Characterization and modulation of gene expression and enzymatic activity of delta-6 desaturase in teleosts: A review

Aquaculture

Volumn 315, Issue 1-2, 2011, Pages 131-143

  Vagner, M ^a   Santigosa, E ^a  

^a IFREMER   (France)

Author keywords

Delta 6 desaturase; Environmental modulation; Highly unsaturated fatty acid; Nutritional modulation; Teleosts

Indexed keywords

ADAPTATION; AQUACULTURE PRODUCTION; ARTIFICIAL DIET; BIOCHEMICAL COMPOSITION; COMMERCIAL SPECIES; ENZYME ACTIVITY; ESSENTIAL OIL; FATTY ACID; FISH CULTURE; GENE EXPRESSION; HORMONE; LIFE CYCLE; LITERATURE REVIEW; LOW TEMPERATURE; MOLECULAR ANALYSIS; REPLACEMENT; SALINITY; SMOLT; TELEOST;

SALMONIDAE; TELEOSTEI;

EID: 79954592630     PISSN: 00448486     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aquaculture.2010.11.031     Document Type: Review

References (151)

1. Aki T., Shimada Y., Inagaki K., Higashimoto H., Kawamoto S., Shiget S., Ono K., Suzuki O. Molecular cloning and functional characterisation of rat δ6 fatty acid desaturase. Biochem. Biophys. Res. Commun. 1999, 255:575-579.
2. Andersen O., Eijsink V.G., Thomassen M. Multiple variants of the peroxisome proliferator-activated receptor gene from the marine flatfish, the plaice (Pleuronectes platessa). Mar. Environ. Res. 2000, 46:75-79.
3. Argyropoulou V., Kalogeropoulos N., Alexis M.N. Effect of dietary lipids on growth and tissue fatty acid composition of grey mullet (Mugil cephalus). Comp. Biochem. Physiol. A 1992, 101:129-135.
4. Bell M.V., Henderson R.J., Pirie B.J.S., Sargent J.R. Effects of dietary polyunsaturated fatty acid deficiencies on mortality, growth and gill structure in the turbot (Scophthalmus maximus, Linnaeus). J. Fish Biol. 1985, 26:181-191.
5. Bell J.G., Dick J.R., Vicar M.C., Sargent J.R., Thompson K.D. Dietary sunflower, linseed and fish oils affect phospholipid fatty acid composition, development of cardiac lesions, phospholipase activity and eicosanoid production in Atlantic salmon. Prostaglandins Leukot. Essent. Fatty Acids 1993, 49:665-673.
6. Bell J.G., Ashton I., Secombes C.J., Weitzel B.R., Dick J.R., Sargent J.R. Dietary lipid affects phospholipid fatty acid compositions, ecosanoid production and immune function in Atlantic salmon (Salmo salar). Prostaglandins Leukot. Essent. Fatty Acids 1996, 54:173-182.
7. Bell J.G., Tocher D.R., Farndale B.M., Cox D.I., McKinney R.W., Sargent J.R. The effect of dietary lipid on polyunsaturated fatty acid metabolism in Atlantic salmon (Salmo salar) undergoing parr-smolt transformation. Lipids 1997, 32:515-525.
8. Bell J.G., McEvoy J., Tocher D.R., McGhee F., Campbell P.J., Sargent J.R. Replacement of fish oil with rapeseed oil in diets of Atlantic salmon (Salmo salar) affects tissue lipid compositions and hepatocyte fatty acid metabolism. J. Nutr. 2001, 131:1535-1543.
9. Bell J.G., Henderson R.J., Tocher D.R., McGhee F., Dick J.R., Porter A., Smullen R., Sargent J.R. Substituting fish oil with crude palm oil in the diet of Atlantic salmon (Salmo salar) affects tissue fatty acid composition and hepatic fatty acid metabolism. J. Nutr. 2002, 132:222-230.
10. Bell J.G., McGhee F., Campbell P.J., Sargent J.R. Rapeseed oil as an alternative to marine fish oil in diets of post-smolt Atlantic salmon (Salmo salar): changes in flesh fatty acid composition and effectiveness of subsequent fish oil "wash out". Aquaculture 2003, 218:515-528.
11. Bell J.G., Tocher D.R., Henderson R.J., Dick J.R., Crampton V.O. Substitution of marine fish oil with linseed and rapeseed oils in diets for Atlantic salmon (Salmo salar) affects muscle fatty acid composition: restoration of fatty acid composition following "wash out" with fish oil. J. Nutr. 2003, 133:2793-2801.
12. Boukavala E., Antonopoulou E., Favre-Kery L., Diez A., Bautista J.M., Leaver M.J., Tocher D.R., Krey G. Molecular characterization of three peroxisome proliferator-activated receptors from the sea bass (Dicentrarchus labrax). Lipids 2004, 39(11):1085-1092.
