Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity

European Journal of Pharmacology

Volumn 606, Issue 1-3, 2009, Pages 17-24

  Chin, Chen Ni ^a   Dallas Yang, Qing ^a   Liu, Franklin ^a   Ho, Thu ^a   Ellsworth, Kenneth ^a   Fischer, Paul ^a   Natasha, Tajneen ^a   Ireland, Cheryl ^a   Lu, Ping ^a   Li, Cai ^a   Wang, I Ming ^b   Strohl, William ^a   Berger, Joel P ^a   An, Zhiqiang ^a   Zhang, Bei B ^a   Jiang, Guoqiang ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ROSETTA INPHARMATICS   (United States)

Author keywords

Ectonucleotide pyrophosphatase phosphodiesterase; ENPP1; Insulin signaling; PC 1; Plasma cell membrane glycoprotein 1

Indexed keywords

AUTOTAXIN; INSULIN; INSULIN RECEPTOR; SOMATOMEDIN C RECEPTOR;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

CELL LINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MUTATION; PHOSPHORIC DIESTER HYDROLASES; PROTEIN TRANSPORT; PYROPHOSPHATASES; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 60949083043     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.01.016     Document Type: Article

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