Hepatocyte basolateral membrane organic anion transporters

The Liver: Biology and Pathobiology

Volumn , Issue , 2009, Pages 305-321

  Choi, Jo H ^a,b   Murray, John W ^a,b   Wolkoff, Allan W ^a,b  

^a MARION BESSIN LIVER RESEARCH CENTER   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79954472473     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470747919.ch21     Document Type: Chapter

References (144)

1. Scharschmidt, B.F., Waggoner, J.G. and Berk, P.D. (1975) Hepatic organic anion uptake in the rat. J Clin Invest, 56, 1280-92.
2. Stollman, Y.R., Gartner, U., Theilmann, L., Ohmi, N. and Wolkoff, A.W. (1983) Hepatic bilirubin uptake in the isolated perfused rat liver is not facilitated by albumin binding. J Clin Invest, 72, 718-23.
3. Inoue, M., Hirata, E., Morino, Y., Nagase, S., Chowdhury, J.R., Chowdhury, N.R. and Arias, I.M. (1985) The role of albumin in the hepatic transport of bilirubin: studies in mutant analbuminemic rats. J Biochem, 97, 737-43.
4. Goresky, C.A. (1963) A linear method for determining liver sinusoidal and extravascular volumes. Am J Physiol, 204, 626-40.
5. Grisham, J.W., Nopanitaya, W., Compagno, J. and Nagel, A.E.H. (2000) Scanning electron microscopy of normal rat liver: the surface structure of its cells and tissue components. Am J Anat, 144, 295-322.
6. Zucker, S.D., Goessling, W. and Gollan, J.L. (1995) Kinetics of bilirubin transfer between serum albumin and membrane vesicles. J Biol Chem, 270, 1074-81.
7. Meier, P.J. (1995) Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile. Am J Physiol, 269, 801-12.
8. Hagenbuch, B. and Meier, P.J. (1996) Sinusoidal (basolateral) bile salt uptake systems of hepatocytes. Semin Liver Dis, 16, 129-36.
9. Boyer, J.L. and Meier, P.J. (1990) Characterizing mechanisms of hepatic bile acid transport utilizing isolated membrane vesicles. Meth Enzymol, 192, 517-33.
10. Duffy, M.C., Blitzer, B.L. and Boyer, J.L. (1983) Direct determination of the driving forces for taurocholate uptake into rat liver plasma membrane vesicles. J Clin Invest, 72, 1470-81.
11. Meier, P.J. and Boyer, J.L. (1990) Preparation of basolateral (sinusoidal) and canalicular plasma membrane vesicles for the study of hepatic transport processes. Meth Enzymol, 192, 534-45.
12. Reichen, J. and Paumgartner, G. (1976) Uptake of bile acids by perfused rat liver. Am J Physiol, 231, 734-42.
13. Gilmore, I.T. and Thompson, R.P. (1978) Kinetics of 14C-glycocholic acid clearance in normal man and in patients with liver disease. Gut, 19, 1110-15.
14. Clayton, L.M., Gurantz, D., Hofmann, A.F., Hagey, L.R. and Schteingart, C.D. (1989) Role of bile acid conjugation in hepatic transport of dihydroxy bile acids. J Pharmacol Exp Ther, 248, 1130-37.
15. Meier, P.J. and Stieger, B. (2002) Bile salt transporters. Annu Rev Physiol, 64, 635-61.
16. Meier, P.J., Eckhardt, U., Schroeder, A., Hagenbuch, B. and Stieger, B. (1997) Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology, 26, 1667-77.
17. Hardison, W.G., Bellentani, S., Heasley, V. and Shellhamer, D. (1984) Specificity of an Na+-dependent taurocholate transport site in isolated rat hepatocytes. Am J Physiol, 246, 477-83.
18. Hardison, W.G.M., Heasley, V.L. and Shellhamer, D.F. (1991) Specificity of the hepatocyte Na+-dependent taurocholate transporter: Influence of side chain length and charge. Hepatology, 13, 68-72.
19. Hata, S., Wang, P., Eftychiou, N., Ananthanarayanan, M., Batta, A., Salen, G., Pang, K.S. and Wolkoff, A.W. (2003) Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake. Am J Physiol Gastrointest Liver Physiol, 285, 829-39.
