-
1
-
-
2942675088
-
Obesity, metabolic syndrome, and cardiovascular disease
-
DOI 10.1210/jc.2004-0372
-
Grundy SM. Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endo-crinol Metab 2004; 89: 2595-2600. (Pubitemid 38766337)
-
(2004)
Journal of Clinical Endocrinology and Metabolism
, vol.89
, Issue.6
, pp. 2595-2600
-
-
Grundy, S.M.1
-
2
-
-
33845881411
-
Mechanisms linking obesity to insulin resistance and type 2 diabetes
-
DOI 10.1038/nature05482, PII NATURE05482
-
Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006; 444: 840-846. (Pubitemid 46024990)
-
(2006)
Nature
, vol.444
, Issue.7121
, pp. 840-846
-
-
Kahn, S.E.1
Hull, R.L.2
Utzschneider, K.M.3
-
3
-
-
12344266697
-
How obesity causes diabetes: Not a tall tale
-
Lazar MA. How obesity causes diabetes: not a tall tale. Science 2005; 307: 373-375.
-
(2005)
Science
, vol.307
, pp. 373-375
-
-
Ma, L.1
-
4
-
-
47949111598
-
Central obesity and increased risk of dementia more than three decades later
-
Whitmer RA, Gustafson DR, Barrett-Connor E, Haan MN, Gunderson EP, Yaffe K. Central obesity and increased risk of dementia more than three decades later. Neurology 2008; 71: 1057-1064.
-
(2008)
Neurology
, vol.71
, pp. 1057-1064
-
-
Whitmer, R.A.1
Gustafson, D.R.2
Barrett-Connor, E.3
Haan, M.N.4
Gunderson, E.P.5
Yaffe, K.6
-
5
-
-
79953770067
-
Increased leptin supply to hypothalamus by gene therapy confers life-long benefits on energy homeostasis, disease cluster of metabolic syndrome-diabetes type 1 and 2, dyslipidemia and cardiovascular ailments-and bone remodeling
-
Shioda S, Homma I, Kato N (eds) Springer: Tokyo
-
Kalra SP. Increased leptin supply to hypothalamus by gene therapy confers life-long benefits on energy homeostasis, disease cluster of metabolic syndrome-diabetes type 1 and 2, dyslipidemia and cardiovascular ailments-and bone remodeling. In: Shioda S, Homma I, Kato N (eds). Transmitters and modulators in health and disease. Springer: Tokyo, 2009, pp 19-30.
-
(2009)
Transmitters and Modulators in Health and Disease.
, pp. 19-30
-
-
Kalra, S.P.1
-
6
-
-
77951884435
-
The long and winding road to understanding and conquering type 1 diabetes
-
Santamaria P. The long and winding road to understanding and conquering type 1 diabetes. Immunity 2010; 32: 437-445.
-
(2010)
Immunity
, vol.32
, pp. 437-445
-
-
Santamaria, P.1
-
7
-
-
70349316243
-
Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; A benefit beyond weight and appetite regulation
-
Kalra SP. Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation. Peptides 2009; 30: 1957-1963.
-
(2009)
Peptides
, vol.30
, pp. 1957-1963
-
-
Kalra, S.P.1
-
8
-
-
2942683422
-
Abdominal obesity and dyslipidemia in the metabolic syndrome: Importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk
-
DOI 10.1210/jc.2004-0432
-
Carr MC, Brunzell JD. Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk. J Clin Endocrinol Metab 2004; 89: 2601-2607. (Pubitemid 38766338)
-
(2004)
Journal of Clinical Endocrinology and Metabolism
, vol.89
, Issue.6
, pp. 2601-2607
-
-
Carr, M.C.1
Brunzell, J.D.2
-
9
-
-
0036217052
-
Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
-
DOI 10.1210/er.23.2.201
-
Lewis GF, Carpentier A, Adeli K, Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 2002; 23: 201-229. (Pubitemid 34299024)
-
(2002)
Endocrine Reviews
, vol.23
, Issue.2
, pp. 201-229
-
-
Lewis, G.F.1
Carpentier, A.2
Adeli, K.3
Giacca, A.4
-
10
-
-
77955491310
-
Neuroendocrine control of energy homeostasis: Update on new insights
-
Kalra SP, Kalra PS. Neuroendocrine control of energy homeostasis: update on new insights. Prog Brain Res 2010; 181: 17-33.
-
(2010)
Prog Brain Res
, vol.181
, pp. 17-33
-
-
Kalra, S.P.1
Kalra, P.S.2
-
11
-
-
77649093965
-
Diabetes: Strategies to prevent the type 2 diabetes mellitus epidemic
-
Robertson RP, Kendall DM, Seaquist ER. Diabetes: strategies to prevent the type 2 diabetes mellitus epidemic. Nat Rev Endocrinol 2010; 6: 128-129.
-
(2010)
Nat Rev Endocrinol
, vol.6
, pp. 128-129
-
-
Robertson, R.P.1
Kendall, D.M.2
Seaquist, E.R.3
-
12
-
-
1542408721
-
The diabetes epidemic: A national and global crisis
-
DOI 10.1016/j.amjmed.2003.10.014, PII S0002934303006715
-
Bonow RO, Gheorghiade M. The diabetes epidemic: a national and global crisis. Am J Med 2004; 116: 2S-10S. (Pubitemid 38333036)
-
(2004)
American Journal of Medicine
, vol.116
, Issue.5 SUPPL. 1
-
-
Bonow, R.O.1
Gheorghiade, M.2
-
14
-
-
0036461347
-
Obesity and metabolic syndrome: Long-term benefits of central leptin gene therapy
-
DOI 10.1358/dot.2002.38.11.740201
-
Kalra PS, Kalra SP. Obesity and metabolic syndrome: long-term benefits of central leptin gene therapy. In: Prous JR (ed). Drugs of Today. Prous Science: Barcelona, Spain, 2002, pp 745-757. (Pubitemid 36090912)
-
(2002)
Drugs of Today
, vol.38
, Issue.11
, pp. 745-757
-
-
Kalra, P.S.1
Kalra, S.P.2
-
15
-
-
30044443649
-
Diabetes and obesity: The twin epidemics
-
DOI 10.1038/nm0106-75
-
Smyth S, Heron A. Diabetes and obesity: the twin epidemics. Nat Med 2006; 12: 75-80. (Pubitemid 43050080)
-
(2006)
Nature Medicine
, vol.12
, Issue.1
, pp. 75-80
-
-
Smyth, S.1
Heron, A.2
-
16
-
-
61449095573
-
Leptin at 14 y of age: An ongoing story
-
Friedman JM. Leptin at 14 y of age: an ongoing story. Am J Clin Nutr 2009; 89: 973S-979S.
