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Volumn 116, Issue 20, 2010, Pages 4130-4140

The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CCX CKR; FREUND ADJUVANT; INTERLEUKIN 23; NEUTRALIZING ANTIBODY; SCAVENGER; SECONDARY LYMPHOID TISSUE CHEMOKINE; UNCLASSIFIED DRUG;

EID: 78549283856     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-01-264390     Document Type: Article
Times cited : (67)

References (42)
  • 1
    • 0032499260 scopus 로고    scopus 로고
    • Chemokines and leukocyte traffic
    • Baggiolini M. Chemokines and leukocyte traffic. Nature. 1998;392(6676):565-568.
    • (1998) Nature , vol.392 , Issue.6676 , pp. 565-568
    • Baggiolini, M.1
  • 2
    • 0037248807 scopus 로고    scopus 로고
    • Lymphoid chemokines CCL19 and CCL21 are expressed in the central nervous system during experimental autoimmune encephalomyelitis: Implications for the maintenance of chronic neuroinflammation
    • Columba-Cabezas S, Serafini B, Ambrosini E, Aloisi F. Lymphoid chemokines CCL19 and CCL21 are expressed in the central nervous system during experimental autoimmune encephalomyelitis: implications for the maintenance of chronic neuroinflammation. Brain Pathol. 2003;13(1):38-51.
    • (2003) Brain Pathol , vol.13 , Issue.1 , pp. 38-51
    • Columba-Cabezas, S.1    Serafini, B.2    Ambrosini, E.3    Aloisi, F.4
  • 3
    • 0037306791 scopus 로고    scopus 로고
    • Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases
    • Christopherson KW 2nd, Hood AF, Travers JB, Ramsey H, Hromas RA. Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases. Blood. 2003;101(3):801-806.
    • (2003) Blood , vol.101 , Issue.3 , pp. 801-806
    • Christopherson II, K.W.1    Hood, A.F.2    Travers, J.B.3    Ramsey, H.4    Hromas, R.A.5
  • 4
    • 4344668118 scopus 로고    scopus 로고
    • CCR7 signals are essential for cortex-medulla migration of developing thymocytes
    • Ueno T, Saito F, Gray DH, et al. CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J Exp Med. 2004;200(4):493-505.
    • (2004) J Exp Med , vol.200 , Issue.4 , pp. 493-505
    • Ueno, T.1    Saito, F.2    Gray, D.H.3
  • 5
    • 0036378142 scopus 로고    scopus 로고
    • Chemokines and dendritic cells: A crucial alliance
    • McColl SR. Chemokines and dendritic cells: a crucial alliance. Immunol Cell Biol. 2002;80(5):489-496.
    • (2002) Immunol Cell Biol , vol.80 , Issue.5 , pp. 489-496
    • McColl, S.R.1
  • 6
    • 0033081760 scopus 로고    scopus 로고
    • Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization
    • Gunn MD, Kyuwa S, Tam C, et al. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J Exp Med. 1999;189(3):451-460.
    • (1999) J Exp Med , vol.189 , Issue.3 , pp. 451-460
    • Gunn, M.D.1    Kyuwa, S.2    Tam, C.3
  • 8
    • 0033214348 scopus 로고    scopus 로고
    • CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    • Forster R, Schubel A, Breitfeld D, et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell. 1999;99(1):23-33.
    • (1999) Cell , vol.99 , Issue.1 , pp. 23-33
    • Forster, R.1    Schubel, A.2    Breitfeld, D.3
  • 9
    • 4143096772 scopus 로고    scopus 로고
    • CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions
    • Ohl L, Mohaupt M, Czeloth N, et al. CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity. 2004;21(2):279-288.
    • (2004) Immunity , vol.21 , Issue.2 , pp. 279-288
    • Ohl, L.1    Mohaupt, M.2    Czeloth, N.3
  • 11
    • 10044243722 scopus 로고    scopus 로고
    • Post-translational control of chemokines: A role for decoy receptors?
    • DOI 10.1016/j.imlet.2004.08.018, PII S0165247804002391
    • Comerford I, Nibbs RJ. Post-translational control of chemokines: a role for decoy receptors? Immunol Lett. 2005;96(2):163-174. (Pubitemid 39600772)
    • (2005) Immunology Letters , vol.96 , Issue.2 , pp. 163-174
    • Comerford, I.1    Nibbs, R.J.B.2
  • 12
    • 33845203351 scopus 로고    scopus 로고
    • Tuning inflammation and immunity by chemokine sequestration: Decoys and more
    • Mantovani A, Bonecchi R, Locati M. Tuning inflammation and immunity by chemokine sequestration: decoys and more. Nat Rev Immunol. 2006;6(12):907-918.
