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Volumn 17, Issue 2, 2011, Pages 80-88

Pharmacogenomic contribution to drug response

Author keywords

breast cancer; colorectal cancer; epidermal growth factor receptor; Pharmacogenomics; tamoxifen; thymidylate synthetase

Indexed keywords

BEVACIZUMAB; BIOLOGICAL MARKER; CYTOCHROME P450 2D6; DIHYDROPYRIMIDINE DEHYDROGENASE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLUOROURACIL; GLUCURONOSYLTRANSFERASE 1A1; IRINOTECAN; K RAS PROTEIN; OXALIPLATIN; PACLITAXEL; TAMOXIFEN; THIOPURINE METHYLTRANSFERASE; THYMIDYLATE SYNTHASE; TRASTUZUMAB;

EID: 79954562811     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0b013e3182147432     Document Type: Review
Times cited : (15)

References (127)
  • 1
    • 77953809368 scopus 로고    scopus 로고
    • Dissecting variability in responses to cancer chemotherapy through systems pharmacology
    • Yang R, Niepel M, Mitchison T, et al. Dissecting variability in responses to cancer chemotherapy through systems pharmacology. Clin Pharmacol Ther. 2010;88:34-38.
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 34-38
    • Yang, R.1    Niepel, M.2    Mitchison, T.3
  • 4
    • 42949142609 scopus 로고    scopus 로고
    • Systemic treatment of colorectal cancer
    • Wolpin BM, Mayer RJ. Systemic treatment of colorectal cancer. Gastroenterology. 2008;134:1296-1310.
    • (2008) Gastroenterology , vol.134 , pp. 1296-1310
    • Wolpin, B.M.1    Mayer, R.J.2
  • 5
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans W, Relling M. Pharmacogenomics: translating functional genomics into rational therapeutics. Science. 1999;286:487-491.
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.1    Relling, M.2
  • 6
    • 0035775486 scopus 로고    scopus 로고
    • Pharmacogenomics: The inherited basis for interindividual differences in drug response
    • DOI 10.1146/annurev.genom.2.1.9
    • Evans W, Johnson J. Pharmacogenomics: the inherited basis for interindividual differences in drug response. Annu Rev Genomics Hum Genet. 2001;2:9-39. (Pubitemid 35264999)
    • (2001) Annual Review of Genomics and Human Genetics , vol.2 , pp. 9-39
    • Evans, W.E.1    Johnson, J.A.2
  • 7
    • 0035033019 scopus 로고    scopus 로고
    • Pharmacogenomics: Unlocking the human genome for better drug therapy
    • DOI 10.1146/annurev.pharmtox.41.1.101
    • McLeod H, Evans W. Pharmacogenomics: unlocking the human genome for better drug therapy. Annu Rev Pharmacol Toxicol. 2001;41: 101-121. (Pubitemid 32385884)
    • (2001) Annual Review of Pharmacology and Toxicology , vol.41 , pp. 101-121
    • McLeod, H.L.1    Evans, W.E.2
  • 8
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics - Drug disposition, drug targets, and side effects
    • DOI 10.1056/NEJMra020526
    • Evans W, McLeod H. PharmacogenomicsVdrug disposition, drug targets, and side effects. N Engl J Med. 2003;348:538-549. (Pubitemid 36159890)
    • (2003) New England Journal of Medicine , vol.348 , Issue.6 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 9
    • 0031826288 scopus 로고    scopus 로고
    • Hypothesis: Comparisons of inter- and intra-individual variations can substitute for twin studies in drug research
    • DOI 10.1097/00008571-199808000-00001
    • Kalow W, Tang B, Endrenyi L. Hypothesis: comparisons of inter- and intra-individual variations can substitute for twin studies in drug research. Pharmacogenetics. 1998;8:283-289. (Pubitemid 28372321)
    • (1998) Pharmacogenetics , vol.8 , Issue.4 , pp. 283-289
    • Kalow, W.1    Tang, B.-K.2    Endrenyi, L.3
  • 10
    • 0842286886 scopus 로고    scopus 로고
    • Cancer pharmacogenetics
    • DOI 10.1038/sj.bjc.6601487
    • Marsh S, McLeod H. Cancer pharmacogenetics. Br J Cancer. 2004; 90:8-11. (Pubitemid 38174930)
    • (2004) British Journal of Cancer , vol.90 , Issue.1 , pp. 8-11
    • Marsh, S.1    McLeod, H.L.2
  • 12
    • 0033486029 scopus 로고    scopus 로고
    • Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus
    • Relling M, Hancock M, Rivera G, et al. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. J Natl Cancer Inst. 1999;91:2001-2008.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 2001-2008
    • Relling, M.1    Hancock, M.2    Rivera, G.3
  • 13
    • 0033135738 scopus 로고    scopus 로고
    • Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia
    • Relling M, Hancock M, Boyett J, et al. Prognostic importance of 6- mercaptopurine dose intensity in acute lymphoblastic leukemia. Blood. 1999;93:2817-2823. (Pubitemid 29200771)
    • (1999) Blood , vol.93 , Issue.9 , pp. 2817-2823
    • Relling, M.V.1    Hancock, M.L.2    Boyett, J.M.3    Pui, C.-H.4    Evans, W.E.5
  • 14
    • 0035522659 scopus 로고    scopus 로고
    • Thymidylate synthase pharmacogenetics in colorectal cancer
    • discussion 9-81
    • Marsh S, McLeod H. Thymidylate synthase pharmacogenetics in colorectal cancer. Clin Colorectal Cancer. 2001;1:175-178; discussion 9-81.
