-
2
-
-
58149232649
-
Unraveling the biologic and clinical complexities of HER2
-
Park JW, Neve RM, Szollosi J, et al: Unraveling the biologic and clinical complexities of HER2. Clin Breast Cancer 8:392-401, 2008
-
(2008)
Clin Breast Cancer
, vol.8
, pp. 392-401
-
-
Park, J.W.1
Neve, R.M.2
Szollosi, J.3
-
3
-
-
2142843806
-
Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions
-
Pinkas-Kramarski R, Soussan L, Waterman H, et al: Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J 15:2452-2467, 1996
-
(1996)
EMBO J
, vol.15
, pp. 2452-2467
-
-
Pinkas-Kramarski, R.1
Soussan, L.2
Waterman, H.3
-
4
-
-
0030944455
-
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
-
Graus-Porta D, Beerli RR, Daly JM, et al: ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J 16:1647-1655, 1997
-
(1997)
EMBO J
, vol.16
, pp. 1647-1655
-
-
Graus-Porta, D.1
Beerli, R.R.2
Daly, J.M.3
-
5
-
-
0032142749
-
ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase
-
Hellyer NJ, Cheng K, Koland JG: ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase. Biochem J 333:757-763, 1998
-
(1998)
Biochem J
, vol.333
, pp. 757-763
-
-
Hellyer, N.J.1
Cheng, K.2
Koland, J.G.3
-
6
-
-
0036963448
-
Co-targeting HER2/ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells
-
Camirand A, Lu Y, Pollak M: Co-targeting HER2/ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells. Med Sci Monit 8:BR521-PR526, 2002
-
(2002)
Med Sci Monit
, vol.8
-
-
Camirand, A.1
Lu, Y.2
Pollak, M.3
-
7
-
-
0035915421
-
Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
-
Lu Y, Zi X, Zhao Y, et al: Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 93:1852-1857, 2001
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1852-1857
-
-
Lu, Y.1
Zi, X.2
Zhao, Y.3
-
8
-
-
33947246109
-
Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer
-
Harris LN, You F, Schnitt SJ, et al: Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer. Clin Cancer Res 13:1198-1207, 2007
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1198-1207
-
-
Harris, L.N.1
You, F.2
Schnitt, S.J.3
-
9
-
-
0344333420
-
Prognostic and predictive value of c-erbB-2 overexpression in primary breast cancer, alone and in combination with other prognostic markers
-
Sjögren S, Inganas M, Lindgren A, et al: Prognostic and predictive value of c-erbB-2 overexpression in primary breast cancer, alone and in combination with other prognostic markers. J Clin Oncol 16:462-469, 1998
-
(1998)
J Clin Oncol
, vol.16
, pp. 462-469
-
-
Sjögren, S.1
Inganas, M.2
Lindgren, A.3
-
10
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, et al: Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235:177-182, 1987
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
-
11
-
-
3042622482
-
HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues
-
Owens MA, Horten BC, Da Silva MM: HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues. Clin Breast Cancer 5:63-69, 2004
-
(2004)
Clin Breast Cancer
, vol.5
, pp. 63-69
-
-
Owens, M.A.1
Horten, B.C.2
Da Silva, M.M.3
-
12
-
-
33846457870
-
Cancer statistics, 2007
-
Jemal A, Siegel R, Ward E, et al: Cancer statistics, 2007. CA Cancer J Clin 57:43-66, 2007
-
(2007)
CA Cancer J Clin
, vol.57
, pp. 43-66
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
-
13
-
-
33847638137
-
Estimates of the cancer incidence and mortality in Europe in 2006
-
Ferlay J, Autier P, Boniol M, et al: Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 18:581-592, 2007
-
(2007)
Ann Oncol
, vol.18
, pp. 581-592
-
-
Ferlay, J.1
Autier, P.2
Boniol, M.3
-
14
-
-
2342641439
-
Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway
-
Makino K, Day CP, Wang SC, et al: Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway. Oncogene 23:3883-3887, 2004
-
(2004)
Oncogene
, vol.23
, pp. 3883-3887
-
-
Makino, K.1
Day, C.P.2
Wang, S.C.3
-
15
-
-
0037118575
-
AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival
-
Bacus SS, Altomare DA, Lyass L, et al: AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival. Oncogene 21:3532-3540, 2002
-
(2002)
Oncogene
, vol.21
, pp. 3532-3540
-
-
Bacus, S.S.1
Altomare, D.A.2
Lyass, L.3
-
16
-
-
32944460139
-
Regulation of survivin by ErbB2 signaling: Therapeutic implications for ErbB2-overexpressing breast cancers
-
Xia W, Bisi J, Strum J, et al: Regulation of survivin by ErbB2 signaling: Therapeutic implications for ErbB2-overexpressing breast cancers. Cancer Res 66:1640-1647, 2006
-
(2006)
Cancer Res
, vol.66
, pp. 1640-1647
-
-
Xia, W.1
Bisi, J.2
Strum, J.3
-
17
-
-
0037099532
-
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
-
Yakes FM, Chinratanalab W, Ritter CA, et al: Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res 62:4132-4141, 2002
-
(2002)
Cancer Res
, vol.62
, pp. 4132-4141
-
-
Yakes, F.M.1
Chinratanalab, W.2
Ritter, C.A.3
-
18
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, et al: Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344:783-792, 2001
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
19
-
-
0025145020
-
The extracellular domain of HER2/neu is a potential immunogen for active specific immunotherapy of breast cancer
-
Fendly BM, Kotts C, Vetterlein D, et al: The extracellular domain of HER2/neu is a potential immunogen for active specific immunotherapy of breast cancer. J Biol Response Mod 9:449-455, 1990
-
(1990)
J Biol Response Mod
, vol.9
, pp. 449-455
-
-
Fendly, B.M.1
Kotts, C.2
Vetterlein, D.3
-
20
-
-
0027375130
-
Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies
-
Lewis GD, Figari I, Fendly B, et al: Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies. Cancer Immunol Immunother 37:255-263, 1993
-
(1993)
Cancer Immunol Immunother
, vol.37
, pp. 255-263
-
-
Lewis, G.D.1
Figari, I.2
Fendly, B.3
-
21
-
-
0026610881
-
Humanization of an anti-p185HER2 antibody for human cancer therapy
-
Carter P, Presta L, Gorman CM, et al: Humanization of an anti-p185HER2 antibody for human cancer therapy. Proc Natl Acad Sci U S A 89:4285-4289, 1992