20. Hagenbuch, B.M. and Meier, P.J. (1996) Sinusoidal (basolateral) bile salt uptake systems of hepatocytes. Semin Liver Dis, 16, 129-36.
21. Kramer, W., Stengelin, S., Baringhaus, K.H., Enhsen, A., Heuer, H., Becker, W., Corsiero, D., Girbig, F., Noll, R. and Weyland, C. (1999) Substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transporters. J Lipid Res, 40, 1604-17.
22. Baringhaus, K.H., Matter, H., Stengelin, S. and Kramer, W. (1999) Substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters of the rabbit. II. A reliable 3D QSAR pharmacophore model for the ileal Na(+)/bile acid cotransporter. J Lipid Res, 40, 2158-68.
23. Blitzer, B.L. and Lyons, L. (1985) Enhancement of Na+-dependent bile acid uptake by albumin: direct demonstration in rat basolateral liver plasma membrane vesicles. Am J Physiol, 249, 34-38.
24. Lidofsky, S.D., Fitz, J.G., Weisiger, R.A. and Scharschmidt, B.F. (1993) Hepatic taurocholate uptake is electrogenic and influenced by transmembrane potential difference. Am J Physiol, 264, 478-85.
25. Weinman, S.A. and Weeks, R.P. (1993) Electrogenicity of Na-coupled bile salt transport in isolated rat hepatocytes. Am J Physiol, 265, 73-80.
26. Hagenbuch, B., Stieger, B., Foguet, M., Lubbert, H. and Meier, P.J. (1991) Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc Natl Acad Sci U S A, 88, 10629-33.
27. Love, M.W. and Dawson, P.A. (1998) New insights into bile acid transport. Curr Opin Lipidol, 9, 225-29.
28. Hardikar, W., Ananthanarayanan, M. and Suchy, F.J. (1995) Differential ontogenic regulation of basolateral and canalicular bile acid transport proteins in rat liver. J Biol Chem, 270, 20841-46.
29. Hallen, S., Mareninova, O., Branden, M. and Sachs, G. (2002) Organization of the membrane domain of the human liver sodium/bile acid cotransporter. Biochemistry, 41, 7253-66.
30. Mareninova, O., Shin, J.M., Vagin, O., Turdikulova, S., Hallen, S. and Sachs, G. (2005) Topography of the membrane domain of the liver Na+-dependent bile acid transporter. Biochemistry, 44, 13702-12.
31. Hagenbuch, B. and Meier, P.J. (1994) Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter. J Clin Invest, 93, 1326-31.
32. Cohn, M.A., Rounds, D.J., Karpen, S.J., Ananthanarayanan, M. and Suchy, F.J. (1995) Assignment of a rat liver Na+/bile acid cotransporter gene to chromosome 6q24. Mamm Genome, 6, 60.
33. Cattori, V., Eckhardt, U. and Hagenbuch, B. (1999) Molecular cloning and functional characterization of two alternatively spliced Ntcp isoforms from mouse liver1. Biochim Biophys Acta, 1445, 154-59.
34. Hagenbuch, B., Scharschmidt, B.F. and Meier, P.J. (1996) Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes. Biochem J, 316, 901-4.
35. Wolkoff, A.W. and Cohen, D.E. (2003) Bile acid regulation of hepatic physiology: I. Hepatocyte transport of bile acids. Am J Physiol Gastrointest Liver Physiol, 284, 175-79.
36. Gordon, N. and Newton, R.W. (2003) Glucose transporter type1 (GLUT-1) deficiency. Brain Dev, 25, 477-80.
37. De Vivo, D.C., Wang, D., Pascual, J.M. and Ho, Y.Y. (2002) Glucose transporter protein syndromes. Int Rev Neurobiol, 51, 259-88.
38. Martin, M.G., Lostao, M.P., Turk, E., Lam, J., Kreman, M. and Wright, E.M. (1997) Compound missense mutations in the sodium/D-glucose cotransporter result in trafficking defects. Gastroenterology, 112, 1206-12.
39. Dawson, P.A., Haywood, J., Craddock, A.L., Wilson, M., Tietjen, M., Kluckman, K., Maeda, N. and Parks, J.S. (2003) Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice. J Biol Chem, 278, 33920-27.
40. Oelkers, P., Kirby, L.C., Heubi, J.E. and Dawson, P.A. (1997) Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). J Clin Invest, 99, 1880-87.