    • (2001) Clin Colorectal Cancer , vol.1 , pp. 175-178
    • Marsh, S.1    McLeod, H.2
  • 15
    • 0033427561 scopus 로고    scopus 로고
    • Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers
    • Kawakami K, Omura K, Kanehira E, et al. Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers. Anticancer Res. 1999;19: 3249-3252. (Pubitemid 30042617)
    • (1999) Anticancer Research , vol.19 , Issue.4 B , pp. 3249-3252
    • Kawakami, K.1    Omura, K.2    Kanehira, E.3    Watanabe, Y.4
  • 17
    • 0029122937 scopus 로고
    • Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5′-terminal regulatory region of the human gene for thymidylate synthase
    • Horie N, Aiba H, Oguro K, et al. Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5′-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct Funct. 1995;20:191-197.
    • (1995) Cell Struct Funct , vol.20 , pp. 191-197
    • Horie, N.1    Aiba, H.2    Oguro, K.3
  • 19
    • 53449098390 scopus 로고    scopus 로고
    • Predictive value of thymidylate synthase expression in advanced colorectal cancer patients receiving fluoropyrimidine-based chemotherapy: Evidence from 24 studies
    • Qiu L, Tang Q, Bai J, et al. Predictive value of thymidylate synthase expression in advanced colorectal cancer patients receiving fluoropyrimidine- based chemotherapy: evidence from 24 studies. Int J Cancer. 2008;123:2384-2389.
    • (2008) Int J Cancer , vol.123 , pp. 2384-2389
    • Qiu, L.1    Tang, Q.2    Bai, J.3
  • 21
    • 1442290323 scopus 로고    scopus 로고
    • Thymidylate-synthase expression and prognosis in colorectal cancer: A systematic review and meta-analysis
    • DOI 10.1200/JCO.2004.05.064
    • Popat S, Matakidou A, Houlston R. Thymidylate synthase expression and prognosis in colorectal cancer: a systematic review and metaanalysis. J Clin Oncol. 2004;22:529-536. (Pubitemid 41079782)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.3 , pp. 529-536
    • Popat, S.1    Matakidou, A.2    Houlston, R.S.3
  • 24
    • 0034486207 scopus 로고    scopus 로고
    • Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil
    • Aschele C, Debernardis D, Tunesi G, et al. Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil. Clin Cancer Res. 2000;6:4797-4802. (Pubitemid 32110422)
    • (2000) Clinical Cancer Research , vol.6 , Issue.12 , pp. 4797-4802
    • Aschele, C.1    Debernardis, D.2    Tunesi, G.3    Maley, F.4    Sobrero, A.5
  • 27
    • 77954358129 scopus 로고    scopus 로고
    • Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: Results from North American Gastrointestinal Intergroup Trial N9741
    • McLeod HL, Sargent DJ, Marsh S, et al. Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741. J Clin Oncol. 2010;28:3227-3233.
    • (2010) J Clin Oncol , vol.28 , pp. 3227-3233
    • McLeod, H.L.1    Sargent, D.J.2    Marsh, S.3
  • 28
    • 79952356214 scopus 로고    scopus 로고
    • Thymidylate synthase genotypeY directed neoadjuvant chemoradiation for patients with rectal adenocarcinoma
    • Tan BR, Thomas F, Myerson RJ, et al. Thymidylate synthase genotypeY directed neoadjuvant chemoradiation for patients with rectal adenocarcinoma. J Clin Oncol. 2011;29:875-883.