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 4285-4289
-
-
Carter, P.1
Presta, L.2
Gorman, C.M.3
-
22
-
-
0033118889
-
Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers
-
Pegram M, Hsu S, Lewis G, et al: Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers. Oncogene 18:2241-2251, 1999
-
(1999)
Oncogene
, vol.18
, pp. 2241-2251
-
-
Pegram, M.1
Hsu, S.2
Lewis, G.3
-
23
-
-
2942659576
-
Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer
-
Pegram MD, Konecny GE, O'Callaghan C, et al: Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer. J Natl Cancer Inst 96:739-749, 2004
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 739-749
-
-
Pegram, M.D.1
Konecny, G.E.2
O'Callaghan, C.3
-
24
-
-
0028200221
-
Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells
-
Pietras RJ, Fendly BM, Chazin VR, et al: Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells. Oncogene 9:1829-1838, 1994
-
(1994)
Oncogene
, vol.9
, pp. 1829-1838
-
-
Pietras, R.J.1
Fendly, B.M.2
Chazin, V.R.3
-
25
-
-
0032578797
-
Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs
-
Pietras RJ, Pegram MD, Finn RS, et al: Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs. Oncogene 17:2235-2249, 1998
-
(1998)
Oncogene
, vol.17
, pp. 2235-2249
-
-
Pietras, R.J.1
Pegram, M.D.2
Finn, R.S.3
-
26
-
-
0025986825
-
A monoclonal antibody against the c-erbB-2 protein enhances the cytotoxicity of cis-diamminedichloroplatinum against human breast and ovarian tumor cell lines
-
Hancock MC, Langton BC, Chan T, et al: A monoclonal antibody against the c-erbB-2 protein enhances the cytotoxicity of cis-diamminedichloroplatinum against human breast and ovarian tumor cell lines. Cancer Res 51:4575-4580, 1991
-
(1991)
Cancer Res
, vol.51
, pp. 4575-4580
-
-
Hancock, M.C.1
Langton, B.C.2
Chan, T.3
-
27
-
-
0032127350
-
Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts
-
Baselga J, Norton L, Albanell J, et al: Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. Cancer Res 58:2825-2831, 1998
-
(1998)
Cancer Res
, vol.58
, pp. 2825-2831
-
-
Baselga, J.1
Norton, L.2
Albanell, J.3
-
28
-
-
0031903646
-
Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER-2/neu monoclonal antibody plus cisplatin in patients with HER-2/neu overexpressing metastatic breast cancer refractory to chemotherapy treatment
-
Pegram M, Lipton A, Hayes DF, et al: Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER-2/neu monoclonal antibody plus cisplatin in patients with HER-2/neu overexpressing metastatic breast cancer refractory to chemotherapy treatment. J Clin Oncol 16:2659-2671, 1998
-
(1998)
J Clin Oncol
, vol.16
, pp. 2659-2671
-
-
Pegram, M.1
Lipton, A.2
Hayes, D.F.3
-
29
-
-
0034473393
-
Trastuzumab and chemotherapeutics: Drug interactions and synergies
-
discussion 92-100
-
Pegram MD, Lopez A, Konecny G, et al: Trastuzumab and chemotherapeutics: Drug interactions and synergies. Semin Oncol 27:21-25, 2000 (suppl 11); discussion 92-100
-
(2000)
Semin Oncol
, vol.27
, Issue.SUPPL. 11
, pp. 21-25
-
-
Pegram, M.D.1
Lopez, A.2
Konecny, G.3
-
30
-
-
0036860304
-
In vitro comparative evaluation of trastuzumab (Herceptin) combined with paclitaxel (Taxol) or docetaxel (Taxotere) in HER2-expressing human breast cancer cell lines
-
Merlin JL, Barberi-Heyob M, Bachmann N: In vitro comparative evaluation of trastuzumab (Herceptin) combined with paclitaxel (Taxol) or docetaxel (Taxotere) in HER2-expressing human breast cancer cell lines. Ann Oncol 13:1743-1748, 2002
-
(2002)
Ann Oncol
, vol.13
, pp. 1743-1748
-
-
Merlin, J.L.1
Barberi-Heyob, M.2
Bachmann, N.3
-
31
-
-
1642406972
-
Synergistic interaction between tamoxifen and trastuzumab
-
Argiris A, Wang C-X, Whalen SG, et al: Synergistic interaction between tamoxifen and trastuzumab. Clin Cancer Res 10:1409-1420, 2004
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1409-1420
-
-
Argiris, A.1
Wang, C.-X.2
Whalen, S.G.3
-
32
-
-
33645218704
-
Engineered antibody Fc variants with enhanced effector function
-
Lazar GA, Dang W, Karki S, et al: Engineered antibody Fc variants with enhanced effector function. Proc Natl Acad Sci U S A 103:4005-4010, 2006
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 4005-4010
-
-
Lazar, G.A.1
Dang, W.2
Karki, S.3
-
33
-
-
0034076307
-
Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
-
Clynes RA, Towers TL, Presta LG, et al: Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 6:443-446, 2000
-
(2000)
Nat Med
, vol.6
, pp. 443-446
-
-
Clynes, R.A.1
Towers, T.L.2
Presta, L.G.3
-
34
-
-
0032885461
-
Natural killer cell cytotoxicity of breast cancer targets is enhanced by two distinct mechanisms of antibodydependent cellular cytotoxicity against LFA-3 and HER2/neu
-
Cooley S, Burns LJ, Repka T, et al: Natural killer cell cytotoxicity of breast cancer targets is enhanced by two distinct mechanisms of antibodydependent cellular cytotoxicity against LFA-3 and HER2/neu. Exp Hematol 27:1533-1541, 1999
-
(1999)
Exp Hematol
, vol.27
, pp. 1533-1541
-
-
Cooley, S.1
Burns, L.J.2
Repka, T.3
-
35
-
-
27244450053
-
Trastuzumab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinoma
-
Mimura M, Kono K, Hanawa M, et al: Trastuzumab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinoma. Clin Cancer Res 11:4898-4904, 2005
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4898-4904
-
-
Mimura, M.1
Kono, K.2
Hanawa, M.3
-
36
-
-
0037479973
-
Trastuzumab and interleukin-2 in HER2-positive metastatic breast cancer: A pilot study
-
Repka T, Chiorean EG, Gay J, et al: Trastuzumab and interleukin-2 in HER2-positive metastatic breast cancer: A pilot study. Clin Cancer Res 9:2440-2446, 2003
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2440-2446
-
-
Repka, T.1
Chiorean, E.G.2
Gay, J.3
-
37
-
-
31444451572
-
Trastuzumab-based treatment of HER2-positive breast cancer: An antibody-dependent cellular cytotoxicity mechanism?