41. Wong, M.H., Oelkers, P. and Dawson, P.A. (1995) Identification of a mutation in the ileal sodiumdependent bile acid transporter gene that abolishes transport activity. J Biol Chem, 270, 27228-34.
42. De, L.V., Ginter, C.S. and Carrasco, N. (2004) The Q267E mutation in the sodium/iodide symporter (NIS) causes congenital iodide transport defect (ITD) by decreasing the NIS turnover number. J Cell Sci, 117, 677-87.
43. Pascual, J.M., Wang, D., Lecumberri, B., Yang, H., Mao, X., Yang, R. and De Vivo, D.C. (2004) GLUT1 deficiency and other glucose transporter diseases. Eur J Endocrinol, 150, 627-33.
44. Fujiwara, H., Tatsumi, K., Tanaka, S., Kimura, M., Nose, O. and Amino, N. (2000) A novel V59E missense mutation in the sodium iodide symporter gene in a family with iodide transport defect. Thyroid, 10, 471-74.
45. Ho, R.H., Leake, B.F., Roberts, R.L., Lee, W. and Kim, R.B. (2004) Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition. J Biol Chem, 279, 7213-22.
46. Meerman, L., Koopen, N.R., Bloks, V. van, Goor, H., Havinga, R., Wolthers, B.G., Kramer, W., Stengelin, S., Muller, M., Kuipers, F. and Jansen, P.L. (1999) Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyria. Gastroenterology, 117, 696-705.
47. Gartung, C., Ananthanarayanan, M., Rahman, M.A., Schuele, S., Nundy, S., Soroka, C.J., Stolz, A., Suchy, F.J. and Boyer, J.L. (1996) Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology, 110, 199-209.
48. Boyer, J.L., Hagenbuch, B., Ananthanarayanan, M., Suchy, F., Stieger, B. and Meier, P.J. (1993) Phylogenic and ontogenic expression of hepatocellular bile acid transport. Proc Natl Acad Sci U S A, 90, 435-38.
49. Suchy, F.J., Bucuvalas, J.C., Goodrich, A.L., Moyer, M.S. and Blitzer, B.L. (1986) Taurocholate transport and Na+-K+-ATPase activity in fetal and neonatal rat liver plasma membrane vesicles. Am J Physiol, 251, 665-73.
50. Kouzuki, H., Suzuki, H., Stieger, B., Meier, P.J. and Sugiyama, Y. (2000) Characterization of the transport properties of organic anion transporting polypeptide 1 (oatp1) and Na+/taurocholate cotransporting polypeptide (ntcp): comparative studies on the inhibitory effect of their possible substrates in hepatocytes and cDNA-transfected COS-7 cells. J Pharm Exper Ther, 292, 505-11.
51. Schroeder, A., Eckhardt, U., Stieger, B., Tynes, R., Schteingart, C.D., Hofmann, A.F., Meier, P.J. and Hagenbuch, B. (1998) Substrate specificity of the rat Na+-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells. Am J Physiol, 274, 370-75.
52. Platte, H.D., Honscha, W., Schuh, K. and Petzinger, E. (1996) Functional characterization of the hepatic sodium-dependent taurocholate transporter stably transfected into an immortalized liver-derived cell line and V79 fibroblasts. Eur J Cell Biol, 70, 54-60.
53. Karpen, S.J., Sun, A.-Q., Kudish, B., Hagenbuch, B., Meier, P.J., Ananthanarayanan, M. and Suchy, F.J. (1996) Multiple factors regulate the rat liver basolateral sodium-dependent bile acid cotransporter gene promoter. J Biol Chem, 271, 15211-21.
54. Geier, A., Martin, I.V., Dietrich, C.G., Balasubramaniyan, N., Strauch, S., Suchy, F.J., Gartung, C., Trautwein, C. and Ananthanarayanan, M. (2008) Hepatocyte nuclear factor 4 is a central transactivator of the mouse Ntcp gene. Am J Physiol Gastrointest Liver Physiol, 295, 226-33.
55. Trauner, M., Arrese, M., Lee, H., Boyer, J.L. and Karpen, S.J. (1998) Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J Clin Invest, 101, 2092-100.
56. Anwer, M.S. (2004) Cellular regulation of hepatic bile acid transport in health and cholestasis. Hepatology, 39, 581-90.