13. Brenner R.R. The oxidative desaturation of unsaturated fatty acids in animals. Mol. Cell. Biochem. 1974, 3:41-52.
14. Brenner R.R. Early effects of essential fatty acid deficiency on structure and enzymatic activity of rat liver microsomes. Prog. Lipid Res. 1981, 20:41-47.
15. Brenner R.R. Nutritional and hormonal factors influencing desaturation of essential fatty acids in animals. Prog. Lipid Res. 1981, 20:41-47.
16. Brown J.A., Bucknall R.M. Antidiuretic and cardiovascular actions of PGE2 in the rainbow trout Salmo gairdneri. Gen. Comp. Endocrinol. 1986, 61:330-337.
17. Buzzi M., Henderson R.J., Sargent J.R. The desaturation and elongation of linolenic acid and ecosapentaenoic acid by hepatocytes and liver microsomes from rainbow trout (Oncorhynchus mykiss) fed diets containing fish oil or olive oil. Biochem. Biophys. Acta 1996, 1299:235-244.
18. Buzzi M., Henderson R.J., Sargent J.R. Biosynthesis of docosahexaenoic acid in trout hepatocytes proceeds via 24-carbon intermediates. Comp. Biochem. Physiol. 1997, 116B:263-267.
19. Cao J.M., Blond J.P., Juaneda P., Durand G., Bezard J. Effects of low levels of dietary fish oils on fatty acid desaturation and tissue fatty acids in obese and lean rats. Lipids 1995, 30:825-832.
20. Cho H.P., Nakamura M.T., Clarke S.D. Cloning, expression and nutritional regulation of the human δ6 desaturase. J. Biol. Chem. 1999, 274:471-477.
21. Cho H.P., Nakamura M.T., Clarke S.D. Cloning expression and nutritional regulation of the human D5 desaturase. J. Biol. Chem. 1999, 274:37335-37339.
22. Christiansen E.N., Lund J.S., Rørtveit T., Rustan A.C. Effects of dietary n-3 and n-6 fatty acids on fatty acid desaturation in rat liver. Biochim. Biophys. Acta 1991, 1082:57-62.
23. Clandinin M.T., Foot M., Robson L. Plasma membrane: can its structure and function be modulated by dietary fat?. Comp. Biochem. Physiol. 1983, 76B:335-339.
24. Cossins A.R. Adaptative responses of fish membranes to altered environmental temperature. Biochem. Soc. Trans. 1983, 11:332-333.
25. Cossins A.R., Bowler K. Temperature Biology of Animals 1987, 156-203. Chapman & Hall, London.
26. D'Andrea S., Guillou H., Jan S., Catheline D., Thibault J.N., Bourriel M., Rioux V., Legrand P. The same rat δ6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very long chain polyunsaturated fatty acid biosynthesis. Biochem. J. 2002, 364:49-55.
27. De Antueno R.J., Knickle L.C., Smith H., Elliot M.L., Allen S.J., Nwaka S., Winther M.D. Activity of human D5 and D6 desaturases on multiple n-3 and n-6 polyunsaturated fatty acids. FEBS Lett. 2001, 509:77-80.
28. De Torrengo M.P., Brenner R.R. Influence of environmental temperature on the fatty acid desaturation and elongation activity of fish (Pimelodus maculatus) liver microsomes. Biochim. Biophys. Acta 1976, 424:36-44.
29. Delarue J., Matzinger O., Binnert C., Schneiter P., Chiolero R., Tappy L. Fish oil prevents the adrenal activation elicited by mental stress in healthy men. Diab. Metab. 2003, 29(3):289-295.
30. Delarue J., LeFoll C., Corporeau C., Lucas D. N-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity?. Reprod. Nutr. Dev. 2004, 44(3):289-299.
31. Desvergne B., Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 1999, 20:649-688.
32. Di Constanzo G., Duportail G., Florents A., Leray C. The brush border membrane of trout intestine: influence of its lipid composition on ion permeability, enzyme activity and membrane fluidity. Mol. Physiol. 1983, 4:279-290.
33. Dreyer C., Krey G., Keller H., Givel F., Helftenbein G., Wahli W. Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors. Cell 1992, 68:879-887.
34. Eder K., Slomma N., Becker K. Trans-10, cis-12 conjugated linoleic acid suppresses the desaturation of linoleic and α-linoleic acids in HepG2 cells. J. Nutr. 2002, 132:1115-1121.
35. Escher P., Braissant O., Basu-Modak S., Michalik L., Wahli W., Desvergne B. Rat PPAR: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology 2001, 142:4195-4202.
36. Folmar L.C., Dickhoff W.W. The parr-smolt transformation (smoltification) and seawater adaptation in salmonids: a review of selected literature. Aquaculture 1980, 21:1-37.