-
Arnould L, Gelly M, Penault-Llorca F, et al: Trastuzumab-based treatment of HER2-positive breast cancer: An antibody-dependent cellular cytotoxicity mechanism? Br J Cancer 94:259-267, 2006
-
(2006)
Br J Cancer
, vol.94
, pp. 259-267
-
-
Arnould, L.1
Gelly, M.2
Penault-Llorca, F.3
-
38
-
-
33646826851
-
Administration of anti-HER2 antibody after nonmyeloablative allogeneic stem cell transplantation in metastatic breast cancer
-
Banna GL, Aversa SM, Crivellari G: Administration of anti-HER2 antibody after nonmyeloablative allogeneic stem cell transplantation in metastatic breast cancer. Br J Cancer 94:1550-1552, 2006
-
(2006)
Br J Cancer
, vol.94
, pp. 1550-1552
-
-
Banna, G.L.1
Aversa, S.M.2
Crivellari, G.3
-
39
-
-
4444372733
-
Pilot study of the mechanism of action of preoperative trastuzumab in patients with primary operable breast tumors overexpressing HER2
-
Gennari R, Menard S, Fagnoni F, et al: Pilot study of the mechanism of action of preoperative trastuzumab in patients with primary operable breast tumors overexpressing HER2. Clin Cancer Res 10:5650-5655, 2004
-
(2004)
Clin Cancer Res
, vol.10
, pp. 5650-5655
-
-
Gennari, R.1
Menard, S.2
Fagnoni, F.3
-
40
-
-
42949157368
-
Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer
-
Musolino A, Naldi N, Bortesi B, et al: Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer. J Clin Oncol 26:1789-1796, 2008
-
(2008)
J Clin Oncol
, vol.26
, pp. 1789-1796
-
-
Musolino, A.1
Naldi, N.2
Bortesi, B.3
-
41
-
-
42949108274
-
The "other" signaling of trastuzumab: Antibodies are immunocompetent drugs
-
Gianni L: The "other" signaling of trastuzumab: Antibodies are immunocompetent drugs. J Clin Oncol 26:1778-1780, 2008
-
(2008)
J Clin Oncol
, vol.26
, pp. 1778-1780
-
-
Gianni, L.1
-
42
-
-
3543086886
-
Monitoring the circulating levels of the HER2/neu oncoprotein in breast cancer
-
Carney WP, Neumann R, Lipton A, et al: Monitoring the circulating levels of the HER2/neu oncoprotein in breast cancer. Clin Breast Cancer 5:105-116, 2004
-
(2004)
Clin Breast Cancer
, vol.5
, pp. 105-116
-
-
Carney, W.P.1
Neumann, R.2
Lipton, A.3
-
43
-
-
14644401104
-
Serum HER2 extracellular domain in metastatic breast cancer patients treated with weekly trastuzumab and paclitaxel: Association with HER2 status by immunohistochemistry and fluorescence in situ hybridization and with response rate
-
Fornier MN, Seidman AD, Schwartz MK, et al: Serum HER2 extracellular domain in metastatic breast cancer patients treated with weekly trastuzumab and paclitaxel: Association with HER2 status by immunohistochemistry and fluorescence in situ hybridization and with response rate. Ann Oncol 16:234-239, 2005
-
(2005)
Ann Oncol
, vol.16
, pp. 234-239
-
-
Fornier, M.N.1
Seidman, A.D.2
Schwartz, M.K.3
-
44
-
-
3042552362
-
HER-2 gene amplification can be acquired as breast cancer progresses
-
Meng S, Tripathy D, Shete S, et al: HER-2 gene amplification can be acquired as breast cancer progresses. Proc Natl Acad Sci U S A 101:9393-9398, 2004
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 9393-9398
-
-
Meng, S.1
Tripathy, D.2
Shete, S.3
-
45
-
-
2442613063
-
Monitoring of serum Her-2/neu predicts histopathological response to neoadjuvant trastuzumab-based therapy for breast cancer
-
Köstler WJ, Steger GG, Soleiman A, et al: Monitoring of serum Her-2/neu predicts histopathological response to neoadjuvant trastuzumab-based therapy for breast cancer. Anticancer Res 24:1127-1130, 2004
-
(2004)
Anticancer Res
, vol.24
, pp. 1127-1130
-
-
Köstler, W.J.1
Steger, G.G.2
Soleiman, A.3
-
46
-
-
34247588567
-
Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
-
Scaltriti M, Rojo F, Ocana A, et al: Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst 99:628-638, 2007
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 628-638
-
-
Scaltriti, M.1
Rojo, F.2
Ocana, A.3
-
47
-
-
0035874981
-
Trastuzumab (Herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells
-
Molina MA, Codony-Servat J, Albanell J, et al: Trastuzumab (Herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells. Cancer Res 61:4744-4749, 2001
-
(2001)
Cancer Res
, vol.61
, pp. 4744-4749
-
-
Molina, M.A.1
Codony-Servat, J.2
Albanell, J.3
-
48
-
-
1242273590
-
Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016
-
Xia W, Liu L-H, Ho P, Spector NL: Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016. Oncogene 23:646-653, 2004
-
(2004)
Oncogene
, vol.23
, pp. 646-653
-
-
Xia, W.1
Liu, L.-H.2
Ho, P.3
Spector, N.L.4
-
49
-
-
33746290773
-
Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation
-
Anido J, Scaltriti M, Bech Serra JJ, et al: Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation. EMBO J 25:3234-3244, 2006
-
(2006)
EMBO J
, vol.25
, pp. 3234-3244
-
-
Anido, J.1
Scaltriti, M.2
Bech Serra, J.J.3
-
50
-
-
0037019186
-
Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells
-
Neve RM, Holbro T, Hynes NE: Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells. Oncogene 21:4567-4576, 2002