-
(2009)
Am J Clin Nutr
, vol.89
-
-
Friedman, J.M.1
-
17
-
-
2942687840
-
The pediatric obesity epidemic: Causes and controversies
-
DOI 10.1210/jc.2003-031449
-
Slyper AH. The pediatric obesity epidemic: causes and controversies. J Clin Endo-crinol Metab 2004; 89: 2540-2547. (Pubitemid 38766329)
-
(2004)
Journal of Clinical Endocrinology and Metabolism
, vol.89
, Issue.6
, pp. 2540-2547
-
-
Slyper, A.H.1
-
19
-
-
20144363712
-
A potential decline in life expectancy in the United States in the 21st century
-
DOI 10.1056/NEJMsr043743
-
Olshansky SJ, Passaro DJ, Hershow RC, Layden J, Carnes BA, Brody J et al. A potential decline in life expectancy in the United States in the 21st century. N Engl J Med 2005; 352: 1138-1145. (Pubitemid 40365358)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.11
, pp. 1138-1145
-
-
Olshansky, S.J.1
Passaro, D.J.2
Hershow, R.C.3
Layden, J.4
Carnes, B.A.5
Brody, J.6
Hayflick, L.7
Butler, R.N.8
Allison, D.B.9
Ludwig, D.S.10
-
21
-
-
77950228972
-
Diabetes: Treatment of type 2 diabetes mellitus with bariatric surgery
-
Clifton P. Diabetes: treatment of type 2 diabetes mellitus with bariatric surgery. Nat Rev Endocrinol 2010; 6: 191-193.
-
(2010)
Nat Rev Endocrinol
, vol.6
, pp. 191-193
-
-
Clifton, P.1
-
22
-
-
0032532147
-
WAT-free mice: Diabetes without obesity
-
McKnight SL. WAT-free mice: diabetes without obesity. Genes Dev 1998; 12: 3145-3148. (Pubitemid 28496258)
-
(1998)
Genes and Development
, vol.12
, Issue.20
, pp. 3145-3148
-
-
McKnight, S.L.1
-
23
-
-
61449105725
-
Leptin: A pivotal regulator of human energy homeostasis
-
Farooqi IS, ORahilly S. Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 2009; 89: 980S-984S.
-
(2009)
Am J Clin Nutr
, vol.89
-
-
Farooqi, I.S.1
Orahilly, S.2
-
24
-
-
0032848779
-
Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin
-
DOI 10.2337/diabetes.48.9.1822
-
Ogawa Y, Masuzaki H, Hosoda K, Aizawa-Abe M, Suga J, Suda M et al. Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin. Diabetes 1999; 48: 1822-1829. (Pubitemid 29415203)
-
(1999)
Diabetes
, vol.48
, Issue.9
, pp. 1822-1829
-
-
Ogawa, Y.1
Masuzaki, H.2
Hosoda, K.3
Aizawa-Abe, M.4
Suga, J.5
Suda, M.6
Ebihara, K.7
Iwai, H.8
Matsuoka, N.9
Satoh, N.10
Odaka, H.11
Kasuga, H.12
Fujisawa, Y.13
Inoue, G.14
Nishimura, H.15
Yoshimasa, Y.16
Nakao, K.17
-
25
-
-
57349192938
-
Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients
-
Paz-Filho G, Esposito K, Hurwitz B, Sharma A, Dong C, Andreev V et al. Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients. Am J Physiol Endocrinol Metab 2008; 295: E1401-E1408.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.295
-
-
Paz-Filho, G.1
Esposito, K.2
Hurwitz, B.3
Sharma, A.4
Dong, C.5
Reev, V.6
-
26
-
-
0033517284
-
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
-
Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 1999; 401: 73-76.
-
(1999)
Nature
, vol.401
, pp. 73-76
-
-
Shimomura, I.1
Hammer, R.E.2
Ikemoto, S.3
Brown, M.S.4
Goldstein, J.L.5
-
27
-
-
33846950833
-
Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy
-
Ebihara K, Kusakabe T, Hirata M, Masuzaki H, Miyanaga F, Kobayashi N et al. Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy. J Clin Endocrinol Metab 2007; 92: 532-541.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 532-541
-
-
Ebihara, K.1
Kusakabe, T.2
Hirata, M.3
Masuzaki, H.4
Miyanaga, F.5
Kobayashi, N.6
-
28
-
-
0036114844
-
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
-
DOI 10.1172/JCI200215001
-
Petersen KF, Oral EA, Dufour S, Befroy D, Ariyan C, Yu C et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Clin Invest 2002; 109: 1345-1350. (Pubitemid 34546899)
-
(2002)
Journal of Clinical Investigation
, vol.109
, Issue.10
, pp. 1345-1350
-
-
Petersen, K.F.1
Oral, E.A.2
Dufour, S.3
Befroy, D.4
Ariyan, C.5
Yu, C.6
Cline, G.W.7
DePaoli, A.M.8
Taylor, S.I.9
Gorden, P.10
Shulman, G.I.11
-
30
-
-
0035448570
-
Insulins today and beyond
-
DOI 10.1016/S0140-6736(01)05842-1
-
Owens DR, Zinman B, Bolli GB. Insulins today and beyond. Lancet 2001; 358: 739-746. (Pubitemid 32823407)
-
(2001)
Lancet
, vol.358
, Issue.9283
, pp. 739-746
-
-
Owens, D.R.1
Zinman, B.2
Bolli, G.B.3
-
31
-
-
54249151936
-
Diabetes. paradoxical effects of tightly controlled blood sugar
-
Taubes G. Diabetes. paradoxical effects of tightly controlled blood sugar. Science 2008; 322: 365-367.