    • (2006) Nat Rev Immunol , vol.6 , Issue.12 , pp. 907-918
    • Mantovani, A.1    Bonecchi, R.2    Locati, M.3
  • 13
    • 0034653894 scopus 로고    scopus 로고
    • Cutting edge: Identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK
    • Gosling J, Dairaghi DJ, Wang Y, et al. Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J Immunol. 2000;164(6):2851-2856.
    • (2000) J Immunol , vol.164 , Issue.6 , pp. 2851-2856
    • Gosling, J.1    Dairaghi, D.J.2    Wang, Y.3
  • 14
    • 0036099747 scopus 로고    scopus 로고
    • Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/ mCCL21 and MIP-3beta/mCCL19: Comparison to human CCX-CKR
    • Townson JR, Nibbs RJ. Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/ mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR. Eur J Immunol. 2002;32(5):1230-1241.
    • (2002) Eur J Immunol , vol.32 , Issue.5 , pp. 1230-1241
    • Townson, J.R.1    Nibbs, R.J.2
  • 15
    • 33746238518 scopus 로고    scopus 로고
    • The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro
    • DOI 10.1002/eji.200535716
    • Comerford I, Milasta S, Morrow V, Milligan G, Nibbs R. The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro. Eur J Immunol. 2006;36(7):1904-1916. (Pubitemid 44089056)
    • (2006) European Journal of Immunology , vol.36 , Issue.7 , pp. 1904-1916
    • Comerford, I.1    Milasta, S.2    Morrow, V.3    Milligan, G.4    Nibbs, R.5
  • 16
    • 34347240977 scopus 로고    scopus 로고
    • A silent chemokine receptor regulates steady-state leukocyte homing in vivo
    • Heinzel K, Benz C, Bleul CC. A silent chemokine receptor regulates steady-state leukocyte homing in vivo. Proc Natl Acad Sci U S A. 2007;104(20):8421-8426.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.20 , pp. 8421-8426
    • Heinzel, K.1    Benz, C.2    Bleul, C.C.3
  • 17
    • 64849093508 scopus 로고    scopus 로고
    • Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response
    • Liston A, Kohler RE, Townley S, et al. Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response. J Immunol. 2009;182(5):3121-3130.
    • (2009) J Immunol , vol.182 , Issue.5 , pp. 3121-3130
    • Liston, A.1    Kohler, R.E.2    Townley, S.3
  • 19
    • 0035871823 scopus 로고    scopus 로고
    • Coregulation of CXC chemokine receptor and CD4 expression on T lymphocytes during allogeneic activation
    • Ebert LM, McColl SR. Coregulation of CXC chemokine receptor and CD4 expression on T lymphocytes during allogeneic activation. J Immunol. 2001;166(8):4870-4878.
    • (2001) J Immunol , vol.166 , Issue.8 , pp. 4870-4878
    • Ebert, L.M.1    McColl, S.R.2
  • 20
    • 0041571664 scopus 로고    scopus 로고
    • Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis
    • Ryckman C, McColl SR, Vandal K, et al. Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis. Arthritis Rheum. 2003;48(8):2310-2320.
    • (2003) Arthritis Rheum , vol.48 , Issue.8 , pp. 2310-2320
    • Ryckman, C.1    McColl, S.R.2    Vandal, K.3
  • 21
    • 51249099760 scopus 로고    scopus 로고
    • Antagonism of the chemokine receptors CXCR3 and CXCR4 reduces the pathology of experimental autoimmune encephalomyelitis
    • Kohler RE, Comerford I, Townley S, Haylock-Jacobs S, Clark-Lewis I, McColl SR. Antagonism of the chemokine receptors CXCR3 and CXCR4 reduces the pathology of experimental autoimmune encephalomyelitis. Brain Pathol. 2008;18(4):504-516.
