Antibiotics GE23077, novel inhibitors of bacterial RNA polymerase. Part 3: Chemical derivatization

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 16, 2005, Pages 3748-3752

  Mariani, Riccardo ^b   Granata, Giorgio ^a   Maffioli, Sonia I ^a   Serina, Stefania ^a   Brunati, Cristina ^a   Sosio, Margherita ^a   Marazzi, Alessandra ^a   Vannini, Alfredo ^a   Patel, Dinesh ^c   White, Richard ^a   Ciabatti, Romeo ^a  

^a Vicuron Pharmaceuticals   (Italy)

^b Gentium SpA   (Italy)

^c Miikana Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ENZYME INHIBITOR; GE 23077; GLUTAMINE DERIVATIVE; MALONIC ACID DERIVATIVE; PROPIONIC ACID DERIVATIVE; RNA POLYMERASE;

ARTICLE; CONTROLLED STUDY; DEACYLATION; DERIVATIZATION; ENZYME ACTIVITY; EPIMERIZATION; IC 50; LIPOPHILICITY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ACTINOMYCETALES; ANTI-BACTERIAL AGENTS; DNA-DIRECTED RNA POLYMERASES; ENZYME INHIBITORS; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC; STRUCTURE-ACTIVITY RELATIONSHIP;

ACTINOMADURA SP.;

EID: 22844441221     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.060     Document Type: Article

References (10)

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9. 50, that is a concentration giving 50% inhibition.
10. The Minimal inhibitory concentrations (MIC) of GE23077 and its derivatives were determined by the broth microdilution method according to standard methods (NCCLS document M7-A6 Vol.23 No.2, 2003). The strain of Moraxella catharralis tested belonged to the Vicuron Italia Srl collection.