메뉴 건너뛰기




Volumn 1, Issue 4, 2010, Pages 595-611

Transport of drugs across the blood-brain barrier in Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; ALBUMIN; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; ANG 1005; ANG 1007; BREAST CANCER RESISTANCE PROTEIN; CLIOQUINOL; DIAZEPAM; DOXORUBICIN; ETOPOSIDE; FLUORESCEIN SODIUM; GLYCOPROTEIN P; IMMUNOGLOBULIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL; UNCLASSIFIED DRUG;

EID: 79954483841     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.10.41     Document Type: Review
Times cited : (15)

References (169)
  • 1
    • 2942623871 scopus 로고    scopus 로고
    • Evidence for bulk flow of brain interstitial fluid: Significance for physiology and pathology
    • DOI 10.1016/j.neuint.2003.11.006, PII S0197018603002675, Role of Non-synaptic Communication in Information Processing
    • Abbott NJ. Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology. Neurochem. Int. 45(4), 545-552 (2004). (Pubitemid 38739482)
    • (2004) Neurochemistry International , vol.45 , Issue.4 , pp. 545-552
    • Abbott, N.J.1
  • 3
    • 0032754657 scopus 로고    scopus 로고
    • Microvessel organization and structure in experimental brain tumors: Microvessel populations with distinctive structural and functional properties
    • DOI 10.1006/mvre.1999.2188
    • Schlageter KE, Molnar P, Lapin GD, Groothuis DR. Microvessel organization and structure in experimental brain tumors: microvessel populations with distinctive structural and functional properties. Microvasc. Res. 58(3), 312-328 (1999). (Pubitemid 29531878)
    • (1999) Microvascular Research , vol.58 , Issue.3 , pp. 312-328
    • Schlageter, K.E.1    Molnar, P.2    Lapin, G.D.3    Groothuis, D.R.4
  • 4
    • 0037083385 scopus 로고    scopus 로고
    • William Pardridge discusses the lack of BBB research. Interview by Rebecca N Lawrence
    • Pardridge WM. William Pardridge discusses the lack of BBB research. Interview by Rebecca N Lawrence. Drug Discov. Today 7(4), 223-226 (2002).
    • (2002) Drug Discov. Today , vol.7 , Issue.4 , pp. 223-226
    • Pardridge, W.M.1
  • 5
    • 12344273726 scopus 로고    scopus 로고
    • The blood-brain barrier: Bottleneck in brain drug development
    • DOI 10.1602/neurorx.2.1.3
    • Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2(1), 3-14 (2005). (Pubitemid 40128022)
    • (2005) NeuroRx , vol.2 , Issue.1 , pp. 3-14
    • Pardridge, W.M.1
  • 6
    • 0014109002 scopus 로고
    • Fine structural localization of a blood-brain barrier to exogenous peroxidase
    • Reese TS, Karnovsky MJ. Fine structural localization of a blood-brain barrier to exogenous peroxidase. J. Cell Biol. 34(1), 207-217 (1967).
    • (1967) J. Cell Biol. , vol.34 , Issue.1 , pp. 207-217
    • Reese, T.S.1    Karnovsky, M.J.2
  • 7
    • 0014481056 scopus 로고
    • Junctions between intimately apposed cell membranes in the vertebrate brain
    • Brightman MW, Reese TS. Junctions between intimately apposed cell membranes in the vertebrate brain. J. Cell Biol. 40(3), 648-677 (1969).
    • (1969) J. Cell Biol. , vol.40 , Issue.3 , pp. 648-677
    • Brightman, M.W.1    Reese, T.S.2
  • 8
    • 0036319335 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions and blood-brain barrier permeability
    • DOI 10.1046/j.1469-7580.2002.00064.x
    • Abbott NJ. Astrocyte-endothelial interactions and blood-brain barrier permeability. J. Anat. 200(6), 629-638 (2002). (Pubitemid 34823054)
    • (2002) Journal of Anatomy , vol.200 , Issue.6 , pp. 629-638
    • Abbott, N.J.1
  • 9
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • DOI 10.1124/pr.57.2.4
    • Hawkins BT, Davis TP. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 57(2), 173-185 (2005). (Pubitemid 41043883)
    • (2005) Pharmacological Reviews , vol.57 , Issue.2 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 10
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 57(2), 178-201 (2008).
    • (2008) Neuron. , vol.57 , Issue.2 , pp. 178-201
    • Zlokovic, B.V.1
  • 12
    • 0032489875 scopus 로고    scopus 로고
    • ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin
    • DOI 10.1083/jcb.141.1.199
    • Haskins J, Gu L, Wittchen ES, Hibbard J, Stevenson BR. ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin. J. Cell Biol. 141(1), 199-208 (1998). (Pubitemid 28182652)
    • (1998) Journal of Cell Biology , vol.141 , Issue.1 , pp. 199-208
    • Haskins, J.1    Gu, L.2    Wittchen, E.S.3    Hibbard, J.4    Stevenson, B.R.5
  • 13
    • 0028287035 scopus 로고
    • Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein
    • Jesaitis LA, Goodenough DA. Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J. Cell Biol. 124(6), 949-961 (1994). (Pubitemid 24109397)
    • (1994) Journal of Cell Biology , vol.124 , Issue.6 , pp. 949-961
    • Jesaitis, L.A.1    Goodenough, D.A.2
  • 14
    • 33646754516 scopus 로고    scopus 로고
    • Multidrug resistance-associated proteins: Expression and function in the central nervous system
    • Dallas S, Miller DS, Bendayan R. Multidrug resistance-associated proteins: expression and function in the central nervous system. Pharmacol. Rev. 58(2), 140-161 (2006).
    • (2006) Pharmacol. Rev. , vol.58 , Issue.2 , pp. 140-161
    • Dallas, S.1    Miller, D.S.2    Bendayan, R.3
  • 15
    • 63349094264 scopus 로고    scopus 로고
    • Drug transport across the blood-brain barrier and the impact of breast cancer resistance protein (ABCG2)
    • Nicolazzo JA, Katneni K. Drug transport across the blood-brain barrier and the impact of breast cancer resistance protein (ABCG2). Curr. Top. Med. Chem. 9(2), 130-147 (2009).
    • (2009) Curr. Top. Med. Chem. , vol.9 , Issue.2 , pp. 130-147
    • Nicolazzo, J.A.1    Katneni, K.2
  • 16
    • 0033526176 scopus 로고    scopus 로고
    • P-Glycoprotein, a gatekeeper in the blood-brain barrier
    • DOI 10.1016/S0169-409X(98)00085-4, PII S0169409X98000854
    • Schinkel AH. P-Glycoprotein, a gatekeeper in the blood-brain barrier. Adv. Drug. Deliv. Rev. 36(2-3), 179-194 (1999). (Pubitemid 29121971)
    • (1999) Advanced Drug Delivery Reviews , vol.36 , Issue.2-3 , pp. 179-194
    • Schinkel, A.H.1
  • 19
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • Juliano RL, Ling V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim. Biophys. Acta 455(1), 152-162 (1976).
    • (1976) Biochim. Biophys. Acta , vol.455 , Issue.1 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 20
    • 0033756459 scopus 로고    scopus 로고
    • Transporter-mediated permeation of drugs across the blood-brain barrier
    • Tamai I, Tsuji A. Transporter-mediated permeation of drugs across the blood-brain barrier. J. Pharm. Sci. 89(11), 1371-1388 (2000).
    • (2000) J. Pharm. Sci. , vol.89 , Issue.11 , pp. 1371-1388
    • Tamai, I.1    Tsuji, A.2
  • 21
    • 0344889004 scopus 로고    scopus 로고
    • A co-culture of brain capillary endothelial cells and astrocytes: An in vitro blood-brain barrier for studying drug transport to the brain
    • In vitro and In vivo Techniques. de Boer AG, Sutanto W (Eds), Harwood Academic Publishers, Amsterdam, The Netherlands
    • Dehouck B, Cecchelli R, Dehouck M. A co-culture of brain capillary endothelial cells and astrocytes: an in vitro blood-brain barrier for studying drug transport to the brain. In:Drug Transport Across the Blood-Brain Barrier - In vitro and In vivo Techniques. de Boer AG, Sutanto W (Eds), Harwood Academic Publishers, Amsterdam, The Netherlands, 69-79 (1997).