    • (2011) J Clin Oncol , vol.29 , pp. 875-883
    • Tan, B.R.1    Thomas, F.2    Myerson, R.J.3
  • 29
    • 0036362181 scopus 로고    scopus 로고
    • Why the epidermal growth factor receptor? The rationale for cancer therapy
    • Baselga J. Why the epidermal growth factor receptor? The rationale for cancer therapy. Oncologist. 2002;7(suppl 4):2-8. (Pubitemid 34977157)
    • (2002) Oncologist , vol.7 , Issue.SUPPL. 4 , pp. 2-8
    • Baselga, J.1
  • 32
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis C, Khambata-Ford S, Jonker D, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med. 2008;359:1757-1765.
    • (2008) N Engl J Med , vol.359 , pp. 1757-1765
    • Karapetis, C.1    Khambata-Ford, S.2    Jonker, D.3
  • 33
    • 77949887855 scopus 로고    scopus 로고
    • Pharmacogenomic and pharmacoproteomic studies of cetuximab in metastatic colorectal cancer: Biomarker analysis of a phase i dose-escalation study
    • Tabernero J, Cervantes A, Rivera F, et al. Pharmacogenomic and pharmacoproteomic studies of cetuximab in metastatic colorectal cancer: biomarker analysis of a phase I dose-escalation study. J Clin Oncol. 2010;28:1181-1189.
    • (2010) J Clin Oncol , vol.28 , pp. 1181-1189
    • Tabernero, J.1    Cervantes, A.2    Rivera, F.3
  • 34
    • 78049341541 scopus 로고    scopus 로고
    • Association of KRAS p.G13D mutation with outcome in patients with chemotherapyrefractory metastatic colorectal cancer treated with cetuximab
    • De Roock W, Jonker DJ, Di Nicolantonio F, et al. Association of KRAS p.G13D mutation with outcome in patients with chemotherapyrefractory metastatic colorectal cancer treated with cetuximab. JAMA. 2010;304:1812-1820.
    • (2010) JAMA , vol.304 , pp. 1812-1820
    • De Roock, W.1    Jonker, D.J.2    Di Nicolantonio, F.3
  • 35
    • 79957523828 scopus 로고    scopus 로고
    • KRAS BRAF PIK3CA and PTEN mutations: Implications for targeted therapies in metastatic colorectal cancer
    • Epub ahead of print, December 14, 2010
    • Roock WD, Vriendt VD, Normanno N, et al. KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. Lancet Oncol. Epub ahead of print, December 14, 2010.
    • Lancet Oncol
    • Roock, W.D.1    Vriendt, V.D.2    Normanno, N.3
  • 36
    • 0345596364 scopus 로고    scopus 로고
    • Toxicity of fluorouracil in patients with advanced colorectal cancer: Effect of administration schedule and prognostic factors
    • Meta-Analysis Group In Cancer
    • Meta-Analysis Group In Cancer. Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors. J Clin Oncol. 1998;16:3537-3541.
    • (1998) J Clin Oncol , vol.16 , pp. 3537-3541
  • 37
    • 0023187085 scopus 로고
    • Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile
    • Heggie G, Sommadossi J, Cross D, et al. Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res. 1987;47:2203-2206. (Pubitemid 17074634)
    • (1987) Cancer Research , vol.47 , Issue.8 , pp. 2203-2206
    • Heggie, G.D.1    Sommadossi, J.-P.2    Cross, D.S.3
  • 40
    • 0037144354 scopus 로고    scopus 로고
    • Increased risk of grade IV neutropenia after administration of 5-fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: High prevalence of the IVS14+1G>A mutation
    • DOI 10.1002/ijc.10599
    • Van Kuilenburg A, Meinsma R, Zoetekouw L, Van Gennip A. Increased risk of grade IV neutropenia after administration of 5-fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: high prevalence of the IVS14+1g9a mutation. Int J Cancer. 2002;101:253-258. (Pubitemid 34970893)
    • (2002) International Journal of Cancer , vol.101 , Issue.3 , pp. 253-258
    • Van Kuilenburg, A.B.P.1    Meinsma, R.2    Zoetekouw, L.3    Van Gennip, A.H.4
