-
1
-
-
34547638220
-
Bacterial RNA polymerase: A promising target for the discovery of new antimicrobial agents
-
Chopra, I. Bacterial RNA polymerase: a promising target for the discovery of new antimicrobial agents. Curr. Opin. Investig. Drugs., 2007, 8(8), 600-607.
-
(2007)
Curr. Opin. Investig. Drugs.
, vol.8
, Issue.8
, pp. 600-607
-
-
Chopra, I.1
-
2
-
-
33847332243
-
Progress in targeting bacterial transcription
-
Villain-Guillot, P.; Bastide, L.; Gualtieri, M.; Leonetti, J. P. Progress in targeting bacterial transcription. Drug Discov Today, 2007, 12(5-6), 200-208.
-
(2007)
Drug Discov Today
, vol.12
, Issue.5-6
, pp. 200-208
-
-
Villain-Guillot, P.1
Bastide, L.2
Gualtieri, M.3
Leonetti, J.P.4
-
3
-
-
53549103877
-
Tie me up, tie me down: Inhibiting RNA polymerase
-
Sousa, R. Tie me up, tie me down: inhibiting RNA polymerase. Cell, 2008, 135(2), 205-207.
-
(2008)
Cell
, vol.135
, Issue.2
, pp. 205-207
-
-
Sousa, R.1
-
4
-
-
0034026376
-
RNA polymerase structure-function: Insights into points of transcriptional regulation
-
Severinov, K. RNA polymerase structure-function: insights into points of transcriptional regulation. Curr. Opin. Microb., 2000, 3(2), 118-125.
-
(2000)
Curr. Opin. Microb.
, vol.3
, Issue.2
, pp. 118-125
-
-
Severinov, K.1
-
5
-
-
0036468364
-
Multisubunit RNA polymerases, Current Opinion in Structural Biology
-
Cramer, P. Multisubunit RNA polymerases, Current Opinion in Structural Biology. Curr. Opin. Struc. Biol., 2002, 12(1), 89-97.
-
(2002)
Curr. Opin. Struc. Biol.
, vol.12
, Issue.1
, pp. 89-97
-
-
Cramer, P.1
-
6
-
-
73649093377
-
Molecular Evolution of Multisubunit RNA Polymerases: Structural Analysis
-
Lane, W. J.; Darst, S. A. Molecular Evolution of Multisubunit RNA Polymerases: Structural Analysis. J. Mol. Biol., 2010, 395(4), 686-704.
-
(2010)
J. Mol. Biol.
, vol.395
, Issue.4
, pp. 686-704
-
-
Lane, W.J.1
Darst, S.A.2
-
7
-
-
77953711880
-
Translocation by multisubunit RNA polymerases
-
Kireeva, M.; Kashlev, M.; Burton, Z. F. Translocation by multisubunit RNA polymerases. Biochim. Biophys. Acta., 2005, 1799(5-6), 389-401.
-
(2005)
Biochim. Biophys. Acta.
, vol.1799
, Issue.5-6
, pp. 389-401
-
-
Kireeva, M.1
Kashlev, M.2
Burton, Z.F.3
-
8
-
-
0027211078
-
Antimalarial activity of rifampicin in vitro and in rodent models
-
Strath, M.; Scott-Finnigan, T.; Gardner, M.; Williamson, D.; Wilson, I. Antimalarial activity of rifampicin in vitro and in rodent models. T Roysoctrop Med H, 2003, 87(2), 211-216.
-
(2003)
T Roysoctrop Med H
, vol.87
, Issue.2
, pp. 211-216
-
-
Strath, M.1
Scott-Finnigan, T.2
Gardner, M.3
Williamson, D.4
Wilson, I.5
-
9
-
-
41149109976
-
Stationary phase induced alterations in mycobacterial RNA polymerase assembly: A cue to its phenotypic resistance towards rifampicin
-
Mukherjee, R.; Chatterji, D. Stationary phase induced alterations in mycobacterial RNA polymerase assembly: A cue to its phenotypic resistance towards rifampicin. Biochem Bioph Res Co, 2008, 369(3), 899-904.
-
(2008)
Biochem Bioph Res Co
, vol.369
, Issue.3
, pp. 899-904
-
-
Mukherjee, R.1
Chatterji, D.2
-
10
-
-
70549114083
-
Structures of RNA polymerase-antibiotic complexes
-
Ho, M. X.; Hudson, B. P.; Das, K.; Arnold, E.; Ebright, R. H. Structures of RNA polymerase-antibiotic complexes. Curr. Opin. Struct. Biol., 2009, 19(6), 715-723.
-
(2009)
Curr. Opin. Struct. Biol.
, vol.19
, Issue.6
, pp. 715-723
-
-
Ho, M.X.1
Hudson, B.P.2
Das, K.3
Arnold, E.4
Ebright, R.H.5
-
11
-
-
4644242447
-
Antibacterial research and development in the 21st Century-an industry perspective of the challenges
-
Thomson, C. J.; Power, E.; Ruebsamen-Waigmann, H.; Labischinski, H. Antibacterial research and development in the 21st Century-an industry perspective of the challenges. Curr. Opin. Microb., 2004, 7(5), 445-450.
-
(2004)
Curr. Opin. Microb.
, vol.7
, Issue.5
, pp. 445-450
-
-
Thomson, C.J.1
Power, E.2
Ruebsamen-Waigmann, H.3
Labischinski, H.4
-
12
-
-
0036791627
-
New (and not so new) antibacterial targets-from where and when will the novel drugs come?
-
Projan, S. J. New (and not so new) antibacterial targets-from where and when will the novel drugs come? Curr. Opin. Pharmacol., 2002, 2(5), 513-522.
-
(2002)
Curr. Opin. Pharmacol.
, vol.2
, Issue.5
, pp. 513-522
-
-
Projan, S.J.1
-
13
-
-
0035993441
-
Rational identification of new antibacterial drug targets that are essential for viability using a genomics-based approach
-
Chalker, A. F.; Lunsford, R. D. Rational identification of new antibacterial drug targets that are essential for viability using a genomics-based approach. Pharmacol. Therapeut., 2002, 95(1), 1-20.
-
(2002)
Pharmacol. Therapeut.
, vol.95
, Issue.1
, pp. 1-20
-
-
Chalker, A.F.1
Lunsford, R.D.2
-
14
-
-
33646112903
-
Antibacterial drug discovery and structure-based design
-
Barker, J. J. Antibacterial drug discovery and structure-based design. Drug Discov. Today, 2006, 11(9-10), 391-404.
-
(2006)
Drug Discov. Today
, vol.11
, Issue.9-10
, pp. 391-404
-
-
Barker, J.J.1
-
15
-
-
33645244284
-
Is it easy to stop RNA polymerase?
-
Artsimovitch, I.; Vassylyev, D. G. Is it easy to stop RNA polymerase? Cell. Cycle., 2006, 5(4), 399-404.
-
(2006)
Cell. Cycle.
, vol.5
, Issue.4
, pp. 399-404
-
-
Artsimovitch, I.1
Vassylyev, D.G.2
-
16
-
-
39849097831
-
RNA polymerase: The vehicle of transcription
-
Borukhov, S.; Nudler, E. RNA polymerase: the vehicle of transcription. Trends Microbiol., 2008, 16(3), 126-134.
-
(2008)
Trends Microbiol.
