Effects of FTDP-17 mutations on the in vitro phosphorylation of tau by glycogen synthase kinase 3β identified by mass spectrometry demonstrate certain mutations exert long-range conformational changes

FEBS Letters

Volumn 493, Issue 1, 2001, Pages 40-44

  Connell, James W ^a   Gibb, Graham M ^a   Betts, Joanna C ^b   Blackstock, Walter P ^b   Gallo, Jean Marc ^a   Lovestone, Simon ^a   Hutton, Michael ^c   Anderton, Brian H ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c MAYO CLINIC   (United States)

Author keywords

Frontotemporal dementia with Parkinsonism linked to chromosome 17; Glycogen synthase kinase 3 ; Mass spectrometry; Phosphorylation; Tau; Two dimensional phosphopeptide mapping

Indexed keywords

CELLULOSE; GLYCOGEN SYNTHASE KINASE 3BETA; ISOPROTEIN; MUTANT PROTEIN; PHOSPHOPEPTIDE; SERINE; THREONINE;

ANIMAL CELL; ARTICLE; CHROMOSOME 17; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FRONTOTEMPORAL DEMENTIA; GENE MAPPING; GENE STRUCTURE; HUMAN; MASS SPECTROMETRY; MUTANT; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECOMBINANT GENE; SITE DIRECTED MUTAGENESIS;

CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; EXONS; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; HUMANS; MASS SPECTROMETRY; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; MUTATION, MISSENSE; PEPTIDE MAPPING; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TAU PROTEINS;

EID: 0035937481     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(01)02267-0     Document Type: Article

References (35)