    • (1997) Drug Transport Across the Blood-Brain Barrier , pp. 69-79
    • Dehouck, B.1    Cecchelli, R.2    Dehouck, M.3
  • 23
    • 0031819596 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein: Rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier
    • DOI 10.1023/A:1011913723928
    • Fenart L, Buée-Scherrer V, Descamps L et al. Inhibition of P-glycoprotein: rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier. Pharm. Res. 15(7), 993-1000 (1998). (Pubitemid 28356913)
    • (1998) Pharmaceutical Research , vol.15 , Issue.7 , pp. 993-1000
    • Fenart, L.1    Buee-Scherrer, V.2    Descamps, L.3    Duhem, C.4    Poullain, M.-G.5    Cecchelli, R.6    Dehouck, M.-P.7
  • 24
    • 0033638592 scopus 로고    scopus 로고
    • Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier
    • Gaillard PJ, van der Sandt ICJ, Voorwinden LH et al. Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier. Pharm. Res. 17(10), 1198-1205 (2000).
    • (2000) Pharm. Res. , vol.17 , Issue.10 , pp. 1198-1205
    • Gaillard, P.J.1    Van Der Sandt Icj2    Voorwinden, L.H.3
  • 25
    • 25444463573 scopus 로고    scopus 로고
    • Endothelial/pericyte interactions
    • DOI 10.1161/01.RES.0000182903.16652.d7
    • Armulik A, Abramsson A, Betsholtz C. Endothelial/pericyte interactions. Circ. Res. 97(6), 512-523 (2005). (Pubitemid 41361741)
    • (2005) Circulation Research , vol.97 , Issue.6 , pp. 512-523
    • Armulik, A.1    Abramsson, A.2    Betsholtz, C.3
  • 26
    • 33947723274 scopus 로고    scopus 로고
    • The impact of glia-derived extracellular matrices on the barrier function of cerebral endothelial cells: An in vitro study
    • DOI 10.1016/j.yexcr.2007.01.024, PII S0014482707000444
    • Hartmann C, Zozulya A, Wegener H, Galla HJ. The impact of glia-derived extracellular matrices on the barrier function of cerebral endothelial cells: an in vitro study. Exp. Cell Res. 313(7), 1318-1325 (2007). (Pubitemid 46507445)
    • (2007) Experimental Cell Research , vol.313 , Issue.7 , pp. 1318-1325
    • Hartmann, C.1    Zozulya, A.2    Wegener, J.3    Galla, H.-J.4
  • 28
    • 0035047718 scopus 로고    scopus 로고
    • Cerebral microvascular pathology in aging and Alzheimer's disease
    • DOI 10.1016/S0301-0082(00)00068-X, PII S030100820000068X
    • Farkas E, Luiten PG. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog. Neurobiol. 64(6), 575-611 (2001). (Pubitemid 32304447)
    • (2001) Progress in Neurobiology , vol.64 , Issue.6 , pp. 575-611
    • Farkas, E.1    Luiten, P.G.M.2
  • 30
    • 0031843634 scopus 로고    scopus 로고
    • Basement membrane proteins influence brain capillary endothelial barrier function in vitro
    • Tilling T, Korte D, Hoheisel D, Galla HJ. Basement membrane proteins influence brain capillary endothelial barrier function in vitro. J. Neurochem. 71(3), 1151-1157 (1998). (Pubitemid 28390269)
    • (1998) Journal of Neurochemistry , vol.71 , Issue.3 , pp. 1151-1157
    • Tilling, T.1    Korte, D.2    Hoheisel, D.3    Galla, H.-J.4
  • 32
    • 0033771212 scopus 로고    scopus 로고
    • The effect of altered cerebral blood flow on the cerebral kinetics of thiopental and propofol in sheep
    • Upton RN, Ludbrook GL, Grant C, Doolette DJ. The effect of altered cerebral blood flow on the cerebral kinetics of thiopental and propofol in sheep. Anesthesiology 93(4), 1085-1094 (2000).
    • (2000) Anesthesiology , vol.93 , Issue.4 , pp. 1085-1094
    • Upton, R.N.1    Ludbrook, G.L.2    Grant, C.3    Doolette, D.J.4
  • 33
  • 35
    • 61849149792 scopus 로고    scopus 로고
    • Role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative disorders
    • Stolp HB, Dziegielewska KM. Role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative disorders. Neuropath. Appl. Neurobiol. 35(2), 132-146 (2009).
    • (2009) Neuropath. Appl. Neurobiol. , vol.35 , Issue.2 , pp. 132-146
    • Stolp, H.B.1    Dziegielewska, K.M.2
  • 36
    • 77949336151 scopus 로고    scopus 로고
    • 2010 Alzheimer's disease facts and figures
    • Alzheimer's Asociation
    • Alzheimer's Asociation. 2010 Alzheimer's disease facts and figures. Alzheimers Dement. 6(2), 158-194 (2010).
    • (2010) Alzheimers Dement. , vol.6 , Issue.2 , pp. 158-194
  • 37
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81(2), 741-766 (2001).
    • (2001) Physiol. Rev. , vol.81 , Issue.2 , pp. 741-766
    • Selkoe, D.J.1
  • 38
    • 0028169925 scopus 로고
    • Visualization of Ab42(43) and Ab40 in senile plaques with end-specific Ab monoclonals: Evidence that an initially deposited species is Ab42(43)
    • Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of Ab42(43) and Ab40 in senile plaques with end-specific Ab monoclonals: evidence that an initially deposited species is Ab42(43). Neuron 13(1), 45-53 (1994).
    • (1994) Neuron , vol.13 , Issue.1 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, N.5    Ihara, Y.6
  • 39
    • 0028168336 scopus 로고
    • Amyloid-b aggregation: Selective inhibition of aggregation in mixtures of amyloid with different chain lengths
    • Snyder SW, Ladror US, Wade WS et al. Amyloid-b aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths. Biophys. J. 67(3), 1216-1228 (1994).
    • (1994) Biophys. J. , vol.67 , Issue.3 , pp. 1216-1228
    • Snyder, S.W.1    Ladror, U.S.2    Wade, W.S.3
  • 40
    • 7644219821 scopus 로고    scopus 로고
    • Amyloid angiopathy-related vascular cognitive impairment
    • DOI 10.1161/01.STR.0000143224.36527.44
    • Greenberg SM, Gurol ME, Rosand J, Smith EE. Amyloid angiopathy-related vascular cognitive impairment. Stroke 35(11 Suppl 1), 2616-2619 (2004) (Pubitemid 39458351)
    • (2004) Stroke , vol.35 , Issue.11 SUPPL. 1 , pp. 2616-2619
    • Greenberg, S.M.1    Gurol, M.E.2    Rosand, J.3    Smith, E.E.4
  • 41
    • 0028915895 scopus 로고
    • Amyloid b protein (Ab) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at Ab40 or Ab42(43)
    • Gravina SA, Ho L, Eckman CB et al. Amyloid b protein (Ab) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at Ab40 or Ab42(43). J. Biol. Chem. 270(13), 7013-7016 (1995).
    • (1995) J. Biol. Chem. , vol.270 , Issue.13 , pp. 7013-7016
    • Gravina, S.A.1    Ho, L.2    Eckman, C.B.3
  • 43
    • 0027332081 scopus 로고
    • B-amyloid1-42 is a major component of cerebrovascular amyloid deposits: Implications for the pathology of Alzheimer disease
    • Roher AE, Lowenson JD, Clarke S et al. b-amyloid1-42 is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc. Natl Acad. Sci. USA 90(22), 10836-10840 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , Issue.22 , pp. 10836-10840
    • Roher, A.E.1    Lowenson, J.D.2    Clarke, S.3
  • 44
    • 67349093525 scopus 로고    scopus 로고
    • Clearance mechanisms of Alzheimer's amyloid-b peptide: Implications for therapeutic design and diagnostic tests
    • Bates KA, Verdile G, Li QX et al. Clearance mechanisms of Alzheimer's amyloid-b peptide: implications for therapeutic design and diagnostic tests. Mol. Psychiatry 14(5), 469-486 (2009).