-
(2008)
Science
, vol.322
, pp. 365-367
-
-
Taubes, G.1
-
32
-
-
57349087022
-
Changes in the neuroendocrine control of energy homeostasis by adiposity signals during aging
-
Carrascosa JM, Ros M, Andres A, Fernandez-Agullo T, Arribas C. Changes in the neuroendocrine control of energy homeostasis by adiposity signals during aging. Exp Gerontol 2009; 44: 20-25.
-
(2009)
Exp Gerontol
, vol.44
, pp. 20-25
-
-
Carrascosa, J.M.1
Ros, M.2
Andres, A.3
Fernandez-Agullo, T.4
Arribas, C.5
-
33
-
-
0033038418
-
Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
-
DOI 10.1210/er.20.1.68
-
Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 1999; 20: 68-100. (Pubitemid 29092036)
-
(1999)
Endocrine Reviews
, vol.20
, Issue.1
, pp. 68-100
-
-
Kalra, S.P.1
Dube, M.G.2
Pu, S.3
Xu, B.4
Horvath, T.L.5
Kalra, P.S.6
-
34
-
-
70350774226
-
Feeding signals and brain circuitry
-
Dietrich MO, Horvath TL. Feeding signals and brain circuitry. Eur J Neurosci 2009; 30: 1688-1696.
-
(2009)
Eur J Neurosci
, vol.30
, pp. 1688-1696
-
-
Dietrich, M.O.1
Horvath, T.L.2
-
35
-
-
0037471351
-
Rhythmic, reciprocal ghrelin and leptin signaling: New insight in the development of obesity
-
DOI 10.1016/S0167-0115(02)00305-1
-
Kalra SP, Bagnasco M, Otukonyong EE, Dube MG, Kalra PS. Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity. Regul Pept 2003; 111: 1-11. (Pubitemid 36254743)
-
(2003)
Regulatory Peptides
, vol.111
, Issue.1-3
, pp. 1-11
-
-
Kalra, S.P.1
Bagnasco, M.2
Otukonyong, E.E.3
Dube, M.G.4
Kalra, P.S.5
-
36
-
-
0033037727
-
Leptin restores euglycemia and normalizes glucose turnover in insulin- deficient diabetes in the rat
-
DOI 10.2337/diabetes.48.7.1487
-
Chinookoswong N, Wang JL, Shi ZQ. Leptin restores euglycemia and normalizes glucose turnover in insulin- deficient diabetes in the rat. Diabetes 1999; 48: 1487-1492. (Pubitemid 29297316)
-
(1999)
Diabetes
, vol.48
, Issue.7
, pp. 1487-1492
-
-
Chinookoswong, N.1
Wang, J.-L.2
Shi, Z.-Q.3
-
37
-
-
18344374382
-
Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats
-
DOI 10.1096/fj.01-0164com
-
Hidaka S, Yoshimatsu H, Kondou S, Tsuruta Y, Oka K, Noguchi H et al. Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats. FA S E B J 2002; 16: 509-518. (Pubitemid 34273234)
-
(2002)
FASEB Journal
, vol.16
, Issue.6
, pp. 509-518
-
-
Hidaka, S.1
Yoshimatsu, H.2
Kondou, S.3
Tsuruta, Y.4
Kyoko, O.K.A.5
Noguchi, H.6
Okamoto, K.7
Sakino, H.8
Teshima, Y.9
Okeda, T.10
Sakata, T.11
-
39
-
-
27944502118
-
Central leptin differentially modulates ultradian secretory patterns of insulin, leptin and ghrelin independent of effects on food intake and body weight
-
DOI 10.1016/j.peptides.2005.04.015, PII S0196978105001889
-
Otukonyong EE, Dube MG, Torto R, Kalra PS, Kalra SP. Central leptin differentially modulates ultradian secretory patterns of insulin, leptin and ghrelin independent of effects on food intake and body weight. Peptides 2005; 26: 2559-2566. (Pubitemid 41676732)
-
(2005)
Peptides
, vol.26
, Issue.12
, pp. 2559-2566
-
-
Otukonyong, E.E.1
Dube, M.G.2
Torto, R.3
Kalra, P.S.4
Kalra, S.P.5
-
40
-
-
25144497560
-
High fat diet-induced ultradian leptin and insulin hypersecretion and ghrelin is absent in obesity-resistant rats
-
Otukonyong EE, Dube MG, Torto R, Kalra PS, Kalra SP. High fat diet-induced ultradian leptin and insulin hypersecretion and ghrelin is absent in obesity-resistant rats. Obes Res 2005; I13: 991-999.
-
(2005)
Obes Res
, vol.13
, pp. 991-999
-
-
Otukonyong, E.E.1
Dube, M.G.2
Torto, R.3
Kalra, P.S.4
Kalra, S.P.5
-
41
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
DOI 10.1038/372425a0
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-432. (Pubitemid 24365442)
-
(1994)
Nature
, vol.372
, Issue.6505
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
42
-
-
37249046860
-
Central leptin insufficiency syndrome: An interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions
-
DOI 10.1016/j.peptides.2007.10.017, PII S0196978107004305
-
Kalra SP. Central leptin insufficiency syndrome: an interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions. Peptides 2008; 29: 127-138. (Pubitemid 350266118)
-
(2008)
Peptides
, vol.29
, Issue.1
, pp. 127-138
-
-
Kalra, S.P.1
-
43
-
-
0034714036
-
Dynamic regulation of leptin entry into brain by the blood-brain barrier
-
Kastin AJ, Pan W. Dynamic regulation of leptin entry into brain by the blood-brain barrier. Regul Pept 2000; 92: 37-43.
-
(2000)
Regul Pept
, vol.92
, pp. 37-43
-
-
Kastin, A.J.1
Pan, W.2
-
44
-
-
0033395851
-
Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor
-
DOI 10.1016/S0196-9781(99)00156-4, PII S0196978199001564
-
Kastin AJ, Pan W, Maness LM, Koletsky RJ, Ernsberger P. Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides 1999; 20: 1449-1453. (Pubitemid 30069891)
-
(1999)
Peptides
, vol.20
, Issue.12
, pp. 1449-1453
-
-
Kastin, A.J.1
Pan, W.2
Maness, L.M.3
Koletsky, R.J.4
Ernsberger, P.5
-
45
-
-
66149141484
-
Leptin targets in the mouse brain
-
Scott MM, Lachey JL, Sternson SM, Lee CE, Elias CF, Friedman JM et al. Leptin targets in the mouse brain. J Comp Neurol 2009; 514: 518-532.