37. Fonseca-Madrigal J., Karalazos V., Campbell P.J., Bell J.G., Tocher D.R. Influence of dietary palm oil on growth and tissue fatty acid compositions, and fatty acid metabolism in liver and intestine in rainbow trout (Onchorhynchus mykiss). Aquacult. Nutr. 2005, 11:241-250.
38. Fonseca-Madrigal J., Bell J.G., Tocher D.R. Nutritional and environmental regulation of the synthesis of highly unsaturated fatty acids and fatty-acid oxidation in Atlantic salmon (Salmo salar L.) enterocytes and hepatocytes. Fish Physiol. Biochem. 2006, 32:317-328.
39. Forman B.M., Chen J., Evans R.M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:4312-4317.
40. Francis D.S., Turchini G.M., Jones P.L., De Silva S.S. Dietary lipid source modulates in vivo fatty acid metabolism in the freshwater fish, Murray cod (Maccullochella peelii peelii). J. Agric. Food Chem. 2007, 55:1582-1591.
41. Francis D.S., Peters D.J., Turchini G.M. Apparent in vivo delta-6 desaturase activity, efficiency, and affinity are affected by total dietary C18 PUFA in the freshwater fish Murray cod. J. Agric. Food Chem. 2009, 57:4381-4390.
42. Garg M., Sebokova E., Thomson A., Clandini M. Delta-6 desaturase activity in liver microsomes of rats fed diets enriched with cholesterol and/or omega-3 fatty acids. Biochem. J. 1988, 249:351-356.
43. Gerbi A., Zerouga M., Debray M., Durand G., Chanez C., Bourre J.M. Effect of fish oil diet on fatty acid composition of phospholipids on brain membranes and on kinetic properties of Na+, K+-ATPase isoenzymes of weaned and adult rats. J. Neurochem. 1994, 62:1560-1569.
44. Ghioni C., Tocher D.R., Bell M.V., Dick J.R., Sargent J.R. Low C18 to C20 fatty acid elongase activity and limited conversion of stearidonic acid, 18:4n-3, to eicosapentaenoic acid, 20:5n-3, in a cell line from the turbot, Scophthalmus maximus. Biochim. Biophys. Acta 1999, 1437:170-181.
45. González-Rovira A., Mourente G., Zheng X., Tocher D.R., Pendon C. Molecular and functional characterization and expression analysis of a delta-6 fatty acyl desaturase cDNA of European sea bass (Dicentrarchus labrax L.). Aquaculture 2009, 298:90-100.
46. Gregoire F.M., Smas C.M., Sul H.S. Understanding adipocyte differentiation. Physiol. Rev. 1998, 78:783-809.
47. Gulick T., Cresci S., Caira T., Moore D.D., Kelly D.P. The peroxisome proliferators-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:11012-11016.
48. Hagar A.F., Hazel J.R. Changes in desaturase activity and the fatty acid composition of microsomal membranes from liver tissue of thermally-acclimating rainbow trout. J. Comp. Physiol. B 1985, 156:35-42.
49. Hastings N., Agaba M., Tocher D.R., Leaver M.J., Dick J.R., Sargent J.R., Teale A.J. A vertebrate fatty acid desaturase with δ5 and δ6 activities. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:14304-14309.
50. Hastings N., Agaba M.K., Tocher D.R., Zheng X., Dickson C.A., Dick J.R., Teale A.J. Molecular cloning and functional characterization of fatty acyl desaturase and elongase cDNAs involved in the production of eicosapentaenoic and docosahexaenoic acids from α-linolenic acid in Atlantic salmon (Salmo salar). Mar. Biotechnol. 2005, 6:463-474.
51. Hazel J.R. Effects of temperature on the structure and metabolism of cell membranes in fish. Am. J. Physiol. 1995, 246:460-470.
52. Henderson R.J., Tocher D.R. Lipid composition and biochemistry of freshwater fish. Prog. Lipid Res. 1987, 26:281-347.
53. Henderson R.J., Park M.T., Sargent J.R. The desaturation and elongation of 14C-labelled polyunsaturated fatty acids by pike (Esox lucius L.) in vivo. Fish Physiol. Biochem. 1995, 14:223-235.
54. Hihi A.K., Michalik L., Wahli W. PPARs: transcriptional effectors of fatty acids and their derivatives. Cell. Mol. Life Sci. 2002, 59:790-798.
55. Holman R.T. Control of polyunsaturated fatty acids in tissue lipids. J. Am. Coll. Nutr. 1986, 5:183-211.
56. Horrobin D.F. Interactions between n-3 and n-6 essential fatty acids (EFAs) in the regulation of cardiovascular disorders and inflammation. Prostaglandins Leukot. Essent. Fatty Acids 1991, 44:127-131.
