메뉴 건너뛰기




Volumn 17, Issue 6, 1999, Pages 1760-1770

Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil- based chemotherapy

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID; METHOTREXATE; THYMIDYLATE SYNTHASE;

EID: 0032997572     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/jco.1999.17.6.1760     Document Type: Article
Times cited : (203)

References (53)
  • 1
    • 0030966645 scopus 로고    scopus 로고
    • Colorectal cancer: Is there an alternative to 5-FU?
    • Bleiberg H: Colorectal cancer: Is there an alternative to 5-FU? Eur J Cancer 33:536-541, 1997
    • (1997) Eur J Cancer , vol.33 , pp. 536-541
    • Bleiberg, H.1
  • 2
    • 0026721532 scopus 로고
    • Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate
    • Advanced Colorectal Cancer Meta-Analysis Project: Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate. J Clin Oncol 10:896-903, 1992
    • (1992) J Clin Oncol , vol.10 , pp. 896-903
  • 3
    • 0024539308 scopus 로고
    • A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid-Atlantic Oncology Program study
    • Lokich JJ, Ahlgren JD, Gullo JJ, et al: A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid-Atlantic Oncology Program study. J Clin Oncol 7:425-432, 1989
    • (1989) J Clin Oncol , vol.7 , pp. 425-432
    • Lokich, J.J.1    Ahlgren, J.D.2    Gullo, J.J.3
  • 4
    • 0031014682 scopus 로고    scopus 로고
    • Thymidylate synthase inhibitors in cancer therapy: Direct and indirect inhibitors
    • Rustum YM, Harstrick A, Cao S, et al: Thymidylate synthase inhibitors in cancer therapy: Direct and indirect inhibitors. J Clin Oncol 15:389-400, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 389-400
    • Rustum, Y.M.1    Harstrick, A.2    Cao, S.3
  • 5
    • 9044245305 scopus 로고    scopus 로고
    • ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer - Tomudex Colorectal Study Group
    • Zalcberg JR, Cunningham D, Van Cutsem E, et al: ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer - Tomudex Colorectal Study Group. J Clin Oncol 14:716-721, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 716-721
    • Zalcberg, J.R.1    Cunningham, D.2    Van Cutsem, E.3
  • 6
    • 0028099423 scopus 로고
    • Phase II trial of uracil and tegafur plus oral leucovorin: An effective oral regimen of metastatic colorectal carcinoma
    • Pazdur R, Lasseve Y, Rhodes V, et al: Phase II trial of uracil and tegafur plus oral leucovorin: An effective oral regimen of metastatic colorectal carcinoma. J Clin Oncol 12:2288-2295, 1994
    • (1994) J Clin Oncol , vol.12 , pp. 2288-2295
    • Pazdur, R.1    Lasseve, Y.2    Rhodes, V.3
  • 7
    • 0010267929 scopus 로고    scopus 로고
    • New oral anticancer agent: S1
    • abstr
    • Taguchi T, Shirasaka T: New oral anticancer agent: S1. Ann Oncol 7:66, 1996 (abstr) (suppl 7)
    • (1996) Ann Oncol , vol.7 , Issue.7 SUPPL. , pp. 66
    • Taguchi, T.1    Shirasaka, T.2
  • 8
    • 0000344523 scopus 로고    scopus 로고
    • A randomised phase II study of Xeloda™ (capecitabine) in patients with advanced colorectal cancer
    • abstr 798
    • Findlay M, Van Cutsem E, Kocha W, et al: A randomised phase II study of Xeloda™ (capecitabine) in patients with advanced colorectal cancer. Proc Am Soc Clin Oncol 16:227a, 1997 (abstr 798)
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Findlay, M.1    Van Cutsem, E.2    Kocha, W.3
  • 9
    • 0000798693 scopus 로고    scopus 로고
    • Phase II/pharmacology study of UFT (BMS-200604) and leucovorin in refractory colorectal cancer patients
    • abstr 959
    • Pazdur R, Patt Y, Ajani J, et al: Phase II/pharmacology study of UFT (BMS-200604) and leucovorin in refractory colorectal cancer patients. Proc Am Soc Clin 16:270a, 1997 (abstr 959)
