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Volumn 28, Issue 11, 2007, Pages 2398-2403

Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis

Author keywords

[No Author keywords available]

Indexed keywords

GLUCURONOSYLTRANSFERASE 1A6; N BUTYL N (4 HYDROXYBUTYL)NITROSAMINE; PROTEIN BAX; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; TRANSCRIPTION FACTOR NRF2;

EID: 36148977625     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgm146     Document Type: Article
Times cited : (74)

References (34)
  • 1
    • 0014188061 scopus 로고
    • Organotropic carcinogenic effects of 65 various N-nitroso-compounds on BD rats
    • Druckrey,H. et al. (1967) Organotropic carcinogenic effects of 65 various N-nitroso-compounds on BD rats. Z. Krebsforsch., 69, 103-201.
    • (1967) Z. Krebsforsch , vol.69 , pp. 103-201
    • Druckrey, H.1
  • 3
    • 0017615412 scopus 로고
    • Metabolic fate of N-n-butyl-N (4-hydroxybutyl)- introsamine and its analogues. Selective induction of urinary bladder tumours in the rat
    • Okada,M. et al. (1977) Metabolic fate of N-n-butyl-N (4-hydroxybutyl)- introsamine and its analogues. Selective induction of urinary bladder tumours in the rat. Xenobiotica, 7, 11-24.
    • (1977) Xenobiotica , vol.7 , pp. 11-24
    • Okada, M.1
  • 4
    • 0014557091 scopus 로고
    • Histogenesis of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats
    • Ito,N. et al. (1969) Histogenesis of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats. Gann, 60, 401-410.
    • (1969) Gann , vol.60 , pp. 401-410
    • Ito, N.1
  • 5
    • 0023759438 scopus 로고
    • Pharmacokinetic profile and metabolism of N-nitrosobutyl-(4-hydroxybutyl)amine in rats
    • Bonfanti,M. et al. (1988) Pharmacokinetic profile and metabolism of N-nitrosobutyl-(4-hydroxybutyl)amine in rats. Cancer Res., 48, 3666-3669.
    • (1988) Cancer Res , vol.48 , pp. 3666-3669
    • Bonfanti, M.1
  • 6
    • 0028172493 scopus 로고
    • Detection of O6-butyl- and O6-(4-hydroxybutyl)-guanine in urothelial and hepatic DNA of rats given the bladder carcinogen N-nitrosobutyl (4-hydroxybutyl) amine
    • Airoldi,L. et al. (1994) Detection of O6-butyl- and O6-(4-hydroxybutyl)-guanine in urothelial and hepatic DNA of rats given the bladder carcinogen N-nitrosobutyl (4-hydroxybutyl) amine. Carcinogenesis, 10, 2297-2301.
    • (1994) Carcinogenesis , vol.10 , pp. 2297-2301
    • Airoldi, L.1
  • 7
    • 0016309277 scopus 로고
    • In vitro neoplastic transformation of epithelial cells of rat urinary bladder by nitrosamines
    • Hashimoto,Y et al. (1974) In vitro neoplastic transformation of epithelial cells of rat urinary bladder by nitrosamines. Nature 252, 497-499.
    • (1974) Nature , vol.252 , pp. 497-499
    • Hashimoto, Y.1
  • 8
    • 4644328941 scopus 로고    scopus 로고
    • Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis
    • Iida,K. et al. (2004) Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. Cancer Res., 64, 6424-6431.
    • (2004) Cancer Res , vol.64 , pp. 6424-6431
    • Iida, K.1
  • 9
    • 0025894713 scopus 로고
    • p53 mutations in human cancers
    • Hollstein,M. et al. (1991) p53 mutations in human cancers. Science, 253, 49-53.
    • (1991) Science , vol.253 , pp. 49-53
    • Hollstein, M.1
  • 10
    • 0036258111 scopus 로고    scopus 로고
    • The IARC TP53 database: New online mutation analysis and recommendations to users
    • Olivier,M. et al. (2002) The IARC TP53 database: New online mutation analysis and recommendations to users. Hum. Mutat., 19 607-614.
    • (2002) Hum. Mutat , vol.19 , pp. 607-614
    • Olivier, M.1
  • 11
    • 0028051625 scopus 로고
    • Accumulation of nuclear p53 and tumor progression in bladder cancer
    • Esrig,D. et al. (1994) Accumulation of nuclear p53 and tumor progression in bladder cancer. N. Engl. J. Med., 331, 1259-1264.
    • (1994) N. Engl. J. Med , vol.331 , pp. 1259-1264
    • Esrig, D.1
  • 12
    • 0027411102 scopus 로고
    • Detection of p53 mutations in superficial (T1) bladder carcinomas as a marker of disease progression