-
(2009)
J Comp Neurol
, vol.514
, pp. 518-532
-
-
Scott, M.M.1
Lachey, J.L.2
Sternson, S.M.3
Lee, C.E.4
Elias, C.F.5
Friedman, J.M.6
-
46
-
-
49749107875
-
Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic syndrome:new therapeutic approaches
-
Kalra SP. Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic syndrome:new therapeutic approaches. Nutrition 2008; 24: 820-826.
-
(2008)
Nutrition
, vol.24
, pp. 820-826
-
-
Kalra, S.P.1
-
47
-
-
18844409595
-
Brain-adipose tissue cross talk
-
DOI 10.1079/PNS2004409
-
Bartness TJ, Kay Song C, Shi H, Bowers RR, Foster MT. Brain-adipose tissue cross talk. Proc Nutr Soc 2005; 64: 53-64. (Pubitemid 40685752)
-
(2005)
Proceedings of the Nutrition Society
, vol.64
, Issue.1
, pp. 53-64
-
-
Bartness, T.J.1
Song, C.K.2
Shi, H.3
Bowers, R.R.4
Foster, M.T.5
-
48
-
-
32644451260
-
Tracing from fat tissue, liver, and pancreas: A neuroanatomical framework for the role of the brain in type 2 diabetes
-
DOI 10.1210/en.2005-0667
-
Kreier F, Kap YS, Mettenleiter TC, Van Heijningen C, Van der Vliet J, Kalsbeek A et al. Tracing from fat tissue, liver, and pancreas: a neuroanatomical framework for the role of the brain in type 2 diabetes. Endocrinology 2006; 147: 1140-1147. (Pubitemid 43244345)
-
(2006)
Endocrinology
, vol.147
, Issue.3
, pp. 1140-1147
-
-
Kreier, F.1
Kap, Y.S.2
Mettenleiter, T.C.3
Van Heijningen, C.4
Van Der Vliet, J.5
Kalsbeek, A.6
Sauerwein, H.P.7
Fliers, E.8
Romijn, J.A.9
Buijs, R.M.10
-
49
-
-
4944221846
-
Neural connections between the hypothalamus and the liver
-
DOI 10.1002/ar.a.20086
-
Uyama N, Geerts A, Reynaert H. Neural connections between the hypothalamus and the liver. Anat Rec A Discov Mol Cell Evol Biol 2004; 280: 808-820. (Pubitemid 39330960)
-
(2004)
Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology
, vol.280
, Issue.1
, pp. 808-820
-
-
Uyama, N.1
Geerts, A.2
Reynaert, H.3
-
50
-
-
0035911803
-
Parasympathetic and sympathetic control of the pancreas: A role for the suprachiasmatic nucleus and other hypothalamic centers that are involved in the regulation of food intake
-
DOI 10.1002/1096-9861(20010319)431:4<405::AID-CNE1079>3.0.CO;2-D
-
Buijs RM, Chun SJ, Niijima A, Romijn HJ, Nagai K. Parasympathetic and sympathetic control of the pancreas: a role for the suprachiasmatic nucleus and other hypothalamic centers that are involved in the regulation of food intake. J Comp Neurol 2001; 431: 405-423. (Pubitemid 32178945)
-
(2001)
Journal of Comparative Neurology
, vol.431
, Issue.4
, pp. 405-423
-
-
Buijs, R.M.1
Chun, S.J.2
Niijima, A.3
Romijn, H.J.4
Nagai, K.5
-
51
-
-
33044493099
-
Permanent interruption of information flow between hypothalamus and hindbrain produces obesity accompanied by a selective dark-phase hyperphagia and hyperinsulinemia
-
Society for Neuroscience: New Orleans, LA Abstract no. 831.837
-
Pu S, Dube MG, Kalra SP, Kalra PS. Permanent interruption of information flow between hypothalamus and hindbrain produces obesity accompanied by a selective dark-phase hyperphagia and hyperinsulinemia. 33rd Annual Society for Neuro-science Meeting. Society for Neuroscience: New Orleans, LA, 2003, pp W-33, Abstract no. 831.837.
-
(2003)
33rd Annual Society for Neuro-science Meeting
-
-
Pu, S.1
Dube, M.G.2
Kalra, S.P.3
Kalra, P.S.4
-
52
-
-
33745781499
-
Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy
-
DOI 10.1210/jc.2005-1545
-
Lee JH, Chan JL, Sourlas E, Raptopoulos V, Mantzoros CS. Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy. J Clin Endocrinol Metab 2006; 91: 2605-2611. (Pubitemid 44024625)
-
(2006)
Journal of Clinical Endocrinology and Metabolism
, vol.91
, Issue.7
, pp. 2605-2611
-
-
Lee, J.H.1
Chan, J.L.2
Sourlas, E.3
Raptopoulos, V.4
Mantzoros, C.S.5
-
53
-
-
38149012112
-
Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: The effect of long-term leptin therapy
-
Park JY, Chong AY, Cochran EK, Kleiner DE, Haller MJ, Schatz DA et al. Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: the effect of long-term leptin therapy. J Clin Endocrinol Metab 2008; 93: 26-31.
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 26-31
-
-
Park, J.Y.1
Chong, A.Y.2
Cochran, E.K.3
Kleiner, D.E.4
Haller, M.J.5
Schatz, D.A.6
-
54
-
-
33750948987
-
Hypothalamic clamp on insulin release by leptin-transgene expression
-
DOI 10.1016/j.peptides.2006.07.022, PII S0196978106003482
-
Boghossian S, Dube MG, Torto R, Kalra PS, Kalra SP. Hypothalamic clamp on insulin release by leptin-transgene expression. Peptides 2006; 27: 3245-3254. (Pubitemid 44738167)
-
(2006)
Peptides
, vol.27
, Issue.12
, pp. 3245-3254
-
-
Boghossian, S.1
Dube, M.G.2
Torto, R.3
Kalra, P.S.4
Kalra, S.P.5
-
55
-
-
4344675633
-
Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy
-
DOI 10.1210/en.2004-0262
-
Ueno N, Dube MG, Inui A, Kalra PS, Kalra SP. Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy. Endocrinology 2004; 145: 4176-4184. (Pubitemid 39120566)
-
(2004)
Endocrinology
, vol.145
, Issue.9
, pp. 4176-4184
-
-
Ueno, N.1
Dube, M.G.2
Inui, A.3
Kalra, P.S.4
Kalra, S.P.5
-
56
-
-
33746886648
-
Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice
-
DOI 10.1016/j.peptides.2006.03.006, PII S0196978106001100
-
Ueno N, Inui A, Kalra SP, Kalra PS. Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice. Peptides 2006; 27: 2332-2342. (Pubitemid 44189608)
-
(2006)
Peptides
, vol.27
, Issue.9
, pp. 2332-2342
-
-
Ueno, N.1
Inui, A.2
Kalra, P.S.3
Kalra, S.P.4
-
57
-
-
74249091373
-
Leptin deficiency: Clinical implications and opportunities for therapeutic interventions
-
Bluher S, Shah S, Mantzoros CS. Leptin deficiency: clinical implications and opportunities for therapeutic interventions. J Investig Med 2009; 57: 784-788.