57. Botham, K.M. and Suckling, K.E. (1986) The effect of dibutyryl cyclic AMP on the uptake of taurocholic acid by isolated rat liver cells. Biochim Biophys Acta, 883, 26-32.
58. Grune, S., Engelking, L.R. and Anwer, M.S. (1993) Role of intracellular calcium and protein kinases in the activation of hepatic Na+/taurocholate cotransport by cyclic AMP. J Biol Chem, 268, 17734-41.
59. Mukhopadhayay, S., Ananthanarayanan, M., Stieger, B., Meier, P.J., Suchy, F.J. and Anwer, M.S. (1997) cAMP increases liver Na+-taurocholate cotransport by translocating transporter to plasma membranes. Am J Physiol, 273, 842-48.
60. Sarkar, S., Bananis, E., Nath, S., Anwer, M.S., Wolkoff, A.W. and Murray, J.W. (2006) PKC ζ is required for microtubule-based motility of vesicles containing the ntcp transporter. Traffic, 7, 1078-91.
61. Mukhopadhyay, S., Ananthanarayanan, M., Stieger, B., Meier, P.J., Suchy, F.J. and Anwer, M.S. (1998) Sodium taurocholate cotransporting polypeptide is a serine, threonine phosphoprotein and is dephosphorylated by cyclic adenosine monophosphate. Hepatology, 28, 1629-36.
62. Mukhopadhyay, S., Webster, C.R.L. and Anwer, M.S. (1998) Role of protein phosphatases in cyclic AMPmediated stimulation of hepatic Na+/tauro-cholate cotransport. J Biol Chem, 273, 30039-45.
63. Dranoff, J.A., McClure, M., Burgstahler, A.D., Denson, L.A., Crawford, A.R., Crawford, J.M., Karpen, S.J. and Nathanson, M.H. (1999) Short-term regulation of bile acid uptake by microfilament-dependent translocation of rat ntcp to the plasma membrane. Hepatology, 30, 223-29.
64. Murray, J.W., Bananis, E. and Wolkoff, A.W. (2000) Reconstitution of ATP-dependent movement of endocytic vesicles along microtubules in vitro: an oscillatory bidirectional process. Mol Biol Cell, 11, 419-33.
65. Bananis, E., Murray, J.W., Stockert, R.J., Satir, P. and Wolkoff, A.W. (2000) Microtubule and motor-dependent endocytic vesicle sorting in vitro. J Cell Biol, 151, 179-86.
66. Bananis, E., Nath, S., Gordon, K., Satir, P., Stockert, R.J., Murray, J.W. and Wolkoff, A.W. (2004) Microtubule-dependent movement of late endocytic vesicles in vitro: requirements for Dynein and Kinesin. Mol Biol Cell, 15, 3688-97.
67. Murray, J.W. and Wolkoff, A.W. (2005) Assay of Rab4-dependent trafficking on microtubules. Methods Enzymol, 403, 92-107.
68. Webster, C.R., Srinivasulu, U., Ananthanarayanan, M., Suchy, F.J. and Anwer, M.S. (2002) Protein kinase B/Akt mediates cAMP- and cell swelling-stimulated Na+/taurocholate cotransport and Ntcp translocation. J Biol Chem, 277, 28578-83.
69. McConkey, M., Gillin, H., Webster, C.R. and Anwer, M.S. (2004) Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes. J Biol Chem, 279, 20882-88.
70. Webster, C.R.L. and Anwer, M.S. (1999) Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver ntcp. Am J Physiol, 277, 1165-72.
71. Kullak-Ublick, G.A., Stieger, B. and Meier, P.J. (2004) Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology, 126, 322-42.
72. Trauner, M. and Boyer, J.L. (2003) Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev, 83, 633-71.
73. Lee, J.M., Trauner, M., Soroka, C.J., Stieger, B., Meier, P.J. and Boyer, J.L. (2000) Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology, 118, 163-72.
74. Lee, J. and Boyer, J.L. (2000) Molecular alterations in hepatocyte transport mechanisms in acquired cholestatic liver disorders. Semin Liver Dis, 20, 373-84.