    • Sarkis,A.S. et al. (1993) Detection of p53 mutations in superficial (T1) bladder carcinomas as a marker of disease progression. J. Natl. Cancer Inst., 85, 53-59.
    • (1993) J. Natl. Cancer Inst , vol.85 , pp. 53-59
    • Sarkis, A.S.1
  • 13
    • 0037228782 scopus 로고    scopus 로고
    • Allelic loss of p53 gene is associated with genesis and maintenance, but not invasion, of mouse carcinoma in situ of the bladder
    • Cheng,J. et al. (2003) Allelic loss of p53 gene is associated with genesis and maintenance, but not invasion, of mouse carcinoma in situ of the bladder. Cancer Res., 63, 179-185.
    • (2003) Cancer Res , vol.63 , pp. 179-185
    • Cheng, J.1
  • 14
    • 0028036255 scopus 로고    scopus 로고
    • Spruck,C.H.III et al. (1994) Two molecular pathways to transitional cell carcinoma of the bladder. Cancer Res., 54, 784-788.
    • Spruck,C.H.III et al. (1994) Two molecular pathways to transitional cell carcinoma of the bladder. Cancer Res., 54, 784-788.
  • 15
    • 17644448277 scopus 로고    scopus 로고
    • High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele
    • Ozaki,K et al. (1998) High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele. Cancer Res., 58, 3806-3811.
    • (1998) Cancer Res , vol.58 , pp. 3806-3811
    • Ozaki, K.1
  • 16
    • 0042330074 scopus 로고
    • Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:qUinone oxidoreductase 1 gene: Reassessment of the ARE consensus sequence
    • Nioi,P. et al. (1993) Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:qUinone oxidoreductase 1 gene: Reassessment of the ARE consensus sequence. Biochem. J., 374, 337-348.
    • (1993) Biochem. J , vol.374 , pp. 337-348
    • Nioi, P.1
  • 17
    • 0031000208 scopus 로고    scopus 로고
    • Functional antioxidant responsive elements
    • Wasserman, W.W. et al. (1997) Functional antioxidant responsive elements. Proc. Natl Acad. Sci. USA, 94, 5361-5366.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 5361-5366
    • Wasserman, W.W.1
  • 18
    • 0025948113 scopus 로고
    • The antioxidant responsive element
    • Rushtnore,T.H. et al. (1991) The antioxidant responsive element. J. Biol. Chem., 266, 11632-11639.
    • (1991) J. Biol. Chem , vol.266 , pp. 11632-11639
    • Rushtnore, T.H.1
  • 19
    • 0029043995 scopus 로고
    • Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins
    • Itoh,K. et al. (1995) Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins. Mol. Cell. Biol., 15, 4184-4193.
    • (1995) Mol. Cell. Biol , vol.15 , pp. 4184-4193
    • Itoh, K.1
  • 20
    • 0028061444 scopus 로고
    • Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region
    • Moi,P. et al. (1994) Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc. Natl Acad. Sci. USA, 91, 9926-9930.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 9926-9930
    • Moi, P.1
  • 21
    • 0029906134 scopus 로고    scopus 로고
    • Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:qUinone oxidoreductase1 gene
    • Venugopal,R. et al. (1996) Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:qUinone oxidoreductase1 gene. Proc. Natl Acad. Sci. USA, 93, 14960-14965.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 14960-14965
    • Venugopal, R.1
  • 22
    • 0031577292 scopus 로고    scopus 로고
    • An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
    • Itoh,K. et al. (1997) An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun., 236, 313-322.
    • (1997) Biochem. Biophys. Res. Commun , vol.236 , pp. 313-322
    • Itoh, K.1
  • 23
    • 0018234365 scopus 로고
    • Syntheses of N-alkyl-N (omega-carboxyalkyl)nitrosamines related to N-butyl-N (3-carboxypropyl)nitrosamine, principal urinary metabolite of a potent bladder carcinogen N-butyl-N-(4-hydroxybutyl) nitrosamine
    • Okada,M. et al. (1978) Syntheses of N-alkyl-N (omega-carboxyalkyl)nitrosamines related to N-butyl-N (3-carboxypropyl)nitrosamine, principal urinary metabolite of a potent bladder carcinogen N-butyl-N-(4-hydroxybutyl) nitrosamine. Chem. Pharm. Bull., 26, 3909-3913.