-
(2009)
J Investig Med
, vol.57
, pp. 784-788
-
-
Bluher, S.1
Shah, S.2
Mantzoros, C.S.3
-
58
-
-
61449175863
-
R-metHuLeptin improves highly active antiretroviral therapy-induced lipoatrophy and the metabolic syndrome but not through altering circulating IGF and IGF-binding protein levels: Observational and interventional studies in humans
-
Brennan AM, Lee JH, Tsiodras S, Chan JL, Doweiko J, Chimienti SN et al. r-metHuLeptin improves highly active antiretroviral therapy-induced lipoatrophy and the metabolic syndrome, but not through altering circulating IGF and IGF-binding protein levels: observational and interventional studies in humans. Eur J Endocrinol 2009; 160: 173-176.
-
(2009)
Eur J Endocrinol
, vol.160
, pp. 173-176
-
-
Brennan, A.M.1
Lee, J.H.2
Tsiodras, S.3
Chan, J.L.4
Doweiko, J.5
Chimienti, S.N.6
-
59
-
-
65249130126
-
The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia
-
Mulligan K, Khatami H, Schwarz JM, Sakkas GK, DePaoli AM, Tai VW et al. The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia. J Clin Endocrinol Metab 2009; 94: 1137-1144.
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 1137-1144
-
-
Mulligan, K.1
Khatami, H.2
Schwarz, J.M.3
Sakkas, G.K.4
Depaoli, A.M.5
Tai, V.W.6
-
60
-
-
0034776770
-
Selective deletion of leptin receptor in neurons leads to obesity
-
DOI 10.1172/JCI200113914
-
Cohen P, Zhao C, Cai X, Montez JM, Rohani SC, Feinstein P et al. Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest 2001; 108: 1113-1121. (Pubitemid 32995369)
-
(2001)
Journal of Clinical Investigation
, vol.108
, Issue.8
, pp. 1113-1121
-
-
Cohen, P.1
Zhao, C.2
Cai, X.3
Montez, J.M.4
Rohani, S.C.5
Feinstein, P.6
Mombaerts, P.7
Friedman, J.M.8
-
61
-
-
25144497089
-
AAV-mediated leptin receptor installation improves energy balance and the reproductive status of obese female Koletsky rats
-
DOI 10.1016/j.peptides.2005.05.027, PII S0196978105002871
-
Keen-Rhinehart E, Kalra SP, Kalra PS. AAV mediated leptin receptor installation improves energy balance and the reproductive status of obese female Koletsky rats. Peptides 2005; 26: 2567-2578. (Pubitemid 41676733)
-
(2005)
Peptides
, vol.26
, Issue.12
, pp. 2567-2578
-
-
Keen-Rhinehart, E.1
Kalra, S.P.2
Kalra, P.S.3
-
62
-
-
0032763709
-
Impaired transport of leptin across the blood-brain barrier in obesity
-
Banks WA, DiPalma CR, Farrell CL. Impaired transport of leptin across the blood-brain barrier in obesity. Peptides 1999; 20: 1341-1345.
-
(1999)
Peptides
, vol.20
, pp. 1341-1345
-
-
Banks, W.A.1
Dipalma, C.R.2
Farrell, C.L.3
-
63
-
-
33745224149
-
The effects of high fat diets on the blood-brain barrier transport of leptin: Failure or adaptation?
-
Banks WA, Farr SA, Morley JE. The effects of high fat diets on the blood-brain barrier transport of leptin: failure or adaptation? Physiol Behav 2006; 88: 244-248.
-
(2006)
Physiol Behav
, vol.88
, pp. 244-248
-
-
Banks, W.A.1
Farr, S.A.2
Morley, J.E.3
-
65
-
-
0033937071
-
Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats
-
Burguera B, Couce ME, Curran GL, Jensen MD, Lloyd RV, Cleary MP et al. Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats. Diabetes 2000; 49: 1219-1223. (Pubitemid 30439098)
-
(2000)
Diabetes
, vol.49
, Issue.7
, pp. 1219-1223
-
-
Burguera, B.1
Couce, M.E.2
Curran, G.L.3
Jensen, M.D.4
Lloyd, R.V.5
Cleary, M.P.6
Poduslo, J.F.7
-
66
-
-
0030594830
-
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
-
DOI 10.1016/S0140-6736(96)03173-X
-
Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996; 348: 159-161. (Pubitemid 26238099)
-
(1996)
Lancet
, vol.348
, Issue.9021
, pp. 159-161
-
-
Caro, J.F.1
Kolaczynski, J.W.2
Nyce, M.R.3
Ohannesian, J.P.4
Opentanova, I.5
Goldman, W.H.6
Lynn, R.B.7
Zhang, P.-L.8
Sinha, M.K.9
Considine, R.V.10
-
68
-
-
33645851989
-
Intranasal leptin: Blood-brain barrier bypass (BBBB) for obesity?
-
Kastin AJ, Pan W. Intranasal leptin: blood-brain barrier bypass (BBBB) for obesity? Endocrinology 2006; 147: 2086-2087.