-
(2002)
Oncogene
, vol.21
, pp. 4567-4576
-
-
Neve, R.M.1
Holbro, T.2
Hynes, N.E.3
-
51
-
-
2542640227
-
Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients
-
Xia W, Chen JS, Zhou X, et al: Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients. Clin Cancer Res 10:3815-3824, 2004
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3815-3824
-
-
Xia, W.1
Chen, J.S.2
Zhou, X.3
-
52
-
-
0037068741
-
Anti-tumor activity of GW572016: A dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways
-
Xia W, Mullin RJ, Keith BR, et al: Anti-tumor activity of GW572016: A dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. Oncogene 21:6255-6263, 2002
-
(2002)
Oncogene
, vol.21
, pp. 6255-6263
-
-
Xia, W.1
Mullin, R.J.2
Keith, B.R.3
-
53
-
-
28244490602
-
Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells
-
Asanuma H, Torigoe T, Kamiguchi K, et al: Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells. Cancer Res 65:11018-11025, 2005
-
(2005)
Cancer Res
, vol.65
, pp. 11018-11025
-
-
Asanuma, H.1
Torigoe, T.2
Kamiguchi, K.3
-
54
-
-
12544250381
-
Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling
-
Le XF, Lammayot A, Gold D, et al: Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. J Biol Chem 280:2092-2104, 2005
-
(2005)
J Biol Chem
, vol.280
, pp. 2092-2104
-
-
XF, L.1
Lammayot, A.2
Gold, D.3
-
55
-
-
0035963274
-
Heregulin-dependent translocation and hyperphosphorylation of ErbB-2
-
Zhou W, Carpenter G: Heregulin-dependent translocation and hyperphosphorylation of ErbB-2. Oncogene 20:3918-3920, 2001
-
(2001)
Oncogene
, vol.20
, pp. 3918-3920
-
-
Zhou, W.1
Carpenter, G.2
-
56
-
-
0033588217
-
Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated transcriptionally dependent apoptosis
-
Sabbatini P, McCormick F: Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated transcriptionally dependent apoptosis. J Biol Chem 274:24263-24269, 1999
-
(1999)
J Biol Chem
, vol.274
, pp. 24263-24269
-
-
Sabbatini, P.1
McCormick, F.2
-
57
-
-
0038607569
-
The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition
-
Le XF, Claret FX, Lammayot A, et al: The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition. J Biol Chem 278:23441-23450, 2003
-
(2003)
J Biol Chem
, vol.278
, pp. 23441-23450
-
-
XF, L.1
Claret, F.X.2
Lammayot, A.3
-
58
-
-
22844439340
-
HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways
-
Le XF, Pruefer F, Bast RC Jr: HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways. Cell Cycle 4:87-95, 2005
-
(2005)
Cell Cycle
, vol.4
, pp. 87-95
-
-
XF, L.1
Pruefer, F.2
Bast Jr, R.C.3
-
59
-
-
0034873273
-
Modulation of p27/Cdk2 complex formation through 4D5-mediated inhibition of HER2 receptor signaling
-
suppl 12
-
Lane HA, Motoyama AB, Beuvink I, et al: Modulation of p27/Cdk2 complex formation through 4D5-mediated inhibition of HER2 receptor signaling. Ann Oncol 1:S21-S22, 2001 (suppl 12)
-
(2001)
Ann Oncol
, vol.1
-
-
Lane, H.A.1
Motoyama, A.B.2
Beuvink, I.3
-
60
-
-
0037149539
-
Tumor biology: Herceptin acts as an anti-angiogenic cocktail
-
Izumi Y, Xu L, di Tomasco E, et al: Tumor biology: Herceptin acts as an anti-angiogenic cocktail. Nature 416:279-280, 2002
-
(2002)
Nature
, vol.416
, pp. 279-280
-
-
Izumi, Y.1
Xu, L.2
di Tomasco, E.3
-
61
-
-
0033559619
-
Monoclonal antibody to HER-2/neu receptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of breast cancer cells overexpressing this oncogene
-
Pietras RJ, Poen JC, Gallardo D, et al: Monoclonal antibody to HER-2/neu receptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of breast cancer cells overexpressing this oncogene. Cancer Res 59:1347-1355, 1999
-
(1999)
Cancer Res
, vol.59
, pp. 1347-1355
-
-
Pietras, R.J.1
Poen, J.C.2
Gallardo, D.3
-
62
-
-
21644480047
-
Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells
-
Soderlund K, Perez-Tenorio G, Stal O: Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells. Int J Oncol 26:25-32, 2005
-
(2005)
Int J Oncol
, vol.26
, pp. 25-32
-
-
Soderlund, K.1
Perez-Tenorio, G.2
Stal, O.3
-
63
-
-
0034638917
-
Overexpression of ErbB2 in cancer and ErbB2-targeting strategies
-
Yu D, Hung MC: Overexpression of ErbB2 in cancer and ErbB2-targeting strategies. Oncogene 19:6115-6121, 2000
-
(2000)
Oncogene
, vol.19
, pp. 6115-6121
-
-
Yu, D.1
Hung, M.C.2
-
64
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
Vogel CL, Cobleigh MA, Tripathy D, et al: Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 20:719-726, 2002
-
(2002)
J Clin Oncol
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
-
65
-
-
0032850677
-
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
-
Cobleigh MA, Vogel CL, Tripathy D, et al: Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 17:2639-2648, 1999
-
(1999)
J Clin Oncol
, vol.17
, pp. 2639-2648
-
-
Cobleigh, M.A.1
Vogel, C.L.2
Tripathy, D.3
-
66
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy operable HER2-positive breast cancer
-