57. Horton J.D., Goldstein J.L., Brown M.S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 2002, 109:1125-1131.
58. Izquierdo M.S., Robaina L., Juárez-Carrillo E., Oliva V., Hernandez-Cruz C.M., Afonso J.M. Regulation of growth, fatty acid composition and delta-6 desaturase expression by dietary lipids in gilthead seabream larvae (Sparus aurata). Fish Physiol. Biochem. 2008, 34:117-127.
59. Kajikawa M., Yamato K.T., Kohzu Y., Nojiri M., Sakuradani E., Shimizu S., Sakai Y., Fukuzawa H., Ohyama K. Isolation and characterization of D6-desaturase, an ELO-like enzyme and D5-desaturase from the liverwort Marchantia Polymorpha and production of arachidonic and ecosapentaenoic acids in the methylotrophic yeast Pichia Pastoris. Plant Mol. Biol. 2004, 54:335-352.
60. Kanazawa A., Teshima S.I., Ono K. Relationship between essential fatty acid requirements of aquatic animals and the capacity for bioconversion of linoleic acid to highly unsaturated fatty acids. Comp. Biochem. Physiol. 1978, 63B:295-298.
61. Kennedy S.R., Campbell P.J., Porter A., Tocher D.R. Influence of dietary conjugated linoleic acid (CLA) on lipid and fatty acid composition in liver and flesh of Atlantic salmon (Salmo salar). Comp. Biochem. Physiol. B 2005, 141:168-178.
62. Kennedy S.R., Leaver M.J., Campbell P.J., Zheng X., Dick J.R., Tocher D.R. Influence of dietary oil content and conjugated linoleic acid (CLA) on lipid metabolism enzyme activities and gene expression in tissues of Atlantic salmon (Salmo salar). Lipids 2006, 41(5):423-436.
63. Kliewer S.A., Sundseth S.S., Jones S.A., Brown P.J., Wisely G.B., Koble C.S., Devchand P., Wahli W., Willson T.M., Lenhard J.M., Lehmann J.M. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 1997, 83:813-819.
64. Krey G., Braissant O., L'Horset F., Kalkhoven E., Perroud M., Parker M.G., Wahli W. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferators-activated receptors by coactivator-dependant receptor ligand assay. Mol. Endocrinol. 1997, 11:779-791.
65. Lands W.E.M. Dose-response relationships for ω3/ω6. Effects, in health effects of ω3 polyunsaturated fatty acids in seafoods 1991, 177-194. Karger, Basel. A.P. Simopoulos, R.R. Kifer, R.E. Martin, S.M. Barlow (Eds.).
66. Lauritzen L., Hansen H.S., Jorgensen M.H., Michaelsen K.F. The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog. Lipid Res. 2001, 40:1-94.
67. Leaver M.J., Boukouvala E., Antonopoulou E., Diez A., Favre-Krey L., Ezaz M.T., Tocher D.R., Batista J.M., Krey G. Three peroxisomal proliferator-activated receptor (PPAR) isotypes from each of two species of marine fish. Endocrinology 2005, 146:3150-3162.
68. Leaver M.J., Tocher D.R., Obach A., Jensen L., Henderson R.J., Porter A.R., Krey G. Effect of dietary conjugated linoleic acid (CLA) on lipid composition, metabolism and gene expression in Atlantic salmon (Salmo salar) tissues. Comp. Biochem. Physiol. A 2006, 145:258-267.
69. Leger C., Fremont L., Boudon M. Fatty acid composition of lipids in the trout-I. Influence of dietary fatty acids on the triglyceride fatty acid desaturation in serum, adipose tissue, liver, white and red muscle. Comp. Biochem. Physiol. 1981, 69B:99-105.
70. Li H.O., Yamada J. Changes of the fatty acid composition in smolts of masu salmon (Oncorhynchus masou) associated with desmoltification and seawater transfer. Comp. Biochem. Physiol. 1992, 103A:221-226.
71. Li Y., Hu C., Zheng Y., Xia X., Xu W., Wang S., Chen W., Sun Z., Huang J. The effects of dietary fatty acids on liver fatty acid composition and delta-6 desaturase expression differ with ambient salinities in Siganus canaliculatus. Comp. Biochem. Physiol. B 2008, 151:183-190.
72. Maglish J.M., Caravella J.A., Lambert M.H., Willson T.M., Moore J.T., Ramamurthy L. The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily. Nucleic Acids Res. 2003, 31:4051-4058.
73. Matsuzaka T., Shimano H., Yahagi N., Amemiya-Kudo M., Yoshikawa T., Hasty A.H., Tamura Y., Osuga J.I., Okazaki H., Iizuka Y., Takahashi A., Sone H., Gotoda T., Ishibashi S., Yamada N. Dual regulation of mouse δ5 and δ6-desaturase gene expression by SREBP-1 and PPAR α. J. Lipid Res. 2002, 43:107-114.
74. McMurchie E.J. Dietary lipids and the regulation of membrane fluidity and function. Physiological Regulation of Membrane Fluidity 1988, 189-337. Alan R. Liss, New York. R.C. Aloia, C.C. Curtain, L.M. Gordon (Eds.).
