Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

FASEB Journal

Volumn 25, Issue 5, 2011, Pages 1664-1679

  Li, Yu ^a   Xu, Shanqin ^a   Giles, Amber ^a   Nakamura, Kazuto ^a   Lee, Jong Woo ^a   Hou, Xiuyun ^a   Donmez, Gizem ^b   Li, Ji ^c   Luo, Zhijun ^a   Walsh, Kenneth ^a   Guarente, Leonard ^b   Zang, Mengwei ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Hepatic steatosis; Insulin signaling; mTORC1; Unfolded protein response; XBP 1 splicing

Indexed keywords

GLUCOSE REGULATED PROTEIN 78; INSULIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; NICOTINAMIDE; RECOMBINANT HUMAN INSULIN; RESVERATROL; SIRTUIN 1; TUNICAMYCIN; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL STRAIN HEPG2; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; FIBROBLAST; GENE OVEREXPRESSION; GENE TRANSFER; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER HISTOLOGY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SPLICING; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

ANIMALS; CELLS, CULTURED; ENDOPLASMIC RETICULUM; GLUCOSE TOLERANCE TEST; HEP G2 CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; OBESITY; RECEPTORS, LDL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIRTUIN 1; UNFOLDED PROTEIN RESPONSE;

ADENOVIRIDAE; MAMMALIA; MUS;

EID: 79955661493     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-173492     Document Type: Article

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