, vol.16
, Issue.3
, pp. 126-134
-
-
Borukhov, S.1
Nudler, E.2
-
17
-
-
0035312415
-
Bacterial RNA polymerase
-
Darst, A. Bacterial RNA polymerase. Curr. Opin. Struc. Biol., 2001, 11(2), 155-162.
-
(2001)
Curr. Opin. Struc. Biol.
, vol.11
, Issue.2
, pp. 155-162
-
-
Darst, A.1
-
18
-
-
70549108206
-
Macromolecular micromovements: How RNA polymerase translocates
-
Svetlov, V.; Nudler, E. Macromolecular micromovements: how RNA polymerase translocates. Curr. Opin. Struc. Biol., 2009, 19(6), 701-707.
-
(2009)
Curr. Opin. Struc. Biol.
, vol.19
, Issue.6
, pp. 701-707
-
-
Svetlov, V.1
Nudler, E.2
-
19
-
-
77955653271
-
Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase
-
Seibold, S. A.; Singh, B. N.; Zhang, C.; Kireeva, M.; Domecq, C.; Bouchard, A.; Nazione, A. M.; Feig, M.; Cukier, R. I.; Coulombe, B.; Kashlev, M.; Hampsey, M.; Burton, Z. F. Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase. Biochim. Biophys. Acta., 2010, 1799(8), 575-587.
-
(2010)
Biochim. Biophys. Acta.
, vol.1799
, Issue.8
, pp. 575-587
-
-
Seibold, S.A.1
Singh, B.N.2
Zhang, C.3
Kireeva, M.4
Domecq, C.5
Bouchard, A.6
Nazione, A.M.7
Feig, M.8
Cukier, R.I.9
Coulombe, B.10
Kashlev, M.11
Hampsey, M.12
Burton, Z.F.13
-
20
-
-
0036537298
-
Transcription factor complexes
-
Burley, S. K.; Kamada, K. Transcription factor complexes. Curr. Opin. Struc. Biol., 2002, 12(2), 225-230.
-
(2002)
Curr. Opin. Struc. Biol.
, vol.12
, Issue.2
, pp. 225-230
-
-
Burley, S.K.1
Kamada, K.2
-
21
-
-
42249085944
-
A Kinetic Model of Transcription Initiation by RNA Polymerase
-
Xue, X. C.; Liu, F.; Ou-Yang, Z. C. A Kinetic Model of Transcription Initiation by RNA Polymerase. J. Mol. Biol., 2008, 378(3), 520-529.
-
(2008)
J. Mol. Biol.
, vol.378
, Issue.3
, pp. 520-529
-
-
Xue, X.C.1
Liu, F.2
Ou-Yang, Z.C.3
-
22
-
-
0034702972
-
Interaction of [sigma]70 with Escherichia coli RNA polymerase core enzyme studied by surface plasmon resonance
-
Ferguson, A. L.; Hughes, A. D.; Tufail, U.; Baumann, C. G.; Scott, D. J.; Hoggett, J. G. Interaction of [sigma]70 with Escherichia coli RNA polymerase core enzyme studied by surface plasmon resonance. FEBS Lett., 2000, 481(3), 281-284.
-
(2000)
FEBS Lett.
, vol.481
, Issue.3
, pp. 281-284
-
-
Ferguson, A.L.1
Hughes, A.D.2
Tufail, U.3
Baumann, C.G.4
Scott, D.J.5
Hoggett, J.G.6
-
23
-
-
0034625251
-
Structural Organization of the RNA Polymerase-Promoter Open Complex
-
Naryshkin, N.; Revyakin, A.; Kim, Y.; Mekler, V.; Ebright, R. H. Structural Organization of the RNA Polymerase-Promoter Open Complex. Cell, 2000, 101(6), 601-611.
-
(2000)
Cell
, vol.101
, Issue.6
, pp. 601-611
-
-
Naryshkin, N.1
Revyakin, A.2
Kim, Y.3
Mekler, V.4
Ebright, R.H.5
-
24
-
-
57349199452
-
Analysis of RNA polymerase-promoter complex formation
-
Ross, W.; Gourse, R. L. Analysis of RNA polymerase-promoter complex formation. Methods, 2009, 47(1), 13-24.
-
(2009)
Methods
, vol.47
, Issue.1
, pp. 13-24
-
-
Ross, W.1
Gourse, R.L.2
-
25
-
-
42049122814
-
Regulation of bacterial RNA polymerase [sigma] factor activity: A structural perspective
-
Campbell, E. A.; Westblade, L. F.; Darst, S. A. Regulation of bacterial RNA polymerase [sigma] factor activity: a structural perspective. Curr. Opin. Microb., 2008, 11(2), 121-127.
-
(2008)
Curr. Opin. Microb.
, vol.11
, Issue.2
, pp. 121-127
-
-
Campbell, E.A.1
Westblade, L.F.2
Darst, S.A.3
-
26
-
-
67349131535
-
Incorporation of 8-hydroxyguanosine (8-oxo-7,8-dihydroguanosine) 5'-triphosphate by bacterial and human RNA polymerases
-
Kamiya, H.; Suzuki, A.; Yamaguchi, Y.; Handa, H.; Harashima, H. Incorporation of 8-hydroxyguanosine (8-oxo-7,8-dihydroguanosine) 5'-triphosphate by bacterial and human RNA polymerases. Free. Radical. Bio. Med., 2009, 46(12), 1703-1707.
-
(2009)
Free. Radical. Bio. Med.
, vol.46
, Issue.12
, pp. 1703-1707
-
-
Kamiya, H.1
Suzuki, A.2
Yamaguchi, Y.3
Handa, H.4
Harashima, H.5
-
27
-
-
66549126163
-
A movie of the RNA polymerase nucleotide addition cycle
-
Brueckner, F.; Ortiz, J.; Cramer, P. A movie of the RNA polymerase nucleotide addition cycle. Curr. Opin. Struc. Biol., 2009, 19(3), 294-299.
-
(2009)
Curr. Opin. Struc. Biol.
, vol.19
, Issue.3
, pp. 294-299
-
-
Brueckner, F.1
Ortiz, J.2
Cramer, P.3
-
28
-
-
34447513771
-
Structural basis for substrate loading in bacterial RNA polymerase
-
Vassylyev, D. G.; Vassylyeva, M. N.; Zhang, J.; Palangat, M.; Artsimovitch, I.; Landick, R. Structural basis for substrate loading in bacterial RNA polymerase. Nature, 2007, 448(7150), 163-168.
-
(2007)
Nature
, vol.448
, Issue.7150
, pp. 163-168
-
-
Vassylyev, D.G.1
Vassylyeva, M.N.2
Zhang, J.3
Palangat, M.4
Artsimovitch, I.5
Landick, R.6
-
29
-
-
7444253928
-
Sequence-dependent Kinetic Model for Transcription Elongation by RNA Polymerase
-
Bai, L.; Shundrovsky, A.; Wang, M. D. Sequence-dependent Kinetic Model for Transcription Elongation by RNA Polymerase. J. Mol. Biol., 2004, 344(2), 335-349.
-
(2004)
J. Mol. Biol.
, vol.344
, Issue.2
, pp. 335-349
-
-
Bai, L.1
Shundrovsky, A.2
Wang, M.D.3
-
30
-
-
27644473223
-
Holoenzyme Switching and Stochastic Release of Sigma Factors from RNA Polymerase In Vivo
-
Raffaelle, M.; Kanin, E. I.; Vogt, J.; Burgess, R. R.; Ansari, A. Z. Holoenzyme Switching and Stochastic Release of Sigma Factors from RNA Polymerase In Vivo. Mol. Cell, 2005, 20(3), 357-366.