    • (1978) Chem. Pharm. Bull , vol.26 , pp. 3909-3913
    • Okada, M.1
  • 24
    • 0018123868 scopus 로고
    • Induction of tumors in heterotopic bladder by topical application of N-methyl-N-nitrosourea and N butyl-N-(3-carboxypropyl) nitrosamine
    • Oyasu,R. et al. (1978) Induction of tumors in heterotopic bladder by topical application of N-methyl-N-nitrosourea and N butyl-N-(3-carboxypropyl) nitrosamine. Cancer Res., 38 3019-3025.
    • (1978) Cancer Res , vol.38 , pp. 3019-3025
    • Oyasu, R.1
  • 25
    • 0035153227 scopus 로고    scopus 로고
    • High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression, of ARE-regulated drug metabolizing enzymes and antioxidant genes
    • Enomoto,A. et al. (2001) High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression, of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol. Sci., 59, 169-177.
    • (2001) Toxicol. Sci , vol.59 , pp. 169-177
    • Enomoto, A.1
  • 26
    • 0035969989 scopus 로고    scopus 로고
    • Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1
    • Asher,G. et al. (2001) Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1. Proc. Natl Acad. Sci. USA, 98, 1188-1193.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 1188-1193
    • Asher, G.1
  • 27
    • 0028069445 scopus 로고
    • Participation of cytochrome P450-2B and -2D isozymes in the demethylenation of methylenedioxymethamphetamine enantiomers by rats
    • Kumagai,Y. et al. (1994) Participation of cytochrome P450-2B and -2D isozymes in the demethylenation of methylenedioxymethamphetamine enantiomers by rats. Mol. Pharmacol., 45, 359-365.
    • (1994) Mol. Pharmacol , vol.45 , pp. 359-365
    • Kumagai, Y.1
  • 28
    • 28644447272 scopus 로고    scopus 로고
    • The antioxidant function of the p53 tumor suppressor
    • Sablina,A.A., et al. (2005) The antioxidant function of the p53 tumor suppressor. Nat. Med., 11, 1306-1313.
    • (2005) Nat. Med , vol.11 , pp. 1306-1313
    • Sablina, A.A.1
  • 29
    • 33645508531 scopus 로고    scopus 로고
    • Chronic inflammation: A common and important factor in the pathogenesis of neoplasia
    • Schottenfeld,D., et al. (2006) Chronic inflammation: A common and important factor in the pathogenesis of neoplasia. CA Cancer J. Clin. 56, 69-93.
    • (2006) CA Cancer J. Clin , vol.56 , pp. 69-93
    • Schottenfeld, D.1
  • 30
    • 1342344820 scopus 로고    scopus 로고
    • The role of oxidative stress in carcinogenesis
    • Klaunig,J.E. et al. (2004) The role of oxidative stress in carcinogenesis. Annu. Rev. Pharmacol. Toxicol., 44, 239-267.
    • (2004) Annu. Rev. Pharmacol. Toxicol , vol.44 , pp. 239-267
    • Klaunig, J.E.1
  • 31
    • 0028842645 scopus 로고
    • Cellular responses to DNA damage: Cell-cycle checkpoints, apoptosis and the roles of p53 and ATM
    • Enoch,T. et al. (1995) Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM. Trends Biochem. Sci., 20, 426-430.
    • (1995) Trends Biochem. Sci , vol.20 , pp. 426-430
    • Enoch, T.1
  • 32
    • 33846000687 scopus 로고    scopus 로고
    • p53 suppresses the Nrf2-dependent transcription of antioxidant response genes
    • Faraonio,R. et al. (2006) p53 suppresses the Nrf2-dependent transcription of antioxidant response genes. J. Biol. Chem., 281, 39776-39784.
    • (2006) J. Biol. Chem , vol.281 , pp. 39776-39784
    • Faraonio, R.1
  • 33
    • 0032473917 scopus 로고    scopus 로고
    • Activation of protein kinase C delta by the c-Abl tyrosine kinase in response to ionizing radiation
    • Yuan,Z.M. et al. (1998) Activation of protein kinase C delta by the c-Abl tyrosine kinase in response to ionizing radiation. Oncogene 16, 1643-1648.
    • (1998) Oncogene , vol.16 , pp. 1643-1648
    • Yuan, Z.M.1
  • 34
    • 3543084994 scopus 로고    scopus 로고
    • Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta
    • Li,B. et al. (2004) Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta. Genes Dev. 18, 1824-1837.
    • (2004) Genes Dev , vol.18 , pp. 1824-1837
    • Li, B.1


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