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Volumn 591, Issue 1-2, 2005, Pages 93-102

Nrf2 as a target for cancer chemoprevention

Author keywords

Chemoprevention; Keap1; Nrf2; Phase 2 enzymes; Transcription factors

Indexed keywords

ACTIN BINDING PROTEIN; ANTIOXIDANT; CARCINOGEN; CHAPERONE; COMPLEMENTARY DNA; CYCLOOXYGENASE 2 INHIBITOR; DITHIOL DERIVATIVE; DITHIOLETHIONE DERIVATIVE; GLUTATHIONE TRANSFERASE; ISOTHIOCYANIC ACID DERIVATIVE; OLTIPRAZ; PROTEASOME; PROTEIN KEAP1; SULFORAPHANE; TOBACCO SMOKE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

EID: 27844612530     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2005.04.017     Document Type: Article
Times cited : (200)

References (49)
  • 2
    • 0000147542 scopus 로고    scopus 로고
    • Recent advances in chemoprevention of cancer
    • M.B. Sporn, and W.K. Hong Recent advances in chemoprevention of cancer Science 278 1997 1073 1077
    • (1997) Science , vol.278 , pp. 1073-1077
    • Sporn, M.B.1    Hong, W.K.2
  • 3
    • 0023871977 scopus 로고
    • Glutathione S-transferase Ya subunit gene: Identification of regulatory elements required for basal level and inducible expression
    • C.A. Telakowski-Hopkins, R.G. King, and C.B. Pickett Glutathione S-transferase Ya subunit gene: identification of regulatory elements required for basal level and inducible expression Proc. Natl. Acad. Sci. U.S.A. 85 1988 1000 1004
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 1000-1004
    • Telakowski-Hopkins, C.A.1    King, R.G.2    Pickett, C.B.3
  • 5
    • 0027365542 scopus 로고
    • Isolation of cDNA encoding the human NF-E2 protein
    • J.Y. Chan, X.L. Han, and Y.W. Kan Isolation of cDNA encoding the human NF-E2 protein Proc. Natl. Acad. Sci. U.S.A. 90 1993 11366 11370
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 11366-11370
    • Chan, J.Y.1    Han, X.L.2    Kan, Y.W.3
  • 6
    • 0027360226 scopus 로고
    • Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast
    • J.Y. Chan, X.L. Han, and Y.W. Kan Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast Proc. Natl. Acad. Sci. U.S.A. 90 1993 11371 11375
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 11371-11375
    • Chan, J.Y.1    Han, X.L.2    Kan, Y.W.3
  • 7
    • 0029043995 scopus 로고
    • Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins
    • K. Itoh, K. Igarashi, N. Hayashi, M. Nishizawa, and M. Yamamoto Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins Mol. Cell. Biol. 15 1995 4184 4193
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4184-4193
    • Itoh, K.1    Igarashi, K.2    Hayashi, N.3    Nishizawa, M.4    Yamamoto, M.5
  • 9
    • 0029906134 scopus 로고    scopus 로고
    • Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene
    • R. Venugopal, and A.K. Jaiswal Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene Proc. Natl. Acad. Sci. U.S.A. 93 1996 14960 14965
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 14960-14965
    • Venugopal, R.1    Jaiswal, A.K.2
  • 11
    • 0033584867 scopus 로고    scopus 로고
    • Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2
    • A.C. Wild, H.R. Moinova, and R.T. Mulcahy Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2 J. Biol. Chem. 274 1999 33627 33636
    • (1999) J. Biol. Chem. , vol.274 , pp. 33627-33636
    • Wild, A.C.1    Moinova, H.R.2    Mulcahy, R.T.3
  • 12
    • 0033546686 scopus 로고    scopus 로고
    • Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element
    • H.R. Moinova, and R.T. Mulcahy Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element Biochem. Biophys. Res. Commun. 261 1999 661 668
    • (1999) Biochem. Biophys. Res. Commun. , vol.261 , pp. 661-668
    • Moinova, H.R.1    Mulcahy, R.T.2
  • 13
    • 0033543566 scopus 로고    scopus 로고
    • Nrf2, a Cap'n' collar transcription factor, regulates induction of the heme oxygenase-1 gene
    • J. Alam, D. Stewart, C. Toughzrd, S. Boinapally, A.M. Choi, and J.L. Cook Nrf2, a Cap'n' collar transcription factor, regulates induction of the heme oxygenase-1 gene J. Biol. Chem. 274 1999 26071 26078
