PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation

Journal of Autoimmunity

Volumn 36, Issue 3-4, 2011, Pages 278-287

  Haylock Jacobs, Sarah ^a   Comerford, Iain ^a   Bunting, Mark ^a   Kara, Ervin ^a   Townley, Scott ^a   Klingler Hoffmann, Manuela ^a   Vanhaesebroeck, Bart ^b   Puri, Kamal D ^c   McColl, Shaun R ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c Calistoga Pharmaceuticals Inc   (United States)

Author keywords

Apoptosis; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Phosphoinositide 3 kinase delta; Th17

Indexed keywords

2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; PHOSPHATIDYLINOSITOL 3 KINASE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL ACTIVATION; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; IN VITRO STUDY; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL; TH17 CELL;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNOLOGIC MEMORY; MALE; MICE; MICE, INBRED C57BL; PHOSPHATIDYLINOSITOL 3-KINASES; T-LYMPHOCYTES; TH1 CELLS; TH17 CELLS;

EID: 79954603523     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2011.02.006     Document Type: Article

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