    • (2008) Brain Pathol , vol.18 , Issue.4 , pp. 504-516
    • Kohler, R.E.1    Comerford, I.2    Townley, S.3    Haylock-Jacobs, S.4    Clark-Lewis, I.5    McColl, S.R.6
  • 22
    • 0029840351 scopus 로고    scopus 로고
    • Diverging signal transduction pathways activated by interleukin 8 (IL- 8) and related chemokines in human neutrophils. IL-8 and Gro-alpha differentially stimulate calcium influx through IL-8 receptors a and B
    • DOI 10.1074/jbc.271.34.20540
    • Damaj BB, McColl SR, Neote K, Hebert CA, Naccache PH. Diverging signal transduction pathways activated by interleukin 8 (IL-8) and related chemokines in human neutrophils. IL-8 and Gro-alpha differentially stimulate calcium influx through IL-8 receptors A and B. J Biol Chem. 1996;271(34):20540-20544. (Pubitemid 26281829)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.34 , pp. 20540-20544
    • Damaj, B.B.1    McColl, S.R.2    Neote, K.3    Heber, C.A.4    Naccache, P.H.5
  • 23
    • 0028928642 scopus 로고
    • Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: Interleukin-8, but not NAP-2 or GRO alpha, stimulates phospholipase D activity
    • L'Heureux GP, Bourgoin S, Jean N, McColl SR, Naccache PH. Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: interleukin-8, but not NAP-2 or GRO alpha, stimulates phospholipase D activity. Blood. 1995;85(2):522-531.
    • (1995) Blood , vol.85 , Issue.2 , pp. 522-531
    • L'Heureux, G.P.1    Bourgoin, S.2    Jean, N.3    McColl, S.R.4    Naccache, P.H.5
  • 24
    • 0023805092 scopus 로고
    • Propionic acid-induced calcium mobilization in human neutrophils
    • Naccache PH, Faucher N, Caon AC, McColl SR. Propionic acid-induced calcium mobilization in human neutrophils. J Cell Physiol. 1988;136(1):118-124.
    • (1988) J Cell Physiol , vol.136 , Issue.1 , pp. 118-124
    • Naccache, P.H.1    Faucher, N.2    Caon, A.C.3    McColl, S.R.4
  • 25
    • 0032145404 scopus 로고    scopus 로고
    • Induction of acute inflammation in vivo by staphylococcal superantigens. II. Critical role for chemokines, ICAM-1, and TNF-alpha
    • Tessier PA, Naccache PH, Diener KR, et al. Induction of acute inflammation in vivo by staphylococcal superantigens. II. Critical role for chemokines, ICAM-1, and TNF-alpha. J Immunol. 1998;161(3):1204-1211.
    • (1998) J Immunol , vol.161 , Issue.3 , pp. 1204-1211
    • Tessier, P.A.1    Naccache, P.H.2    Diener, K.R.3
  • 26
    • 33748803591 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis develops in CC chemokine receptor 7-deficient mice with altered T-cell responses
    • Pahuja A, Maki RA, Hevezi PA, et al. Experimental autoimmune encephalomyelitis develops in CC chemokine receptor 7-deficient mice with altered T-cell responses. Scand J Immunol. 2006;64(4):361-369.
    • (2006) Scand J Immunol , vol.64 , Issue.4 , pp. 361-369
    • Pahuja, A.1    Maki, R.A.2    Hevezi, P.A.3
  • 27
    • 48249143387 scopus 로고    scopus 로고
    • Mitigation of experimental allergic encephalomyelitis by TGF-beta induced FoxP3+ regulatory T lymphocytes through the induction of anergy and infectious tolerance
    • Selvaraj RK, Geiger TL. Mitigation of experimental allergic encephalomyelitis by TGF-beta induced FoxP3+ regulatory T lymphocytes through the induction of anergy and infectious tolerance. J Immunol. 2008;180(5):2830-2838.
    • (2008) J Immunol , vol.180 , Issue.5 , pp. 2830-2838
    • Selvaraj, R.K.1    Geiger, T.L.2
  • 28
    • 37849027594 scopus 로고    scopus 로고
    • FoxP3+ regulatory T cells in the control of experimental CNS autoimmune disease
    • O'Connor RA, Anderton SM. FoxP3+ regulatory T cells in the control of experimental CNS autoimmune disease. J Neuroimmunol. 2008;193(1-2):1-11.