    • (1997) Proc Am Soc Clin , vol.16
    • Pazdur, R.1    Patt, Y.2    Ajani, J.3
  • 10
    • 0027408915 scopus 로고
    • Prolonged continuous infusion of fluorouracil with weekly bolus leucovorin: A phase II study in patients with disseminated colorectal cancer
    • Leichman CG, Leichman L, Spears CP, et al: Prolonged continuous infusion of fluorouracil with weekly bolus leucovorin: A phase II study in patients with disseminated colorectal cancer. J Natl Cancer Inst 85:41-44, 1993
    • (1993) J Natl Cancer Inst , vol.85 , pp. 41-44
    • Leichman, C.G.1    Leichman, L.2    Spears, C.P.3
  • 11
    • 0031019918 scopus 로고    scopus 로고
    • Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: A French Intergroup study
    • de Gramont A, Bosset JF, Milan C, et al: Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: A French Intergroup study. J Clin Oncol 15:808-815, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 808-815
    • De Gramont, A.1    Bosset, J.F.2    Milan, C.3
  • 12
    • 9444270969 scopus 로고    scopus 로고
    • Modulation of high dose infusional fluorouracil by low dose methotrexate in patients with advanced or metastatic colorectal cancer: Final results of a randomized European Organization for Research and Treatment of Cancer Study
    • Blijham G, Wagener T, Wils J, et al: Modulation of high dose infusional fluorouracil by low dose methotrexate in patients with advanced or metastatic colorectal cancer: Final results of a randomized European Organization for Research and Treatment of Cancer Study. J Clin Oncol 14:2266-2273, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 2266-2273
    • Blijham, G.1    Wagener, T.2    Wils, J.3
  • 13
    • 0030154340 scopus 로고    scopus 로고
    • High-dose infusional 5-FU in the treatment of advanced colorectal cancer: A summary of the European experience
    • Wils JA: High-dose infusional 5-FU in the treatment of advanced colorectal cancer: A summary of the European experience. J Infus Chemother 6:145-148, 1996
    • (1996) J Infus Chemother , vol.6 , pp. 145-148
    • Wils, J.A.1
  • 14
    • 0000269364 scopus 로고    scopus 로고
    • Raltitrexed (Tomudex) versus 5-fluorouracil and leucovorin (5-FU + LV) in patients with advanced colorectal cancer (ACC): Results of a randomized, multicenter, North American trial
    • abstr 801
    • Pazdur R, Vincent M, for the Tomudex Colorectal Cancer Study Group: Raltitrexed (Tomudex) versus 5-fluorouracil and leucovorin (5-FU + LV) in patients with advanced colorectal cancer (ACC): Results of a randomized, multicenter, North American trial. Proc Am Soc Clin Oncol 16:228a, 1997 (abstr 801)
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Pazdur, R.1    Vincent, M.2
  • 15
    • 0010695948 scopus 로고    scopus 로고
    • Final results and final data of a large randomised trial of 'Tomudex' in advanced colorectal cancer (ACC) confirm comparable efficacy to fluorouracil plus leucovorin (5FU + LV)
    • abstr 446
    • Seitz JF, Cunningham D, Rath U, et al from the 'Tomudex' Study Group and Zeneca Pharmaceuticals: Final results and final data of a large randomised trial of 'Tomudex' in advanced colorectal cancer (ACC) confirm comparable efficacy to fluorouracil plus leucovorin (5FU + LV). Proc Am Soc Clin Oncol 15:201a, 1996 (abstr 446)
    • (1996) Proc Am Soc Clin Oncol , vol.15
    • Seitz, J.F.1    Cunningham, D.2    Rath, U.3
  • 16
    • 0029919598 scopus 로고    scopus 로고
    • Irinotecan is an active agent in untreated patients with metastatic colorectal cancer
    • Conti JA, Kemeny NE, Saltz LB, et al: Irinotecan is an active agent in untreated patients with metastatic colorectal cancer. J Clin Oncol 14:709-715, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 709-715
