Blood-brain barrier integrity in Alzheimer's disease patients and elderly control subjects

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 10, Issue 1, 1998, Pages 78-84

  Caserta, Maria T ^a   Caccioppo, Daniel ^b   Lapin, Gregory D ^b   Ragin, Ann ^b   Groothuis, Dennis R ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; MEGLUMINE IOTALAMATE;

AGED; ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DATA ANALYSIS; EXTRACELLULAR SPACE; FEMALE; HUMAN; MALE; PRIORITY JOURNAL;

EID: 0031894903     PISSN: 08950172     EISSN: None     Source Type: Journal    
DOI: 10.1176/jnp.10.1.78     Document Type: Article

References (46)

1. Strittmatter WJ, Roses AD: Apolipoprotein E and Alzheimer disease. Proc Natl Acad Sci USA 1995; 92:4725-4727
2. St. George-Hyslop PH, Tangi RE, Polinsky RJ, et al: The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science 1987; 235:885-890
3. Rogaev EI, Sherrington R, Rogaeva EA, et al: Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 1995; 376:775-778
4. Schellenberg GD, Bird TD, Wijsman EM, et al: Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 1992; 258:668-671
5. Mullan M, Houlden H, Windelspecht M, et al: A locus for familial early onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1 antichymotrypsin gene. Nat Genet 1992; 2:340-342
6. Bush AI, Pettingell WH, Multhaup G, et al: Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 1995; 265:1464-1467
7. Kalaria RN: The immunopathology of Alzheimer's disease and some related disorders. Brain Pathol 1993; 3:333-347
8. Meier-Ruge W, Bertoni-Freddari C, Iwangoff P: Changes in brain glucose metabolism as a key to the pathogenesis of Alzheimer's disease. Gerontol 1994; 40:246-252
9. Price DL, Borchelt DR, Sisodia SS: Alzheimer disease and the prion disorders β-amyloid protein and prion protein amyloidoses. Proc Natl Acad Sci USA 1993; 90:6381-6384
10. Itzhaki RF: Possible factors in the etiology of Alzheimer's disease. Mol Neurobiol 1994; 9:1-13
11. Wong CW, Quaranta V, Glenner CG: Neuritic plaques and cerebrovascular amyloid in Alzheimer's disease are antigenically related. Proc Natl Acad Sci USA 1985; 82:8729-8732
12. Kang J, Lemaire HG, Unterbeck A, et al: The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987; 325:733-736
13. Kalaria RN: The blood-brain barrier and cerebral microcirculation in Alzheimer disease. Cerebrovascular Brain Metabolism Review 1992; 4:226-260
14. Freidland RP, Yano Y, Budinger TF, et al: Quantitative evaluation of blood-brain barrier integrity in Alzheimer type dementia: positron emission tomographic studies with rubidium-82. Eur Neurol 1983; 22(suppl 2):15-20
15. 68Ga]EDTA and positron emission tomography. J Cereb Blood Flow Metab 1987; 7:1-8
16. McKhann G, Drachman D, Folstein M, et al: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984; 34:939-944
17. Folstein M, Folstein S, McHugh PR: "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189-198
18. Corbel H, Domoto K, Nobel K, et al: Interdisciplinary approach to the development of a cognitive screening test for the institutionalized elderly. Presented to the Gerontological Society of America, San Francisco, CA, 1983
19. Groothuis DR, Vriesendorp FJ, Lapin GD, et al: Quantitative measurement of transcapillary transport of iodinated compounds in canine brain tumors with computed tomography. J Cereb Blood Flow Metab 1991; 11:939-948
20. Groothuis DR, Vriesendorp FJ, Kupfer B, et al: Quantitative measurements of capillary transport in human brain tumors by computed tomography. Ann Neurol 1991; 30:581-588
21. Lapin DG, Allen CA, Groothuis DR: Noninvasive measurement of arterial blood plasma concentration of iodinated contrast agents from CT scans of human brain. J Comput Assist Tomogr 1994; 18:363-369
22. Perlmutter LS: Microvascular pathology and vascular basement membrane components in Alzheimer's disease. Mol Neurobiol 1994; 9:33-40