    • (2009) Mol. Psychiatry , vol.14 , Issue.5 , pp. 469-486
    • Bates, K.A.1    Verdile, G.2    Li, Q.X.3
  • 45
    • 33748753481 scopus 로고    scopus 로고
    • Clearance of amyloid-b in Alzheimer's disease: Progress, problems and perspectives
    • Wang YJ, Zhou HD, Zhou XF. Clearance of amyloid-b in Alzheimer's disease: progress, problems and perspectives. Drug Discov. Today. 11(19-20), 931-938 (2006).
    • (2006) Drug Discov. Today. , vol.11 , Issue.19-20 , pp. 931-938
    • Wang, Y.J.1    Zhou, H.D.2    Zhou, X.F.3
  • 46
    • 67349142021 scopus 로고    scopus 로고
    • Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    • Bell RD, Zlokovic BV. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol. 118(1), 103-113 (2009).
    • (2009) Acta Neuropathol. , vol.118 , Issue.1 , pp. 103-113
    • Bell, R.D.1    Zlokovic, B.V.2
  • 47
    • 33644853531 scopus 로고    scopus 로고
    • Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease: Towards presymptomatic diagnosis, prevention and therapy
    • DOI 10.1016/j.neures.2005.12.015, PII S0168010205003330
    • Saido TC, Iwata N. Metabolism of amyloid b peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy. Neurosci. Res. 54(4), 235-253 (2006). (Pubitemid 43374441)
    • (2006) Neuroscience Research , vol.54 , Issue.4 , pp. 235-253
    • Saido, T.C.1    Iwata, N.2
  • 48
    • 0037385370 scopus 로고    scopus 로고
    • Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: Defining the perivascular route for the elimination of amyloid β from the human brain
    • DOI 10.1046/j.1365-2990.2003.00424.x
    • Preston SD, Steart PV, Wilkinson A, Nicoll JA, Weller RO. Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid b from the human brain. Neuropath. Appl. Neurobiol. 29(2), 106-117 (2003). (Pubitemid 36408329)
    • (2003) Neuropathology and Applied Neurobiology , vol.29 , Issue.2 , pp. 106-117
    • Preston, S.D.1    Steart, P.V.2    Wilkinson, A.3    Nicoll, J.A.R.4    Weller, R.O.5
  • 49
    • 34147183707 scopus 로고    scopus 로고
    • Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease
    • Deane R, Zlokovic BV. Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease. Curr. Alzheimer Res. 4(2), 197-197 (2007).
    • (2007) Curr. Alzheimer Res. , vol.4 , Issue.2 , pp. 197-197
    • Deane, R.1    Zlokovic, B.V.2
  • 50
    • 0141867783 scopus 로고    scopus 로고
    • Efflux of human and mouse amyloid β proteins 1-40 and 1-42 from brain: Impairment in a mouse model of alzheimer's disease
    • DOI 10.1016/S0306-4522(03)00474-3
    • Banks WA, Robinson SM, Verma S, Morley JE. Efflux of human and mouse amyloid b proteins 1-40 and 1-42 from brain: impairment in a mouse model of Alzheimer's disease. Neuroscience 12(2), 487-492 (2003). (Pubitemid 37176936)
    • (2003) Neuroscience , vol.121 , Issue.2 , pp. 487-492
    • Banks, W.A.1    Robinson, S.M.2    Verma, S.3    Morley, J.E.4
  • 51
    • 19444363990 scopus 로고    scopus 로고
    • Pharmacokinetic analysis of the blood-brain barrier transport of 125I-amyloid b protein 40 in wild-type and Alzheimer's disease transgenic mice (APP,PS1) and its implications for amyloid plaque formation
    • Kandimalla KK, Curran GL, Holasek SS, Gilles EJ, Wengenack TM, Poduslo JF. Pharmacokinetic analysis of the blood-brain barrier transport of 125I-amyloid b protein 40 in wild-type and Alzheimer's disease transgenic mice (APP,PS1) and its implications for amyloid plaque formation. J. Pharmacol. Exp. Ther. 313(3), 1370-1380 (2005).
    • (2005) J. Pharmacol. Exp. Ther. , vol.313 , Issue.3 , pp. 1370-1380
    • Kandimalla, K.K.1    Curran, G.L.2    Holasek, S.S.3    Gilles, E.J.4    Wengenack, T.M.5    Poduslo, J.F.6
  • 52
    • 13544268809 scopus 로고    scopus 로고
    • Neurovascular mechanisms of Alzheimer's neurodegeneration
    • Zlokovic BV. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci. 28(4), 202-208 (2005).
    • (2005) Trends Neurosci. , vol.28 , Issue.4 , pp. 202-208
    • Zlokovic, B.V.1
  • 53
    • 1242331823 scopus 로고    scopus 로고
    • Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma and dialectics
    • de la Torre JC. Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma and dialectics. Lancet Neurol. 3(3), 184-190 (2004).
    • (2004) Lancet Neurol. , vol.3 , Issue.3 , pp. 184-190
    • De La Torre, J.C.1
  • 54
    • 0030452414 scopus 로고    scopus 로고
    • Cerebral vessels in ageing and Alzheimer's disease
    • DOI 10.1016/S0163-7258(96)00116-7, PII S0163725896001167
    • Kalaria RN. Cerebral vessels in aging and Alzheimer's disease. Pharmacol. Ther. 72(3), 193-214 (1996). (Pubitemid 26425810)
    • (1996) Pharmacology and Therapeutics , vol.72 , Issue.3 , pp. 193-214
    • Kalaria, R.N.1
  • 55
    • 0033391684 scopus 로고    scopus 로고
    • The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease
    • Kalaria RN. The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease. Ann. N. Y. Acad. Sci. 893, 113-125 (1999). (Pubitemid 30038071)
    • (1999) Annals of the New York Academy of Sciences , vol.893 , pp. 113-125
    • Kalaria, R.N.1
  • 56
    • 0014126538 scopus 로고
    • Albumin exchange between plasma and cerebrospinal fluid
    • Cutler MP, Deuel RM, Barlow CF. Albumin exchange between plasma and cerebrospinal fluid. Arch. Neurol. 17(3), 261-270 (1967).
    • (1967) Arch. Neurol. , vol.17 , Issue.3 , pp. 261-270
    • Cutler, M.P.1    Deuel, R.M.2    Barlow, C.F.3
  • 58
  • 59
    • 0019993831 scopus 로고
    • Immunoglobulins and complement factors in senile plaques. An immunoperoxidase study
    • DOI 10.1007/BF00685397
    • Eikelenboom P, Stam FC. Immunoglobulins and complement factors in senile plaques. An immunoperoxidase study. Acta Neuropathol. 57(2-3), 239-242 (1982). (Pubitemid 12085182)
    • (1982) Acta Neuropathologica , vol.57 , Issue.2-3 , pp. 239-242
    • Eikelenboom, P.1    Stam, F.C.2
  • 60
    • 0017110280 scopus 로고
    • Immuno-electron microscopic localization of immunoglobulins in amyloid fibrils of senile plaques
    • Ishii T, Haga S. Immuno-electron microscopic localization of immunoglobulins in amyloid fibrils of senile plaques. Acta Neuropathol. 36(3), 243-249 (1976).
    • (1976) Acta Neuropathol. , vol.36 , Issue.3 , pp. 243-249
    • Ishii, T.1    Haga, S.2
  • 61
    • 0020348267 scopus 로고
    • Evidence of blood-brain barrier changes in senile dementia of the Alzheimer type (SDAT)
    • Wisniewski HM, Kozlowski PB. Evidence for blood-brain barrier changes in senile dementia of the Alzheimer type (SDAT). Ann. N. Y. Acad. Sci. 396, 119-129 (1982). (Pubitemid 13073501)
    • (1982) Annals of the New York Academy of Sciences , vol.396 , pp. 119-129
    • Wisniewski, H.M.1    Kozlowski, P.B.2
  • 62
    • 0023191678 scopus 로고
    • Serum and cerebrospinal fluid proteins and the blood-brain barrier in Alzheimer's disease and multi-infarct dementia
    • Elovaara I, Palo J, Erkinjuntti T, Sulkava R. Serum and cerebrospinal fluid proteins and the blood-brain barrier in Alzheimer's disease and multi-infarct dementia. Eur. Neurol. 26(4), 229-234 (1987). (Pubitemid 17077709)
    • (1987) European Neurology , vol.26 , Issue.4 , pp. 229-234
    • Elovaara, I.1    Palo, J.2    Erkinjuntti, T.3    Sulkava, R.4
  • 63
    • 0031922362 scopus 로고    scopus 로고
    • A population study on blood-brain barrier function in 85-year-olds
    • Skoog I, Wallin A, Fredman P et al. A population study on blood-brain barrier function in 85-year-olds. Neurology 50(4), 966-971 (1998).