Romond EH, Perez EA, Bryant J, et al: Trastuzumab plus adjuvant chemotherapy operable HER2-positive breast cancer. N Engl J Med 353:1673-1684, 2005
-
(2005)
N Engl J Med
, vol.353
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
-
67
-
-
36148961294
-
Updated results of the combined analysis of NCCTG N9831 and NSABP B-31 adjuvant chemotherapy with/without trastuzumab in patients with HER2-positive breast cancer
-
suppl 18; abstr 512, 6s
-
Perez EA, Romond EH, Suman V, et al: Updated results of the combined analysis of NCCTG N9831 and NSABP B-31 adjuvant chemotherapy with/without trastuzumab in patients with HER2-positive breast cancer. J Clin Oncol 25:6s, 2007 (suppl 18; abstr 512)
-
(2007)
J Clin Oncol
, vol.25
-
-
Perez, E.A.1
Romond, E.H.2
Suman, V.3
-
68
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al: Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 353:1659-1672, 2005
-
(2005)
N Engl J Med
, vol.353
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland-Jones, B.3
-
69
-
-
33845914783
-
2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: A randomised controlled trial
-
Smith I, Proter M, Gelber RD, et al: 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: A randomised controlled trial. Lancet 369:29-36, 2007
-
(2007)
Lancet
, vol.369
, pp. 29-36
-
-
Smith, I.1
Proter, M.2
Gelber, R.D.3
-
70
-
-
43449132159
-
Phase III trial comparing AC-T with AC-TH and with TCH in the adjuvant treatment of HER2-positive early breast cancer patients: Second interim efficacy analysis
-
abstr 52
-
Slamon DJ, Eiermann W, Robert N, et al: Phase III trial comparing AC-T with AC-TH and with TCH in the adjuvant treatment of HER2-positive early breast cancer patients: Second interim efficacy analysis. Breast Cancer Res Treat 100, 2006 (suppl 63; abstr 52)
-
(2006)
Breast Cancer Res Treat
, vol.100
, Issue.SUPPL. 63
-
-
Slamon, D.J.1
Eiermann, W.2
Robert, N.3
-
71
-
-
70249150812
-
Update of the FINHER trial based on 5 years of followup
-
suppl 1; abstr S24
-
Joensuu H, Bono P, Kataja V, et al: Update of the FINHER trial based on 5 years of followup. Breast 18:S10, 2009 (suppl 1; abstr S24)
-
(2009)
Breast
, vol.18
-
-
Joensuu, H.1
Bono, P.2
Kataja, V.3
-
72
-
-
33847147313
-
American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
-
Wolff AC, Hammond ME, Schwartz JN, et al: American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol 25:118-145, 2007
-
(2007)
J Clin Oncol
, vol.25
, pp. 118-145
-
-
Wolff, A.C.1
Hammond, M.E.2
Schwartz, J.N.3
-
73
-
-
40449087743
-
HER2+ breast cancer: Review of biologic relevance and optimal use of diagnostic tools
-
Hicks DG, Kulkarni S: HER2+ breast cancer: Review of biologic relevance and optimal use of diagnostic tools. Am J Clin Pathol 129:263-273, 2008
-
(2008)
Am J Clin Pathol
, vol.129
, pp. 263-273
-
-
Hicks, D.G.1
Kulkarni, S.2
-
74
-
-
41449105551
-
HER2 status and benefit from adjuvant trastuzumab in breast cancer
-
Paik S: HER2 status and benefit from adjuvant trastuzumab in breast cancer. N Engl J Med 358:1409-1411, 2008
-
(2008)
N Engl J Med
, vol.358
, pp. 1409-1411
-
-
Paik, S.1
-
75
-
-
39549093225
-
CALGB 150002: Correlation of HER2 and chromosome 17 (ch17) copy number with trastuzumab (T) efficacy in CALGB 9840, paclitaxel (P) with or without T in HER2 and HER2- metastatic breast cancer (MBC)
-
suppl 18; abstr 1009, 34s
-
Kaufman PA, Broadwater G, Lezon-Geyda K: CALGB 150002: correlation of HER2 and chromosome 17 (ch17) copy number with trastuzumab (T) efficacy in CALGB 9840, paclitaxel (P) with or without T in HER2 and HER2- metastatic breast cancer (MBC). J Clin Oncol 25:34s, 2007 (suppl 18; abstr 1009)
-
(2007)
J Clin Oncol
, vol.25
-
-
Kaufman, P.A.1
Broadwater, G.2
Lezon-Geyda, K.3
-
76
-
-
33745435244
-
Trastuzumab sensitivity of breast cancer with co-amplification of HER2 and cMYC suggests pro-apoptotic function of dysregulated cMYC in vivo
-
suppl 1, abstr 46
-
Kim C, Bryant J, Horne Z, et al: Trastuzumab sensitivity of breast cancer with co-amplification of HER2 and cMYC suggests pro-apoptotic function of dysregulated cMYC in vivo. Breast Cancer Res Treat 94:S6, 2005 (suppl 1, abstr 46)
-
(2005)
Breast Cancer Res Treat
, vol.94
-
-
Kim, C.1
Bryant, J.2
Horne, Z.3
-
77
-
-
77949533806
-
C-MYC amplification and correlation with patient outcome in early stage HER2+ breast cancer from the NCCTG adjuvant intergroup trial N9831
-
suppl; abstr 56, 76s
-
Perez EA, Reinholz MM, Dueck AC, et al: C-MYC amplification and correlation with patient outcome in early stage HER2+ breast cancer from the NCCTG adjuvant intergroup trial N9831. Cancer Res 69:76s, 2009 (suppl; abstr 56)
-
(2009)
Cancer Res
, vol.69
-
-
Perez, E.A.1
Reinholz, M.M.2
Dueck, A.C.3
-
78
-
-
33747377549
-
Trastuzumab in combination with heregulin-activated Her-2 (erbB-2) triggers a receptor-enhanced chemosensitivity effect in the absence of Her-2 overexpression
-
Menendez JA, Mehmi I, Lupu R: Trastuzumab in combination with heregulin-activated Her-2 (erbB-2) triggers a receptor-enhanced chemosensitivity effect in the absence of Her-2 overexpression. J Clin Oncol 24:3735-3746, 2006