-
(2005)
Mol. Cell
, vol.20
, Issue.3
, pp. 357-366
-
-
Raffaelle, M.1
Kanin, E.I.2
Vogt, J.3
Burgess, R.R.4
Ansari, A.Z.5
-
31
-
-
0030576532
-
Function of E. coli RNA Polymerase [sigma] Factor-[sigma]70 in Promoter-Proximal Pausing
-
Ring, B. Z.; Yarnell, W. S.; Roberts, J. W. Function of E. coli RNA Polymerase [sigma] Factor-[sigma]70 in Promoter-Proximal Pausing. Cell, 1996, 86(3), 485-493.
-
(1996)
Cell
, vol.86
, Issue.3
, pp. 485-493
-
-
Ring, B.Z.1
Yarnell, W.S.2
Roberts, J.W.3
-
32
-
-
70549105133
-
Elongation by RNA polymerase: A race through roadblocks
-
Vassylyev, D. G. Elongation by RNA polymerase: a race through roadblocks. Curr. Opin. Struc. Biol., 2009, 19(6), 691-700.
-
(2009)
Curr. Opin. Struc. Biol.
, vol.19
, Issue.6
, pp. 691-700
-
-
Vassylyev, D.G.1
-
33
-
-
32044451311
-
Functional interplay between the jaw domain of bacterial RNA polymerase and allele-specific residues in the product RNA-binding pocket
-
Ederth, J.; Mooney, R. A.; Isaksson, L. A.; Landick, R. Functional interplay between the jaw domain of bacterial RNA polymerase and allele-specific residues in the product RNA-binding pocket. J. Mol. Biol., 2006, 356(5), 1163-1179.
-
(2006)
J. Mol. Biol.
, vol.356
, Issue.5
, pp. 1163-1179
-
-
Ederth, J.1
Mooney, R.A.2
Isaksson, L.A.3
Landick, R.4
-
34
-
-
0035943446
-
Translocation of [sigma]70 with RNA Polymerase during Transcription: Fluorescence Resonance Energy Transfer Assay for Movement Relative to DNA
-
Mukhopadhyay, J.; Kapanidis, A. N.; Mekler, V.; Kortkhonjia, E.; Ebright, Y. W.; Ebright, R. H. Translocation of [sigma]70 with RNA Polymerase during Transcription: Fluorescence Resonance Energy Transfer Assay for Movement Relative to DNA. Cell, 2001, 106(4), 453-463.
-
(2001)
Cell
, vol.106
, Issue.4
, pp. 453-463
-
-
Mukhopadhyay, J.1
Kapanidis, A.N.2
Mekler, V.3
Kortkhonjia, E.4
Ebright, Y.W.5
Ebright, R.H.6
-
35
-
-
1842558298
-
Control of the alternative sigma factor [sigma] E in Escherichia coli
-
Ades, S. E. Control of the alternative sigma factor [sigma] E in Escherichia coli. Curr. Opin. Microb., 2004, 7(2), 157-162.
-
(2004)
Curr. Opin. Microb.
, vol.7
, Issue.2
, pp. 157-162
-
-
Ades, S.E.1
-
36
-
-
0037261948
-
The sigma70 family of sigma factors
-
Paget, M. S.; Helmann, J. D. The sigma70 family of sigma factors. Genome Biol., 2003, 4(1), 203.
-
(2003)
Genome Biol.
, vol.4
, Issue.1
, pp. 203
-
-
Paget, M.S.1
Helmann, J.D.2
-
37
-
-
31544454456
-
Novel synthetic molecules targeting the bacterial RNA polymerase assembly
-
Andre, E.; Bastide, L.; Michaux-Charachon, S.; Gouby, A.; Villain-Guillot, P.; Latouche, J.; Bouchet, A.; Gualtieri, M.; Leonetti, J. P. Novel synthetic molecules targeting the bacterial RNA polymerase assembly. J. Antimicrob. Chemother., 2006, 57(2), 245-251.
-
(2006)
J. Antimicrob. Chemother.
, vol.57
, Issue.2
, pp. 245-251
-
-
Andre, E.1
Bastide, L.2
Michaux-Charachon, S.3
Gouby, A.4
Villain-Guillot, P.5
Latouche, J.6
Bouchet, A.7
Gualtieri, M.8
Leonetti, J.P.9
-
38
-
-
33746757739
-
A new class of small molecule RNA polymerase inhibitors with activity against rifampicin-resistant Staphylococcus aureus
-
Arhin, F.; Belanger, O.; Ciblat, S.; Dehbi, M.; Delorme, D.; Dietrich, E.; Dixit, D.; Lafontaine, Y.; Lehoux, D.; Liu, J.; McKay, G. A.; Moeck, G.; Reddy, R.; Rose, Y.; Srikumar, R.; Tanaka, K. S.; Williams, D. M.; Gros, P.; Pelletier, J.; Parr, T. R., Jr.; Far, A. R. A new class of small molecule RNA polymerase inhibitors with activity against rifampicin-resistant Staphylococcus aureus. Bioorg. Med. Chem., 2006, 14(17), 5812-5832.
-
(2006)
Bioorg. Med. Chem.
, vol.14
, Issue.17
, pp. 5812-5832
-
-
Arhin, F.1
Belanger, O.2
Ciblat, S.3
Dehbi, M.4
Delorme, D.5
Dietrich, E.6
Dixit, D.7
Lafontaine, Y.8
Lehoux, D.9
Liu, J.10
McKay, G.A.11
Moeck, G.12
Reddy, R.13
Rose, Y.14
Srikumar, R.15
Tanaka, K.S.16
Williams, D.M.17
Gros, P.18
Pelletier, J.19
Parr Jr., T.R.20
Far, A.R.21
more..
-
39
-
-
0017811680
-
Inhibitors of bacterial DNAdependent RNA polymerase, Pharmacology & Therapeutics. Part A: Chemotherapy
-
Krakow, J. S.; Anand Kumar, S. Inhibitors of bacterial DNAdependent RNA polymerase, Pharmacology & Therapeutics. Part A: Chemotherapy. Pharmacol. Therapeu., 1978, 2(2), 261-280.
-
(1978)
Pharmacol. Therapeu.
, vol.2
, Issue.2
, pp. 261-280
-
-
Krakow, J.S.1
Anand Kumar, S.2
-
40
-
-
63449096360
-
Bacterial RNA polymerase inhibitors: An organized overview of their structure, derivatives, biological activity and current clinical development status
-
Mariani, R.; Maffioli, S. I. Bacterial RNA polymerase inhibitors: an organized overview of their structure, derivatives, biological activity and current clinical development status. Curr. Med. Chem., 2009, 16(4), 430-454.
-
(2009)
Curr. Med. Chem.
, vol.16
, Issue.4
, pp. 430-454
-
-
Mariani, R.1
Maffioli, S.I.2
-
41
-
-
23744489566
-
Modulation of the RNA Polymerase Catalytic Reaction Is an Essential Component of Transcription Control by Rifamycins
-
Artsimovitch, I.; Vassylyeva, M. N.; Svetlov, D.; Svetlov, V.; Perederina, A.; Igarashi, N.; Matsugaki, N.; Wakatsuki, S.; Tahirov, T. H.; Vassylyev, D. G. Modulation of the RNA Polymerase Catalytic Reaction Is an Essential Component of Transcription Control by Rifamycins. Cell, 2005, 122(3), 351-363.