75. Dumont, M., Jacquemin, E., D’Hont, C., Descout, C., Cresteil, D., Haouzi, D., Desrochers, M., Stieger, B. and Hadchouel, M. (1997) Expression of the liver Na+-independent organic anion transporting polypeptide (oatp-1) in rats with bile duct ligation. J Hepatol, 27, 1051-56.
76. Cleland, D.P., Bartholomew, T.C. and Billing, B.H. (1984) Hepatic transport of sulfated and nonsulfated bile acids in the rat following relief of bile duct obstruction. Hepatology, 4, 477-85.
77. Fricker, G., Landmann, L. and Meier, P.J. (1989) Extrahepatic obstructive cholestasis reverses the bile salt secretory polarity of rat hepatocytes. J Clin Invest, 84, 876-85.
78. Baumgartner, U., Scholmerich, J., Weitzel, C., Ihling, C., Sellinger, M., Lohle, E., Ruf, G., Gerok, W. and Farthmann, E.H. (1995) Pattern of bile acid regurgitation and metabolism during perfusion of the bile duct obstructed rat liver. J Hepatol, 22, 208-18.
79. Green, R.M., Gollan, J.L., Hagenbuch, B., Meier, P.J. and Beier, D.R. (1997) Regulation of hepatocyte bile salt transporters during hepatic regeneration. Am J Physiol, 273, 621-27.
80. Gerloff, T., Geier, A., Stieger, B., Hagenbuch, B., Meier, P.J., Matern, S. and Gartung, C. (1999) Differential expression of basolateral and canalicular organic anion transporters during regeneration of rat liver. Gastroenterology, 117, 1408-15.
81. Vos, T.A., Ros, J.E., Havinga, R., Moshage, H., Kuipers, F., Jansen, P.L.M. and Müller, M. (1999) Regulation of hepatic transport systems involved in bile secretion during liver regeneration in rats. Hepatology, 29, 1833-39.
82. von Dippe, P., Amoui, M., Alves, C. and Levy, D. (1993) Na+-dependent bile acid transport by hepatocytes is mediated by a protein similar to microsomal epoxide hydrolase. Am J Physiol, 264, 528-34.
83. von Dippe, P., Amoui, M., Stellwagen, R.H. and Levy, D. (1996) The functional expression of sodium-dependent bile acid transport in Madin-Darby canine kidney cells transfected with the cDNA for microsomal epoxide hydrolase. J Biol Chem, 271, 18176-80.
84. Zhu, Q., von Dippe, P., Xing, W. and Levy, D. (1999) Membrane topology and cell surface targeting of microsomal epoxide hydrolase. Evidence for multiple topological orientations. J Biol Chem, 274, 27898-904.
85. Zhu, Q.S., Xing, W., Qian, B., von Dippe, P., Shneider, B.L., Fox, V.L. and Levy, D. (2003) Inhibition of human m-epoxide hydrolase gene expression in a case of hypercholanemia. Biochim Biophys Acta, 1638, 208-16.
86. von Dippe, P., Zhu, Q.S. and Levy, D. (2003) Cell surface expression and bile acid transport function of one topological form of m-epoxide hydrolase. Biochem Biophys Res Commun, 309, 804-9.
87. Honscha, W., Platte, H.D., Oesch, F. and Friedberg, T. (1995) Relationship between the microsomal epoxide hydrolase and the hepatocellular transport of bile acids and xenobiotics. Biochem J, 311, 975-79.
88. Altin, J.G. and Pagler, E.B. (1995) A one-step procedure for biotinylation and chemical cross-linking of lymphocyte surface and intracellular membraneassociated molecules. Anal Biochem, 224, 382-89.
89. Min, A.D., Johansen, K.J., Campbell, C.G. and Wolkoff, A.W. (1991) Role of chloride and intracellular pH on the activity of the rat hepatocyte organic anion transporter. J Clin Invest, 87, 1496-502.
90. Stremmel, W., Gerber, M.A., Glezerov, V., Thung, S.N., Kochwa, S. and Berk, P.D. (1983) Physicochemical and immunohistological studies of a sulfobromophthalein- and bilirubin-binding protein from rat liver plasma membranes. J Clin Invest, 71, 1796-805.
91. Stremmel, W. and Berk, P.D. (1986) Hepatocellular uptake of sulfobromophthalein and bilirubin is selectively inhibited by an antibody to the liver plasma membrane sulfobromophthalein/bilirubin binding protein. J Clin Invest, 78, 822-26.