  • 41
    • 0036798968 scopus 로고    scopus 로고
    • High prevalence of the IVS14 + 1G>A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity
    • DOI 10.1097/00008571-200210000-00007
    • Van Kuilenburg A, Meinsma R, Zoetekouw L, et al. High prevalence of the IVS14 + 1G9A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracilYassociated toxicity. Pharmacogenetics. 2002;12:555-558. (Pubitemid 35177085)
    • (2002) Pharmacogenetics , vol.12 , Issue.7 , pp. 555-558
    • Van Kuilenburg, A.B.P.1    Meinsma, R.2    Zoetekouw, L.3    Van Gennip, A.H.4
  • 42
    • 0034808681 scopus 로고    scopus 로고
    • Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5′-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls
    • Raida M, Schwabe W, Häusler P, et al. Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5′-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)Yrelated toxicity compared with controls. Clin Cancer Res. 2001;7:2832-2839. (Pubitemid 32911393)
    • (2001) Clinical Cancer Research , vol.7 , Issue.9 , pp. 2832-2839
    • Raida, M.1    Schwabe, W.2    Hausler, P.3    Van Kuilenburg, A.B.P.4    Van Gennip, A.H.5    Behnke, D.6    Hoffken, K.7
  • 44
    • 0141615759 scopus 로고    scopus 로고
    • Use of pyrosequencing to detect clinically relevant polymorphisms in dihydropyrimidine dehydrogenase
    • DOI 10.1373/49.10.1661
    • Ahluwalia R, Freimuth R, McLeod H, et al. Use of pyrosequencing to detect clinically relevant polymorphisms in dihydropyrimidine dehydrogenase. Clin Chem. 2003;49:1661-1664. (Pubitemid 37194222)
    • (2003) Clinical Chemistry , vol.49 , Issue.10 , pp. 1661-1664
    • Ahluwalia, R.1    Freimuth, R.2    McLeod, H.L.3    Marsh, S.4
  • 45
    • 29344443013 scopus 로고    scopus 로고
    • Methylation of the DPYD promoter: An alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients
    • DOI 10.1158/1078-0432.CCR-05-1520
    • Ezzeldin H, Lee A, Mattison L, et al. Methylation of the DPYD promoter: an alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients. Clin Cancer Res. 2005;11:8699-8705. (Pubitemid 43005919)
    • (2005) Clinical Cancer Research , vol.11 , Issue.24 , pp. 8699-8705
    • Ezzeldin, H.H.1    Lee, A.M.2    Mattison, L.K.3    Diasio, R.B.4
  • 47
    • 33745711758 scopus 로고    scopus 로고
    • Methylation of the DPYD promoter and dihydropyrimidine dehydrogenase deficiency [1]
    • DOI 10.1158/1078-0432.CCR-06-0549
    • Yu JS, McLeod HL. Methylation of the DPYD promoter and dihydropyrimidine dehydrogenase deficiency. Clin Cancer Res. 2006;12:3864. (Pubitemid 44000269)
    • (2006) Clinical Cancer Research , vol.12 , Issue.12 , pp. 3864
    • Yu, J.1    McLeod, H.L.2
  • 48
    • 33947588763 scopus 로고    scopus 로고
    • Should DPD analysis be required prior to prescribing fluoropyrimidines?
    • DOI 10.1016/j.ejca.2007.01.030, PII S0959804907000950
    • Yen J, McLeod H. Should DPD analysis be required prior to prescribing fluoropyrimidines? Eur J Cancer. 2007;43:1011-1016. (Pubitemid 46483039)
    • (2007) European Journal of Cancer , vol.43 , Issue.6 , pp. 1011-1016
    • Yen, J.L.1    McLeod, H.L.2
  • 50
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group
    • Saltz L, Cox J, Blanke C, et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med. 2000;343:905-914.
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.1    Cox, J.2    Blanke, C.3
  • 51
    • 0027140524 scopus 로고
    • Phase i and pharmacokinetic trial of weekly CPT-11
    • Rothenberg M, Kuhn J, Burris HA 3rd, et al. Phase I and pharmacokinetic trial of weekly CPT-11. J Clin Oncol. 1993;11:2194-2204.