    • (1998) Neurology , vol.50 , Issue.4 , pp. 966-971
    • Skoog, I.1    Wallin, A.2    Fredman, P.3
  • 64
    • 0020616406 scopus 로고
    • Albumin and immunoglobulin in plasma and cerebrospinal fluid, and blood-cerebrospinal fluid barrier function in patients with dementia of Alzheimer type and multi-infarct dementia
    • DOI 10.1016/0022-510X(83)90157-0
    • Alafuzoff I, Adolfsson R, Bucht G, Winblad B. Albumin and immunoglobulin in plasma and cerebrospinal fluid, and blood-cerebrospinal fluid barrier function in patients with dementia of Alzheimer type and multi-infarct dementia. J. Neurol. Sci. 60(3), 465-472 (1983). (Pubitemid 13051197)
    • (1983) Journal of the Neurological Sciences , vol.60 , Issue.3 , pp. 465-472
    • Alafuzoff, I.1    Adolfsson, R.2    Bucht, G.3    Winblad, B.4
  • 66
    • 0028848312 scopus 로고
    • Evidence of blood-cerebrospinal fluid-barrier impairment in a subgroup of patients with dementia of the Alzheimer type and major depression: A possible indicator for immunoactivation
    • Hampel H, Muller-Spahn F, Berger C, Haberl A, Ackenheil M, Hock C. Evidence of blood-cerebrospinal fluid-barrier impairment in a subgroup of patients with dementia of the Alzheimer type and major depression: a possible indicator for immunoactivation. Dementia 6(6), 348-354 (1995).
    • (1995) Dementia , vol.6 , Issue.6 , pp. 348-354
    • Hampel, H.1    Muller-Spahn, F.2    Berger, C.3    Haberl, A.4    Ackenheil, M.5    Hock, C.6
  • 67
    • 0032087962 scopus 로고    scopus 로고
    • Blood-Brain Barrier Permeability of the Demented Elderly as Studied by Cerebrospinal Fluid-Serum Albumin Ratio
    • Wada H. Blood-brain barrier permeability of the demented elderly as studied by cerebrospinal fluid-serum albumin ratio. Intern. Med. 37(6), 509-513 (1998). (Pubitemid 128520872)
    • (1998) Internal Medicine , vol.37 , Issue.6 , pp. 509-513
    • Wada, H.1
  • 68
    • 23644440809 scopus 로고    scopus 로고
    • Enhanced prospects for drug delivery and brain targeting by the choroid plexus-CSF route
    • DOI 10.1007/s11095-005-6039-0
    • Johanson CE, Duncan JA, Stopa EG, Baird A. Enhanced prospects for drug delivery and brain targeting by the choroid plexus-CSF route. Pharm. Res. 22(7), 1011-1037 (2005). (Pubitemid 41130789)
    • (2005) Pharmaceutical Research , vol.22 , Issue.7 , pp. 1011-1037
    • Johanson, C.E.1    Duncan, J.A.2    Stopa, E.G.3    Baird, A.4
  • 69
    • 34248645424 scopus 로고    scopus 로고
    • The integrity of the blood-brain barrier in Alzheimer's disease
    • DOI 10.1111/j.1600-0404.2007.00823.x
    • Algotsson A, Winblad B. The integrity of the blood-brain barrier in Alzheimer's disease. Acta. Neurol. Scand. 115(6), 403-408 (2007). (Pubitemid 46776325)
    • (2007) Acta Neurologica Scandinavica , vol.115 , Issue.6 , pp. 403-408
    • Algotsson, A.1    Winblad, B.2
  • 70
    • 34249040510 scopus 로고    scopus 로고
    • Blood-brain barrier impairment in Alzheimer disease: Stability and functional significance
    • DOI 10.1212/01.wnl.0000262031.18018.1a, PII 0000611420070522000008
    • Bowman GL, Kaye JA, Moore M, Waichunas D, Carlson NE, Quinn JF. Blood-brain barrier impairment in Alzheimer disease: stability and functional significance. Neurology 68(1), 1809-1814 (2007). (Pubitemid 46791393)
    • (2007) Neurology , vol.68 , Issue.21 , pp. 1809-1814
    • Bowman, G.L.1    Kaye, J.A.2    Moore, M.3    Waichunas, D.4    Carlson, N.E.5    Quinn, J.F.6
  • 72
    • 0023237250 scopus 로고
    • Blood-brain barrier in Alzheimer dementia and in non-demented elderly. An immunocytochemical study
    • DOI 10.1007/BF00693782
    • Alafuzoff I, Adolfsson R, Grundke-Iqbal I, Winblad B. Blood-brain barrier in Alzheimer dementia and in nondemented elderly. An immunocytochemical study. Acta Neuropathol. 73(2), 160-166 (1987). (Pubitemid 17060012)
    • (1987) Acta Neuropathologica , vol.73 , Issue.2 , pp. 160-166
    • Alafuzoff, I.1    Adolfsson, R.2    Grundke-Iqbal, I.3    Winblad, B.4
  • 73
    • 0023110541 scopus 로고
    • CSF and serum concentrations of albumin and IgG in Alzheimer's disease
    • DOI 10.1016/0197-4580(87)90053-4
    • Kay AD, May C, Papadopoulos NM et al. CSF and serum concentrations of albumin and IgG in Alzheimer's disease. Neurobiol. Aging 8(1), 21-25 (1987). (Pubitemid 17034561)
    • (1987) Neurobiology of Aging , vol.8 , Issue.1 , pp. 21-25
    • Kay, A.D.1    May, C.2    Papadopoulos, N.M.3
  • 74
    • 0025870546 scopus 로고
    • Blood-brain barrier in a geriatric population: Barrier function in degenerative and vascular dementias
    • Mecocci P, Parnetti L, Reboldi GP et al. Blood-brain barrier in a geriatric population: barrier function in degenerative and vascular dementias. Acta Neurol. Scand. 84(3), 210-213 (1991).
    • (1991) Acta Neurol. Scand. , vol.84 , Issue.3 , pp. 210-213
    • Mecocci, P.1    Parnetti, L.2    Reboldi, G.P.3
  • 75
    • 0024156029 scopus 로고
    • Lack of evidence for dysfunction of the blood-brain barrier in Alzheimer's disease: An immunohistochemical study
    • Rozemuller JM, Eikelenboom P, Kamphorst W, Stam FC. Lack of evidence for dysfunction of the blood-brain barrier in Alzheimer's disease: an immunohistochemical study. Neurobiol. Aging 9(4), 383-391 (1988). (Pubitemid 19262071)
    • (1988) Neurobiology of Aging , vol.9 , Issue.4 , pp. 383-391
    • Rozemuller, J.M.1    Eikelenboom, P.2    Kamphorst, W.3    Stam, F.C.4
  • 77
    • 0021986721 scopus 로고
    • The integrity of the blood-brain barrier in Alzheimer's Type and multi-infarct dementia evaluated by the study of albumin and IgG in serum and cerebrospinal fluid
    • DOI 10.1016/0022-510X(85)90121-2
    • Leonardi A, Gandolfo C, Caponnetto C, Arata L, Vecchia R. The integrity of the blood-brain barrier in Alzheimer's type and multi-infarct dementia evaluated by the study of albumin and IgG in serum and cerebrospinal fluid. J. Neurol. Sci. 67(2), 253-261 (1985). (Pubitemid 15130767)
    • (1985) Journal of the Neurological Sciences , vol.67 , Issue.2 , pp. 253-261
    • Leonardi, A.1    Gandolfo, C.2    Caponnetto, C.3
  • 79
    • 0001772654 scopus 로고
    • Quantitative evaluation of blood-brain barrier integrity in Alzheimer type dementia: Positron emission tomographic studies with rubidium-82
    • Friedland RP, Yano Y, Budinger TF et al. Quantitative evaluation of blood-brain barrier integrity in Alzheimer type dementia: positron emission tomographic studies with rubidium-82. Eur. Neurol. 22 (Suppl. 2), 15-20 (1983).