92. Mullock, B.M., Branch, W.J., van Schaik, M., Gilbert, L.K. and Luzio, J.P. (1989) Reconstitution of an endosome-lysosome interaction in a cell-free system. J Cell Pharmacol, 108, 2093-99.
93. Wolkoff, A.W. and Chung, C.T. (1980) Identification, purification, and partial characterization of an organic anion binding protein from rat liver cell plasma membrane. J Clin Invest, 65, 1152-61.
94. Goeser, T., Nakata, R., Braly, L.F., Sosiak, A., Campbell, C.G., Dermietzel, R., Novikoff, P.M., Stockert, R.J., Burk, R.D. and Wolkoff, A.W. (1990) The rat hepatocyte plasma membrane organic anion binding protein is immunologically related to the mitochondrial F1 adenosine triphosphatase beta-subunit. J Clin Invest, 86, 220-27.
95. Sottocasa, G.L., Baldini, G., Sandri, G., Lunazzi, G. and Tiribelli, C. (1982) Reconstitution in vitro of sulfobromophthalein transport by bilitranslocase. Biochim Biophys Acta, 685, 123-28.
96. Battiston, L., Passamonti, S., Macagno, A. and Sottocasa, G.L. (1998) The bilirubin-binding motif of bilitranslocase and its relation to conserved motifs in ancient biliproteins. Biochem Biophys Res Commun, 247, 687-92.
97. Battiston, L., Macagno, A., Passamonti, S., Micali, F. and Sottocasa, G.L. (1999) Specific sequence-directed anti-bilitranslocase antibodies as a tool to detect potentially bilirubin-binding proteins in different tissues of the rat. FEBS Lett, 453, 351-55.
98. Jacquemin, E., Hagenbuch, B., Stieger, B., Wolkoff, A.W. and Meier, P.J. (1991) Expression of the hepatocellular chloride-dependent sulfobromophthalein uptake system in Xenopus laevis oocytes. J Clin Invest, 88, 2146-49.
99. Jacquemin, E., Hagenbuch, B., Stieger, B., Wolkoff, A.W. and Meier, P.J. (1994) Expression cloning of a rat liver Na+-independent organic anion transporter. Proc Natl Acad Sci U S A, 91, 133-37.
100. Wolkoff, A.W. (1996) Hepatocellular sinusoidal membrane organic anion transport and transporters. Semin Liver Dis, 16, 121-27.
101. Hagenbuch, B. and Meier, P.J. (2003) The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta, 1609, 1-18.
102. Hagenbuch, B. and Meier, P.J. (2004) Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch, 447, 653-65.
103. Konig, J., Seithel, A., Gradhand, U. and Fromm, M.F. (2006) Pharmacogenomics of human OATP transporters. Naunyn Schmiedebergs Arch Pharmacol, 372, 432-43.
104. Evers, R. and Chu, X. (2008) Perspective: role of the murine organic-anion transporting polypeptide 1b2 (oatp1b2) in drug disposition and hepatoxicity (relates to article by Zaher et al., FastForward 15 April 08). Mol Pharmacol, 74, 309-11.
105. Stockert, R.J., Potvin, B., Nath, S., Wolkoff, A.W. and Stanley, P. (2007) New liver cell mutants defective in the endocytic pathway. Biochim Biophys Acta, 1768, 1741-49.
106. Chen, C., Stock, J.L., Liu, X., Shi, J., Van Deusen, J.W., Dimattia, D.A., Dullea, R.G. and Morais, S.M. (2008) Utility of the oatp1b2 knockout mouse model for evaluating the role of oatp1b2 in the hepatic uptake of model compounds. Drug Metab Dispos, 36, 1840-45.
107. Zaher, H., Meyer Zu Schwabedissen, H.E., Tirona, R.G., Cox, M.L., Obert, L.A., Agrawal, N., Palandra, J., Stock, J.L., Kim, R.B. and Ware, J.A. (2008) Targeted disruption of murine organic anion-transporting polypeptide 1b2 (oatp1b2/Slco1b2) significantly alters disposition of prototypical drug substrates pravastatin and rifampin. Mol Pharmacol, 74, 320-29.
108. Lu, H., Choudhuri, S., Ogura, K., Csanaky, I.L., Lei, X., Cheng, X., Song, P.Z. and Klaassen, C.D. (2008) Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicol Sci, 103, 35-45.