-
(2005)
Cell
, vol.122
, Issue.3
, pp. 351-363
-
-
Artsimovitch, I.1
Vassylyeva, M.N.2
Svetlov, D.3
Svetlov, V.4
Perederina, A.5
Igarashi, N.6
Matsugaki, N.7
Wakatsuki, S.8
Tahirov, T.H.9
Vassylyev, D.G.10
-
42
-
-
0021069991
-
Synthesis and antibacterial activity of 3-amidino-and of 4-aminoimidazolo[4,5-c] rifamycin derivatives
-
Novel rifamycins. III
-
Marsili, L.; Franceschi, G.; Ballabio, M.; Oronzo, G.; Vigevani, A.; Ungheri, D.; Della, B. C.; Sanfilippo, A. Novel rifamycins. III. Synthesis and antibacterial activity of 3-amidino-and of 4-aminoimidazolo[4,5-c] rifamycin derivatives. J. Antibiot. (Tokyo), 1983, 36(11), 1495-1501.
-
(1983)
J. Antibiot. (Tokyo)
, vol.36
, Issue.11
, pp. 1495-1501
-
-
Marsili, L.1
Franceschi, G.2
Ballabio, M.3
Oronzo, G.4
Vigevani, A.5
Ungheri, D.6
Della, B.C.7
Sanfilippo, A.8
-
43
-
-
0031916245
-
Inhibition of RNA synthesis as a therapeutic strategy against Aspergillus and Fusarium: Demonstration of in vitro synergy between rifabutin and amphotericin B
-
Clancy, C. J.; Yu, Y. C.; Lewin, A.; Nguyen, M. H. Inhibition of RNA synthesis as a therapeutic strategy against Aspergillus and Fusarium: demonstration of in vitro synergy between rifabutin and amphotericin B. Antimicrob. Agents Chemother., 1998, 42(3), 509-513.
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, Issue.3
, pp. 509-513
-
-
Clancy, C.J.1
Yu, Y.C.2
Lewin, A.3
Nguyen, M.H.4
-
44
-
-
33745267677
-
Development potential of rifalazil and other benzoxazinorifamycins
-
Rothstein, D. M.; Shalish, C.; Murphy, C. K.; Sternlicht, A.; Campbell, L. A. Development potential of rifalazil and other benzoxazinorifamycins. Expert. Opin. Investig. Drugs, 2006, 15(6), 603-623.
-
(2006)
Expert. Opin. Investig. Drugs
, vol.15
, Issue.6
, pp. 603-623
-
-
Rothstein, D.M.1
Shalish, C.2
Murphy, C.K.3
Sternlicht, A.4
Campbell, L.A.5
-
45
-
-
0016639187
-
Lipiarmycin: An antibiotic inhibiting nucleic acid polymerases
-
Talpaert, M.; Campagnari, F.; Clerici, L. Lipiarmycin: An antibiotic inhibiting nucleic acid polymerases. Biochem Bioph Res Co, 1975, 63(1), 328-334.
-
(1975)
Biochem Bioph Res Co
, vol.63
, Issue.1
, pp. 328-334
-
-
Talpaert, M.1
Campagnari, F.2
Clerici, L.3
-
46
-
-
77955423906
-
The transcription inhibitor lipiarmycin blocks DNA fitting into the RNA polymerase catalytic site
-
Tupin, A.; Gualtieri, M.; Leonetti, J. P.; Brodolin, K. The transcription inhibitor lipiarmycin blocks DNA fitting into the RNA polymerase catalytic site. EMBO J., 2010, 29(15), 2527-2537.
-
(2010)
EMBO J.
, vol.29
, Issue.15
, pp. 2527-2537
-
-
Tupin, A.1
Gualtieri, M.2
Leonetti, J.P.3
Brodolin, K.4
-
47
-
-
29944444405
-
Mutation in the Bacillus subtilis RNA polymerase beta' subunit confers resistance to lipiarmycin
-
Gualtieri, M.; Villain-Guillot, P.; Latouche, J.; Leonetti, J. P.; Bastide, L. Mutation in the Bacillus subtilis RNA polymerase beta' subunit confers resistance to lipiarmycin. Antimicrob. Agents Chemother., 2006, 50(1), 401-402.
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, Issue.1
, pp. 401-402
-
-
Gualtieri, M.1
Villain-Guillot, P.2
Latouche, J.3
Leonetti, J.P.4
Bastide, L.5
-
48
-
-
33947304450
-
Drug evaluation: OPT-80, a narrow-spectrum macrocyclic antibiotic
-
Johnson, A. P. Drug evaluation: OPT-80, a narrow-spectrum macrocyclic antibiotic. Curr. Opin. Investig. Drugs, 2007, 8(2), 168-173.
-
(2007)
Curr. Opin. Investig. Drugs
, vol.8
, Issue.2
, pp. 168-173
-
-
Johnson, A.P.1
-
49
-
-
22844441221
-
Antibiotics GE23077, novel inhibitors of bacterial RNA polymerase. Part 3: Chemical derivatization
-
Mariani, R.; Granata, G.; Maffioli, S. I.; Serina, S.; Brunati, C.; Sosio, M.; Marazzi, A.; Vannini, A.; Patel, D.; White, R.; Ciabatti, R. Antibiotics GE23077, novel inhibitors of bacterial RNA polymerase. Part 3: Chemical derivatization. Bioorg. Med. Chem. Lett., 2005, 15(16), 3748-3752.
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, Issue.16
, pp. 3748-3752
-
-
Mariani, R.1
Granata, G.2
Maffioli, S.I.3
Serina, S.4
Brunati, C.5
Sosio, M.6
Marazzi, A.7
Vannini, A.8
Patel, D.9
White, R.10
Ciabatti, R.11
-
50
-
-
3242881098
-
Mode of action of the microbial metabolite GE23077, a novel potent and selective inhibitor of bacterial RNA polymerase
-
Sarubbi, E.; Monti, F.; Corti, E.; Miele, A.; Selva, E. Mode of action of the microbial metabolite GE23077, a novel potent and selective inhibitor of bacterial RNA polymerase. Eur. J. Biochem., 2004, 271(15), 3146-3154.
-
(2004)
Eur. J. Biochem.
, vol.271
, Issue.15
, pp. 3146-3154
-
-
Sarubbi, E.1
Monti, F.2
Corti, E.3
Miele, A.4
Selva, E.5
-
51
-
-
24044497229
-
Structural Basis of Transcription Inhibition by Antibiotic Streptolydigin
-
Temiakov, D.; Zenkin, N.; Vassylyeva, M. N.; Perederina, A.; Tahirov, T. H.; Kashkina, E.; Savkina, M.; Zorov, S.; Nikiforov, V.; Igarashi, N.; Matsugaki, N.; Wakatsuki, S.; Severinov, K.; Vassylyev, D. G. Structural Basis of Transcription Inhibition by Antibiotic Streptolydigin. Mol. Cell, 2005, 19(5), 655-666.