    • (1983) Eur. Neurol. , vol.22 , Issue.SUPPL. 2 , pp. 15-20
    • Friedland, R.P.1    Yano, Y.2    Budinger, T.F.3
  • 81
    • 61349102361 scopus 로고    scopus 로고
    • Blood-brain barrier permeability in Alzheimer's disease: A case-control MRI study
    • Starr JM, Farrall AJ, Armitage P, McGurn B, Wardlaw J. Blood-brain barrier permeability in Alzheimer's disease: a case-control MRI study. Psychiatry Res. 171(3), 232-241 (2009).
    • (2009) Psychiatry Res. , vol.171 , Issue.3 , pp. 232-241
    • Starr, J.M.1    Farrall, A.J.2    Armitage, P.3    McGurn, B.4    Wardlaw, J.5
  • 82
    • 58549098084 scopus 로고    scopus 로고
    • Blood-brain barrier: Aging and microvascular disease - Systematic review and meta-analysis
    • Farrall AJ, Wardlaw J. Blood-brain barrier: aging and microvascular disease - systematic review and meta-analysis. Neurobiol. Aging 30(3), 337-352 (2009).
    • (2009) Neurobiol. Aging , vol.30 , Issue.3 , pp. 337-352
    • Farrall, A.J.1    Wardlaw, J.2
  • 83
    • 0033528254 scopus 로고    scopus 로고
    • Intravascular infusions of soluble β-amyloid compromise the blood- brain barrier, activate CNS glial cells and induce peripheral hemorrhage
    • DOI 10.1016/S0006-8993(98)01143-3, PII S0006899398011433
    • Su GC, Arendash GW, Kalaria RN, Bjugstad KB, Mullan M. Intravascular infusions of soluble b-amyloid compromise the blood-brain barrier, activate CNS glial cells and induce peripheral hemorrhage. Brain Res. 818(1), 105-117 (1999). (Pubitemid 29227289)
    • (1999) Brain Research , vol.818 , Issue.1 , pp. 105-117
    • Su, G.C.1    Arendash, G.W.2    Kalaria, R.N.3    Bjugstad, K.B.4    Mullan, M.5
  • 85
    • 0037701180 scopus 로고    scopus 로고
    • Beta-amyloid peptide-induced blood-brain barrier disruption facilitates T-cell entry into the rat brain
    • DOI 10.1078/0065-1281-00696
    • Farkas IG, Czigner A, Farkas E et al. b-amyloid peptide-induced blood-brain barrier disruption facilitates T-cell entry into the rat brain. Acta Histochem. 105(2), 115-125 (2003). (Pubitemid 36734149)
    • (2003) Acta Histochemica , vol.105 , Issue.2 , pp. 115-125
    • Farkas, I.G.1    Czigner, A.2    Farkas, E.3    Dobo, E.4    Soos, K.5    Penke, B.6    Endresz, V.7    Mihaly, A.8
  • 86
  • 88
    • 0031004788 scopus 로고    scopus 로고
    • Amyloid β-peptide induces cell monolayer albumin permeability, impairs glucose transport, and induces apoptosis in vascular endothelial cells
    • Blanc EM, Toborek M, Mark RJ, Hennig B, Mattson MP. Amyloid b-peptide induces cell monolayer albumin permeability, impairs glucose transport, and induces apoptosis in vascular endothelial cells. J. Neurochem. 68(5), 1870-1881 (1997). (Pubitemid 27176122)
    • (1997) Journal of Neurochemistry , vol.68 , Issue.5 , pp. 1870-1881
    • Blanc, E.M.1    Toborek, M.2    Mark, R.J.3    Hennig, B.4    Mattson, M.P.5
  • 90
    • 33747436236 scopus 로고    scopus 로고
    • 1-42 alters tight junction protein distribution and expression in brain microvessel endothelial cells
    • DOI 10.1016/j.neulet.2006.03.047, PII S0304394006002850
    • Marco S, Skaper SD. Amyloid b-peptide1-42 alters tight junction protein distribution and expression in brain microvessel endothelial cells. Neurosci. Lett. 401(3), 219-224 (2006). (Pubitemid 44250979)
    • (2006) Neuroscience Letters , vol.401 , Issue.3 , pp. 219-224
    • Marco, S.1    Skaper, S.D.2
  • 91
    • 53149133922 scopus 로고    scopus 로고
    • Soluble aggregates of the amyloid-b protein selectively stimulate permeability in human brain microvascular endothelial monolayers
    • Gonzales-Velasques FJ, Kotarek JA, Moss MA. Soluble aggregates of the amyloid-b protein selectively stimulate permeability in human brain microvascular endothelial monolayers. J. Neurochem. 107(2), 466-477 (2008).
    • (2008) J. Neurochem. , vol.107 , Issue.2 , pp. 466-477
    • Gonzales-Velasques, F.J.1    Kotarek, J.A.2    Moss, M.A.3
  • 93
    • 77954711307 scopus 로고    scopus 로고
    • Amyloid-b-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation
    • Tai LM, Holloway KA, Male DK, Loughlin AJ, Romero IA. Amyloid-b-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation. J. Cell. Mol. Med. 14(5), 1101-12 (2010).
    • (2010) J. Cell. Mol. Med. , vol.14 , Issue.5 , pp. 1101-1112
    • Tai, L.M.1    Holloway, K.A.2    Male, D.K.3    Loughlin, A.J.4    Romero, I.A.5
  • 94
    • 3442894794 scopus 로고    scopus 로고
    • Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model
    • DOI 10.1038/sj.mn.7800212
    • Ujiie M, Dickstein DL, Carlow DA, Jefferies WA. Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model. Microcirculation 10(6), 463-470 (2003). (Pubitemid 39004272)
    • (2003) Microcirculation , vol.10 , Issue.6 , pp. 463-470
    • Ujiie, M.1    Dickstein, D.L.2    Carlow, D.A.3    Jefferies, W.A.4
  • 96
    • 60349096101 scopus 로고    scopus 로고
    • Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease
    • Bourasset F, Mélissa O, Tremblay C et al. Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease. Neuropharmacology 56(4), 808-813 (2009).
    • (2009) Neuropharmacology , vol.56 , Issue.4 , pp. 808-813
    • Bourasset, F.1    Mélissa, O.2    Tremblay, C.3
  • 100
    • 0018889221 scopus 로고
    • Thickening of the basement membrane of cortical capillaries in Alzheimer's disease
    • Mancardi GL, Perdelli F, Rivano C, Leonardi A, Bugiani O. Thickening of the basement membrane of cortical capillaries in Alzheimer's disease. Acta Neuropathol. 49(1), 79-83 (1980). (Pubitemid 10139968)
    • (1980) Acta Neuropathologica , vol.49 , Issue.1 , pp. 79-83
    • Mancardi, G.L.1    Perdelli, F.2    Rivano, C.3
  • 103
    • 77954940188 scopus 로고    scopus 로고
    • CNS penetration for small molecule therapeutics do not increase in multiple sclerosis (MS) and Alzheimer's disease (AD) related animal models despite reported blood-brain barrier disruption
    • Cheng Z, Zhang J, Liu H, Li Y, Zhao Y, Yang E. CNS penetration for small molecule therapeutics do not increase in multiple sclerosis (MS) and Alzheimer's disease (AD) related animal models despite reported blood-brain barrier disruption. Drug Metab. Dispos. 38(8), 1355-1361 (2010).