    • (1993) J Clin Oncol , vol.11 , pp. 2194-2204
    • Rothenberg, M.1    Kuhn, J.2    Burris III, H.A.3
  • 54
    • 0037364658 scopus 로고    scopus 로고
    • Phase III comparison of two irinotecan dosing regimens in second-line therapy of metastatic colorectal cancer
    • DOI 10.1200/JCO.2003.08.058
    • Fuchs C, Moore M, Harker G, et al. Phase III comparison of two irinotecan dosing regimens in second-line therapy of metastatic colorectal cancer. J Clin Oncol. 2003;21:807-814. (Pubitemid 46606439)
    • (2003) Journal of Clinical Oncology , vol.21 , Issue.5 , pp. 807-814
    • Fuchs, C.S.1    Moore, M.R.2    Harker, G.3    Villa, L.4    Rinaldi, D.5    Hecht, J.R.6
  • 56
    • 0025996996 scopus 로고
    • Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11
    • Kawato Y, Aonuma M, Hirota Y, et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991;51:4187-4191.
    • (1991) Cancer Res , vol.51 , pp. 4187-4191
    • Kawato, Y.1    Aonuma, M.2    Hirota, Y.3
  • 57
    • 0032519431 scopus 로고    scopus 로고
    • Genetic predisposition to the metabolism of irinotecan (CPT-11): Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes
    • Iyer L, King C, Whitington P, et al. Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. J Clin Invest. 1998;101:847-854. (Pubitemid 28096082)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.4 , pp. 847-854
    • Iyer, L.1    King, C.D.2    Whitington, P.F.3    Green, M.D.4    Roy, S.K.5    Tephly, T.R.6    Coffman, B.L.7    Ratain, M.J.8
  • 58
  • 60
    • 0032493441 scopus 로고    scopus 로고
    • Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism?
    • DOI 10.1073/pnas.95.14.8170
    • Beutler E, Gelbart T, Demina A. Racial variability in the UDPglucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci U S A. 1998;95:8170-8174. (Pubitemid 28326085)
    • (1998) Proceedings of the National Academy of Sciences of the United States of America , vol.95 , Issue.14 , pp. 8170-8174
    • Beutler, E.1    Gelbart, T.2    Demina, A.3
  • 62
    • 0035864610 scopus 로고    scopus 로고
    • Association of plasma bilirubin with coronary heart disease and segregation of bilirubin as a major gene trait: The NHLBI family heart study
    • DOI 10.1016/S0021-9150(00)00420-2, PII S0021915000004202
    • Hunt S, Kronenberg F, Eckfeldt J, et al. Association of plasma bilirubin with coronary heart disease and segregation of bilirubin as a major gene trait: the NHLBI family heart study. Atherosclerosis. 2001;154:747-754. (Pubitemid 32232174)
    • (2001) Atherosclerosis , vol.154 , Issue.3 , pp. 747-754
    • Hunt, S.C.1    Kronenberg, F.2    Eckfeldt, J.H.3    Hopkins, P.N.4    Myers, R.H.5    Heiss, G.6
  • 64
    • 0344333420 scopus 로고    scopus 로고
    • Prognostic and predictive value of c-erbB-2 overexpression in primary breast cancer, alone and in combination with other prognostic markers
    • Sjögren S, Inganäs M, Lindgren A, et al. Prognostic and predictive value of c-erbB-2 overexpression in primary breast cancer, alone and in combination with other prognostic markers. J ClinOncol. 1998;16:462-469. (Pubitemid 28135587)
    • (1998) Journal of Clinical Oncology , vol.16 , Issue.2 , pp. 462-469
    • Sjogren, S.1    Inganas, M.2    Lindgren, A.3    Holmberg, L.4    Bergh, J.5
  • 65
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon D, Clark G,Wong S, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987;235:177-182. (Pubitemid 17231334)
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 66
    • 3042622482 scopus 로고    scopus 로고
    • HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues
    • Owens M, Horten B, Da Silva M. HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues. Clin Breast Cancer. 2004;5:63-69. (Pubitemid 38821193)
    • (2004) Clinical Breast Cancer , vol.5 , Issue.1 , pp. 63-69
    • Owens, M.A.1    Horten, B.C.2    Da Silva, M.M.3
  • 67
    • 34547854801 scopus 로고    scopus 로고
    • The oncogene HER2: Its signaling and transforming functions and its role in human cancer pathogenesis
    • DOI 10.1038/sj.onc.1210477, PII 1210477
    • Moasser M. The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene. 2007;26: 6469-6487. (Pubitemid 47530601)
    • (2007) Oncogene , vol.26 , Issue.45 , pp. 6469-6487
    • Moasser, M.M.1
  • 68
    • 46949101939 scopus 로고    scopus 로고
    • EGFR/HER2 in breast cancer: A biological approach for molecular diagnosis and therapy
    • DOI 10.1586/14737159.8.4.417
    • Milanezi F, Carvalho S, Schmitt F. EGFR/HER2 in breast cancer: a biological approach for molecular diagnosis and therapy. Expert Rev Mol Diagn. 2008;8:417-434. (Pubitemid 351962088)
    • (2008) Expert Review of Molecular Diagnostics , vol.8 , Issue.4 , pp. 417-434
    • Milanezi, F.1    Carvalho, S.2    Schmitt, F.C.3
  • 69
    • 62449090881 scopus 로고    scopus 로고
    • Guidelines for human epidermal growth factor receptor 2 testing: Biologic and methodologic considerations
    • Sauter G, Lee J, Bartlett J, et al. Guidelines for human epidermal growth factor receptor 2 testing: biologic and methodologic considerations. J Clin Oncol. 2009;27:1323-1333.