-
(2005)
Mol. Cell
, vol.19
, Issue.5
, pp. 655-666
-
-
Temiakov, D.1
Zenkin, N.2
Vassylyeva, M.N.3
Perederina, A.4
Tahirov, T.H.5
Kashkina, E.6
Savkina, M.7
Zorov, S.8
Nikiforov, V.9
Igarashi, N.10
Matsugaki, N.11
Wakatsuki, S.12
Severinov, K.13
Vassylyev, D.G.14
-
52
-
-
23944521364
-
Inhibition of Bacterial RNA Polymerase by Streptolydigin: Stabilization of a Straight-Bridge-Helix Active-Center Conformation
-
Tuske, S.; Sarafianos, S. G.; Wang, X.; Hudson, B.; Sineva, E.; Mukhopadhyay, J.; Birktoft, J. J.; Leroy, O.; Ismail, S.; Clark, J.; Dharia, C.; Napoli, A.; Laptenko, O.; Lee, J.; Borukhov, S.; Ebright, R. H.; Arnold, E. Inhibition of Bacterial RNA Polymerase by Streptolydigin: Stabilization of a Straight-Bridge-Helix Active-Center Conformation. Cell, 2005, 122(4), 541-552.
-
(2005)
Cell
, vol.122
, Issue.4
, pp. 541-552
-
-
Tuske, S.1
Sarafianos, S.G.2
Wang, X.3
Hudson, B.4
Sineva, E.5
Mukhopadhyay, J.6
Birktoft, J.J.7
Leroy, O.8
Ismail, S.9
Clark, J.10
Dharia, C.11
Napoli, A.12
Laptenko, O.13
Lee, J.14
Borukhov, S.15
Ebright, R.H.16
Arnold, E.17
-
53
-
-
71149121326
-
Deciphering Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin and Generation of Glycosylated Derivatives
-
Olano, C.; Gómez, C.; Pérez, M.; Palomino, M.; Pineda-Lucena, A.; Carbajo, R. J.; Braña, A. F.; Méndez, C.; Salas, J. A. Deciphering Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin and Generation of Glycosylated Derivatives. Chem Biol, 2009, 16(10), 1031-1044.
-
(2009)
Chem Biol
, vol.16
, Issue.10
, pp. 1031-1044
-
-
Olano, C.1
Gómez, C.2
Pérez, M.3
Palomino, M.4
Pineda-Lucena, A.5
Carbajo, R.J.6
Braña, A.F.7
Méndez, C.8
Salas, J.A.9
-
54
-
-
15444374664
-
-
Campbell, E. A.; Pavlova, O.; Zenkin, N.; Leon, F.; Irschik, H.; Jansen, R.; Severinov, K.; Darst, S. A. EMBO J., 2005, 24(4), 674-682.
-
(2005)
EMBO J.
, vol.24
, Issue.4
, pp. 674-682
-
-
Campbell, E.A.1
Pavlova, O.2
Zenkin, N.3
Leon, F.4
Irschik, H.5
Jansen, R.6
Severinov, K.7
Darst, S.8
-
55
-
-
2942635581
-
Molecular mechanism of transcription inhibition by peptide antibiotic Microcin J25
-
Adelman, K.; Yuzenkova, J.; La, P. A.; Zenkin, N.; Lee, J.; Lis, J. T.; Borukhov, S.; Wang, M. D.; Severinov, K. Molecular mechanism of transcription inhibition by peptide antibiotic Microcin J25. Mol. Cell, 2004, 14(6), 753-762.
-
(2004)
Mol. Cell
, vol.14
, Issue.6
, pp. 753-762
-
-
Adelman, K.1
Yuzenkova, J.2
La, P.A.3
Zenkin, N.4
Lee, J.5
Lis, J.T.6
Borukhov, S.7
Wang, M.D.8
Severinov, K.9
-
56
-
-
2942696237
-
Mol. Antibacterial Peptide Microcin J25 Inhibits Transcription by Binding within and Obstructing the RNA Polymerase Secondary Channel
-
Mukhopadhyay, J.; Sineva, E.; Knight, J.; Levy, R. M.; Ebright, R. H. Mol. Antibacterial Peptide Microcin J25 Inhibits Transcription by Binding within and Obstructing the RNA Polymerase Secondary Channel. Cell, 2004, 14(6), 739-751.
-
(2004)
Cell
, vol.14
, Issue.6
, pp. 739-751
-
-
Mukhopadhyay, J.1
Sineva, E.2
Knight, J.3
Levy, R.M.4
Ebright, R.H.5
-
57
-
-
0141919821
-
Structure of microcin J25, a peptide inhibitor of bacterial RNA polymerase, is a lassoed tail
-
Wilson, K. A.; Kalkum, M.; Ottesen, J.; Yuzenkova, J.; Chait, B. T.; Landick, R.; Muir, T.; Severinov, K.; Darst, S. A. Structure of microcin J25, a peptide inhibitor of bacterial RNA polymerase, is a lassoed tail. J. Am. Chem. Soc., 2003, 125(41), 12475-12483.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, Issue.41
, pp. 12475-12483
-
-
Wilson, K.A.1
Kalkum, M.2
Ottesen, J.3
Yuzenkova, J.4
Chait, B.T.5
Landick, R.6
Muir, T.7
Severinov, K.8
Darst, S.A.9
-
58
-
-
0029161954
-
The ripostatins, novel inhibitors of eubacterial RNA polymerase isolated from myxobacteria
-
Irschik, H.; Augustiniak, H.; Gerth, K.; Hofle, G.; Reichenbach, H. The ripostatins, novel inhibitors of eubacterial RNA polymerase isolated from myxobacteria. J. Antibiot. (Tokyo), 1995, 48(8), 787-792.
-
(1995)
J. Antibiot. (Tokyo)
, vol.48
, Issue.8
, pp. 787-792
-
-
Irschik, H.1
Augustiniak, H.2
Gerth, K.3
Hofle, G.4
Reichenbach, H.5
-
59
-
-
17044462175
-
Solution-phase parallel synthesis of a 1140-member ureidothiophene carboxylic acid library
-
Le Foulon, F. X.; Braud, E.; Fabis, F.; Lancelot, J. C.; Rault, S. Solution-phase parallel synthesis of a 1140-member ureidothiophene carboxylic acid library. J. Comb. Chem., 2005, 7(2), 253-257.
-
(2005)
J. Comb. Chem.
, vol.7
, Issue.2
, pp. 253-257
-
-
Le Foulon, F.X.1
Braud, E.2
Fabis, F.3
Lancelot, J.C.4
Rault, S.5
-
60
-
-
5144224308
-
Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation
-
Doundoulakis, T.; Xiang, A. X.; Lira, R.; Agrios, K. A.; Webber, S. E.; Sisson, W.; Aust, R. M.; Shah, A. M.; Showalter, R. E.; Appleman, J. R.; Simonsen, K. B. Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation. Bioorg. Med. Chem. Lett., 2004, 14(22), 5667-5672.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, Issue.22
, pp. 5667-5672
-
-
Doundoulakis, T.1
Xiang, A.X.2
Lira, R.3
Agrios, K.A.4
Webber, S.E.5
Sisson, W.6
Aust, R.M.7
Shah, A.M.8
Showalter, R.E.9
Appleman, J.R.10
Simonsen, K.B.11
-
61
-
-
35848947512
-
Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase
-
Lira, R.; Xiang, A. X.; Doundoulakis, T.; Biller, W. T.; Agrios, K. A.; Simonsen, K. B.; Webber, S. E.; Sisson, W.; Aust, R. M.; Shah, A. M.; Showalter, R. E.; Banh, V. N.; Steffy, K. R.; Appleman, J. R. Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase. Bioorg. Med. Chem. Lett., 2007, 17(24), 6797-6800.