-
(2006)
Endocrinology
, vol.147
, pp. 2086-2087
-
-
Kastin, A.J.1
Pan, W.2
-
70
-
-
25144507707
-
Gene-transfer technology: A preventive neurotherapy to curb obesity, ameliorate metabolic syndrome and extend life expectancy
-
DOI 10.1016/j.tips.2005.08.008, PII S0165614705002063
-
Kalra SP, Kalra PS. Gene transfer technology: a preventive neurotherapy to curb obesity, ameliorate metabolic syndrome and extend life-expectancy. Trends Pharmacol Sci 2005; 26: 488-495. (Pubitemid 41338558)
-
(2005)
Trends in Pharmacological Sciences
, vol.26
, Issue.10
, pp. 488-495
-
-
Kalra, S.P.1
Kalra, P.S.2
-
71
-
-
15044363514
-
Adeno-associated virus and AAV vectors for gene delivery
-
Templeton-Smith N (ed) Marcel Dekker: New York, NY
-
Carter BJ, Burstein H. Adeno-associated virus and AAV vectors for gene delivery. In: Templeton-Smith N (ed). Theruapeutics Mechanisms and Strategies. Marcel Dekker: New York, NY, 2004, pp 71-1011.
-
(2004)
Theruapeutics Mechanisms and Strategies
, pp. 71-1011
-
-
Carter, B.J.1
Burstein, H.2
-
72
-
-
0034714042
-
Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change
-
Dhillon H, Ge Y, Minter RM, Prima V, Moldawer LL, Muzyczka N et al. Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change. Regul Pept 2000; 92: 97-105.
-
(2000)
Regul Pept
, vol.92
, pp. 97-105
-
-
Dhillon, H.1
Ge, Y.2
Minter, R.M.3
Prima, V.4
Moldawer, L.L.5
Muzyczka, N.6
-
73
-
-
0034882656
-
Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus
-
DOI 10.1006/mthe.2001.0427
-
Dhillon H, Kalra SP, Kalra PS. Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus. Mol Ther 2001; 4: 139-145. (Pubitemid 32776505)
-
(2001)
Molecular Therapy
, vol.4
, Issue.2
, pp. 139-145
-
-
Dhillon, H.1
Kalra, S.P.2
Kalra, P.S.3
-
74
-
-
0035876708
-
Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: A long-term study
-
DOI 10.1016/S0167-0115(01)00237-3, PII S0167011501002373
-
Dhillon H, Kalra SP, Prima V, Zolotukhin S, Scarpace PJ, Moldawer LL et al. Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study. Regul Pept 2001; 99: 69-77. (Pubitemid 32522533)
-
(2001)
Regulatory Peptides
, vol.99
, Issue.2-3
, pp. 69-77
-
-
Dhillon, H.1
Kalra, S.P.2
Prima, V.3
Zolotukhin, S.4
Scarpace, P.J.5
Moldawer, L.L.6
Muzyczka, N.7
Kalra, P.S.8
-
75
-
-
0142029960
-
Leptin as an adjunct of insulin therapy in insulin-deficient diabetes
-
DOI 10.1007/s00125-003-1193-6
-
Miyanaga F, Ogawa Y, Ebihara K, Hidaka S, Tanaka T, Hayashi S et al. Leptin as an adjunct of insulin therapy in insulin-deficient diabetes. Diabetologia 2003; 46: 1329-1337. (Pubitemid 37297202)
-
(2003)
Diabetologia
, vol.46
, Issue.10
, pp. 1329-1337
-
-
Miyanaga, F.1
Ogawa, Y.2
Ebihara, K.3
Hidaka, S.4
Tanaka, T.5
Hayashi, S.6
Masuzaki, H.7
Nakao, K.8
-
76
-
-
33645345693
-
Leptin and renal disease
-
DOI 10.1111/j.1525-139X.2006.00119.x
-
Briley LP, Szczech LA. Leptin and renal disease. Semin Dial 2006; 19: 54-59. (Pubitemid 43479011)
-
(2006)
Seminars in Dialysis
, vol.19
, Issue.1
, pp. 54-59
-
-
Briley, L.P.1
Szczech, L.A.2
-
77
-
-
33749487087
-
Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome
-
DOI 10.1111/j.1463-1326.2005.00562.x
-
Correia MLG, Rahmouni K. Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome. Diabetes, Obes Metab 2006; 8: 603-610. (Pubitemid 44515557)
-
(2006)
Diabetes, Obesity and Metabolism
, vol.8
, Issue.6
, pp. 603-610
-
-
Correia, M.L.G.1
Rahmouni, K.2
-
78
-
-
0029908857
-
Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy
-
DOI 10.1073/pnas.93.25.14795
-
Chen G, Koyama K, Yuan X, Lee Y, Zhou YT, ODoherty R et al. Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proc Natl Acad Sci USA 1996; 93: 14795-14799. (Pubitemid 26419048)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.25
, pp. 14795-14799
-
-
Chen, G.1
Koyama, K.2
Yuan, X.3
Lee, Y.4
Zhou, Y.-T.5
O'Doherty, R.6
Newgard, C.B.7
Unger, R.H.8
-
79
-
-
0032529029
-
Resistance to adenovirally induced hyperleptinemia in rats: Comparison of ventromedial hypothalamic lesions and mutated leptin receptors
-
Koyama K, Shimabukuro M, Chen G, Wang MY, Lee Y, Kalra PS et al. Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypo-thalamic lesions and mutated leptin receptors. J Clin Invest 1998; 102: 728-733. (Pubitemid 28399605)
-
(1998)
Journal of Clinical Investigation
, vol.102
, Issue.4
, pp. 728-733
-
-
Koyama, K.1
Shimabukuro, M.2
Chen, G.3
Wang, M.-Y.4
Lee, Y.5
Kalra, P.S.6
Dube, M.G.7
Kalra, S.P.8
Newgard, C.B.9
Unger, R.H.10
-
80
-
-
0034714046
-
Single intracerebroventricular bolus injection of a recombinant adenovirus expressing leptin results in reduction of food intake and body weight in both lean and obese Zucker fa/fa rats
-
Muzzin P, Cusin I, Charnay Y, Rohner-Jeanrenaud F. Single intracerebroventricular bolus injection of a recombinant adenovirus expressing leptin results in reduction of food intake and body weight in both lean and obese Zucker fa/fa rats. Regul Pept 2000; 92: 57-64.
