Peptide nucleic acids conjugated to short basic peptides show improved pharmacokinetics and antisense activity in adipose tissue

Journal of Medicinal Chemistry

Volumn 53, Issue 10, 2010, Pages 3919-3926

  Wancewicz, Edward V ^a   Maier, Martin A ^c   Siwkowski, Andrew M ^a   Albertshofer, Klaus ^d   Winger, Theodore M ^e   Berdeja, Andres ^a   Gaus, Hans ^a   Vickers, Timothy A ^a   Bennett, C Frank ^a   Monia, Brett P ^a   Griffey, Richard H ^f   Nulf, Christopher J ^b   Hu, Jiaxin ^b   Corey, David R ^b   Swayze, Eric E ^a   Kinberger, Garth A ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c ALNYLAM PHARMACEUTICALS   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e Advanced Liquid Logic Inc   (United States)

^f SCIENCE APPLICATIONS INTERNATIONAL CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; INSULIN RECEPTOR; LYSINE; MESSENGER RNA; PEPTIDE NUCLEIC ACID; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ADIPOSE TISSUE; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTISENSE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; KIDNEY PARENCHYMA; LIVER; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; WESTERN BLOTTING;

ADIPOSE TISSUE; ANIMALS; CELL LINE; DRUG CARRIERS; KIDNEY; LIVER; MALE; MICE; MICE, INBRED BALB C; OLIGOPEPTIDES; PEPTIDE NUCLEIC ACIDS; PTEN PHOSPHOHYDROLASE; RECEPTOR, INSULIN; RNA SPLICE SITES; RNA SPLICING; RNA, ANTISENSE; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 77952737907     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901489k     Document Type: Article

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