75. Merrill A.H., Schroeder J.J. Lipid modulation of cell function. Annu. Rev. Nutr. 1993, 13:529-559.
76. Mourente G., Dick J.R. Influence of partial substitution of dietary fish oil by vegetable oils on the metabolism of [1-14C] 18:3n-3 in isolated hepatocytes of European sea bass (Dicentrarchus labrax L.). Fish Physiol. Biochem. 2002, 26:297-308.
77. Mourente G., Tocher D.R. In vivo metabolism of [1-14C] linolenic acid (18:3n-3) and [1-14C] eicosapentaenoic acid (20:5n-3) in marine fish: Time-course of the desaturation/elongation pathway. Biochim. Biophys. Acta 1994, 1212:109-118.
78. Mourente G., Good J.E., Bell J.G. Partial substitution of fish oil with rapeseed, linseed and olive oils in diets for European sea bass (Dicentrarchus labrax L.) Effects on flesh fatty acid composition, plasma prostaglandins E2 and F2α, immune function and effectiveness of a fish oil finishing diet. Aquacult. Nutr. 2005, 11:25-40.
79. Mourente G., Dick J.R., Bell J.G., Tocher D.R. Effect of partial substitution of dietary fish oil by vegetable oils on desaturation and oxidation of [1-14C]18:3n-3 and [1-14C]20:5n-3 in hepatocytes and enterocytes of European sea bass (Dicentrarchus labrax L.). Aquaculture 2005, 248:173-186.
80. Moya-Camarena S.Y., Van den Heuvel J.P., Blanchard S.G., Leesnitzer L.M., Belury M.A. Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPAR α. J. Lipid Res. 1999, 40:1426-1433.
81. Moya-Falcón C., Hvattumb E., Tranc T.N., Thomassen M.S., Skorved E.J., Ruyter B. Phospholipid molecular species, β-oxidation, desaturation and elongation of fatty acids in Atlantic salmon hepatocytes: effects of temperature and 3-thia fatty acids. Comp. Biochem. Physiol. B 2006, 145:68-80.
82. Mustafa T., Srivastava K.C. Prostaglandins (eicosanoids) and their role in ectothermic organisms. Adv. Comp. Environ. Physiol. 1989, 5:157-207.
83. Nakamura M.T., Nara T.Y. Gene regulation of mammalian desaturases. Biochem. Soc. Trans. 2002, 30(6):1076-1079.
84. Nakamura M.T., Nara T.Y. Essential fatty acid synthesis and its regulation in mammals. PLEFA 2003, 68:145-150.
85. Nara T.Y., He W.S., Tang C., Clarke S.D., Nakamura M.T. The E-box like sterol regulatory element mediates the suppression of human delta-6 desaturase gene by highly unsaturated fatty acids. Biochem. Biophys. Res. Commun. 2002, 296:111-117.
86. Ninno R.E., de Torrengo M.A.P., Castuma J.C., Brenner R.R. Specificity of 5- and 6-fatty acid desaturases in rat and fish. Biochim. Biophys. Acta 1974, 360:124-133.
87. Olsen R.E., Ringo E. Lipids of arctic charr, Salvelinus alpinus (L.) II. Influence of dietary fatty acids on the elongation and desaturation of linoleic and linolenic acid. Fish Physiol. Biochem. 1992, 9:393-399.
88. Owen J.M., Adron J.W., Middleton C., Cowey C.B. Elongation and desaturation of dietary fatty acids in turbot (Scophtalamus maximus L.), and rainbow trout (Salmo gairdnerii Rich.). Lipids 1975, 10(9):528-531.
89. Padley F.B., Gunstone F.D., Harwood J.L. Occurrence and characteristics of oils and fats. The lipid handbook 1986, 49-170. Chapman and Hall, London. F.D. Gunstone, J.L. Harwood, F.B. Padley (Eds.).
90. Peters J.M., Park Y., Gonzales F.J., Pariza M.W. Influence of conjugated linoleic acid on body composition and target gene expression in peroxisome proliferator-activated receptor γ-Null mice. Biochim. Biophys. Acta 2001, 1533:233-241.
91. Pike I.H. Eco-efficiency in aquaculture: global catch of wild fish used in aquaculture. Int. Aquafeed 2005, 8:38-39.
92. Rivers J.P.W., Sinclair A.J., Crawford M.A. Inability of the cat to desaturate essential fatty acids. Nature 1975, 258:171-173.
93. Robertson J.C., Hazel J.R. Influence of temperature and membrane lipid composition on the osmotic water permeability of teleost gills. Physiol. Biochem. Zool. 1999, 72(5):623-632.
94. Robinson-Rechavi M., Marchand O., Escriva H., Bardet P.L., Zelus D., Hughes S., Laudet V. Euteleost fish genomes are characterized by expansion of gene families. Genome Res. 2001, 11(5):781-788.