-
(2000)
Regul Pept
, vol.92
, pp. 57-64
-
-
Muzzin, P.1
Cusin, I.2
Charnay, Y.3
Rohner-Jeanrenaud, F.4
-
81
-
-
0031471130
-
Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin
-
DOI 10.1073/pnas.94.25.13921
-
Murphy JE, Zhou S, Giese K, Williams LT, Escobedo JA, Dwarki VJ. Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin. Proc Natl Acad Sci USA 1997; 94: 13921-13926. (Pubitemid 28009685)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.25
, pp. 13921-13926
-
-
Murphy, J.E.1
Zhou, S.2
Giese, K.3
Williams, L.T.4
Escobedo, J.A.5
Dwarki, V.J.6
-
82
-
-
0036827697
-
Evidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic site-specific leptin gene therapy
-
DOI 10.1210/en.2002-220505
-
Bagnasco M, Dube MG, Kalra PS, Kalra SP. Evidence for the existence of distinct central appetite and energy expenditure pathways and stimulation of ghrelin as revealed by hypothalamic site-specific leptin gene therapy. Endocrinology 2002; 143: 4409-4421. (Pubitemid 35239575)
-
(2002)
Endocrinology
, vol.143
, Issue.11
, pp. 4409-4421
-
-
Bagnasco, M.1
Dube, M.G.2
Kalra, P.S.3
Kalra, S.P.4
-
83
-
-
2142687620
-
Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin
-
Bagnasco M, Dube MG, Katz A, Kalra PS, Kalra SP. Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin. Obes Res 2003; 11: 1463-1470. (Pubitemid 41127330)
-
(2003)
Obesity Research
, vol.11
, Issue.12
, pp. 1463-1470
-
-
Bagnasco, M.1
Dube, M.G.2
Katz, A.3
Kalra, P.S.4
Kalra, S.P.5
-
84
-
-
21244460769
-
New recombinant serotypes of AAV vectors
-
DOI 10.2174/1566523054065057
-
Gao G, Vandenberghe LH, Wilson JM. New recombinant serotypes of AAV vectors. Curr Gene Ther 2005; 5: 285-297. (Pubitemid 40895013)
-
(2005)
Current Gene Therapy
, vol.5
, Issue.3
, pp. 285-297
-
-
Gao, G.1
Vandenberghe, L.H.2
Wilson, J.M.3
-
85
-
-
34247271439
-
Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain
-
DOI 10.1089/hum.2006.178
-
Taymans JM, Vandenberghe LH, Haute CV, Thiry I, Deroose CM, Mortelmans L et al. Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain. Hum Gene Ther 2007; 18: 195-206. (Pubitemid 46626459)
-
(2007)
Human Gene Therapy
, vol.18
, Issue.3
, pp. 195-206
-
-
Taymans, J.-M.1
Vandenberghe, L.H.2
Van Den Haute, C.3
Thiry, I.4
Deroose, C.M.5
Mortelmans, L.6
Wilson, J.M.7
Debyser, Z.8
Baekelandt, V.9
-
86
-
-
85047681825
-
Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: Effects on serum ghrelin and appetite-regulating genes
-
DOI 10.1203/01.PDR.0000023496.70201.8E
-
Beretta E, Dube MG, Kalra PS, Kalra SP. Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: effects on serum ghrelin and appetite-regulating genes. Pediatr Res 2002; 52: 189-198. (Pubitemid 34827239)
-
(2002)
Pediatric Research
, vol.52
, Issue.2
, pp. 189-198
-
-
Beretta, E.1
Dube, M.G.2
Kalra, P.S.3
Kalra, S.P.4
-
87
-
-
22544464405
-
Suppression of fat deposition for the life time with gene therapy
-
DOI 10.1016/j.peptides.2005.03.039, PII S0196978105001294, International Symposium on Peptides Receptors, from Gene to Therapy
-
Boghossian S, Lecklin AH, Torto R, Kalra PS, Kalra SP. Suppression of fat deposition for the life time of rodents with gene therapy. Peptides 2005; 26: 1512-1519. (Pubitemid 41021489)
-
(2005)
Peptides
, vol.26
, Issue.8
, pp. 1512-1519
-
-
Boghossian, S.1
Lecklin, A.2
Torto, R.3
Kalra, P.S.4
Kalra, S.P.5
-
88
-
-
34547770365
-
Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin
-
DOI 10.1016/j.neurobiolaging.2006.08.010, PII S0197458006003058
-
Boghossian S, Ueno N, Dube MG, Kalra P, Kalra S. Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin. Neurobiol Aging 2007; 28: 1594-1604. (Pubitemid 47238536)
-
(2007)
Neurobiology of Aging
, vol.28
, Issue.10
, pp. 1594-1604
-
-
Boghossian, S.1
Ueno, N.2
Dube, M.G.3
Kalra, P.4
Kalra, S.5
-
89
-
-
0032918044
-
A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse
-
Wang J, Takeuchi T, Tanaka S, Kubo SK, Kayo T, Lu D et al. A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse. J Clin Invest 1999; 103: 27-37. (Pubitemid 29031160)
-
(1999)
Journal of Clinical Investigation
, vol.103
, Issue.1
, pp. 27-37
-
-
Wang, J.1
Takeuchi, T.2
Tanaka, S.3
Kubo, S.-K.4
Kayo, T.5
Lu, D.6
Takata, K.7
Koizumi, A.8
Izumi, T.9
-
90
-
-
61949427618
-
Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis
-
Malhotra A, Vashistha H, Yadav VS, Dube MG, Kalra SP, Abdellatif M et al. Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis. Am J Physiol Heart Circ Physiol 2009; 296: H380-H388.