    • Conti, J.A.1    Kemeny, N.E.2    Saltz, L.B.3
  • 17
    • 0029966672 scopus 로고    scopus 로고
    • Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer
    • Rothemberg ML, Eckardt JR, Kuhn JG, et al: Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer. J Clin Oncol 14:1128-1135, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 1128-1135
    • Rothemberg, M.L.1    Eckardt, J.R.2    Kuhn, J.G.3
  • 18
    • 0031014627 scopus 로고    scopus 로고
    • Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy
    • Rougier P, Bugat R, Douillard JY. et al: Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy. J Clin Oncol 15:251-260, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 251-260
    • Rougier, P.1    Bugat, R.2    Douillard, J.Y.3
  • 19
    • 0012797224 scopus 로고    scopus 로고
    • Two consecutive phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines
    • Machover D, Diaz-Rubio E, de Gramont A, et al: Two consecutive phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines. Ann Oncol 7:95-98, 1996
    • (1996) Ann Oncol , vol.7 , pp. 95-98
    • Machover, D.1    Diaz-Rubio, E.2    De Gramont, A.3
  • 20
    • 0030888321 scopus 로고    scopus 로고
    • Oxaliplatin with high-dose leucovorin and 5-fluorouracil 48-hour continuous infusion in pretreated metastatic colorectal cancer
    • de Gramont A, Vignoud J, Tournigand C, et al: Oxaliplatin with high-dose leucovorin and 5-fluorouracil 48-hour continuous infusion in pretreated metastatic colorectal cancer. Eur J Cancer 33:214-219, 1997
    • (1997) Eur J Cancer , vol.33 , pp. 214-219
    • De Gramont, A.1    Vignoud, J.2    Tournigand, C.3
  • 21
    • 0345658354 scopus 로고
    • Increased levels of thymidylate synthase in cells exposed to 5-fluorouracil
    • Washtein WL: Increased levels of thymidylate synthase in cells exposed to 5-fluorouracil. Mol Pharmacol 28:461-467, 1987
    • (1987) Mol Pharmacol , vol.28 , pp. 461-467
    • Washtein, W.L.1
  • 22
    • 0022344622 scopus 로고
    • Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells
    • Berger SH, Jenh CH, Johnson LF, et al: Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells. Mol Pharmacol 28:461-467, 1985
    • (1985) Mol Pharmacol , vol.28 , pp. 461-467
    • Berger, S.H.1    Jenh, C.H.2    Johnson, L.F.3
  • 23
    • 0026030052 scopus 로고
    • Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines
    • Chu E, Drake JC, Koeller DM, et al: Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines. Mol Pharmacol 39:136-143, 1991
    • (1991) Mol Pharmacol , vol.39 , pp. 136-143
    • Chu, E.1    Drake, J.C.2    Koeller, D.M.3
  • 24
    • 0023111335 scopus 로고
    • Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy
    • Clark JL, Berger SH, Mittelman A, et al: Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy. Cancer Treat Rep 71:261-265, 1987
    • (1987) Cancer Treat Rep , vol.71 , pp. 261-265
    • Clark, J.L.1    Berger, S.H.2    Mittelman, A.3
  • 25
    • 0028019880 scopus 로고
    • Thymidylate synthase inhibition after administration of fluorouracil with and without leucovorin in colon cancer patients: Implication for treatment with fluorouracil
    • Peters GJ, Van Der Wilt CL, Van Groeningen CJ, et al: Thymidylate synthase inhibition after administration of fluorouracil with and without leucovorin in colon cancer patients: Implication for treatment with fluorouracil. J Clin Oncol 12:2035-2042, 1994
    • (1994) J Clin Oncol , vol.12 , pp. 2035-2042
    • Peters, G.J.1    Van Der Wilt, C.L.2    Van Groeningen, C.J.3
  • 26
    • 0028609523 scopus 로고
    • Thymidylate synthase levels in tumor biopsies from patients with colorectal cancer