    • (2010) Drug Metab. Dispos. , vol.38 , Issue.8 , pp. 1355-1361
    • Cheng, Z.1    Zhang, J.2    Liu, H.3    Li, Y.4    Zhao, Y.5    Yang, E.6
  • 104
    • 0029583225 scopus 로고
    • Increased collagen content of cerebral microvessels in Alzheimer's disease
    • DOI 10.1016/0006-8993(95)01250-8
    • Kalaria RN, Pax AB. Increased collagen content of cerebral microvessels in Alzheimer's disease. Brain Res. 705(1-2), 349-352 (1995). (Pubitemid 26037378)
    • (1995) Brain Research , vol.705 , Issue.1-2 , pp. 349-352
    • Kalaria, R.N.1    Pax, A.B.2
  • 105
    • 30644465969 scopus 로고    scopus 로고
    • Vascular remodeling versus amyloid β-induced oxidative stress in the cerebrovascular dysfunctions associated with alzheimer's disease
    • DOI 10.1523/JNEUROSCI.4031-05.2005
    • Tong XK, Nicolakakis N, Kocharyan A, Hamel E. Vascular remodeling versus amyloid b-induced oxidative stress in the cerebrovascular dysfunctions associated with Alzheimer's disease. J. Neurosci. 25(4), 11165-11174 (2005). (Pubitemid 43089561)
    • (2005) Journal of Neuroscience , vol.25 , Issue.48 , pp. 11165-11174
    • Tong, X.-K.1    Nicolakakis, N.2    Kocharyan, A.3    Hamel, E.4
  • 107
    • 13844298168 scopus 로고    scopus 로고
    • Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: Initial experience
    • DOI 10.1148/radiol.2343040197
    • Johnson NA, Jahng GH, Weiner MW et al. Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience. Radiology 234(3), 851-859 (2005). (Pubitemid 40250829)
    • (2005) Radiology , vol.234 , Issue.3 , pp. 851-859
    • Johnson, N.A.1    Jahng, G.-H.2    Weiner, M.W.3    Miller, B.L.4    Chui, H.C.5    Jagust, W.J.6    Gorno-Tempini, M.L.7    Schuff, N.8
  • 109
    • 0036176504 scopus 로고    scopus 로고
    • Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein
    • DOI 10.1006/nbdi.2001.0460
    • Niwa K, Kazama K, Younkin SG, Carlson GA, Iadecola C. Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein. Neurobiol. Dis. 9(1), 61-68 (2002). (Pubitemid 34174565)
    • (2002) Neurobiology of Disease , vol.9 , Issue.1 , pp. 61-68
    • Niwa, K.1    Kazama, K.2    Younkin, S.G.3    Carlson, G.A.4    Iadecola, C.5
  • 110
    • 67650097328 scopus 로고    scopus 로고
    • Cortical hypoperfusion in the B6.PS2APP mouse model for Alzheimer's disease: Comprehensive phenotyping of vascular and tissular parameters by MRI
    • Weidensteiner C, Metzger F, Bruns A, Bohrmann B, Kuennecke B, von Kienlin M. Cortical hypoperfusion in the B6.PS2APP mouse model for Alzheimer's disease: comprehensive phenotyping of vascular and tissular parameters by MRI. Magn. Reson. Med. 62(1), 35-45 (2009).
    • (2009) Magn. Reson. Med. , vol.62 , Issue.1 , pp. 35-45
    • Weidensteiner, C.1    Metzger, F.2    Bruns, A.3    Bohrmann, B.4    Kuennecke, B.5    Von Kienlin, M.6
  • 111
    • 0033975029 scopus 로고    scopus 로고
    • Development of an in situ mouse brain perfusion model and its application to mdr1a P-glycoprotein-deficient mice
    • Dagenais C, Rousselle C, Pollack GM, Scherrmann JM. Development of an in situ mouse brain perfusion model and its application to MDR1A P-glycoprotein-deficient mice. J. Cereb. Blood Flow Metab. 20(2), 381-386 (2000). (Pubitemid 30108457)
    • (2000) Journal of Cerebral Blood Flow and Metabolism , vol.20 , Issue.2 , pp. 381-386
    • Dagenais, C.1    Rousselle, C.2    Pollack, G.M.3    Scherrmann, J.-M.4
  • 114
    • 0037526448 scopus 로고    scopus 로고
    • Cerebral and lung kinetics of morphine in conscious sheep after short intravenous infusions
    • DOI 10.1093/bja/aeg131
    • Upton RN, Ludbrook GL, Martinez AM, Grant C, Milne RW. Cerebral and lung kinetics of morphine in conscious sheep after short intravenous infusions Br. J. Anaesth. 90(6), 750-758 (2003). (Pubitemid 36700779)
    • (2003) British Journal of Anaesthesia , vol.90 , Issue.6 , pp. 750-758
    • Upton, R.N.1    Ludbrook, G.L.2    Martinez, A.M.3    Grant, C.4    Milne, R.W.5
  • 115
    • 0034836428 scopus 로고    scopus 로고
    • LRP: A multifunctional scavenger and signaling receptor
    • DOI 10.1172/JCI200113992
    • Herz J, Strickland DK. LRP: a multifunctional scavenger and signalling receptor. J. Clin. Invest. 108(6), 779-784 (2001). (Pubitemid 32880284)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.6 , pp. 779-784
    • Herz, J.1    Strickland, D.K.2
  • 118
    • 67849099661 scopus 로고    scopus 로고
    • Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance and increases brain levels of amyloid-b protein and impairs cognition
    • Jaeger LB, Dohgu S, Hwang MC et al. Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance and increases brain levels of amyloid-b protein and impairs cognition. J. Alz. Dis. 17(3), 553-570 (2009).
    • (2009) J. Alz. Dis. , vol.17 , Issue.3 , pp. 553-570
    • Jaeger, L.B.1    Dohgu, S.2    Hwang, M.C.3
  • 119
    • 77954574985 scopus 로고    scopus 로고
    • Reduction of brain Ab by fluvastatin, an HMG-CoA reductase inhibitor, through increase in degradation of APP-CTFs and Ab clearance
    • Shinohara M, Sato N, Kurinami H et al. Reduction of brain Ab by fluvastatin, an HMG-CoA reductase inhibitor, through increase in degradation of APP-CTFs and Ab clearance. J. Biol. Chem. 285(29) 22091-22102 (2010).
    • (2010) J. Biol. Chem. , vol.285 , Issue.29 , pp. 22091-22102
    • Shinohara, M.1    Sato, N.2    Kurinami, H.3
  • 120
    • 33749157416 scopus 로고    scopus 로고
    • RAGE, LRP-1, and amyloid-b protein in Alzheimer's disease
    • Donahue JE, Flaherty SL, Johanson CE et al. RAGE, LRP-1, and amyloid-b protein in Alzheimer's disease. Acta Neuropathol. 112(4), 405-415 (2006).
    • (2006) Acta Neuropathol. , vol.112 , Issue.4 , pp. 405-415
    • Donahue, J.E.1    Flaherty, S.L.2    Johanson, C.E.3
  • 121
    • 36448976927 scopus 로고    scopus 로고
    • Cerebral clearance of human amyloid-β peptide (1-40) across the blood-brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes
    • DOI 10.1111/j.1471-4159.2007.04938.x
    • Ito S, Ohtsuki S, Kamiie J, Nezu Y, Terasaki T. Cerebral clearance of human amyloid-b peptide 1-40 across the blood-brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes. J. Neurochem. 103(6), 2482-2490 (2007). (Pubitemid 350173573)
    • (2007) Journal of Neurochemistry , vol.103 , Issue.6 , pp. 2482-2490
    • Ito, S.1    Ohtsuki, S.2    Kamiie, J.3    Nezu, Y.4    Terasaki, T.5
  • 122
    • 77951934845 scopus 로고    scopus 로고
    • Lack of brain-to-blood efflux transport activity of low-density lipoprotein receptor-related protein-1 (LRP-1) for amyloid-b peptide 1-40 in mouse: Involvement of an LRP-1-independent pathway
    • Ito S, Ueno T, Ohtsuki S, Terasaki T. Lack of brain-to-blood efflux transport activity of low-density lipoprotein receptor-related protein-1 (LRP-1) for amyloid-b peptide 1-40 in mouse: involvement of an LRP-1-independent pathway. J. Neurochem. 113(5), 1356-1363 (2010).