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, Issue.24
, pp. 6797-6800
-
-
Lira, R.1
Xiang, A.X.2
Doundoulakis, T.3
Biller, W.T.4
Agrios, K.A.5
Simonsen, K.B.6
Webber, S.E.7
Sisson, W.8
Aust, R.M.9
Shah, A.M.10
Showalter, R.E.11
Banh, V.N.12
Steffy, K.R.13
Appleman, J.R.14
-
62
-
-
53549085430
-
The RNA polymerase "switch region" is a target for inhibitors
-
Mukhopadhyay, J.; Das, K.; Ismail, S.; Koppstein, D.; Jang, M.; Hudson, B.; Sarafianos, S.; Tuske, S.; Patel, J.; Jansen, R.; Irschik, H.; Arnold, E.; Ebright, R. H. The RNA polymerase "switch region" is a target for inhibitors. Cell, 2008, 135(2), 295-307.
-
(2008)
Cell
, vol.135
, Issue.2
, pp. 295-307
-
-
Mukhopadhyay, J.1
Das, K.2
Ismail, S.3
Koppstein, D.4
Jang, M.5
Hudson, B.6
Sarafianos, S.7
Tuske, S.8
Patel, J.9
Jansen, R.10
Irschik, H.11
Arnold, E.12
Ebright, R.H.13
-
63
-
-
28544453415
-
Structural basis for transcription inhibition by tagetitoxin
-
Vassylyev, D. G.; Svetlov, V.; Vassylyeva, M. N.; Perederina, A.; Igarashi, N.; Matsugaki, N.; Wakatsuki, S.; Artsimovitch, I. Structural basis for transcription inhibition by tagetitoxin. Nat. Struct. Mol. Biol., 2005, 12(12), 1086-1093.
-
(2005)
Nat. Struct. Mol. Biol.
, vol.12
, Issue.12
, pp. 1086-1093
-
-
Vassylyev, D.G.1
Svetlov, V.2
Vassylyeva, M.N.3
Perederina, A.4
Igarashi, N.5
Matsugaki, N.6
Wakatsuki, S.7
Artsimovitch, I.8
-
64
-
-
74049122041
-
Design, synthesis and biological evaluation of simplified analogues of the RNA polymerase inhibitor etnangien
-
Menche, D.; Li, P.; Irschik, H. Design, synthesis and biological evaluation of simplified analogues of the RNA polymerase inhibitor etnangien. Bioorg. Med. Chem. Lett., 2010, 20(3), 939-941.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, Issue.3
, pp. 939-941
-
-
Menche, D.1
Li, P.2
Irschik, H.3
-
65
-
-
0035868463
-
Inhibition of bacterial RNA polymerase by the cyanobacterial metabolites 12-epihapalindole E isonitrile and calothrixin A
-
Doan, N. T.; Stewart, P. R.; Smith, G. D. Inhibition of bacterial RNA polymerase by the cyanobacterial metabolites 12-epihapalindole E isonitrile and calothrixin A. FEMS Microbiol Lett, 2001, 196(2), 135-139.
-
(2001)
FEMS Microbiol Lett
, vol.196
, Issue.2
, pp. 135-139
-
-
Doan, N.T.1
Stewart, P.R.2
Smith, G.D.3
-
66
-
-
22144437663
-
Bacterial resistance to antibiotics: Modified target sites
-
Lambert, P. A. Bacterial resistance to antibiotics: Modified target sites. Adv Drug Deliver Rev, 2005, 57(10), 1471-1485.
-
(2005)
Adv Drug Deliver Rev
, vol.57
, Issue.10
, pp. 1471-1485
-
-
Lambert, P.A.1
-
67
-
-
16844385949
-
Cross-resistance of Escherichia coli RNA polymerases conferring rifampin resistance to different antibiotics
-
Xu, M.; Zhou, Y. N.; Goldstein, B. P.; Jin, D. J. Cross-resistance of Escherichia coli RNA polymerases conferring rifampin resistance to different antibiotics. J. Bacteriol., 2005, 187(8), 2783-2792.
-
(2005)
J. Bacteriol.
, vol.187
, Issue.8
, pp. 2783-2792
-
-
Xu, M.1
Zhou, Y.N.2
Goldstein, B.P.3
Jin, D.J.4
-
68
-
-
0024237544
-
Effects of rifampicin resistant rpoB mutations on antitermination and interaction with nusA in Escherichia coli
-
Jin, D. J.; Cashel, M.; Friedman, D. I.; Nakamura, Y.; Walter, W. A.; Gross, C. A. Effects of rifampicin resistant rpoB mutations on antitermination and interaction with nusA in Escherichia coli. J. Mol. Biol., 1988, 204(2), 247-261.
-
(1988)
J. Mol. Biol.
, vol.204
, Issue.2
, pp. 247-261
-
-
Jin, D.J.1
Cashel, M.2
Friedman, D.I.3
Nakamura, Y.4
Walter, W.A.5
Gross, C.A.6
-
69
-
-
0023721705
-
Characterization of the termination phenotypes of rifampicin-resistant mutants
-
Jin, D. J.; Walter, W. A.; Gross, C. A. Characterization of the termination phenotypes of rifampicin-resistant mutants. J. Mol. Biol., 1988, 202(2), 245-253.
-
(1988)
J. Mol. Biol.
, vol.202
, Issue.2
, pp. 245-253
-
-
Jin, D.J.1
Walter, W.A.2
Gross, C.A.3
-
70
-
-
0023749808
-
Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampicin resistance
-
Jin, D. J.; Gross, C. A. Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampicin resistance. J. Mol. Biol., 1988, 202(1), 45-58.
-
(1988)
J. Mol. Biol.
, vol.202
, Issue.1
, pp. 45-58
-
-
Jin, D.J.1
Gross, C.A.2
-
71
-
-
0028168928
-
RifR mutations in the beginning of the Escherichia coli rpoB gene
-
Severinov, K.; Soushko, M.; Goldfarb, A.; Nikiforov, V. RifR mutations in the beginning of the Escherichia coli rpoB gene. Mol. Gen. Genet., 1994, 244(2), 120-126.
-
(1994)
Mol. Gen. Genet.
, vol.244
, Issue.2
, pp. 120-126
-
-
Severinov, K.1
Soushko, M.2
Goldfarb, A.3
Nikiforov, V.4
-
72
-
-
73349084591
-
Getting a grip on complexes
-
Nie, Y.; Viola, C.; Bieniossek, C.; Trowitzsch, S.; Vijay-Achandran, L. S.; Chaillet, M.; Garzoni, F.; Berger, I. Getting a grip on complexes. Curr. Genomics, 2009, 10(8), 558-572.
-
(2009)
Curr. Genomics
, vol.10
, Issue.8
, pp. 558-572
-
-
Nie, Y.1
Viola, C.2
Bieniossek, C.3
Trowitzsch, S.4
Vijay-Achandran, L.S.5
Chaillet, M.6
Garzoni, F.7
Berger, I.8
-
73
-
-
78751697516
-
Coping with antibiotic resistance: Contributions from genomics
-
Rossolini, G. M.; Thaller, M. C. Coping with antibiotic resistance: contributions from genomics. Genome Med., 2010, 2(2), 15.
-
(2010)
Genome Med.
, vol.2
, Issue.2
, pp. 15
-
-
Rossolini, G.M.1
Thaller, M.C.2
-
74
-
-
33644535147
-
Natural products--The future scaffolds for novel antibiotics?
-
Butler, M. S.; Buss, A. D. Natural products--The future scaffolds for novel antibiotics? Biochem Pharmacol, 2006, 71(7), 919-929.