    • Mulder NH, Timmer-Bosscha H, Meersma GJ, et al: Thymidylate synthase levels in tumor biopsies from patients with colorectal cancer. Anticancer Res 146:2677-2680, 1994
    • (1994) Anticancer Res , vol.146 , pp. 2677-2680
    • Mulder, N.H.1    Timmer-Bosscha, H.2    Meersma, G.J.3
  • 27
    • 0030883708 scopus 로고    scopus 로고
    • Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin
    • Leichman CG, Lenz HJ, Leichman L, et al: Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. J Clin Oncol 15:3223-3229, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 3223-3229
    • Leichman, C.G.1    Lenz, H.J.2    Leichman, L.3
  • 28
    • 0026335113 scopus 로고
    • Production and characterization of monoclonal antibodies that localize human thymidylate synthase in the cytoplasm of human cells and tissue
    • Johnston PG, Liang CM, Henry S, et al: Production and characterization of monoclonal antibodies that localize human thymidylate synthase in the cytoplasm of human cells and tissue. Cancer Res 51:6668-6676, 1991
    • (1991) Cancer Res , vol.51 , pp. 6668-6676
    • Johnston, P.G.1    Liang, C.M.2    Henry, S.3
  • 29
    • 0026560328 scopus 로고
    • Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction
    • Horikoshi T, Danenberg KD, Stadlbauer TH, et al: Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Res 52:108-116, 1992
    • (1992) Cancer Res , vol.52 , pp. 108-116
    • Horikoshi, T.1    Danenberg, K.D.2    Stadlbauer, T.H.3
  • 30
    • 0028151449 scopus 로고
    • The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer
    • Johnston PG, Fisher ER, Rockette HE, et al: The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. J Clin Oncol 12:2640-2647, 1994
    • (1994) J Clin Oncol , vol.12 , pp. 2640-2647
    • Johnston, P.G.1    Fisher, E.R.2    Rockette, H.E.3
  • 31
    • 0028940399 scopus 로고
    • Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
    • Johnston PG, Lenz HG, Leichman CG, et al: Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 55:1407-1412, 1995
    • (1995) Cancer Res , vol.55 , pp. 1407-1412
    • Johnston, P.G.1    Lenz, H.G.2    Leichman, C.G.3
  • 32
    • 0031193602 scopus 로고    scopus 로고
    • High-level expression of human thymidylate synthase
    • Pedersen-Lane J, Maley GF, Chu E, et al: High-level expression of human thymidylate synthase. Protein Expr Purif 10:256-262, 1997
    • (1997) Protein Expr Purif , vol.10 , pp. 256-262
    • Pedersen-Lane, J.1    Maley, G.F.2    Chu, E.3
  • 33
    • 0031947357 scopus 로고    scopus 로고
    • Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma
    • Gorlick R, Metzger R, Danenberg D, et al: Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma. J Clin Oncol 16:1465-1469, 1998
    • (1998) J Clin Oncol , vol.16 , pp. 1465-1469
    • Gorlick, R.1    Metzger, R.2    Danenberg, D.3
  • 34
    • 0031015454 scopus 로고    scopus 로고
    • Fluorouracil in colorectal cancer: A tale of two drugs - Implication for biochemical modulation
    • Sobrero A, Aschele C, Bertino J: Fluorouracil in colorectal cancer: A tale of two drugs - Implication for biochemical modulation. J Clin Oncol 15:368-381, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 368-381
    • Sobrero, A.1    Aschele, C.2    Bertino, J.3
  • 35
    • 0029099290 scopus 로고
    • Schedule-selective biochemical modulation of 5-fluorouracil: A phase II study in advanced colorectal cancer
    • Sobrero AF, Aschele C, Guglielmi AP, et al: Schedule-selective biochemical modulation of 5-fluorouracil: A phase II study in advanced colorectal cancer. Clin Cancer Res 1:955-960, 1995
    • (1995) Clin Cancer Res , vol.1 , pp. 955-960
    • Sobrero, A.F.1    Aschele, C.2    Guglielmi, A.P.3
  • 36
    • 14444267315 scopus 로고    scopus 로고
    • Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer: A multicentric phase n study
    • Aschele C, Guglielmi A, Frassineti GL, et al: Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer: A multicentric phase n study. Br J Cancer 77:341-346, 1998
    • (1998) Br J Cancer , vol.77 , pp. 341-346
    • Aschele, C.1    Guglielmi, A.2    Frassineti, G.L.3
  • 37
    • 0345567424 scopus 로고    scopus 로고
    • Sequential MTX → 5FU vs schedule specific biochemical modulation in advanced colorectal cancer
    • abstr O98
    • Caroti C. Gallo L, Aschele C, et al: Sequential MTX → 5FU vs schedule specific biochemical modulation in advanced colorectal cancer. Proc Eighth Int Congress Anti-Cancer Treat 1998, p 96 (abstr O98)
    • (1998) Proc Eighth Int Congress Anti-Cancer Treat , pp. 96
    • Caroti, C.1    Gallo, L.2    Aschele, C.3
  • 38
    • 0019365237 scopus 로고
    • Reporting results of cancer treatment
    • Miller AB, Hoogstraten B, Staquet M, et al: Reporting results of cancer treatment. Cancer 47:207-214, 1981
    • (1981) Cancer , vol.47 , pp. 207-214
    • Miller, A.B.1    Hoogstraten, B.2    Staquet, M.3
  • 39
    • 0019492861 scopus 로고
    • A comparative study of the peroxidase-antiperoxidase method and an avidin biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies
    • Hsu SM, Raine L, Fanger H: A comparative study of the peroxidase-antiperoxidase method and an avidin biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies. Am J Clin Pathol 5:734-738, 1981
    • (1981) Am J Clin Pathol , vol.5 , pp. 734-738
    • Hsu, S.M.1    Raine, L.2    Fanger, H.3
  • 40
    • 0032496226 scopus 로고    scopus 로고
    • Isolation and characterization of Thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells
    • Tong Y, Liu-Chen X, Ercikan-Abali EA, et al: Isolation and characterization of Thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells. J Biol Chem 273:11611-11618, 1998
    • (1998) J Biol Chem , vol.273 , pp. 11611-11618
    • Tong, Y.1    Liu-Chen, X.2    Ercikan-Abali, E.A.3
  • 41
    • 0344070856 scopus 로고    scopus 로고
    • The utility of monitoring carcinoembryonic antigen (CEA) during systemic therapy for advanced colorectal cancer
    • abstr 954
    • Grem JL, Steinberg SM, Chen AP, et al: The utility of monitoring carcinoembryonic antigen (CEA) during systemic therapy for advanced colorectal cancer. Proc Am Soc Clin Oncol 16:269a, 1997 (abstr 954)
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Grem, J.L.1    Steinberg, S.M.2    Chen, A.P.3
  • 42
    • 0024552372 scopus 로고
    • Prognostic variables in patients with hepatic metastases from colorectal cancer
    • Kemeny N, Niedzwiecki D, Shurgot B, et al: Prognostic variables in patients with hepatic metastases from colorectal cancer. Cancer 63:742-747, 1989
    • (1989) Cancer , vol.63 , pp. 742-747
    • Kemeny, N.1    Niedzwiecki, D.2    Shurgot, B.3
  • 43
    • 0020611334 scopus 로고
    • Prognostic factors in advanced colorectal carcinoma: Importance of lactic dehydrogenase level, performance status, and white blood cell count
    • Kemeny N, Braun DW: Prognostic factors in advanced colorectal carcinoma: Importance of lactic dehydrogenase level, performance status, and white blood cell count. Am J Med 74:786-794, 1983
    • (1983) Am J Med , vol.74 , pp. 786-794
    • Kemeny, N.1    Braun, D.W.2
  • 44
    • 0018886366 scopus 로고
    • Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil
    • Ardalan B, Cooney DA, Jayaram HN, et al: Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil. Cancer Res 40:1431-1437, 1980
    • (1980) Cancer Res , vol.40 , pp. 1431-1437
    • Ardalan, B.1    Cooney, D.A.2    Jayaram, H.N.3
  • 45
    • 0016695115 scopus 로고