    • (1999) J. Biol. Chem. , vol.274 , pp. 26071-26078
    • Alam, J.1    Stewart, D.2    Toughzrd, C.3    Boinapally, S.4    Choi, A.M.5    Cook, J.L.6
  • 14
    • 0038663090 scopus 로고    scopus 로고
    • Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 cells
    • L.M. Zipper, and R.T. Mulcahy Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 cells Toxicol. Sci. 73 2003 124 134
    • (2003) Toxicol. Sci. , vol.73 , pp. 124-134
    • Zipper, L.M.1    Mulcahy, R.T.2
  • 15
    • 0037424262 scopus 로고    scopus 로고
    • Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival
    • M.K. Kwak, N. Wakabayashi, K. Itoh, H. Motohashi, M. Yamamoto, and T.W. Kensler Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival J. Biol. Chem. 278 2003 8135 8145
    • (2003) J. Biol. Chem. , vol.278 , pp. 8135-8145
    • Kwak, M.K.1    Wakabayashi, N.2    Itoh, K.3    Motohashi, H.4    Yamamoto, M.5    Kensler, T.W.6
  • 16
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, K. Igarashi, and M. Yamamoto Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain Genes Dev. 13 1999 76 86
    • (1999) Genes Dev. , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarashi, K.5    Yamamoto, M.6
  • 17
    • 0037821802 scopus 로고    scopus 로고
    • Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
    • M. McMahon, K. Itoh, M. Yamamoto, and J.D. Hayes Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression J. Biol. Chem. 278 2003 21592 21600
    • (2003) J. Biol. Chem. , vol.278 , pp. 21592-21600
    • McMahon, M.1    Itoh, K.2    Yamamoto, M.3    Hayes, J.D.4
  • 18
    • 0037015035 scopus 로고    scopus 로고
    • Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    • A.T. Dinkova-Kostova, W.D. Holtzclaw, R.N. Cole, K. Itoh, and N. Wakabayashi Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants Proc. Natl. Acad. Sci. U.S.A. 99 2002 11908 11913
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 11908-11913
    • Dinkova-Kostova, A.T.1    Holtzclaw, W.D.2    Cole, R.N.3    Itoh, K.4    Wakabayashi, N.5
  • 19
    • 13044304201 scopus 로고    scopus 로고
    • Nrf2 is essential for protection against acute pulmonary injury in mice
    • K. Chan, and Y.W. Kan Nrf2 is essential for protection against acute pulmonary injury in mice Proc. Natl. Acad. Sci. U.S.A. 96 1999 12731 12736
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 12731-12736
    • Chan, K.1    Kan, Y.W.2
  • 21
    • 0037044791 scopus 로고    scopus 로고
    • Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
    • H.C. Huang, T. Nguyen, and C.B. Pickett Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription J. Biol. Chem. 277 2002 42769 42774
    • (2002) J. Biol. Chem. , vol.277 , pp. 42769-42774
    • Huang, H.C.1    Nguyen, T.2    Pickett, C.B.3
  • 22
    • 0013282861 scopus 로고    scopus 로고
    • Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26S proteasome
    • T. Nguyen, P.J. Sherratt, H.C. Huang, C.S. Yang, and C.B. Pickett Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26S proteasome J. Biol. Chem. 278 2003 4536 4541
    • (2003) J. Biol. Chem. , vol.278 , pp. 4536-4541
    • Nguyen, T.1    Sherratt, P.J.2    Huang, H.C.3    Yang, C.S.4    Pickett, C.B.5
  • 23
    • 0037356451 scopus 로고    scopus 로고
    • Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice
    • M. Ramos-Gomez, P.M. Dolan, K. Itoh, M. Yamamoto, and T.W. Kensler Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice Carcinogenesis 24 2003 461 467
    • (2003) Carcinogenesis , vol.24 , pp. 461-467
    • Ramos-Gomez, M.1    Dolan, P.M.2    Itoh, K.3    Yamamoto, M.4    Kensler, T.W.5
  • 24
    • 0034704079 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism
    • R. Yu, C. Chen, Y.Y. Mo, V. Hebbar, E.D. Owuor, T.H. Tan, and A.N. Kong Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism J. Biol. Chem. 275 2000 39907 39913
    • (2000) J. Biol. Chem. , vol.275 , pp. 39907-39913