109. Link, E., Parish, S., Armitage, J., Bowman, L., Heath, S., Matsuda, F., Gut, I., Lathrop, M. and Collins, R. (2008) SLCO1B1 variants and statin-induced myopathy-a genomewide study. N Engl J Med, 359, 789-99.
110. Ho, R.H., Choi, L., Lee, W., Mayo, G., Schwarz, U.I., Tirona, R.G., Bailey, D.G., Michael, S.C. and Kim, R.B. (2007) Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participants. Pharmacogenet Genomics, 17, 647-56.
111. Choi, J.H., Lee, M.G., Cho, J.Y., Lee, J.E., Kim, K.H. and Park, K. (2008) Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans. Clin Pharmacol Ther, 83, 251-57.
112. Ieiri, I., Suwannakul, S., Maeda, K., Uchimaru, H., Hashimoto, K., Kimura, M., Fujino, H., Hirano, M., Kusuhara, H., Irie, S., Higuchi, S. and Sugiyama, Y. (2007) SLCO1B1 (OATP1B1, an uptake transporter) and ABCG2 (BCRP, an efflux transporter) variant alleles and pharmacokinetics of pitavastatin in healthy volunteers. Clin Pharmacol Ther, 82, 541-47.
113. Zhang, W., Chen, B.L., Ozdemir, V., He, Y.J., Zhou, G., Peng, D.D., Deng, S., Xie, Q.Y., Xie, W., Xu, L.Y., Wang, L.C., Fan, L., Wang, A. and Zhou, H.H. (2007) SLCO1B1 521T-->C functional genetic polymorphism and lipid-lowering efficacy of multiple-dose pravastatin in Chinese coronary heart disease patients. Br J Clin Pharmacol, 64, 346-52.
114. Kivisto, K.T. and Niemi, M. (2007) Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans. Pharm Res, 24, 239-47.
115. Wang, P., Hata, S., Xiao, Y., Murray, J.W. and Wolkoff, A.W. (2008) Topological assessment of oatp1a1: a 12 transmembrane domain integral membrane protein with three N-linked carbohydrate chains. Am J Physiol Gastrointest Liver Physiol, 294, 1052-59.
116. Bergwerk, A.J., Shi, X., Ford, A.C., Kanai, N., Jacquemin, E., Burk, R.D., Bai, S., Novikoff, P.M., Stieger, B., Meier, P.J., Schuster, V.L. and Wolkoff, A.W. (1996) Immunologic distribution of an organic anion transport protein in rat liver and kidney. Am J Physiol, 271, 231-38.
117. Radanovic, T., Gisler, S.M., Biber, J. and Murer, H. (2006) Topology of the type IIa Na+/P(i) cotransporter. J Membr Biol, 212, 41-49.
118. Angeletti, R.H., Novikoff, P.M., Juvvadi, S., Fritschy, J.-M., Meier, P.J. and Wolkoff, A.W. (1997) The choroid plexus epithelium is the site of the organic anion transport protein in the brain. Proc Natl Acad Sci U S A, 94, 283-86.
119. Angeletti, R.H., Bergwerk, A.J., Novikoff, P.M. and Wolkoff, A.W. (1998) Dichotomous development of the organic anion transport protein in liver and choroid plexus. Am J Physiol, 275, 882-87.
120. Sheng, M. and Sala, C. (2001) PDZ domains and the organization of supramolecular complexes. Annu Rev Neurosci, 24, 1-29.
121. Hung, A.Y. and Sheng, M. (2002) PDZ domains: structural modules for protein complex assembly. J Biol Chem, 277, 5699-702.
122. Kim, E. and Sheng, M. (2004) PDZ domain proteins of synapses. Nat Rev Neurosci, 5, 771-81.
123. Wang, P., Wang, J.J., Xiao, Y., Murray, J.W., Novikoff, P.M., Angeletti, R.H., Orr, G.A., Lan, D., Silver, D.L. and Wolkoff, A.W. (2005) Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 (OATP1A1) on the hepatocyte surface. J Biol Chem, 280, 30143-49.
124. Kullak-Ublick, G.-A., Hagenbuch, B., Stieger, B., Wolkoff, A.W. and Meier, P.J. (1994) Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Hepatology, 20, 411-16.
