Design, synthesis and biological evaluation of simplified analogues of the RNA polymerase inhibitor etnangien

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 3, 2010, Pages 939-941

  Menche, Dirk ^a   Li, Pengfei ^a   Irschik, Herbert ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Analogues; Antibiotics; Etnangien; RNA polymerase; Structure activity data

Indexed keywords

ANTIINFECTIVE AGENT; ETNANGIEN; ETNANGIEN METHYL ESTER; MACROLIDE; NUCLEOTIDYLTRANSFERASE INHIBITOR; RNA POLYMERASE; UNCLASSIFIED DRUG; DNA DIRECTED RNA POLYMERASE; POLYENE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CORYNEBACTERIUM GLUTAMICUM; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ESCHERICHIA COLI; MICROCOCCUS LUTEUS; MYCOBACTERIUM PHLEI; NONHUMAN; SACCHAROMYCES CEREVISIAE; STAPHYLOCOCCUS AUREUS; ANTAGONISTS AND INHIBITORS; COMPARATIVE STUDY; DRUG EFFECTS; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PROCEDURES; SYNTHESIS;

NEGIBACTERIA; POSIBACTERIA;

DNA-DIRECTED RNA POLYMERASES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ESCHERICHIA COLI; MACROLIDES; POLYENES; STAPHYLOCOCCUS AUREUS;

EID: 74049122041     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.066     Document Type: Article

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