Inhibition of bacterial RNA polymerase by streptolydigin: Stabilization of a straight-bridge-helix active-center conformation

Cell

Volumn 122, Issue 4, 2005, Pages 541-552

  Tuske, Steven ^a,b   Sarafianos, Stefan G ^a,b   Wang, Xinyue ^a,c,d   Hudson, Brian ^a,b   Sineva, Elena ^a,c,d   Mukhopadhyay, Jayanta ^a,c,d   Birktoft, Jens J ^a,b   Leroy, Olivier ^a,c,d   Ismail, Sajida ^a,c,d   Clark Jr , Arthur D ^a,b   Dharia, Chhaya ^a,b   Napoli, Andrew ^a,c   Laptenko, Oleg ^e   Lee, Jookyung ^e   Borukhov, Sergei ^e   Ebright, Richard H ^a,c,d   Arnold, Eddy ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; RNA POLYMERASE; STREPTOLYDIGIN;

ARTICLE; BINDING SITE; DRUG DESIGN; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME STABILITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION;

EID: 23944521364     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2005.07.017     Document Type: Article

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