    • (2010) J. Neurochem. , vol.113 , Issue.5 , pp. 1356-1363
    • Ito, S.1    Ueno, T.2    Ohtsuki, S.3    Terasaki, T.4
  • 124
    • 0033548463 scopus 로고    scopus 로고
    • Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier
    • Fillebeen C, Descamps L, Dehouck MP et al. Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier. J. Biol. Chem. 274(11), 7011-7017 (1999).
    • (1999) J. Biol. Chem. , vol.274 , Issue.11 , pp. 7011-7017
    • Fillebeen, C.1    Descamps, L.2    Dehouck, M.P.3
  • 125
    • 48749095941 scopus 로고    scopus 로고
    • Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2
    • Demeule M, Currie JC, Bertrand Y et al. Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2. J. Neurochem. 106(4), 1534-1544 (2008).
    • (2008) J. Neurochem. , vol.106 , Issue.4 , pp. 1534-1544
    • Demeule, M.1    Currie, J.C.2    Bertrand, Y.3
  • 127
    • 77950563375 scopus 로고    scopus 로고
    • New Angiopep-modified doxorubicin (ANG1007) and etoposide (ANG1009) chemotherapeutics with increased brain penetration
    • Ché C, Yang G, Thiot C, et al. New Angiopep-modified doxorubicin (ANG1007) and etoposide (ANG1009) chemotherapeutics with increased brain penetration. J. Med. Chem. 53(7), 2814-2824 (2010).
    • (2010) J. Med. Chem. , vol.53 , Issue.7 , pp. 2814-2824
    • Ché, C.1    Yang, G.2    Thiot, C.3
  • 128
    • 70350228485 scopus 로고    scopus 로고
    • Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer
    • Thomas FC, Taskar K, Rudraraju V et al. Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer. Pharm. Res. 26(11), 2486-2494 (2009).
    • (2009) Pharm. Res. , vol.26 , Issue.11 , pp. 2486-2494
    • Thomas, F.C.1    Taskar, K.2    Rudraraju, V.3
  • 132
    • 0028851635 scopus 로고
    • The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system
    • Hori O, Brett J, Slattery T et al. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system. J. Biol. Chem. 270(43), 25752-25761 (1995).
    • (1995) J. Biol. Chem. , vol.270 , Issue.43 , pp. 25752-25761
    • Hori, O.1    Brett, J.2    Slattery, T.3
  • 134
    • 74049111316 scopus 로고    scopus 로고
    • Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging
    • Silverberg GD, Miller MC, Messier AA et al. Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging. J. Neuropathol. Exp. Neurol. 69(1), 98-108 (2010).
    • (2010) J. Neuropathol. Exp. Neurol. , vol.69 , Issue.1 , pp. 98-108
    • Silverberg, G.D.1    Miller, M.C.2    Messier, A.A.3
  • 135
    • 54049094343 scopus 로고    scopus 로고
    • Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease
    • Miller MC, Tavares R, Johanson CE et al. Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease. Brain Res. 1230(273-280 (2008)
    • (2008) Brain Res. , vol.1230 , pp. 273-280
    • Miller, M.C.1    Tavares, R.2    Johanson, C.E.3
  • 136
    • 7744223882 scopus 로고    scopus 로고
    • Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: Application to amyloid-β peptide in wild type and Alzheimer's Tg2576 mice
    • DOI 10.1016/j.jneumeth.2004.04.026, PII S0165027004001530
    • LaRue B, Hogg E, Sagare A et al. Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-b peptide in wild type and Alzheimer's Tg2576 mice. J. Neurosci. Methods. 138(1-2), 233-242 (2004). (Pubitemid 39485995)
    • (2004) Journal of Neuroscience Methods , vol.138 , Issue.1-2 , pp. 233-242
    • Larue, B.1    Hogg, E.2    Sagare, A.3    Jovanovic, S.4    Maness, L.5    Maurer, C.6    Deane, R.7    Zlokovic, B.V.8
  • 137
    • 0034693398 scopus 로고    scopus 로고
    • Improved bioavailability to the brain of glycosylated Met-enkephalin analogs
    • Egleton RD, Mitchell SA, Huber JD et al. Improved bioavailability to the brain of glycosylated Met-enkephalin analogs. Brain Res. 881(1), 37-46 (2000).
    • (2000) Brain Res. , vol.881 , Issue.1 , pp. 37-46
    • Egleton, R.D.1    Mitchell, S.A.2    Huber, J.D.3
  • 139
    • 34548278289 scopus 로고    scopus 로고
    • Influence of breast cancer resistance protein (Abcg2) and p-glycoprotein (Abcb1a) on the transport of imatinib mesylate (Gleevec®) across the mouse blood-brain barrier
    • DOI 10.1111/j.1471-4159.2007.04808.x
    • Bihorel S, Camenisch G, Lemaire C, Scherrmann JM. Influence of breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1A) on the transport of imatinib mesylate (Gleevec) across the mouse blood-brain barrier. J. Neurochem. 102(6), 1749-1757 (2007). (Pubitemid 47329285)
    • (2007) Journal of Neurochemistry , vol.102 , Issue.6 , pp. 1749-1757
    • Bihorel, S.1    Camenisch, G.2    Lemaire, M.3    Scherrmann, J.-M.4
  • 140
    • 34250163664 scopus 로고    scopus 로고
    • Modulation of the brain distribution of imatinib and its metabolites in mice by valspodar, zosuquidar and elacridar
    • DOI 10.1007/s11095-007-9278-4
    • Bihorel S, Camenisch G, Lemaire C, Scherrmann JM. Modulation of the brain distribution of imatinib and its metabolites in mice by valspodar, zosuquidar and elacridar. Pharm. Res. 24(9), 1720-1728 (2007). (Pubitemid 47206611)
    • (2007) Pharmaceutical Research , vol.24 , Issue.9 , pp. 1720-1728
    • Bihorel, S.1    Camenisch, G.2    Lemaire, M.3    Scherrmann, J.-M.4
  • 141
    • 4344577850 scopus 로고    scopus 로고
    • In situ transport of vinblastine and selected P-glycoprotein substrates: Implications for drug-drug interactions at the mouse blood-brain barrier
    • DOI 10.1023/B:PHAM.0000036911.49191.da
    • Cisternino S, Rousselle C, Debray M, Scherrmann JM. In situ transport of vinblastine and selected P-glycoprotein substrates: implications for drug-drug interactions at the mouse blood-brain barrier. Pharm. Res. 21(8), 1382-1389 (2004). (Pubitemid 39149652)
    • (2004) Pharmaceutical Research , vol.21 , Issue.8 , pp. 1382-1389
    • Cisternino, S.1    Rousselle, C.2    Debray, M.3    Scherrmann, J.-M.4
  • 142
    • 35548933763 scopus 로고    scopus 로고
    • P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution
    • DOI 10.1124/dmd.107.017723
    • Shaik N, Giri N, Pan G, Elmquist WF. P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution. Drug Metab. Dispos. 35(11), 2076-2085 (2007). (Pubitemid 350005198)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.11 , pp. 2076-2085
    • Shaik, N.1    Giri, N.2    Pan, G.3    Elmquist, W.F.4
  • 143
    • 0035112889 scopus 로고    scopus 로고
    • B-amyloid efflux mediated by p-glycoprotein
    • Lam FC, Liu R, Lu P et al. b-amyloid efflux mediated by p-glycoprotein. J. Neurochem. 76(4), 1121-1128 (2001).
    • (2001) J. Neurochem. , vol.76 , Issue.4 , pp. 1121-1128
    • Lam, F.C.1    Liu, R.2    Lu, P.3
  • 145
    • 2942723107 scopus 로고    scopus 로고
    • The role of P-glycoprotein in cerebral amyloid angiopathy; Implications for the early pathogenesis of Alzheimer's disease
    • Vogelgesang S, Warzok RW, Cascorbi I et al. The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease. Curr. Alzheimer Res. 1(2), 121-125 (2004).
    • (2004) Curr. Alzheimer Res. , vol.1 , Issue.2 , pp. 121-125
    • Vogelgesang, S.1    Warzok, R.W.2    Cascorbi, I.3
  • 146
    • 77951078680 scopus 로고    scopus 로고
    • Restoring blood-brain barrier P-glycoprotein reduces brain Ab in a mouse model of Alzheimer's disease
    • Hartz AM, Miller DS, Bauer B. Restoring blood-brain barrier P-glycoprotein reduces brain Ab in a mouse model of Alzheimer's disease. Mol. Pharmacol. 77(5), 715-723 (2010).