    • (2009) J Clin Oncol , vol.27 , pp. 1323-1333
    • Sauter, G.1    Lee, J.2    Bartlett, J.3
  • 72
    • 35848933669 scopus 로고    scopus 로고
    • Advances in adjuvant therapy for breast cancer
    • discussion suppl 10; quiz 2 p following suppl
    • Slamon D, Romond E, Perez E, et al. Advances in adjuvant therapy for breast cancer. Clin Adv Hematol Oncol. 2006;4(suppl 1):4-9, discussion suppl 10; quiz 2 p following suppl.
    • (2006) Clin Adv Hematol Oncol , vol.4 , Issue.SUPPL. 1 , pp. 4-9
    • Slamon, D.1    Romond, E.2    Perez, E.3
  • 79
    • 25144453930 scopus 로고    scopus 로고
    • Determination of HER2 gene amplification by fluorescence in situ hybridization and concordance with the clinical trials immunohistochemical assay in women with metastatic breast cancer evaluated for treatment with trastuzumab
    • DOI 10.1007/s10549-004-6275-8
    • Dybdal N, Leiberman G, Anderson S, et al. Determination of HER2 gene amplification by fluorescence in situ hybridization and concordance with the clinical trials immunohistochemical assay in women with metastatic breast cancer evaluated for treatment with trastuzumab. Breast Cancer Res Treat. 2005;93:3-11. (Pubitemid 41355986)
    • (2005) Breast Cancer Research and Treatment , vol.93 , Issue.1 , pp. 3-11
    • Dybdal, N.1    Leiberman, G.2    Anderson, S.3    McCune, B.4    Bajamonde, A.5    Cohen, R.L.6    Mass, R.D.7    Sanders, C.8    Press, M.F.9
  • 83
    • 2042467574 scopus 로고    scopus 로고
    • HER-2 Testing in Breast Cancer Using Immunohistochemical Analysis and Fluorescence In Situ Hybridization: A Single-Institution Experience of 2,279 Cases and Comparison of Dual-Color and Single-Color Scoring
    • DOI 10.1309/VE78-62V2-646B-R6EX
    • Lal P, Salazar P, Hudis C, et al. HER-2 testing in breast cancer using immunohistochemical analysis and fluorescence in situ hybridization: a single-institution experience of 2,279 cases and comparison of dualcolor and single-color scoring. Am J Clin Pathol. 2004;121:631-636. (Pubitemid 38533994)
    • (2004) American Journal of Clinical Pathology , vol.121 , Issue.5 , pp. 631-636
    • Lal, P.1    Salazar, P.A.2    Hudis, C.A.3    Ladanyi, M.4    Chen, B.5
  • 84
    • 57149096463 scopus 로고    scopus 로고
    • Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer
    • Di Leo A, Gomez H, Aziz Z, et al. Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer. J Clin Oncol. 2008; 26:5544-5552.
    • (2008) J Clin Oncol , vol.26 , pp. 5544-5552
    • Di Leo, A.1    Gomez, H.2    Aziz, Z.3
  • 85
    • 59449106972 scopus 로고    scopus 로고
    • HER-2 gene amplification, HER-2 and epidermal growth factor receptor mRNA and protein expression, and lapatinib efficacy in women with metastatic breast cancer
    • Press M, Finn R, Cameron D, et al. HER-2 gene amplification, HER-2 and epidermal growth factor receptor mRNA and protein expression, and lapatinib efficacy in women with metastatic breast cancer. Clin Cancer Res. 2008;14:7861-7870.
    • (2008) Clin Cancer Res , vol.14 , pp. 7861-7870
    • Press, M.1    Finn, R.2    Cameron, D.3
  • 86
    • 74049150299 scopus 로고    scopus 로고
    • HER2+ breast cancer: How to evaluate?
