Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats

Diabetes

Volumn 49, Issue 7, 2000, Pages 1219-1223

  Burguera, Bartolome ^a,c   Couce, Marta E ^a   Curran, Geoffry L ^a   Jensen, Michael D ^a   Lloyd, Ricardo V ^a   Cleary, Margot P ^b   Poduslo, Joseph F ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c BOSTON MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN REGION; CHROMATOGRAPHY; CONTROLLED STUDY; DIABETIC OBESITY; DISEASE ASSOCIATION; ENERGY BALANCE; ENERGY TRANSFER; NONHUMAN; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN TRANSPORT; RAT; REGULATORY MECHANISM;

EID: 0033937071     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.7.1219     Document Type: Article

References (40)

1. Zhang Y, Proenca R, Maffeci M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1994
2. Friedman J, Halaas D: Leptin and the regulation of body composition. Nature 395:763-770, 1998
3. Halaas JL, Boozer C, Blair-West J, Fidahusein N, Denton DA, Friedman JM: Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci U S A 94:8878-8883, 1997
4. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292-295, 1996
5. Casanueva F, Dieguez C, Popovic V, Peino R, Considine R, Caro J: Serum immunoreactive leptin concentrations in patients with anorexia nervosa before and after partial weight recovery. Biochem Mol Med 60:116-120, 1997
6. Cusin I, Rohner-Jeanrenaud F, Stricker-Krongard A, Jeanrenaud B: The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats: reduced sensitivity compared with lean animals. Diabetes 45:1446-1450, 1996
7. Wang T, Hartzell DL, Flatt WP, Martin RJ, Baile CA: Responses of lean and obese Zucker rats to centrally administered leptin. Physiol Behav 65:333-341, 1998
8. Seeley RJ, Van Dijk G, Campfleld LA, Smith F, Bell SM, Woods SC, Schwartz MW: Intracerebroventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats. Horm Metab Res 28:664-668, 1996
9. Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Early AR, Barnett AH, Prins JB, O'Rahilly S: Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387:903-908, 1997
10. Tartaglia LA: The leptin receptor. J Biol Chem 272:6093-6096, 1997
11. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgensten JP: Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-495, 1996
12. Chua SC Jr, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L, Leibel RL: Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271:994-996, 1996
13. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM: Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632-635, 1996
14. Mecer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P: Localization of leptin receptor mRNA and the long form splice variant (OB-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 387:113-116, 1996
15. Hoggard N, Mercer JG, Rayner DV, Moar K, Traghnn P, Williams LM: Localization of leptin receptor mRNA splice variants in murine peripheral tissue by RT-PCR and in situ hybridization. Biochem Biophys Res Commun 232: 383-387, 1997
16. Fei H, Okano HJ, Li C, Lee GH, Zhao C, Darnell R, Friedman JM: Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci U S A 94:7001-7005, 1997
17. Tsuchiya T, Shimizu H, Horie T, Mori M: Expression of leptin receptor in lung: leptin as a growth factor. Eur J Pharmacol 365:273-279, 1999
18. Kutoh E, Boss O, Levasseur F, Giacobino JP: Quantification of the full-length leptin receptor (OB-Rb) in human brown and white adipose tissue. Life Sci 62:445-451, 1998
19. Vaisse C, Halaas JL, Horvath CM, Darnell JE Jr, Stoffel M, Friedman JM: Leptin activation of Stat 3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet 14:95-97, 1996
20. Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougneres P, Lebouc Y, Froguel P, Guy-Grand B: A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392:398-401, 1998
21. Akiyama T, Tachibana I, Shirohara H, Watanabe N, Otsuki M: High-fat hypercaloric diet induces obesity, glucose intolerance and hyperlipidemia in normal adult male Wistar rat. Diabetes Res Clin Pract 31:27-35, 1996
22. Poduslo JF, Curran GL, Berg CT: Macromolecular permeability across the blood-nerve and blood-brain barriers. Proc Natl Acad Sci U S A 91:5705-5709, 1994
23. Poduslo JF, Curran GL: Increased permeability of superoxide dismutase at the blood-nerve and blood-brain barriers with retained enzymatic activity after covalent modification with the naturally occurring polyamine. J Neurochem 67:734-741, 1996
24. Poduslo JF, Curran GL: Polyamine modification increases the permeability of proteins at the blood-nerve and blood-brain barriers. J Neurochem 66: 1599-1609, 1996
25. Wu-Peng XS, Chua SC Jr, Okada N, Liu SM, Nicolson M, Leibel RL: Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): evidence for deficient plasma-to-CSF transport of leptin in both Zucker and Koletsky obese rat. Diabetes 46:513-518, 1997
26. Golden PL, Maccagnan TJ, Partridge WM: Human blood-brain barrier leptin receptor. J Clin Invest 99:14-18, 1997
27. Bjorbaek C, Elmquist JK, Michl P, Ahima RS, van Bueren A, McCall AL, Flier JS: Expression of leptin receptor isoforms in rat brain microvessels. Endocrinology 139:3485-3491, 1998
28. Couce M, Burguera B, Parisi JE, Jensen MD, Lloyd RV: Localization of leptin receptor in human brain. Neuroendocrinology 66:145-150, 1997
29. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM: Leptin enters the brain by a saturable system independent of insulin. Peptides 17:305-311, 1996
30. Burguera B, Couce ME, Long J, Lamsam J, Jensen MD, Parisi JE, Lloyd RV: The long form of the leptin receptor (OB-Rb) is widely expressed in the human brain. Neuroendocrinology 61:187-195, 2000
31. Koistinen HA, Karonen S-L, Iivanainen M, Koivisto VA: Circulating leptin has saturable transport into intrathecal space in humans. Eur J Clin Invest 28:894-897, 1998
32. Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH, Lynn RB, Zhang PL, Sinha MK, Considine RV: Decreased cerebrospinalfluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 348:159-161, 1996
33. Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte D: Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 2:589-593, 1996
34. Flier JS, Maratos-Flier E: Obesity and the hypothalamus: novel peptides for new pathways. Cell 92:437-440, 1998
35. Burguera B, Jensen MD: Obesity: is the brain responsible? Curr Opin Gastroenterol 14:147-150, 1998
36. Karonen S-L, Koistinen HA, Nikkinen P, Koivisto VA: Is brain uptake of leptin in vivo saturable and reduced by fasting? Eur J Nucl Med 25:607-612, 1998
37. Boado RJ, Golden PL, Levin N, Pardridge WM: Up-regulation of blood-brain barrier short-form leptin receptor gene products in rats fed a high fat diet. J Neurochem 71:1761-1764, 1998
38. McKinley MJ, Oldfield BJ: The brain as an endocrine target for peptide hormones. Trends Endocrinol Metab 9:349-354, 1998
39. Weisner G, Vaz M, Collier G, Seals D, Kaye D, Jennings G, Lambert G, Wilkinson D, Esler M: Leptin is released from the human brain: influence of adiposity and gender. J Clin Endocrinol Metab 84:2270-2274, 1999
40. Jin L, Burguera B, Couce ME, Scheithauer BW, Lamsam J, Eberhardt NL, Kulic E, Lloyd RV: Leptin and leptin receptor (OB-Rb) expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation. J Clin Endocrinol Metab 84:2903-2911, 1999