Swedish mutation within amyloid precursor protein modulates global gene expression towards the pathogenesis of Alzheimer's disease

BMB Reports

Volumn 43, Issue 10, 2010, Pages 704-709

  Shin, Jongyeon ^a,b   Yu, Saet Byeol ^a,b   Yu, Un Young ^c   Jo, Sangmee Ahn ^d   Ahn, Jung Hyuck ^c  

^a Seoul National University   (South Korea)

^b Psoma Therapeutics Inc   (South Korea)

^c Ewha Womans University School of Medicine   (South Korea)

^d Korea Centers for Disease Control and Prevention   (South Korea)

Author keywords

Alzheimer's disease; Gene expression; Swedish mutation; Tau protein; Transcriptome sequencing

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ISOPROTEIN;

ALZHEIMER DISEASE; ARTICLE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; MICROARRAY ANALYSIS; MUTATION; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; VALIDATION STUDY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; CELL LINE, TUMOR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MICROARRAY ANALYSIS; MUTATION; PROTEIN ISOFORMS; TRANSFECTION; VALIDATION STUDIES AS TOPIC;

EID: 78649486194     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.3858/BMBRep.2010.43.10.704     Document Type: Article

References (26)

1. Brown, P. O. and Botstein, D. (1999) Exploring the new world of the genome with DNA microarrays. Nat. Genet. 21, 33-37.
2. Lipshutz, R. J., Fodor, S. P., Gingeras, T. R. and Lockhart, D. J. (1999) High density synthetic oligonucleotide arrays. Nat. Genet. 21, 20-24.
3. Scherf, U., Ross, D. T., Waltham, M., Smith, L. H., Lee, J. K., Tanabe, L., Kohn, K. W., Reinhold, W. C., Myers, T. G., Andrews, D. T., Scudiero, D. A., Eisen, M. B., Sausville, E. A., Pommier, Y., Botstein, D., Brown, P. O. and Weinstein, J. N. (2000) A gene expression database for the molecular pharmacology of cancer. Nat. Genet. 24, 236-244.
4. White, K. P. (2001) Functional genomics and the study of development, variation and evolution. Nat. Rev. Genet. 2, 528-537.
5. Rifkin, S. A., Kim, J. and White, K. P. (2003) Evolution of gene expression in the Drosophila melanogaster subgroup. Nat. Genet. 33, 138-144.
6. Passador-Gurgel, G., Hsieh, W. P., Hunt, P., Deighton, N. and Gibson, G. (2007) Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster. Nat. Genet. 39, 264-268.
7. Gautier, L., Cope, L., Bolstad, B. M. and Irizarry, R. A. (2004) affy--analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 20, 307-315.
8. Wang, Z., Gerstein, M. and Snyder, M. (2009) RNA-Seq: a revolutionary tool for transcriptomics. Nat. Rev. Genet. 10, 57-63.
9. Kane, M. D., Jatkoe, T. A., Stumpf, C. R., Lu, J., Thomas, J. D. and Madore, S. J. (2000) Assessment of the sensitivity and specificity of oligonucleotide (50mer) microarrays. Nucleic. Acids. Res. 28, 4552-4557.
10. Cloonan, N., Forrest, A. R., Kolle, G., Gardiner, B. B., Faulkner, G. J., Brown, M. K., Taylor, D. F., Steptoe, A. L., Wani, S., Bethel, G., Robertson, A. J., Perkins, A. C., Bruce, S. J., Lee, C. C., Ranade, S. S., Peckham, H. E., Manning, J. M., McKernan, K. J. and Grimmond, S. M. (2008) Stem cell transcriptome profiling via massive-scale mRNA sequencing. Nat. Methods 5, 613-619.
11. Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L. and Wold, B. (2008) Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat. Methods 5, 621-628.
12. Nagalakshmi, U., Wang, Z., Waern, K., Shou, C., Raha, D., Gerstein, M. and Snyder, M. (2008) The transcriptional landscape of the yeast genome defined by RNA sequencing. Science 320, 1344-1349.
13. Sultan, M., Schulz, M. H., Richard, H., Magen, A., Klingenhoff, A., Scherf, M., Seifert, M., Borodina, T., Soldatov, A., Parkhomchuk, D., Schmidt, D., O'Keeffe, S., Haas, S., Vingron, M., Lehrach, H. and Yaspo, M. L. (2008) A global view of gene activity and alternative splicing by deep sequencing of the human transcriptome. Science 321, 956-960.
14. Wilhelm, B. T., Marguerat, S., Watt, S., Schubert, F., Wood, V., Goodhead, I., Penkett, C. J., Rogers, J. and Bahler, J. (2008) Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution. Nature 453, 1239-1243.
15. Cao, X. and Sudhof, T. C. (2004) Dissection of amyloidbeta precursor protein-dependent transcriptional transactivation. J. Biol. Chem. 279, 24601-24611.
16. Cao, X. and Sudhof, T. C. (2001) A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293, 115-120.
17. Filali, M., Lalonde, R. and Rivest, S. (2009) Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease. Genes Brain Behav. 8, 143-148.
18. Kim, H. S., Kim, E. M., Lee, J. P., Park, C. H., Kim, S., Seo, J. H., Chang, K. A., Yu, E., Jeong, S. J., Chong, Y. H. and Suh, Y. H. (2003) C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression. FASEB J. 17, 1951-1953.
19. Pardossi-Piquard, R., Petit, A., Kawarai, T., Sunyach, C., Alves da Costa, C., Vincent, B., Ring, S., D'Adamio, L., Shen, J., Muller, U., St George Hyslop, P. and Checler, F. (2005) Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron 46, 541-554.
20. von Rotz, R. C., Kohli, B. M., Bosset, J., Meier, M., Suzuki, T., Nitsch, R. M. and Konietzko, U. (2004) The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J. Cell. Sci. 117, 4435-4448.
21. Baek, S. H., Ohgi, K. A., Rose, D. W., Koo, E. H., Glass, C. K. and Rosenfeld, M. G. (2002) Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell 110, 55-67.
22. Huysseune, S., Kienlen-Campard, P., Hebert, S., Tasiaux, B., Leroy, K., Devuyst, O., Brion, J. P., De Strooper, B. and Octave, J. N. (2009) Epigenetic control of aquaporin 1 expression by the amyloid precursor protein. FASEB J. 23, 4158-4167.
23. Lambert, J. C., Wavrant-De Vrieze, F., Amouyel, P. and Chartier-Harlin, M. C. (1998) Association at LRP gene locus with sporadic late-onset Alzheimer's disease. Lancet 351, 1787-1788.
24. Qian, W., Shi, J., Yin, X., Iqbal, K., Grundke-Iqbal, I., Gong, C. X. and Liu, F. (2010) PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. J. Alzheimers Dis. 19, 1221-1229.
25. Zhang, H., Sun, S., Herreman, A., De Strooper, B. and Bezprozvanny, I. (2010) Role of presenilins in neuronal calcium homeostasis. J. Neurosci. 30, 8566-8580.
26. Lindsey, J. C., Lusher, M. E., Anderton, J. A., Gilbertson, R. J., Ellison, D. W. and Clifford, S. C. (2007) Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma. Br. J. Cancer 97, 267-274.