23. Vinters HV, Secor DL, Read SL, et al: Microvasculature in brain biopsy specimens from patients with Alzheimer's disease: an immunohistochemical and ultrastructural study. Ultrastruct Pathol 1994; 18:333-348
24. Buee L, Hof PR, Bouras C, et al: Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders. Acta Neuropathol 1994; 87:469-480
25. Claudio L: Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients. Acta Neuropathol 1996; 91:6-14
26. Kalaria RN, Hedera P: Differential degeneration of the cerebral microvasculature in Alzheimer's disease. NeuroReport 1995; 6:477-480
27. Perlmutter LS, Myers MA, Barron E: Vascular basement membrane components and the lesions of Alzheimer's disease: light and electron microscopic analyses. Microsc Res Tech 1994; 28:204-215
28. Roher AE, Lowenson JD, Clarke S, et al: Beta-amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc Natl Acad Sci USA 1993; 90:10836-10840
29. Behrouz N, Defossez A, Delacourte A, et al: The immunohistochemical evidence of amyloid diffuse deposits as a pathological hallmark in Alzheimer's disease. J Gerontol Biol Sci 1991; 46:B209-B212
30. Eikelenboom P, Stam FC: Neuroimmunological mechanisms in cerebral amyloid deposition in Alzheimer's disease, in Frontiers of Alzheimer Research, edited by Ishii T. Amsterdam, Elsevier, 1991, pp 259-271
31. Rozemuller JM, Eikelenboom P, Kamphorst W, et al: Lack of evidence for dysfunction of the blood-brain barrier in Alzheimer's disease: an immunohistochemical study. Neurobiol Aging 1988; 9:383-391
32. Frolich L, Kornhuber J, Ihl R, et al: Integrity of the blood-CSF barrier in dementia of Alzheimer type: CSF/serum ratios of albumin and IgG. Eur Arch Psychiatry Clin Neurosci 1991; 240:363-366
33. Mattila KM, Pirttila T, Blennow K, et al: Altered blood-brain-barrier function in Alzheimer's disease? Acta Neurol Scand 1994; 89:192-198
34. Wood JH: Physiology, pharmacology, and dynamics of cerebrospinal fluid, in Neurobiology of Cerebrospinal Fluid, edited by Wood JH. New York, Plenum, 1980, pp 1-16
35. Arai H, Sagi N, Noguchi I, et al: An immunohistochemical study of β-protein in Alzheimer-type dementia brains. J Neurol 1989; 236:214-217
36. Miyakawa T, Shomoji A, Kuramoto R, et al: The relationship between senile plaques and cerebral blood vessels in Alzheimer's disease and senile dementia. Virchows Archiv Path 1982; 40:121-129
37. Lippa CF, Hamos JE, Smith TW, et al: Vascular amyloid deposition in Alzheimer's disease: neither necessary nor sufficient for the local formation of plaques or tangles. Arch Neurol 1993; 50:1088-1092
38. Luthert PJ, Williams JA: A quantitative study of the coincidence of blood vessels and A4 protein deposits in Alzheimer's disease. Neurosci Lett 1991; 126:110-112
39. Wisniewski HM, Frackowiak J, Zoltowska AS, et al: Vascular β-amyloid in Alzheimer's disease angiopathy is produced by proliferating and degenerating smooth muscle cells. Int J Exp Clin Invest 1994; 1:8-16
40. Gandy S, Greengard P: Processing of Alzheimer A β-amyloid precursor protein: cell biology, regulation, and role in Alzheimer disease. Int Rev Neurobiol 1994; 36:29-50
41. Selkoe DJ: Cell biology of the amyloid β-protein precursor and the mechanism of Alzheimer's disease. Annu Rev Cell Biol 1994; 10:373-403
42. Maness LM, Banks WA, Podlisny MB, et al: Passage of human amyloid beta-protein 1-40 across the murine blood-brain barrier. Life Sci 1994; 55:1643-1650
43. Zlokovic BV, Ghiso J, Mackic JB, et al: Blood-brain barrier transport of circulating Alzheimer's amyloid beta. Biochem Biophys Res Comm 1993; 197:1034-1040
44. Zlokovic BV, Martel CL, Mackic JB, et al: Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta. Biochem Biophys Res Commun 1994; 205:1431-1437
45. Roses AD: Apolipoprotein E affects the rate of Alzheimer disease expression: β-amyloid burden is a secondary consequence dependent upon APOE genotype and duration of disease. J Neuropathol Exp Neurol 1994; 53:429-437
46. Selkoe DJ: Alzheimer's disease: a central role for amyloid. J Neuropathol Exp Neurol 1994; 53:438-447