    • Yu, R.1    Chen, C.2    Mo, Y.Y.3    Hebbar, V.4    Owuor, E.D.5    Tan, T.H.6    Kong, A.N.7
  • 25
    • 0034687543 scopus 로고    scopus 로고
    • Inhibition of ERK and p38 MAP kinases inhibits binding of Nrf2 and induction of GCS genes
    • L.M. Zipper, and R.T. Mulcahy Inhibition of ERK and p38 MAP kinases inhibits binding of Nrf2 and induction of GCS genes Biochem. Biophys. Res. Commun. 278 2000 484 492
    • (2000) Biochem. Biophys. Res. Commun. , vol.278 , pp. 484-492
    • Zipper, L.M.1    Mulcahy, R.T.2
  • 27
    • 0035827505 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma
    • J.-M. Lee, M.J. Hanson, W.A. Chu, and J.A. Johnson Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma Cells J. Biol. Chem. 276 2001 20011 20016
    • (2001) Cells J. Biol. Chem. , vol.276 , pp. 20011-20016
    • Lee, J.-M.1    Hanson, M.J.2    Chu, W.A.3    Johnson, J.A.4
  • 28
    • 3142570440 scopus 로고    scopus 로고
    • The Pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress
    • T. Nguyen, C.S. Yang, and C.B. Pickett the Pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress Free Radic. Biol. Med. 37 2004 433 441
    • (2004) Free Radic. Biol. Med. , vol.37 , pp. 433-441
    • Nguyen, T.1    Yang, C.S.2    Pickett, C.B.3
  • 29
    • 0036240610 scopus 로고    scopus 로고
    • Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: Role of antioxidant response element-like sequences in the nrf2 promoter
    • M.-K. Kwak, K. Itoh, M. Yamamoto, and T.W. Kensler Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter Mol. Cell. Biol. 22 2002 2883 2892
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 2883-2892
    • Kwak, M.-K.1    Itoh, K.2    Yamamoto, M.3    Kensler, T.W.4
  • 30
    • 0242721624 scopus 로고    scopus 로고
    • Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway
    • M.-K. Kwak, N. Wakabayashi, J.L. Greenlaw, M. Yamamoto, and T.W. Kensler Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway Mol. Cell. Biol. 23 2003 8786 8794
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8786-8794
    • Kwak, M.-K.1    Wakabayashi, N.2    Greenlaw, J.L.3    Yamamoto, M.4    Kensler, T.W.5
  • 31
    • 0037016759 scopus 로고    scopus 로고
    • Microarray analysis reveals an antioxidant responsive element-driven gene set involved in conferring protection from an oxidative stress-induced apoptosis in IMR-32 cells
    • J. Li, J.M. Lee, and J.A. Johnson Microarray analysis reveals an antioxidant responsive element-driven gene set involved in conferring protection from an oxidative stress-induced apoptosis in IMR-32 cells J. Biol. Chem. 277 2002 388 394
    • (2002) J. Biol. Chem. , vol.277 , pp. 388-394
    • Li, J.1    Lee, J.M.2    Johnson, J.A.3
  • 33
    • 0035260034 scopus 로고    scopus 로고
    • Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent 3H-1,2-dithiol-3-thione
    • M.-K. Kwak, K. Itoh, M. Yamamoto, T.R. Sutter, and T.W. Kensler Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent 3H-1,2-dithiol-3-thione Mol. Med. 7 2001 135 145
    • (2001) Mol. Med. , vol.7 , pp. 135-145
    • Kwak, M.-K.1    Itoh, K.2    Yamamoto, M.3    Sutter, T.R.4    Kensler, T.W.5
  • 34
    • 0034717329 scopus 로고    scopus 로고
    • Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
    • T. Ishii, K. Itoh, S. Takahashi, H. Sato, T. Yanagawa, Y. Katoh, S. Bannai, and M. Yamamoto Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages J. Biol. Chem. 275 2000 16023 16029
    • (2000) J. Biol. Chem. , vol.275 , pp. 16023-16029
    • Ishii, T.1    Itoh, K.2    Takahashi, S.3    Sato, H.4    Yanagawa, T.5    Katoh, Y.6    Bannai, S.7    Yamamoto, M.8
  • 35
    • 0035875447 scopus 로고    scopus 로고
    • Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust
    • Y. Aoki, H. Sato, N. Nishimura, S. Takahashi, K. Itoh, and M. Yamamoto Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust Toxicol. Appl. Pharmacol. 173 2001 154 160
    • (2001) Toxicol. Appl. Pharmacol. , vol.173 , pp. 154-160