95. Ruyter B., Røsjø C., Måsøval K., Einen O., Thomassen M.S. Influence of dietary n-3 fatty acids on the desaturation and elongation of [1-14C] 18:2n-6 and [1-14C] 18:3n-3 in Atlantic salmon hepatocytes. Fish Physiol. Biochem. 2000, 23:151-158.
96. Ruyter B., Røsjø C., Grisdale-Helland B., Rosenlund G., Obach A., Thomassen M.S. Influence of temperature and high dietary linoleic acid content on esterification, elongation, and desaturation of PUFA in Atlantic salmon hepatocytes. Lipids 2003, 38(8):833-840.
97. Salem N., Shingu T., Kim H.Y., Hullin F., Bougnoux P., Karanian J.W. Biological membranes: abberrations in membrane structure and function 1988, 319-333. Alan R. Liss, New York. M.L. Karnovsky, L. Bolis, A. Leaf (Eds.).
98. Santigosa E., Geay F., Tonon T., Corcos L., Cahu C., Zambonino-Infante J., Mazurais D. Cloning, tissue expression analysis and functional characterisation of two δ6-desaturase variants of sea bass (Dicentrarchus labrax, L.). Mar. Biotechnol. 2010, 10.1007/s10126-010-9264-4.
99. Sargent J.R., Tacon A. Development of farmed fish: a nutritionally necessary alternative to meat. Proc. Nutr. Soc. 1999, 58:377-383.
100. Sargent J., Bell J.G., Bell M.V., Henderson R.J., Tocher D.R. Requirement criteria for essential fatty acids. J. Appl. Ichthyol. 1995, 11:183-198.
101. Sargent J., McEvoy L., Estevez A., Bell G., Bell M., Henderson J., Tocher D.R. Lipid nutrition of marine fish during early development: current status and future directions. Aquaculture 1999, 179:217-229.
102. Sargent J.R., Tocher D.R., Bell J.G. The lipids, third edition. Fish Nutrition 2002, 182-259. Academic Press, London. J.E. Halver, R.W. Hardy (Eds.).
103. Sayanova O.V., Beaudoin F., Michaelson L.V., Shewry P.R., Napier J.A. Identification of Primula fatty acid δ6-desaturases with n-3 substrate preferences. FEBS Lett. 2003, 542:100-104.
104. Schoonjans K., Staels B., Auwerx J. The peroxisome proliferator-activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochem. Biophys. Acta 1996, 1302:93-109.
105. Schünke M., Wodtke E. Cold-induced increase of δ9- and δ6-desaturase activities in endoplasmic membranes of carp liver. Biochim. Biophys. Acta 1983, 734:70-75.
106. Seierstad S.L., Seljeflot I., Johansen O., Hansen R., Haugen M., Rosenlund G., Frøyland L., Arnsesn H. Dietary intake of differently fed salmon; the influence on markers of human atherosclerosis. Eur. J. Clin. Invest. 2005, 35:52-59.
107. Seiliez I., Panserat S., Kaushik S., Bergot P. Cloning, tissue distribution and nutritional regulation of a delta-6 desaturase-like enzyme in rainbow trout. Comp. Biochem. Physiol. B 2001, 130:83-93.
108. Seiliez I., Panserat S., Corraze G., Kaushik S., Bergot P. Cloning and nutritional regulation of a δ6-desaturase-like enzyme in the marine teleost gilthead seabream (Sparus aurata). Comp. Biochem. Physiol. 2003, 135B:449-460.
109. Sellner P.A., Hazel J.R. Incorporation of polyunsaturated fatty acids into lipids of rainbow trout hepatocytes. Am. J. Physiol. 1982, 243:223-228.
110. Sheridan M.A., Allen W.V., Kerstetter T.H. Changes in the fatty acid composition of steelhead trout, Salmo gairdnerii Richardson, associated with parr-smolt transformation. Comp. Biochem. Physiol. 1985, 80B:671-676.
111. Simopolous A.P. Omega-3 fatty acids in health and disease and in growth and development. Am. J. Clin. Nutr. 1991, 54:438-463.
112. Sinclair A.J., McLean J.G., Monger E.A. Metabolism of linoleic acid in the cat. Lipids 1979, 14:932-936.
113. Sinesky M. Homeoviscous adaptation: a homeostatic process that regulates the viscosity of membrane lipids in Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 1974, 71:522-525.
114. Skalli A., Robin J.H. Requirement of n-3 long chain polyunsaturated fatty acids for European sea bass (Dicentrachus labrax) juveniles: growth and fatty acid composition. Aquaculture 2004, 240:399-415.
115. Skalli A., Robin J.H., Le Bayon N., Le Delliou H., Person-Le Ruyet J. Impact of essential fatty acid deficiency on tissues' fatty acid composition of European sea bass (Dicentrarchus labrax). Aquaculture 2006, 255:223-232.