-
(2006)
J Clin Oncol
, vol.24
, pp. 3735-3746
-
-
Menendez, J.A.1
Mehmi, I.2
Lupu, R.3
-
79
-
-
77949532395
-
The use of proximity ligation assay to identify HER2: HER3 heterodimers in early breast cancers
-
suppl; abstr 2068, 176s
-
Spears M, Munro AF, Taylor KJ, et al: The use of proximity ligation assay to identify HER2: HER3 heterodimers in early breast cancers. Cancer Res 69:176s, 2009 (suppl; abstr 2068)
-
(2009)
Cancer Res
, vol.69
-
-
Spears, M.1
Munro, A.F.2
Taylor, K.J.3
-
80
-
-
84871473355
-
Proximity-based assays for the detection of activated HER3, HER2/HER3 heterodimers and HER3/PI3K complexes in formalin-fixed, paraffin-embedded cell line controls and tumors
-
suppl; abstr 4040, 269s
-
Mukherjee A, Badal Y, Nguyen X-T, et al: Proximity-based assays for the detection of activated HER3, HER2/HER3 heterodimers and HER3/PI3K complexes in formalin-fixed, paraffin-embedded cell line controls and tumors. Cancer Res 69:269s, 2009 (suppl; abstr 4040)
-
(2009)
Cancer Res
, vol.69
-
-
Mukherjee, A.1
Badal, Y.2
Nguyen, X.-T.3
-
81
-
-
33751344602
-
HER2 therapy: Molecular mechanisms of trastuzumab resistance
-
Nahta R, Esteva FJ: HER2 therapy: Molecular mechanisms of trastuzumab resistance. Breast Cancer Res 8:215, 2006
-
(2006)
Breast Cancer Res
, vol.8
, pp. 215
-
-
Nahta, R.1
Esteva, F.J.2
-
82
-
-
33646712747
-
Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
-
Nahta R, Yu D, Hung MC, et al: Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Prac Oncol 3:269-280, 2006
-
(2006)
Nat Clin Prac Oncol
, vol.3
, pp. 269-280
-
-
Nahta, R.1
Yu, D.2
Hung, M.C.3
-
83
-
-
0036606779
-
The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides
-
Motoyama AB, Hynes NE, Lane HA: The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides. Cancer Res 62:3151-3158, 2002
-
(2002)
Cancer Res
, vol.62
, pp. 3151-3158
-
-
Motoyama, A.B.1
Hynes, N.E.2
Lane, H.A.3
-
84
-
-
28244432561
-
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
-
Nahta R, Yuan LX, Zhang B, et al: Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res 65:11118-11128, 2005
-
(2005)
Cancer Res
, vol.65
, pp. 11118-11128
-
-
Nahta, R.1
Yuan, L.X.2
Zhang, B.3
-
85
-
-
2542526069
-
P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells
-
Nahta R, Takahashi T, Ueno NT, et al: P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells. Cancer Res 64:3981-3986, 2004
-
(2004)
Cancer Res
, vol.64
, pp. 3981-3986
-
-
Nahta, R.1
Takahashi, T.2
Ueno, N.T.3
-
86
-
-
0346154748
-
Molecular mechanisms underlying IGF-I-induced attenuation of the growthinhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells
-
Lu Y, Zi X, Pollak M: Molecular mechanisms underlying IGF-I-induced attenuation of the growthinhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells. Int J Cancer 108:334-341, 2004
-
(2004)
Int J Cancer
, vol.108
, pp. 334-341
-
-
Lu, Y.1
Zi, X.2
Pollak, M.3
-
87
-
-
35148885729
-
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
-
Berns K, Horlings HM, Hennessy BT, et al: A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 12:395-402, 2007
-
(2007)
Cancer Cell
, vol.12
, pp. 395-402
-
-
Berns, K.1
Horlings, H.M.2
Hennessy, B.T.3
-
88
-
-
31444444131
-
PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer
-
Fujita T, Doihara H, Kawasaki K, et al: PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer. Br J Cancer 94:247-252, 2006
-
(2006)
Br J Cancer
, vol.94
, pp. 247-252
-
-
Fujita, T.1
Doihara, H.2
Kawasaki, K.3
-
89
-
-
33748159249
-
Proteasome inhibitor bortezomib increases PTEN expression and enhances trastuzumab-induced growth inhibition in trastuzumab-resistant cells
-
Fujita T, Doihara H, Washio K, et al: Proteasome inhibitor bortezomib increases PTEN expression and enhances trastuzumab-induced growth inhibition in trastuzumab-resistant cells. Anticancer Drugs 17:455-462, 2006
-
(2006)
Anticancer Drugs
, vol.17
, pp. 455-462
-
-
Fujita, T.1
Doihara, H.2
Washio, K.3
-
90
-
-
35348917266
-
Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency
-
Lu CH, Wyszomierski SL, Tseng LM, et al: Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency. Clin Cancer Res 13:5883-5888, 2007
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5883-5888
-
-
Lu, C.H.1
Wyszomierski, S.L.2
Tseng, L.M.3
-
91
-
-
5144226211
-
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
-
Nagata Y, Lan KH, Zhou X, et al: PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 6:117-127, 2004
-
(2004)
Cancer Cell
, vol.6
, pp. 117-127
-
-
Nagata, Y.1
Lan, K.H.2
Zhou, X.3
-
92
-
-
12544250996
-
Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line
-
Nagy P, Friedlander E, Tanner M, et al: Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line. Cancer Res 65:473-482, 2005
-
(2005)
Cancer Res
, vol.65
, pp. 473-482
-
-
Nagy, P.1
Friedlander, E.2
Tanner, M.3
-
93
-
-
77949501776
-
Mutations of HER2 gene in HER2-positive metastatic breast cancer