    • Aoki, Y.1    Sato, H.2    Nishimura, N.3    Takahashi, S.4    Itoh, K.5    Yamamoto, M.6
  • 36
    • 0035853157 scopus 로고    scopus 로고
    • Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
    • M. Ramos-Gomez, M.-K. Kwak, P.M. Dolan, K. Itoh, M. Yamamoto, P. Talalay, and T.W. Kensler Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice Proc. Natl. Acad. Sci. U.S.A. 98 2001 3410 3415
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 3410-3415
    • Ramos-Gomez, M.1    Kwak, M.-K.2    Dolan, P.M.3    Itoh, K.4    Yamamoto, M.5    Talalay, P.6    Kensler, T.W.7
  • 41
    • 3142721782 scopus 로고    scopus 로고
    • Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photo-oxidative damage
    • X. Gao, and P. Talalay Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photo-oxidative damage Proc. Natl. Acad. Sci. U.S.A. 101 2004 10446 10451
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 10446-10451
    • Gao, X.1    Talalay, P.2
  • 42
    • 0035870298 scopus 로고    scopus 로고
    • The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes
    • M. McMahon, K. Itoh, M. Yamamoto, S.A. Chanas, C.J. Henderson, L.I. McLellan, C.R. Wolf, C. Cavin, and J.D. Hayes The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes Cancer Res. 61 2001 3299 3307
    • (2001) Cancer Res. , vol.61 , pp. 3299-3307
    • McMahon, M.1    Itoh, K.2    Yamamoto, M.3    Chanas, S.A.4    Henderson, C.J.5    McLellan, L.I.6    Wolf, C.R.7    Cavin, C.8    Hayes, J.D.9
  • 43
    • 0037106099 scopus 로고    scopus 로고
    • Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
    • R.K. Thimmulappa, K.H. Mai, S. Srisuma, T.W. Kensler, M. Yamamoto, and S. Biswal Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray Cancer Res. 62 2002 5196 5203
    • (2002) Cancer Res. , vol.62 , pp. 5196-5203
    • Thimmulappa, R.K.1    Mai, K.H.2    Srisuma, S.3    Kensler, T.W.4    Yamamoto, M.5    Biswal, S.6
  • 44
    • 0035072229 scopus 로고    scopus 로고
    • Degradation of oxidized proteins by the 20S proteasome
    • K.J. Davis Degradation of oxidized proteins by the 20S proteasome Biochimie 83 2001 301 310
    • (2001) Biochimie , vol.83 , pp. 301-310
    • Davis, K.J.1
  • 45
    • 0242721624 scopus 로고    scopus 로고
    • Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway
    • M.-K. Kwak, N. Wakabayashi, J.L. Greenlaw, M. Yamamoto, and T.W. Kensler Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway Mol. Cell. Biol. 23 2003 8786 8794
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8786-8794
    • Kwak, M.-K.1    Wakabayashi, N.2    Greenlaw, J.L.3    Yamamoto, M.4    Kensler, T.W.5
  • 46
    • 16244378900 scopus 로고    scopus 로고
    • Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice
    • M. Tanito, H. Masutani, Y. Kim, M. Nishikawa, A. Ohira, and J. Yodoi Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice Invest. Ophth. Vis. Sci. 46 2005 979 987
    • (2005) Invest. Ophth. Vis. Sci. , vol.46 , pp. 979-987
    • Tanito, M.1    Masutani, H.2    Kim, Y.3    Nishikawa, M.4    Ohira, A.5    Yodoi, J.6
  • 48
    • 2342511435 scopus 로고    scopus 로고
    • Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway
    • H. Motohashi, F. Katsuoka, J.D. Engel, and M. Yamamoto Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway Proc. Natl. Acad. Sci. U.S.A. 101 2004 6379 6384
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 6379-6384
    • Motohashi, H.1    Katsuoka, F.2    Engel, J.D.3    Yamamoto, M.4
  • 49
    • 0033956744 scopus 로고    scopus 로고
    • The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin
    • J.D. Hayes, S.A. Chanas, C.J. Henderson, M. McMahon, C. Sun, G.J. Moffat, C.R. Wolf, and M. Yamamoto The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin Biochem. Soc. Trans. 28 2000 33 41
    • (2000) Biochem. Soc. Trans. , vol.28 , pp. 33-41
    • Hayes, J.D.1    Chanas, S.A.2    Henderson, C.J.3    McMahon, M.4    Sun, C.5    Moffat, G.J.6    Wolf, C.R.7    Yamamoto, M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.