    • Schmitt F. HER2+ breast cancer: how to evaluate? Adv Ther. 2009; 26(suppl 1):S1-S8.
    • (2009) Adv Ther , vol.26 , Issue.SUPPL. 1
    • Schmitt, F.1
  • 88
    • 9244219598 scopus 로고    scopus 로고
    • Breast cancer - Loss of PTEN predicts resistance to treatment
    • DOI 10.1056/NEJMcibr043143
    • Pandolfi P. Breast cancerVloss of PTEN predicts resistance to treatment. N Engl J Med. 2004;351:2337-2338. (Pubitemid 39552753)
    • (2004) New England Journal of Medicine , vol.351 , Issue.22 , pp. 2337-2338
    • Pandolfi, P.P.1
  • 91
    • 73349085919 scopus 로고    scopus 로고
    • Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2Ypositive breast cancer
    • Spector N, Blackwell K. Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2Ypositive breast cancer. J Clin Oncol. 2009;27:5838-5847.
    • (2009) J Clin Oncol , vol.27 , pp. 5838-5847
    • Spector, N.1    Blackwell, K.2
  • 92
    • 77949884661 scopus 로고    scopus 로고
    • Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
    • Blackwell KL, Burstein HJ, Storniolo AM, et al. Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol. 2010;28:1124-1130.
    • (2010) J Clin Oncol , vol.28 , pp. 1124-1130
    • Blackwell, K.L.1    Burstein, H.J.2    Storniolo, A.M.3
  • 95
    • 37849015496 scopus 로고    scopus 로고
    • Gene-expression assays: New tools to individualize treatment of early-stage breast cancer
    • Dobbe E, Gurney K, Kiekow S, et al. Gene-expression assays: new tools to individualize treatment of early-stage breast cancer. Am J Health Syst Pharm. 2008;65:23-28.
    • (2008) Am J Health Syst Pharm , vol.65 , pp. 23-28
    • Dobbe, E.1    Gurney, K.2    Kiekow, S.3
  • 97
    • 45749157664 scopus 로고    scopus 로고
    • Commercialized multigene predictors of clinical outcome for breast cancer
    • DOI 10.1634/theoncologist.2007-0248
    • Ross J, Hatzis C, Symmans W, et al. Commercialized multigene predictors of clinical outcome for breast cancer. Oncologist. 2008;13:477-493. (Pubitemid 351872866)
    • (2008) Oncologist , vol.13 , Issue.5 , pp. 477-493
    • Ross, J.S.1    Hatzis, C.2    Symmans, W.F.3    Pusztai, L.4    Hortobagyi, G.N.5
  • 101
    • 33744808550 scopus 로고    scopus 로고
    • A population-based study of tumor gene expression and risk of breast cancer death among lymph nodeY negative patients
    • Habel L, Shak S, Jacobs M, et al. A population-based study of tumor gene expression and risk of breast cancer death among lymph nodeY negative patients. Breast Cancer Res. 2006;8:R25.
    • (2006) Breast Cancer Res , vol.8
    • Habel, L.1    Shak, S.2    Jacobs, M.3
  • 103
    • 77950859892 scopus 로고    scopus 로고
    • The predictive value of the 70- gene signature for adjuvant chemotherapy in early breast cancer
    • Knauer M, Mook S, Rutgers E, et al. The predictive value of the 70- gene signature for adjuvant chemotherapy in early breast cancer. Breast Cancer Res Treat. 2010;120:655-661.
    • (2010) Breast Cancer Res Treat , vol.120 , pp. 655-661
    • Knauer, M.1    Mook, S.2    Rutgers, E.3
  • 105
    • 0015069359 scopus 로고
    • A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI46474
    • Cole M, Jones C, Todd I. A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI46474. Br J Cancer. 1971; 25:270-275
    • (1971) Br J Cancer , vol.25 , pp. 270-275
    • Cole, M.1    Jones, C.2    Todd, I.3
  • 106
    • 77956028902 scopus 로고
    • Controlled trial of tamoxifen as adjuvant agent in management of early breast cancer
    • Interim analysis at four years by Nolvadex Adjuvant Trial Organisation
    • Controlled trial of tamoxifen as adjuvant agent in management of early breast cancer. Interim analysis at four years by Nolvadex Adjuvant Trial Organisation. Lancet. 1983;1:257-261.