-
suppl 18; abstr 13118, 611s
-
Prempree C, Wongpaksa T: Mutations of HER2 gene in HER2-positive metastatic breast cancer. J Clin Oncol 24:611s, 2006 (suppl 18; abstr 13118)
-
(2006)
J Clin Oncol
, vol.24
-
-
Prempree, C.1
Wongpaksa, T.2
-
94
-
-
54049149104
-
Capecitabine vs. capecitabine + trastuzumab in patients with HER2-positive metastatic breast cancer progressing during trastuzumab treatment: The TBP phase III study (GBG 26/BIG 3-05)
-
suppl 15; abstr 1025, 47s
-
von Minckwitz G, Zielinski C, Maarteense E, et al: Capecitabine vs. capecitabine + trastuzumab in patients with HER2-positive metastatic breast cancer progressing during trastuzumab treatment: The TBP phase III study (GBG 26/BIG 3-05). J Clin Oncol 26:47s, 2008 (suppl 15; abstr 1025)
-
(2008)
J Clin Oncol
, vol.26
-
-
von Minckwitz, G.1
Zielinski, C.2
Maarteense, E.3
-
95
-
-
54249153119
-
A randomized study of lapatinib alone or in combination with trastuzumab in heavily pretreated HER2-positive metastatic breast cancer progressing on trastuzumab therapy
-
suppl 15; abstr 1015, 44s
-
O'Shaughnessy JA, Blackwell KL, Burstein H, et al: A randomized study of lapatinib alone or in combination with trastuzumab in heavily pretreated HER2-positive metastatic breast cancer progressing on trastuzumab therapy. J Clin Oncol 26:44s, 2008 (suppl 15; abstr 1015)
-
(2008)
J Clin Oncol
, vol.26
-
-
O'Shaughnessy, J.A.1
Blackwell, K.L.2
Burstein, H.3
-
96
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
Geyer CE, Forster J, Lindquist D, et al: Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 355:2733-2743, 2006
-
(2006)
N Engl J Med
, vol.355
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
-
97
-
-
1842605531
-
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
-
Franklin MC, Carey KD, Vajdos FF, et al: Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell 5:317-328, 2004
-
(2004)
Cancer Cell
, vol.5
, pp. 317-328
-
-
Franklin, M.C.1
Carey, K.D.2
Vajdos, F.F.3
-
98
-
-
19044380618
-
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
-
Agus DB, Akita RW, Fox WD, et al: Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell 2:127-137, 2002
-
(2002)
Cancer Cell
, vol.2
, pp. 127-137
-
-
Agus, D.B.1
Akita, R.W.2
Fox, W.D.3
-
99
-
-
40649118149
-
A report of cardiac events in a phase II clinical study using trastuzumab combined with pertuzumab in HER2-positive metastatic breast cancer (MBC)
-
suppl 18; abstr 1028, 39s
-
Portera CC, Walshe JM, Denduluri N, et al: A report of cardiac events in a phase II clinical study using trastuzumab combined with pertuzumab in HER2-positive metastatic breast cancer (MBC). J Clin Oncol 25:39s, 2007 (suppl 18; abstr 1028)
-
(2007)
J Clin Oncol
, vol.25
-
-
Portera, C.C.1
Walshe, J.M.2
Denduluri, N.3
-
100
-
-
36248938567
-
Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab (T) in patients (pts) with HER2-positive metastatic breast cancer (MBC) which has progressed during treatment with T
-
suppl 18; abstr 1004, 33s
-
Baselga J, Cameron D, Miles D, et al: Objective response rate in a phase II multicenter trial of pertuzumab (P), a HER2 dimerization inhibiting monoclonal antibody, in combination with trastuzumab (T) in patients (pts) with HER2-positive metastatic breast cancer (MBC) which has progressed during treatment with T. J Clin Oncol 25:33s, 2007 (suppl 18; abstr 1004)
-
(2007)
J Clin Oncol
, vol.25
-
-
Baselga, J.1
Cameron, D.2
Miles, D.3
-
101
-
-
30544450275
-
Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells
-
Xia W, Gerard CM, Liu L, et al: Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene 24:6213-6221, 2005
-
(2005)
Oncogene
, vol.24
, pp. 6213-6221
-
-
Xia, W.1
Gerard, C.M.2
Liu, L.3
-
102
-
-
49149084837
-
Phase I dose escalation and pharmacokinetic study of lapatinib in combination with trastuzumab in patients with advanced ErbB2-positive breast cancer
-
Storniolo AM, Pegram MD, Overmoyer B, et al: Phase I dose escalation and pharmacokinetic study of lapatinib in combination with trastuzumab in patients with advanced ErbB2-positive breast cancer. J Clin Oncol 26:3317-3323, 2008
-
(2008)
J Clin Oncol
, vol.26
, pp. 3317-3323
-
-
Storniolo, A.M.1
Pegram, M.D.2
Overmoyer, B.3
-
103
-
-
59149105382
-
Preliminary safety results of dose-dense (dd) doxorubicin and cyclophosphamide (AC) followed by weekly paclitaxel (P) with trastuzumab (T) and lapatinib (L) in HER2 overexpressed/amplified breast cancer (BCA)
-
suppl 15, 11s
-
Dang CT, Lin NU, Lake D, et al: Preliminary safety results of dose-dense (dd) doxorubicin and cyclophosphamide (AC) followed by weekly paclitaxel (P) with trastuzumab (T) and lapatinib (L) in HER2 overexpressed/amplified breast cancer (BCA). J Clin Oncol 26:11s, 2008 (suppl 15)
-
(2008)
J Clin Oncol
, vol.26
-
-
Dang, C.T.1
Lin, N.U.2
Lake, D.3
-
104
-
-
67049161327
-
Neratinib (HKI-272), an irreversible pan erbB receptor tyrosine kinase inhibitor: Phase 2 results in patients with advanced HER2+ breast cancer
-