    • (2008) J Neuroimmunol , vol.193 , Issue.1-2 , pp. 1-11
    • O'Connor, R.A.1    Anderton, S.M.2
  • 29
    • 46949104323 scopus 로고    scopus 로고
    • IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
    • Kroenke MA, Carlson TJ, Andjelkovic AV, Segal BM. IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J Exp Med. 2008;205(7):1535-1541.
    • (2008) J Exp Med , vol.205 , Issue.7 , pp. 1535-1541
    • Kroenke, M.A.1    Carlson, T.J.2    Andjelkovic, A.V.3    Segal, B.M.4
  • 30
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441(7090):235-238.
    • (2006) Nature , vol.441 , Issue.7090 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3
  • 31
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006;24(2):179-189.
    • (2006) Immunity , vol.24 , Issue.2 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 32
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6(11):1123-1132.
    • (2005) Nat Immunol , vol.6 , Issue.11 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3
  • 33
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces development of the T(H)17 lineage
    • Mangan PR, Harrington LE, O'Quinn DB, et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature. 2006;441(7090):231-234.
    • (2006) Nature , vol.441 , Issue.7090 , pp. 231-234
    • Mangan, P.R.1    Harrington, L.E.2    O'Quinn, D.B.3
  • 36
    • 57849112701 scopus 로고    scopus 로고
    • The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity
    • Pruenster M, Mudde L, Bombosi P, et al. The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity. Nat Immunol. 2009;10(1):101-108.
    • (2009) Nat Immunol , vol.10 , Issue.1 , pp. 101-108
    • Pruenster, M.1    Mudde, L.2    Bombosi, P.3
  • 37
    • 33750112087 scopus 로고    scopus 로고
    • Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression
    • Ariel A, Fredman G, Sun YP, et al. Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression. Nat Immunol. 2006;7(11):1209-1216.
    • (2006) Nat Immunol , vol.7 , Issue.11 , pp. 1209-1216
    • Ariel, A.1    Fredman, G.2    Sun, Y.P.3
  • 38
    • 47649113481 scopus 로고    scopus 로고
    • Scavenging roles of chemokine receptors: Chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues
    • Cardona AE, Sasse ME, Liu L, et al. Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues. Blood. 2008;112(2):256-263.
    • (2008) Blood , vol.112 , Issue.2 , pp. 256-263
    • Cardona, A.E.1    Sasse, M.E.2    Liu, L.3
  • 39
    • 70149097173 scopus 로고    scopus 로고
    • CCR7 ligands are required for development of experimental autoimmune encephalomyelitis through generating IL-23-dependent Th17 cells
    • Kuwabara T, Ishikawa F, Yasuda T, et al. CCR7 ligands are required for development of experimental autoimmune encephalomyelitis through generating IL-23-dependent Th17 cells. J Immunol. 2009;183(4):2513-2521.
    • (2009) J Immunol , vol.183 , Issue.4 , pp. 2513-2521
    • Kuwabara, T.1    Ishikawa, F.2    Yasuda, T.3
  • 40
    • 67649249962 scopus 로고    scopus 로고
    • CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia
    • Buonamici S, Trimarchi T, Ruocco MG, et al. CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature. 2009;459(7249):1000-1004.
    • (2009) Nature , vol.459 , Issue.7249 , pp. 1000-1004
    • Buonamici, S.1    Trimarchi, T.2    Ruocco, M.G.3
  • 41
    • 34247380237 scopus 로고    scopus 로고
    • CCR7 is required for the in vivo function of CD4+CD25+ regulatory T cells
    • Schneider MA, Meingassner JG, Lipp M, Moore HD, Rot A. CCR7 is required for the in vivo function of CD4+CD25+ regulatory T cells. J Exp Med. 2007;204(4):735-745.
    • (2007) J Exp Med , vol.204 , Issue.4 , pp. 735-745
    • Schneider, M.A.1    Meingassner, J.G.2    Lipp, M.3    Moore, H.D.4    Rot, A.5
  • 42
    • 27144480654 scopus 로고    scopus 로고
    • + regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis
    • Reddy J, Waldner H, Zhang X, et al. Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis. J Immunol. 2005;175(9):5591-5595. (Pubitemid 41508036)
    • (2005) Journal of Immunology , vol.175 , Issue.9 , pp. 5591-5595
    • Reddy, J.1    Waldner, H.2    Zhang, X.3    Illes, Z.4    Wucherpfennig, K.W.5    Sobel, R.A.6    Kuchroo, V.K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.