    • (2010) Mol. Pharmacol. , vol.77 , Issue.5 , pp. 715-723
    • Hartz, A.M.1    Miller, D.S.2    Bauer, B.3
  • 150
    • 33750017850 scopus 로고    scopus 로고
    • Functional characterization of the brain-to-blood efflux clearance of human amyloid-b peptide 1-40 across the rat blood-brain barrier
    • Ito S, Ohtsuki S, Terasaki T. Functional characterization of the brain-to-blood efflux clearance of human amyloid-b peptide 1-40 across the rat blood-brain barrier. Neurosci. Res. 56(3), 246-242 (2006).
    • (2006) Neurosci. Res. , vol.56 , Issue.3 , pp. 246-242
    • Ito, S.1    Ohtsuki, S.2    Terasaki, T.3
  • 151
    • 70049084419 scopus 로고    scopus 로고
    • Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: A possible role in progressive neurodegeneration
    • Bartels AL, Kortekaas R, Bart J et al. Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: a possible role in progressive neurodegeneration. Neurobiol. Aging 30(11), 1818-1824 (2009).
    • (2009) Neurobiol. Aging , vol.30 , Issue.11 , pp. 1818-1824
    • Bartels, A.L.1    Kortekaas, R.2    Bart, J.3
  • 152
    • 69249240757 scopus 로고    scopus 로고
    • IC-P3-224: Regional variations in age dependence of P-gp mediated transport across the blood-brain barrier measured using (R)-[11C]verapamil and positron emission tomography
    • van Berckel B, Lubberink M, Luurtsema G, Boellaard R, Lammertsma A. IC-P3-224: Regional variations in age dependence of P-gp mediated transport across the blood-brain barrier measured using (R)-[11C]verapamil and positron emission tomography. Alzheimers Dement. 4(Suppl. 1), T95 (2008).
    • (2008) Alzheimers Dement. , vol.4 , Issue.SUPPL. 1
    • Van Berckel, B.1    Lubberink, M.2    Luurtsema, G.3    Boellaard, R.4    Lammertsma, A.5
  • 153
    • 67649518011 scopus 로고    scopus 로고
    • Alzheimer's disease and blood-brain barrier function - Why have anti-b-amyloid therapies failed to prevent dementia progression?
    • Pahnke J, Walker LC, Scheffler K, Krohn M. Alzheimer's disease and blood-brain barrier function - why have anti-b-amyloid therapies failed to prevent dementia progression? Neurosci. Biobehav. Rev. 33(7), 1099-1108 (2009).
    • (2009) Neurosci. Biobehav. Rev. , vol.33 , Issue.7 , pp. 1099-1108
    • Pahnke, J.1    Walker, L.C.2    Scheffler, K.3    Krohn, M.4
  • 155
    • 65249151331 scopus 로고    scopus 로고
    • Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment
    • Lagas JS, Van Waterschoot RA, van Tilburg VA et al. Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment. Clin. Cancer Res. 15(7), 2344-2351 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.7 , pp. 2344-2351
    • Lagas, J.S.1    Van Waterschoot, R.A.2    Van Tilburg, V.A.3
  • 156
    • 65649142529 scopus 로고    scopus 로고
    • ABCG2 is upregulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Ab1-40 peptides
    • Xiong H, Callaghan D, Jones A et al. ABCG2 is upregulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Ab1-40 peptides. J. Neurosci. 29(17), 5463-5475 (2009).
    • (2009) J. Neurosci. , vol.29 , Issue.17 , pp. 5463-5475
    • Xiong, H.1    Callaghan, D.2    Jones, A.3
  • 157
    • 0141790752 scopus 로고    scopus 로고
    • 217βG) across the blood-brain barrier
    • DOI 10.1023/A:1025749925541
    • Sugiyama D, Kusuhara H, Lee YJ, Sugiyama Y. Involvement of multidrug resistance associated protein 1 (MRP1) in the efflux transport of 17b estradiol-d-17b-glucuronide (E217bG) across the blood-brain barrier. Pharm. Res. 20(9), 1394-1400 (2003). (Pubitemid 37164047)
    • (2003) Pharmaceutical Research , vol.20 , Issue.9 , pp. 1394-1400
    • Sugiyama, D.1    Kusuhara, H.2    Lee, Y.-J.3    Sugiyama, Y.4
  • 158
    • 11144261790 scopus 로고    scopus 로고
    • Oxidatively modified GST and MRP1 in Alzheimer's disease brain: Implications for accumulation of reactive lipid peroxidation products
    • DOI 10.1007/s11064-004-7028-0
    • Sultana R, Butterfield DA. Oxidatively modified GST and MRP1 in Alzheimer's disease brain: implications for accumulation of reactive lipid peroxidation products. Neurochem. Res. 29(12), 2215-2220 (2004). (Pubitemid 40036893)
    • (2004) Neurochemical Research , vol.29 , Issue.12 , pp. 2215-2220
    • Sultana, R.1    Butterfield, D.A.2
  • 159
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
    • DOI 10.1126/science.274.5284.99
    • Hsiao K, Chapman P, Nilsen S et al. Correlative memory deficits, Ab elevation, and amyloid plaques in transgenic mice. Science 274(5284), 99-102 (1996). (Pubitemid 26332733)
    • (1996) Science , vol.274 , Issue.5284 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6    Yang, F.7    Cole, G.8
  • 160
    • 0028810244 scopus 로고
    • Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins
    • Hsiao KK, Borchelt DR, Olson K et al. Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron 15(5), 1203-1218 (1995).
    • (1995) Neuron , vol.15 , Issue.5 , pp. 1203-1218
    • Hsiao, K.K.1    Borchelt, D.R.2    Olson, K.3
  • 163
    • 0034870813 scopus 로고    scopus 로고
    • Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease
    • DOI 10.1006/nbdi.2001.0402
    • Poduslo JF, Curran GL, Wengenack TM, Malester B, Duff K. Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 8(4), 555-567 (2001). (Pubitemid 32758660)
    • (2001) Neurobiology of Disease , vol.8 , Issue.4 , pp. 555-567
    • Poduslo, J.F.1    Curran, G.L.2    Wengenack, T.M.3    Malester, B.4    Duff, K.5
  • 165
    • 0030875698 scopus 로고    scopus 로고
    • Age-related changes in barrier function in mouse brain. II. Accumulation of serum albumin in the olfactory bulb of SAM mice increased with aging
    • DOI 10.1016/S0167-4943(97)00022-8, PII S0167494397000228
    • Ueno M, Akiguchi I, Hosokawa M et al. Age-related changes in barrier function in mouse brain II. Accumulation of serum albumin in the olfactory bulb of SAM mice increased with aging. Arch. Gerentol. Geriatr. 25(3), 321-331 (1997). (Pubitemid 27450397)
    • (1997) Archives of Gerontology and Geriatrics , vol.25 , Issue.3 , pp. 321-331
    • Ueno, M.1    Akiguchi, I.2    Hosokawa, M.3    Shinnou, M.4    Sakamoto, H.5    Takemura, M.6    Higuchi, K.7
  • 166
    • 0027301454 scopus 로고
    • Age-related changes in barrier function in mouse brain I. Accelerated age-related increase of brain transfer of serum albumin in accelerated senescence prone SAM-P/8 mice with deficits in learning and memory
    • DOI 10.1016/0167-4943(93)90035-G
    • Ueno M, Akiguchi I, Yagi H et al. Age-related changes in barrier function in mouse brain I. Accelerated age-related increase of brain transfer of serum albumin in accelerated senescence prone SAM-P/8 mice with deficits in learning and memory. Arch. Gerentol. Geriatr. 16(3), 233-248 (1993). (Pubitemid 23224633)
    • (1993) Archives of Gerontology and Geriatrics , vol.16 , Issue.3 , pp. 233-248
    • Ueno, M.1    Akiguchi, I.2    Yagi, H.3    Naiki, H.4    Fujibayashi, Y.5    Kimura, J.6    Takeda, T.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.