116. Spector A.A., Yorek M.A. Membrane lipid composition and cellular function. J. Lipid Res. 1985, 26:1015-1035.
117. Stubbs C.D., Smith A.D. The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochim. Biophys. Acta 1984, 779:89-137.
118. Tacon A.G. Use of fish meal and fish oil in aquaculture: a global perspective. Aquat. Resour. Cult. Dev. 2004, 1:3-14.
119. Takahashi Y., Kushiro M., Shinohara K., Ide T. Activity and mRNA levels of enzymes involved in hepatic fatty acid synthesis and oxidation in mice fed conjugated linoleic acid. Biochim. Biophys. Acta 2003, 1631:265-273.
120. Tan N.S., Shaw N.S., Vinckenbosh N., Liu P., Yasmin R., Desvergne B., Wahli W., Noy N. Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription. Mol. Cell. Biol. 2002, 22(14):5114-5127.
121. Tang C., Cho H.P., Nakamura M.T., Clarke S.D. Regulation of human D-6 desaturase gene transcription: identification of a functional direct repeat-1 element. J. Lipid Res. 2003, 44:686-694.
122. Tidwell J.H., Allan G.I. Fish as food: aquaculture's contribution. World Aquacult. 2002, 33:44-48.
123. Tiku P.E., Gracey A.Y., Macartney A.I., Beynon R.J., Cossins A.R. Cold-induced expression of delta-9 desaturase in carp by transcriptional and posttranslational mechanisms. Science 1996, 271:815-818.
124. Tocher D.R., Ghioni C. Fatty acid metabolism in marine fish: low activity of delta-5 desaturation in gilthead sea bream (Sparus aurata) cells. Lipids 1999, 34:433-440.
125. Tocher D.R., Bell J.G., Disk J.R., Sargent J.R. Fatty acyl desaturation in isolated hepatocytes from Atlantic salmon (Salmo salar): stimulation by dietary borage oil containing γ-linolenic acid. Lipids 1997, 32:1237-1247.
126. Tocher D.R., Bell J.G., Henderson R.J., McGhee F., Mitchell D., Morris P.C. The effect of dietary linseed and rapeseed oils on polyunsaturated fatty acid metabolism in Atlantic salmon (Salmo salar) undergoing parr-smolt transformation. Fish Physiol. Biochem. 2000, 23:59-73.
127. Tocher D.R., Bell J.G., MacGlaughlin P., McGhee F., Dick J.R. Hepatocyte fatty acid desaturation and polyunsaturated fatty acid composition of liver in salmonids: effects of dietary vegetable oil. Comp. Biochem. Physiol. 2001, 130:257-270.
128. Tocher D.R., Agaba M., Hastings N., Bell J.G., Dick J.R., Teale A.J. Nutritional regulation of hepatocyte fatty acid desaturation and polyunsaturated fatty acid composition in zebrafish (Danio rerio) and tilapia (Oreochromis nilotica). Fish Physiol. Biochem. 2001, 24:309-320.
129. Tocher D.R., Fonseca-Madrigal J., Bell J.G., Dick J.R., Henderson R.J., Sargent J.R. Effects of diet containing linseed oil on fatty acid desaturation and oxidation in hepatocytes and intestinal enterocytes in Atlantic salmon (Salmo salar). Fish Physiol. Biochem. 2002, 26:157-170.
130. Tocher D.R., Bell J.G., Dick J.R., Crampton V.O. Effects of dietary vegetable oil diets on Atlantic salmon hepatocyte fatty acid desaturation and liver fatty acid compositions. Lipids 2003, 38:723-732.
131. Tocher D.R., Bell J.G., McGhee F., Dick J.R., Fonseca-Madrigal J. Effects of dietary lipid level and vegetable oil on fatty acid metabolism in Atlantic salmon (Salmo salar) over the entire production cycle. Fish Physiol. Biochem. 2003, 29:193-209.
132. Tocher D.R., Fonseca-Madrigal J., Dick J.R., Ng W., Bell J.G., Campbell P.J. Effects of water temperature and diet containing palm oil on fatty acid desturation and oxidation in hepatocytes and intestinal enterocytes of rainbow trout (Onchorhynchus mykiss). Comp. Biochem. Physiol. 2004, 137B:49-63.
133. Tocher D., Zheng X., Schlechtriem C., Hastings N., Dick J., Teale A. Highly unsaturated fatty acid synthesis in marine fish: cloning, functional characterization, and nutritional regulation of fatty acyl δ6 desaturase of Atlantic cod (Gadus morhua L.). Lipids 2006, 41(11):1003-1016.
