Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome

PLoS Genetics

Volumn 7, Issue 4, 2011, Pages

  Bohgaki, Toshiyuki ^a   Bohgaki, Miyuki ^a   Cardoso, Renato ^a   Panier, Stephanie ^b   Zeegers, Dimphy ^c   Li, Li ^a   Stewart, Grant S ^d   Sanchez, Otto ^e   Hande, M Prakash ^d   Durocher, Daniel ^b   Hakem, Anne ^a   Hakem, Razqallah ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e UNIVERSITY OF ONTARIO INSTITUTE OF TECHNOLOGY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DOUBLE STRANDED DNA; GENE PRODUCT; HISTONE H2AX; IMMUNOGLOBULIN; MEDIATOR OF DNA DAMAGE CHECKPOINT PROTEIN 1; P53 BINDING PROTEIN 1; PROTEIN P53; RING FINGER PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; NONHISTONE PROTEIN; RNF8 PROTEIN, MOUSE; TRP53BP1 PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CARCINOGENESIS; CONTROLLED STUDY; DISEASE MODEL; DNA STRAND BREAKAGE; FACE DYSMORPHIA; GENE; GENE INACTIVATION; GENE INSERTION; GENE MUTATION; GENE REARRANGEMENT; GENETIC DISORDER; GENETIC RECOMBINATION; GENOMIC INSTABILITY; H2AX GENE; IMMUNE DEFICIENCY; LEARNING DISORDER; MALE; MALIGNANT NEOPLASTIC DISEASE; MDC1 GENE; MOUSE; NONHUMAN; PATHOGENESIS; RADIOSENSITIVITY; RIDDLE SYNDROME; RNF168 GENE; RNF8 GENE; SIGNAL TRANSDUCTION; SPERMATOGENESIS; THYMOCYTE; TUMOR SUPPRESSOR GENE; VDJ EXON; AGE; ANIMAL; DNA REPAIR; DOUBLE STRANDED DNA BREAK; FEMALE; GENETICS; METABOLISM; MOUSE MUTANT; NEOPLASM; RADIATION DOSE; SYNDROME;

EUKARYOTA; MAMMALIA; MUS;

AGE FACTORS; ANIMALS; CHROMOSOMAL PROTEINS, NON-HISTONE; DISEASE MODELS, ANIMAL; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; GENOMIC INSTABILITY; IMMUNOGLOBULIN CLASS SWITCHING; MALE; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; NEOPLASMS; RADIATION TOLERANCE; RECOMBINATION, GENETIC; SIGNAL TRANSDUCTION; SPERMATOGENESIS; SYNDROME; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

EID: 79955627875     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1001381     Document Type: Article

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