Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1799, Issue 8, 2010, Pages 575-587

  Seibold, Steve A ^a,b   Singh, Badri Nath ^c   Zhang, Chunfen ^a   Kireeva, Maria ^d   Domecq, Céline ^e   Bouchard, Annie ^e   Nazione, Anthony M ^a   Feig, Michael ^a,b   Cukier, Robert I ^b   Coulombe, Benoit ^e   Kashlev, Mikhail ^d   Hampsey, Michael ^c   Burton, Zachary F ^a  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Bridge alpha helix; Extended fork loop; Fidelity; Hydration dehydration; Induced fit; Molecular dynamics simulation; RNA polymerase; Trigger loop

Indexed keywords

RNA POLYMERASE; RNA POLYMERASE II;

ALPHA HELIX; ARTICLE; CATALYSIS; COMPUTER MODEL; ENZYME ACTIVE SITE; ENZYME SYNTHESIS; HYDRATION; NONHUMAN; PRIORITY JOURNAL; RNA CONFORMATION; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE; THERMUS THERMOPHILUS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR DYNAMICS; MUTATION; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE;

BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RNA POLYMERASE II; SACCHAROMYCES CEREVISIAE; THERMUS THERMOPHILUS;

SACCHAROMYCES CEREVISIAE; THERMUS THERMOPHILUS;

EID: 77955653271     PISSN: 18749399     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2010.05.002     Document Type: Article

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