-
(2006)
Biochem Pharmacol
, vol.71
, Issue.7
, pp. 919-929
-
-
Butler, M.S.1
Buss, A.D.2
-
75
-
-
0345708154
-
Nucleic acids chemistry and biology
-
Kurreck, J. Nucleic acids chemistry and biology. Angew. Chem. Int. Ed Engl., 2003, 42(44), 5384-5385.
-
(2003)
Angew. Chem. Int. Ed Engl.
, vol.42
, Issue.44
, pp. 5384-5385
-
-
Kurreck, J.1
-
76
-
-
0037733977
-
Improvement through novel chemical modifications
-
Kurreck, J. Improvement through novel chemical modifications. Eur. J. Biochem., 2003, 270(8), 1628-1644.
-
(2003)
Eur. J. Biochem.
, vol.270
, Issue.8
, pp. 1628-1644
-
-
Kurreck, J.1
-
77
-
-
45549091185
-
Locked nucleic acid holds promise in the treatment of cancer
-
Frieden, M.; Orum, H. Locked nucleic acid holds promise in the treatment of cancer. Curr. Pharm. Des, 2008, 14(11), 1138-1142.
-
(2008)
Curr. Pharm. Des
, vol.14
, Issue.11
, pp. 1138-1142
-
-
Frieden, M.1
Orum, H.2
-
78
-
-
77955529012
-
Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry
-
Wiessler, M.; Waldeck, W.; Pipkorn, R.; Kliem, C.; Lorenz, P.; Fleischhacker, H.; Hafner, M.; Braun, K. Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry. Int. J. Med. Sci., 2010, 7(4), 213-223.
-
(2010)
Int. J. Med. Sci.
, vol.7
, Issue.4
, pp. 213-223
-
-
Wiessler, M.1
Waldeck, W.2
Pipkorn, R.3
Kliem, C.4
Lorenz, P.5
Fleischhacker, H.6
Hafner, M.7
Braun, K.8
-
79
-
-
77952564024
-
Antisense phosphorodiamidate morpholino oligomers targeted to an essential gene inhibit Burkholderia cepacia complex
-
Greenberg, D. E.; Marshall-Batty, K. R.; Brinster, L. R.; Zarember, K. A.; Shaw, P. A.; Mellbye, B. L.; Iversen, P. L.; Holland, S. M.; Geller, B. L. Antisense phosphorodiamidate morpholino oligomers targeted to an essential gene inhibit Burkholderia cepacia complex. J. Infect. Dis., 2010, 201(12), 1822-1830.
-
(2010)
J. Infect. Dis.
, vol.201
, Issue.12
, pp. 1822-1830
-
-
Greenberg, D.E.1
Marshall-Batty, K.R.2
Brinster, L.R.3
Zarember, K.A.4
Shaw, P.A.5
Mellbye, B.L.6
Iversen, P.L.7
Holland, S.M.8
Geller, B.L.9
-
80
-
-
18844429452
-
In vivo bioavailability and pharmacokinetics of a c-MYC antisense phosphorodiamidate morpholino oligomer, AVI-4126, in solid tumors
-
Devi, G. R.; Beer, T. M.; Corless, C. L.; Arora, V.; Weller, D. L.; Iversen, P. L. In vivo bioavailability and pharmacokinetics of a c-MYC antisense phosphorodiamidate morpholino oligomer, AVI-4126, in solid tumors. Clin. Cancer Res., 2005, 11(10), 3930-3938.
-
(2005)
Clin. Cancer Res.
, vol.11
, Issue.10
, pp. 3930-3938
-
-
Devi, G.R.1
Beer, T.M.2
Corless, C.L.3
Arora, V.4
Weller, D.L.5
Iversen, P.L.6
-
81
-
-
67650403364
-
Controlled delivery of antisense oligonucleotides: A brief review of current strategies
-
Zhao, X.; Pan, F.; Holt, C. M.; Lewis, A. L.; Lu, J. R. Controlled delivery of antisense oligonucleotides: a brief review of current strategies. Expert. Opin. Drug Deliv., 2009, 6(7), 673-686.
-
(2009)
Expert. Opin. Drug Deliv.
, vol.6
, Issue.7
, pp. 673-686
-
-
Zhao, X.1
Pan, F.2
Holt, C.M.3
Lewis, A.L.4
Lu, J.R.5
-
82
-
-
77952737907
-
Peptide nucleic acids conjugated to short basic peptides show improved pharmacokinetics and antisense activity in adipose tissue
-
Wancewicz, E. V.; Maier, M. A.; Siwkowski, A. M.; Albertshofer, K.; Winger, T. M.; Berdeja, A.; Gaus, H.; Vickers, T. A.; Bennett, C. F.; Monia, B. P.; Griffey, R. H.; Nulf, C. J.; Hu, J.; Corey, D. R.; Swayze, E. E.; Kinberger, G. A. Peptide nucleic acids conjugated to short basic peptides show improved pharmacokinetics and antisense activity in adipose tissue. J. Med. Chem., 2010, 53(10), 3919-3926.
-
(2010)
J. Med. Chem.
, vol.53
, Issue.10
, pp. 3919-3926
-
-
Wancewicz, E.V.1
Maier, M.A.2
Siwkowski, A.M.3
Albertshofer, K.4
Winger, T.M.5
Berdeja, A.6
Gaus, H.7
Vickers, T.A.8
Bennett, C.F.9
Monia, B.P.10
Griffey, R.H.11
Nulf, C.J.12
Hu, J.13
Corey, D.R.14
Swayze, E.E.15
Kinberger, G.A.16
-
83
-
-
71449105039
-
Prospects of antisense therapy technologies
-
Skoblov, M. I. Prospects of antisense therapy technologies. Mol. Biol. (Mosk), 2009, 43(6), 984-998.
-
(2009)
Mol. Biol. (Mosk)
, vol.43
, Issue.6
, pp. 984-998
-
-
Skoblov, M.I.1
-
84
-
-
0030843083
-
Background of the antisense oligonucleotide approach to chemotherapy
-
Zamecnik, P. Background of the antisense oligonucleotide approach to chemotherapy. Antisense Nucleic Acid Drug Dev., 1997, 7(3), 199-202.
-
(1997)
Antisense Nucleic Acid Drug Dev.
, vol.7
, Issue.3
, pp. 199-202
-
-
Zamecnik, P.1
-
85
-
-
69949141181
-
Making sense of antisense in antibiotic drug discovery
-
Wright, G. D. Making sense of antisense in antibiotic drug discovery. Cell Host Microbe, 2009, 6(3), 197-198.
-
(2009)
Cell Host Microbe
, vol.6
, Issue.3
, pp. 197-198
-
-
Wright, G.D.1
-
86
-
-
58849145635
-
Tackling antibiotic resistance: A dose of common antisense?
-
Woodford, N.; Wareham, D. W. Tackling antibiotic resistance: a dose of common antisense? J. Antimicrob. Chemother., 2009, 63(2), 225-229.
-
(2009)
J. Antimicrob. Chemother.
, vol.63
, Issue.2
, pp. 225-229
-
-
Woodford, N.1
Wareham, D.W.2
-
87
-
-
33750529760
-
Coupling the distribution of RNA polymerase to global gene regulation and the dynamic structure of the bacterial nucleoid in Escherichia coli
-
Jin, D. J.; Cabrera, J. E. Coupling the distribution of RNA polymerase to global gene regulation and the dynamic structure of the bacterial nucleoid in Escherichia coli. J. Struc. Biol., 2006, 156(2), 284-291.