125. Kanai, N., Lu, R., Bao, Y., Wolkoff, A.W., Vore, M. and Schuster, V.L. (1996) Estradiol 17βD-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am J Physiol, 270, 326-31.
126. Kanai, N., Lu, R., Bao, Y., Wolkoff, A.W. and Schuster, V.L. (1996) Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am J Physiol, 270, 319-25.
127. Cvetkovic, M., Leake, B., Fromm, M.F., Wilkinson, G.R. and Kim, R.B. (1999) Oatp and p-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Disp, 27, 866-71.
128. Shi, X., Bai, S., Ford, A.C., Burk, R.D., Jacquemin, E., Hagenbuch, B., Meier, P.J. and Wolkoff, A.W. (1995) Stable inducible expression of a functional rat liver organic anion transport protein in HeLa Cells. J Biol Chem, 270, 25591-95.
129. Satlin, L.M., Amin, V. and Wolkoff, A.W. (1997) Organic anion transporting polypeptide mediates organic anion/HCO3-exchange. J Biol Chem, 272, 26340-45.
130. Li, L., Lee, T.K., Meier, P.J. and Ballatori, N. (1998) Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. J Biol Chem, 273, 16184-91.
131. Chan, B.S., Satriano, J.A., Pucci, M. and Schuster, V.L. (1998) Mechanism of prostaglandin E2 transport across the plasma membrane of HeLa cells and Xenopus oocytes expressing the prostaglandin transporter “PGT”. J Biol Chem, 273, 6689-97.
132. Gartner, U., Stockert, R.J., Morell, A.G. and Wolkoff, A.W. (1981) Modulation of the transport of bilirubin and asialoorosomucoid during liver regeneration. Hepatology, 1, 99-106.
133. Oleaga, A., Gonzalez, J. and Esteller, A. (1987) Effects of two-thirds hepatectomy on sulfobromophthalein handling by the rat liver. Comp Biochem Physiol A, 87, 13-19.
134. Ziegler, K., Lins, W. and Frimmer, M. (1991) Hepatocellular transport of cyclosomatostatins: evidence for a carrier system related to the multispecific bile acid transporter. Biochim Biophys Acta, 1061, 287-96.
135. Dubuisson, C., Cresteil, D., Desrochers, M., Decimo, D., Hadchouel, M. and Jacquemin, E. (1996) Ontogenic expression of the Na+-independent organic anion transporting polypeptide (oatp) in rat liver and kidney. J Hepatol, 25, 932-40.
136. Yan, C., Costa, R.H., Darnell, J.E.J., Chen, J.D. and Van Dyke, T.A. (1990) Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice. EMBO J, 9, 869-78.
137. Lund, M., Kang, L., Tygstrup, N., Wolkoff, A.W. and Ott, P. (1999) Effects of LPS on transport of indocyanine green and alanine uptake in perfused rat liver. Am J Physiol, 277, G91-G100.
138. Simon, F.R., Fortune, J., Iwahashi, M., Gartung, C., Wolkoff, A.W. and Sutherland, E. (1996) Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters. Am J Physiol, 271, 1043-52.
139. Zollner, G., Marschall, H.U., Wagner, M. and Trauner, M. (2006) Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. Mol Pharm, 3, 231-51.
140. Cai, S.Y. and Boyer, J.L. (2006) FXR: a target for cholestatic syndromes? Expert Opin Ther Targets, 10, 409-21.
141. Chen, J. and Raymond, K. (2006) Nuclear receptors, bile-acid detoxification, and cholestasis. Lancet, 367, 454-56.
142. Campbell, C.G., Spray, D.C. and Wolkoff, A.W. (1993) Extracellular ATP4-modulates organic anion transport by rat hepatocytes. J Biol Chem, 268, 15399-404.
143. Glavy, J.S., Wu, S.M., Wang, P.J., Orr, G.A. and Wolkoff, A.W. (2000) Down-regulation by extracellular ATP of rat hepatocyte organic anion transport is mediated by serine phosphorylation of oatp1. J Biol Chem, 275, 1479-84.
144. Xiao, Y., Nieves, E., Angeletti, R.H., Orr, G.A. and Wolkoff, A.W. (2006) Rat organic anion transporting protein 1A1 (Oatp1a1): purification and phosphopeptide assignment. Biochemistry, 45, 3357-69.