134. Tocher D.R., Dick J.R., MacGlaughlin P.M., Bell J.G. Effect of diets enriched in δ6 desaturated fatty acids (18:3n-6 and 18:4n-3), on growth, fatty acid composition and highly unsaturated fatty acid synthesis in two populations of Arctic charr (Salvelinus alpinus). Comp. Biochem. Physiol. B 2006, 144:245-253.
135. Torstensen B.E., Lie Ø., Frøyland L. Lipid metabolism and tissue composition in Atlantic salmon (Salmo salar)-effects of capelin-palm- and oleic acid enriched sunflower oil as dietary lipid sources. Lipids 2000, 35:653-664.
136. Tortensen B.E., Bell J.G., Rosenlund G., Henderson R.J., Graff I.E., Tocher D.R., Lie Ø., Sargent J.R. Tailoring of Atlantic salmon (Salmo salar) flesh lipid composition and sensory quality by replacing fish oil with a vegetable oil blend. J. Agric. Food Chem. 2005, 53:10166-10178.
137. Turchini G.M., Francis D.S., De Silva S.S. Fatty acid metabolism in the freshwater fish Murray cod (Maccullochella peelii peelii) deduced by the whole-body fatty acid balance method. Comp. Biochem. Physiol. B 2006, 144(1):110-118.
138. Twibell R.G., Watkins B.A., Rogers L., Brown P.B. Effects of dietary conjugated linoleic acids on hepatic and muscle lipids in hybrid striped bass. Lipids 2000, 35:155-161.
139. Ulmann L., Bouzianne M., Mimouni V., Belleville J., Poisson J.P. Relationship between rat liver microsomal δ6- and δ5-desaturase activities and fatty acid composition: comparative effects of coconut and salmon oils during protein restriction. J. Nutr. Biochem. 1992, 3:188-193.
140. Vagner M., Robin J.H., Zambonino Infante J.L., Person-Le Ruyet J. Combined effect of dietary HUFA level and temperature on sea bass (D. labrax) larvae development. Aquaculture 2007, 266:179-190.
141. Vagner M., Zambonino Infante J.L., Robin J.H., Person-Le Ruyet J. Is it possible to influence European sea bass (Dicentrarchus labrax) juvenile metabolism by a nutritional conditioning during larval stage?. Aquaculture 2007, 267:165-174.
142. Vagner M., Robin J.H., Tocher D.R., Zambonino Infante J.L., Person-Le Ruyet J. Ontogenic effects of early feeding of sea bass (Dicentrarchus labrax) larvae with a range of dietary n-3 HUFA levels on the functioning of polyunsaturated fatty acid desaturation pathways. Br. J. Nutr. 2009, 101:1452-1462.
143. Watanabe T. Lipid nutrition in fish. Comp. Biochem. Physiol. 1982, 73B:3-15.
144. Wodtke E., Cossins A.R. Rapid cold-induced changes in membrane order and delta-9 desaturase activity in endoplasmic reticulum of carp liver: a time-course study of thermal acclimation. Biochim. Biophys. Acta 1991, 1064:343-350.
145. Yu T.C., Sinnhuber R.O. Growth response of rainbow trout to dietary δ3 and δ6 fatty acids. Aquaculture 1976, 8:309-317.
146. Zhang F., Lavan B.E., Gregoire F.M. Selective modulators of PPAR-γ activity: molecular aspects related to obesity and side-effects. PPAR Res. 2006, 2007:7. (article 32696).
147. Zheng X., Seiliez I., Hastings N., Tocher D.R., Panserat S., Dickson C.A., Bergot P., Teale A.J. Characterization and comparison of fatty acyl δ6 desaturase cDNAs from freshwater and marine teleost fish species. Comp. Biochem. Physiol. B 2004, 139:269-279.
148. Zheng X., Tocher D.R., Dickson C.A., Bell J.G., Teale A.J. Effects of diets containing vegetable oil on expression of genes involved in polyunsaturated fatty acid biosynthesis in liver of Atlantic salmon (Salmo salar). Aquaculture 2004, 236:467-483.
149. Zheng X., Torstensen B.E., Tocher D.R., Dick J.R., Henderson R.J., Bell J.G. Environmental and dietary influences on highly unsaturated fatty acid biosynthesis and expression of fatty acyl desaturase and elongase genes in liver of Atlantic salmon (Salmo salar). Biochim. Biophys. Acta 2005, 1734:13-24.
150. Zheng X., Tocher D.R., Dickson C.A., Dick J.R., Bell J.G., Teale A.J. Highly unsaturated fatty acid synthesis in vertebrates: new insights with the cloning and characterization of a δ6 desaturase of Atlantic salmon. Lipids 2005, 40:13-24.
151. Zheng X., King Z., Xu Y., Monroig O., Morais S., Tocher D.R. Physiological roles of fatty acyl desaturases and elongases in marine fish: characterisation of cDNAs of fatty acyl δ6 desaturase and elovl5 elongase of cobia (Rachycentron canadum). Aquaculture 2009, 290:122-131.