-
(2006)
J. Struc. Biol.
, vol.156
, Issue.2
, pp. 284-291
-
-
Jin, D.J.1
Cabrera, J.E.2
-
88
-
-
70349557379
-
Structural genomics and drug discovery for infectious diseases
-
Anderson, W. F. Structural genomics and drug discovery for infectious diseases. Infect. Disord. Drug Targets, 2009, 9(5), 507-517.
-
(2009)
Infect. Disord. Drug Targets
, vol.9
, Issue.5
, pp. 507-517
-
-
Anderson, W.F.1
-
89
-
-
33750986817
-
Rational design and rapid screening of antisense oligonucleotides for prokaryotic gene modulation
-
Shao, Y.; Wu, Y.; Chan, C. Y.; McDonough, K.; Ding, Y. Rational design and rapid screening of antisense oligonucleotides for prokaryotic gene modulation. Nucleic Acids Res., 2006, 34(19), 5660-5669.
-
(2006)
Nucleic Acids Res.
, vol.34
, Issue.19
, pp. 5660-5669
-
-
Shao, Y.1
Wu, Y.2
Chan, C.Y.3
McDonough, K.4
Ding, Y.5
-
90
-
-
2942585676
-
Effective intracellular delivery of oligonucleotides in order to make sense of antisense
-
Shi, F.; Hoekstra, D. Effective intracellular delivery of oligonucleotides in order to make sense of antisense. J. Control Release, 2004, 97(2), 189-209.
-
(2004)
J. Control Release
, vol.97
, Issue.2
, pp. 189-209
-
-
Shi, F.1
Hoekstra, D.2
-
91
-
-
70350090283
-
Promoter recognition by bacterial alternative sigma factors: The price of high selectivity?
-
Feklistov, A.; Darst, S. A. Promoter recognition by bacterial alternative sigma factors: the price of high selectivity? Genes Dev., 2009, 23(20), 2371-2375.
-
(2009)
Genes Dev.
, vol.23
, Issue.20
, pp. 2371-2375
-
-
Feklistov, A.1
Darst, S.A.2
-
92
-
-
0036203066
-
Structure of the bacterial RNA polymerase promoter specificity sigma subunit
-
Campbell, E. A.; Muzzin, O.; Chlenov, M.; Sun, J. L.; Olson, C. A.; Weinman, O.; Trester-Zedlitz, M. L.; Darst, S. A. Structure of the bacterial RNA polymerase promoter specificity sigma subunit. Mol. Cell, 2002, 9(3), 527-539.
-
(2002)
Mol. Cell
, vol.9
, Issue.3
, pp. 527-539
-
-
Campbell, E.A.1
Muzzin, O.2
Chlenov, M.3
Sun, J.L.4
Olson, C.A.5
Weinman, O.6
Trester-Zedlitz, M.L.7
Darst, S.A.8
-
93
-
-
33847243639
-
Region 1.2 of the RNA polymerase sigma subunit controls recognition of the-10 promoter element
-
Zenkin, N.; Kulbachinskiy, A.; Yuzenkova, Y.; Mustaev, A.; Bass, I.; Severinov, K.; Brodolin, K. Region 1.2 of the RNA polymerase sigma subunit controls recognition of the-10 promoter element. EMBO J., 2007, 26(4), 955-964.
-
(2007)
EMBO J.
, vol.26
, Issue.4
, pp. 955-964
-
-
Zenkin, N.1
Kulbachinskiy, A.2
Yuzenkova, Y.3
Mustaev, A.4
Bass, I.5
Severinov, K.6
Brodolin, K.7
-
94
-
-
0344011547
-
Tethering sigma70 to RNA polymerase reveals high in vivo activity of sigma factors and sigma70-dependent pausing at promoter-distal locations
-
Mooney, R. A.; Landick, R. Tethering sigma70 to RNA polymerase reveals high in vivo activity of sigma factors and sigma70-dependent pausing at promoter-distal locations. Genes Dev., 2003, 17(22), 2839-2851.
-
(2003)
Genes Dev.
, vol.17
, Issue.22
, pp. 2839-2851
-
-
Mooney, R.A.1
Landick, R.2
-
95
-
-
77950628123
-
Rifamycins-Obstacles and opportunities
-
Aristoff, P. A.; Garcia, G. A.; Kirchhoff, P. D.; Hollis Showalter, H. D. Rifamycins-Obstacles and opportunities. Tuberculosis, 2010, 90(2), 94-118.
-
(2010)
Tuberculosis
, vol.90
, Issue.2
, pp. 94-118
-
-
Aristoff, P.A.1
Garcia, G.A.2
Kirchhoff, P.D.3
Hollis Showalter, H.D.4
-
96
-
-
77956668282
-
Overview perspective of bacterial resistance
-
Furtado, G. H.; Nicolau, D. P. Overview perspective of bacterial resistance. Expert. Opin. Ther. Pat, 2010, 20(10), 1273-1276.
-
(2010)
Expert. Opin. Ther. Pat
, vol.20
, Issue.10
, pp. 1273-1276
-
-
Furtado, G.H.1
Nicolau, D.P.2
-
97
-
-
33644503872
-
Crystallizing new approaches for antimicrobial drug discovery
-
Schmid, M. B. Crystallizing new approaches for antimicrobial drug discovery. Biochem Pharmacol, 2006, 71(7), 1048-1056.
-
(2006)
Biochem Pharmacol
, vol.71
, Issue.7
, pp. 1048-1056
-
-
Schmid, M.B.1
-
98
-
-
0038013991
-
RNA polymerase holoenzyme: Structure, function and biological implications
-
Borukhov, S.; Nudler, E. RNA polymerase holoenzyme: structure, function and biological implications. Curr. Opin. Microb., 2003, 6(2), 93-100.
-
(2003)
Curr. Opin. Microb.
, vol.6
, Issue.2
, pp. 93-100
-
-
Borukhov, S.1
Nudler, E.2
-
99
-
-
77955550450
-
The NusA N-Terminal Domain Is Necessary and Sufficient for Enhancement of Transcriptional Pausing via Interaction with the RNA Exit Channel of RNA Polymerase
-
Ha, K. S.; Toulokhonov, I.; Vassylyev, D. G.; Landick, R. The NusA N-Terminal Domain Is Necessary and Sufficient for Enhancement of Transcriptional Pausing via Interaction with the RNA Exit Channel of RNA Polymerase. J. Mol. Biol., 2010, 401(5), 708-725.
-
(2010)
J. Mol. Biol.
, vol.401
, Issue.5
, pp. 708-725
-
-
Ha, K.S.1
Toulokhonov, I.2
Vassylyev, D.G.3
Landick, R.4
-
100
-
-
27644560257
-
Sigma and RNA polymerase: An on-again, off-again relationship?
-
Mooney, R. A.; Darst, S. A.; Landick, R. Sigma and RNA polymerase: an on-again, off-again relationship? Mol. Cell, 2005, 20(3), 335-345.
-
(2005)
Mol. Cell
, vol.20
, Issue.3
, pp. 335-345
-
-
Mooney, R.A.1
Darst, S.A.2
Landick, R.3
-
101
-
-
0037308665
-
Bacterial RNA polymerases: The wholo story
-
Murakami, K. S.; Darst, S. A. Bacterial RNA polymerases: the wholo story. Curr. Opin. Struct. Biol., 2003, 13(1), 31-39.
-
(2003)
Curr. Opin. Struct. Biol.
, vol.13
, Issue.1
, pp. 31-39
-
-
Murakami, K.S.1
Darst, S.A.2
|