suppl; abstr 37, 76s
-
Burstein HJ, Sun Y, Tan AR, et al: Neratinib (HKI-272), an irreversible pan erbB receptor tyrosine kinase inhibitor: Phase 2 results in patients with advanced HER2+ breast cancer. Cancer Res 69:76s, 2009 (suppl; abstr 37)
-
(2009)
Cancer Res
, vol.69
-
-
Burstein, H.J.1
Sun, Y.2
Tan, A.R.3
-
105
-
-
34247243265
-
Phase II combined biological therapy targeting the HER2 proto-oncogene and the vascular endothelial growth factor using trastuzumab (T) and bevacizumab (B) as first line treatment of HER2-amplified breast cancer
-
suppl 1; abstr 301
-
Pegram M, Chan D, Dichmann RA, et al: Phase II combined biological therapy targeting the HER2 proto-oncogene and the vascular endothelial growth factor using trastuzumab (T) and bevacizumab (B) as first line treatment of HER2-amplified breast cancer. Breast Cancer Res Treat 100:S28, 2006 (suppl 1; abstr 301)
-
(2006)
Breast Cancer Res Treat
, vol.100
-
-
Pegram, M.1
Chan, D.2
Dichmann, R.A.3
-
106
-
-
0035793546
-
Sensitivity of mature ErbB2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90
-
Xu W, Mimnaugh E, Rosser MFN, et al: Sensitivity of mature ErbB2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. J Biol Chem 276:3702-3708, 2001
-
(2001)
J Biol Chem
, vol.276
, pp. 3702-3708
-
-
Xu, W.1
Mimnaugh, E.2
Rosser, M.F.N.3
-
107
-
-
84871471319
-
Phase II trial of trastuzumab and KOS-953 (tanespimycin) in patients with HER2-positive breast cancer: Preliminary results
-
suppl 1; abstr 1102
-
Modi S, Stopeck A, Linden HM, et al: Phase II trial of trastuzumab and KOS-953 (tanespimycin) in patients with HER2-positive breast cancer: Preliminary results. Breast Cancer Res Treat 100:S72, 2006 (suppl 1; abstr 1102)
-
(2006)
Breast Cancer Res Treat
, vol.100
-
-
Modi, S.1
Stopeck, A.2
Linden, H.M.3
-
108
-
-
0034794636
-
Overexpression of HER-2 as a resistance mechanism to hormonal therapy for breast cancer
-
Dowsett M: Overexpression of HER-2 as a resistance mechanism to hormonal therapy for breast cancer. Endocr Relat Cancer 8:191-195, 2001
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 191-195
-
-
Dowsett, M.1
-
109
-
-
0036835014
-
Restoration of estrogen responsiveness by blocking the HER-2/neupathway
-
Witters L, Engle L, Lipton A: Restoration of estrogen responsiveness by blocking the HER-2/neupathway. Oncol Rep 9:1163-1166, 2002
-
(2002)
Oncol Rep
, vol.9
, pp. 1163-1166
-
-
Witters, L.1
Engle, L.2
Lipton, A.3
-
110
-
-
35549002408
-
Trastuzumab plus anastrozole in postmenopausal women with HER2-positive, HR-positive MBC: Results of the TAnDEM study
-
abstr LBA2, http://annonc.oxfordjournals. org/cgi/reprint/suppl-9/NP
-
Kaufman B, Mackey J, Clemens M, et al: Trastuzumab plus anastrozole in postmenopausal women with HER2-positive, HR-positive MBC: Results of the TAnDEM study. Ann Oncol 17, 2006 (suppl 9; abstr LBA2), http://annonc.oxfordjournals. org/cgi/reprint/suppl-9/NP
-
(2006)
Ann Oncol
, vol.17
, Issue.SUPPL. 9
-
-
Kaufman, B.1
Mackey, J.2
Clemens, M.3
-
111
-
-
34249011160
-
Trastuzumab prolongs progression-free survival in hormone-dependent and HER2-positive metastatic breast cancer
-
suppl 1; abstr 3
-
Mackey JR, Kaufman B, Clemens M, et al: Trastuzumab prolongs progression-free survival in hormone-dependent and HER2-positive metastatic breast cancer. Breast Cancer Res Treat 100:S5, 2006 (suppl 1; abstr 3)
-
(2006)
Breast Cancer Res Treat
, vol.100
-
-
Mackey, J.R.1
Kaufman, B.2
Clemens, M.3
-
112
-
-
70349685919
-
Lapatinib combined with letrozole vs. letrozole alone for front line postmenopausal hormone receptor positive (HR+) metastatic breast cancer (MBC): First results from the EGF30008 Trial
-
suppl; abstr 46, 74s
-
Johnston S, Pegram M, Press M, et al: Lapatinib combined with letrozole vs. letrozole alone for front line postmenopausal hormone receptor positive (HR+) metastatic breast cancer (MBC): First results from the EGF30008 Trial. Cancer Res 69:74s, 2009 (suppl; abstr 46)
-
(2009)
Cancer Res
, vol.69
-
-
Johnston, S.1
Pegram, M.2
Press, M.3
-
113
-
-
65349194552
-
A phase I study of trastuzumab-DM1 (T-DM1), a firstin-class HER2 antibody-drug conjugate (ADC) in patients with advanced HER2+ breast cancer
-
suppl 15; abstr 1028, 48s
-
Beeram M, Burris HA III, Modi S, et al: A phase I study of trastuzumab-DM1 (T-DM1), a firstin-class HER2 antibody-drug conjugate (ADC) in patients with advanced HER2+ breast cancer. J Clin Oncol 26:48s, 2008 (suppl 15; abstr 1028)
-
(2008)
J Clin Oncol
, vol.26
-
-
Beeram, M.1
Burris III, H.A.2
Modi, S.3
-
114
-
-
73349117986
-
A phase II study of trastuzumab-DM1, a first-in-class HER2 antibody-drug conjugate, in patients with HER2+ metastatic breast cancer
-
suppl; abstr 33, 71s
-
Vukelja S, Rugo H, Vogel C, et al: A phase II study of trastuzumab-DM1, a first-in-class HER2 antibody-drug conjugate, in patients with HER2+ metastatic breast cancer. Cancer Res 69:71s, 2009 (suppl; abstr 33)
-
(2009)
Cancer Res
, vol.69
-
-
Vukelja, S.1
Rugo, H.2
Vogel, C.3
|