    • Biochemical determinants of 5-fluorouracil response in vivo: The role of deoxyuridylate pool expansion
    • Myers CE, Young RC, Chabner BA: Biochemical determinants of 5-fluorouracil response in vivo: The role of deoxyuridylate pool expansion. J Clin Invest 56:1231-1238, 1975
    • (1975) J Clin Invest , vol.56 , pp. 1231-1238
    • Myers, C.E.1    Young, R.C.2    Chabner, B.A.3
  • 46
    • 0026637845 scopus 로고
    • Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to different clinically relevant dose schedules
    • Aschele C, Sobrero A, Faderan MA, et al: Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to different clinically relevant dose schedules. Cancer Res 52:1855-1864, 1992
    • (1992) Cancer Res , vol.52 , pp. 1855-1864
    • Aschele, C.1    Sobrero, A.2    Faderan, M.A.3
  • 47
    • 0027317751 scopus 로고
    • Decreased folylpolyglutamate synthetase expression: A novel mechanism of fluorouracil resistance
    • Wang FS, Aschele C, Sobrero A, et al: Decreased folylpolyglutamate synthetase expression: A novel mechanism of fluorouracil resistance. Cancer Res 53:3677-3680, 1993
    • (1993) Cancer Res , vol.53 , pp. 3677-3680
    • Wang, F.S.1    Aschele, C.2    Sobrero, A.3
  • 48
    • 0028073326 scopus 로고
    • Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase
    • Peters GJ, Van Der Wilt CL, Van Groeningen CJ: Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase. Eur J Cancer 10B:1408-1411, 1994
    • (1994) Eur J Cancer , vol.10 B , pp. 1408-1411
    • Peters, G.J.1    Van Der Wilt, C.L.2    Van Groeningen, C.J.3
  • 49
    • 0029738119 scopus 로고    scopus 로고
    • p53 nuclear protein overexpression in colorectal cancer: A dominant predictor of survival in patients with advanced hepatic metastases
    • Belluco C, Guillem JG, Kemeny N, et al: p53 nuclear protein overexpression in colorectal cancer: A dominant predictor of survival in patients with advanced hepatic metastases. J Clin Oncol 14:2696-2701, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 2696-2701
    • Belluco, C.1    Guillem, J.G.2    Kemeny, N.3
  • 50
    • 0030035584 scopus 로고    scopus 로고
    • p53 mutations as a possible predictor of response to chemotherapy in metastatic colorectal carcinomas
    • Benhattar J, Cerottini JP, Saraga E, et al: p53 mutations as a possible predictor of response to chemotherapy in metastatic colorectal carcinomas. Int J Cancer 69:190-192, 1996
    • (1996) Int J Cancer , vol.69 , pp. 190-192
    • Benhattar, J.1    Cerottini, J.P.2    Saraga, E.3
  • 51
    • 0031032481 scopus 로고    scopus 로고
    • Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas
    • Schneider HJ, Sampson SA, Cunningham D, et al: Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas. Br J Cancer 75:427-431, 1997
    • (1997) Br J Cancer , vol.75 , pp. 427-431
    • Schneider, H.J.1    Sampson, S.A.2    Cunningham, D.3
  • 52
    • 0025990937 scopus 로고
    • Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase
    • Chu E, Koeller DM, Casey JL, et al: Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase. Proc Natl Acad Sci U S A 88:8977-8981, 1991
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 8977-8981
    • Chu, E.1    Koeller, D.M.2    Casey, J.L.3
  • 53
    • 0031053520 scopus 로고    scopus 로고
    • Lack of correlation between thymidylate synthase levels in primary colorectal tumours and subsequent response to chemotherapy
    • Findlay MPN, Cunningham D, Morgan G, et al: Lack of correlation between thymidylate synthase levels in primary colorectal tumours and subsequent response to chemotherapy. Br J Cancer 75:903-909, 1997
    • (1997) Br J Cancer , vol.75 , pp. 903-909
    • Findlay, M.P.N.1    Cunningham, D.2    Morgan, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.