    • (1983) Lancet , vol.1 , pp. 257-261
  • 108
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • EBCTCG. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005;365:1687-1717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 109
    • 37549006389 scopus 로고    scopus 로고
    • Tamoxifen pharmacogenomics: The role of CYP2D6 as a predictor of drug response
    • Goetz M, Kamal A, Ames M. Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response. Clin Pharmacol Ther. 2008;83:160-166.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 160-166
    • Goetz, M.1    Kamal, A.2    Ames, M.3
  • 110
    • 0025169332 scopus 로고
    • The clinical and endocrine effects of 4-hydroxyandrostenedione alone and in combination with goserelin in premenopausal women with advanced breast cancer
    • Stein R, Dowsett M, Hedley A, et al. The clinical and endocrine effects of 4-hydroxyandrostenedione alone and in combination with goserelin in premenopausal women with advanced breast cancer. Br J Cancer. 1990;62:679-683. (Pubitemid 20340591)
    • (1990) British Journal of Cancer , vol.62 , Issue.4 , pp. 679-683
    • Stein, R.C.1    Dowsett, M.2    Hedley, A.3    Gazet, J.-C.4    Ford, H.T.5    Coombes, R.C.6
  • 111
    • 19944434201 scopus 로고    scopus 로고
    • CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment
    • Jin Y, Desta Z, Stearns V, et al. CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J Natl Cancer Inst. 2005;97:30-39.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 30-39
    • Jin, Y.1    Desta, Z.2    Stearns, V.3
  • 114
    • 68749113944 scopus 로고    scopus 로고
    • Targeting of tamoxifen to enhance antitumour action for the treatment and prevention of breast cancer: The 'personalised' approach?
    • Brauch H, Jordan V. Targeting of tamoxifen to enhance antitumour action for the treatment and prevention of breast cancer: the 'personalised' approach? Eur J Cancer. 2009;45:2274-2283.
    • (2009) Eur J Cancer , vol.45 , pp. 2274-2283
    • Brauch, H.1    Jordan, V.2
  • 117
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • Sachse C, Brockmö ller J, Bauer S, et al. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet. 1997;60:284-295. (Pubitemid 27058401)
    • (1997) American Journal of Human Genetics , vol.60 , Issue.2 , pp. 284-295
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3    Roots, I.4
  • 118
    • 33847031732 scopus 로고    scopus 로고
    • CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure
    • Sistonen J, Sajantila A, Lao O, et al. CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure. Pharmacogenet Genomics. 2007;17:93-101.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 93-101
    • Sistonen, J.1    Sajantila, A.2    Lao, O.3
  • 119
    • 33644639136 scopus 로고    scopus 로고
    • Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes
    • Goetz M, Rae J, Suman V, et al. Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol. 2005;23:9312-9318.
    • (2005) J Clin Oncol , vol.23 , pp. 9312-9318
    • Goetz, M.1    Rae, J.2    Suman, V.3
  • 122
    • 47749105202 scopus 로고    scopus 로고
    • Association between CYP2D6*10 genotype and survival of breast cancer patients receiving tamoxifen treatment
    • Xu Y, Sun Y, Yao L, et al. Association between CYP2D6*10 genotype and survival of breast cancer patients receiving tamoxifen treatment. Ann Oncol. 2008;19:1423-1429.
    • (2008) Ann Oncol , vol.19 , pp. 1423-1429
    • Xu, Y.1    Sun, Y.2    Yao, L.3
  • 125
    • 29144491089 scopus 로고    scopus 로고
    • Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients
    • Wegman P, Vainikka L, Stål O, et al. Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients. Breast Cancer Res. 2005;7:R284YR290.
    • (2005) Breast Cancer Res , vol.7
    • Wegman, P.1    Vainikka, L.2    Stål, O.3
  • 126
    • 34248208754 scopus 로고    scopus 로고
    • Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer
    • Wegman P, Elingarami S, Carstensen J, et al. Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer. Breast Cancer Res. 2007;9:R7.
    • (2007) Breast Cancer Res , vol.9
    • Wegman, P.1    Elingarami, S.2    Carstensen, J.3
  • 127
    • 72049122975 scopus 로고    scopus 로고
    • Pharmacogenetics of breast cancer therapies
    • Hertz D, McLeod H, Hoskins J. Pharmacogenetics of breast cancer therapies. Breast. 2009;18(suppl 3):S59-S63.
    • (2009) Breast , vol.18 , Issue.SUPPL. 3
    • Hertz, D.1    McLeod, H.2    Hoskins, J.3


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