-
(2009)
Am J Physiol Heart Circ Physiol
, vol.296
-
-
Malhotra, A.1
Vashistha, H.2
Yadav, V.S.3
Dube, M.G.4
Kalra, S.P.5
Abdellatif, M.6
-
91
-
-
0030847432
-
Acute stimulation of glucose metabolism in mice by leptin treatment
-
DOI 10.1038/38717
-
Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 1997; 389: 374-377. (Pubitemid 27415217)
-
(1997)
Nature
, vol.389
, Issue.6649
, pp. 374-377
-
-
Kamohara, S.1
Burcelin, R.2
Halaas, J.L.3
Friedman, J.M.4
Charron, M.J.5
-
92
-
-
0033306791
-
Differential effects of leptin in regulation of tissue glucose utilization in vivo
-
Wang JL, Chinookoswong N, Scully S, Qi M, Shi ZQ. Differential effects of leptin in regulation of tissue glucose utilization in vivo. Endocrinology 1999; 140: 2117-2124. (Pubitemid 30636450)
-
(1999)
Endocrinology
, vol.140
, Issue.5
, pp. 2117-2124
-
-
Wang, J.-L.1
Chinookoswong, N.2
Scully, S.3
Qi, M.4
Shi, Z.-Q.5
-
93
-
-
52949140814
-
Making insulin-deficient type 1 diabetic rodents thrive without insulin
-
Yu X, Park BH, Wang MY, Wang ZV, Unger RH. Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc Natl Acad Sci USA 2008; 105: 14070-14075.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 14070-14075
-
-
Yu, X.1
Park, B.H.2
Wang, M.Y.3
Wang, Z.V.4
Unger, R.H.5
-
94
-
-
77950373635
-
Leptin therapy in insulin-deficient type i diabetes
-
Wang MY, Chen L, Clark GO, Lee Y, Stevens RD, Ilkayeva OR et al. Leptin therapy in insulin-deficient type I diabetes. Proc Natl Acad Sci USA 2010; 107: 4813-4819.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 4813-4819
-
-
Wang, M.Y.1
Chen, L.2
Clark, G.O.3
Lee, Y.4
Stevens, R.D.5
Ilkayeva, O.R.6
-
96
-
-
67349144240
-
Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice
-
Kojima S, Asakawa A, Amitani H, Sakoguchi T, Ueno N, Inui A et al. Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice. Peptides 2009; 30: 962-966.
-
(2009)
Peptides
, vol.30
, pp. 962-966
-
-
Kojima, S.1
Asakawa, A.2
Amitani, H.3
Sakoguchi, T.4
Ueno, N.5
Inui, A.6
-
97
-
-
0036263327
-
Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: Increase in serum ghrelin levels
-
Dube MG, Beretta E, Dhillon H, Ueno N, Kalra PS, Kalra SP. Central leptin gene therapy blocks high fat diet-induced weight gain, hyperleptinemia and hyper-insulinemia: effects on serum ghrelin levels. Diabetes 2002; 51: 1729-1736. (Pubitemid 34564284)
-
(2002)
Diabetes
, vol.51
, Issue.6
, pp. 1729-1736
-
-
Dube, M.G.1
Beretta, E.2
Dhillon, H.3
Ueno, N.4
Kalra, P.S.5
Kalra, S.P.6
-
98
-
-
20444421276
-
Perigestational suppression of weight gain with central leptin gene therapy results in lower weight F1 generation
-
DOI 10.1016/j.peptides.2005.01.021, PII S0196978105000355
-
Lecklin AH, Dube MG, Torto R, Kalra PS, Kalra SP. Perigestational suppression of weight gain with central leptin gene therapy results in lower weight F1 generation. Peptides 2005; 26: 1176-1187. (Pubitemid 40798074)
-
(2005)
Peptides
, vol.26
, Issue.7
, pp. 1176-1187
-
-
Lecklin, A.1
Dube, M.G.2
Torto, R.N.3
Kalra, P.S.4
Kalra, S.P.5
-
99
-
-
40249091255
-
Increased leptin expression selectively in the hypo-thalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice
-
Dube MG, Torto R, Kalra SP. Increased leptin expression selectively in the hypo-thalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice. Peptides 2008; 29: 593-598.
-
(2008)
Peptides
, vol.29
, pp. 593-598
-
-
Dube, M.G.1
Torto, R.2
Kalra, S.P.3
-
100
-
-
34247546688
-
Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice
-
DOI 10.1016/j.peptides.2007.02.001, PII S0196978107000642
-
Iwaniec UT, Boghossian S, Lapke PD, Turner RT, Kalra SP. Central leptin gene therapy corrects skelet al abnormalities in leptin-deficient ob/ob mice. Peptides 2007; 28: 1012-1019. (Pubitemid 46654437)
-
(2007)
Peptides
, vol.28
, Issue.5
, pp. 1012-1019
-
-
Iwaniec, U.T.1
Boghossian, S.2
Lapke, P.D.3
Turner, R.T.4
Kalra, S.P.5
-
101
-
-
67349253844
-
Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay
-
Kalra SP, Dube MG, Iwaniec UT. Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay. Peptides 2009; 30: 967-973.
-
(2009)
Peptides
, vol.30
, pp. 967-973
-
-
Kalra, S.P.1
Dube, M.G.2
Iwaniec, U.T.3
-
102
-
-
34250683023
-
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: An open label, phase I trial
-
DOI 10.1016/S0140-6736(07)60982-9, PII S0140673607609829
-
Kaplitt MG, Feigin A, Tang C, Fitzsimons HL, Mattis P, Lawlor PA et al. Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinsons disease: an open label, phase I trial. Lancet 2007; 369: 2097-2105. (Pubitemid 46935946)
-
(2007)
Lancet
, vol.369
, Issue.9579
, pp. 2097-2105
-
-
Kaplitt, M.G.1
Feigin, A.2
Tang, C.3
Fitzsimons, H.L.4
Mattis, P.5
Lawlor, P.A.6
Bland, R.J.7
Young, D.8
Strybing, K.9
Eidelberg, D.10
During, M.J.11
-
103
-
-
6344283047
-
Clinical trials in neurological disorders using AAV vectors: Promises and challenges
-
Mandel RJ, Burger C. Clinical trials in neurological disorders using AAV vectors: promises and challenges. Curr Opin Mol Ther 2004; 6: 482-490. (Pubitemid 39386597)
-
(2004)
Current Opinion in Molecular Therapeutics
, vol.6
, Issue.5
, pp. 482-490
-
-
Mandel, R.J.1
Burger, C.2
-
104
-
-
44049094771
-
Clinical gene therapy using recombinant adeno-associated virus vectors
-
DOI 10.1038/gt.2008.68, PII GT200868, Special Issue: AAV Vectors for Clinical GeneTherapy
-
Mueller C, Flotte TR. Clinical gene therapy using recombinant adeno-associated virus vectors. Gene Therapy 2008; 15: 858-863. (Pubitemid 351712619)
-
(2008)
Gene Therapy
, vol.15
, Issue.11
, pp. 858-863
-
-
Mueller, C.1
Flotte, T.R.2
|