Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 25, 1997, Pages 13921-13926

  Murphy, John E ^a   Zhou, Shangzhen ^a   Giese, Klaus ^a   Williams, Lewis T ^a   Escobedo, Jaime A ^a   Dwarki, Varavani J ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Adeno associated virus vectors; Gene therapy

Indexed keywords

LEPTIN; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE THERAPY; GLUCOSE INTOLERANCE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN RESISTANCE; LETHARGY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; BLOOD GLUCOSE; DEPENDOVIRUS; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; EATING; FEMALE; GENE THERAPY; GENETIC VECTORS; GLUCOSE TOLERANCE TEST; INJECTIONS, INTRAMUSCULAR; INSULIN; LEPTIN; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; PROTEINS; RECOMBINATION, GENETIC; WEIGHT GAIN;

ADENO-ASSOCIATED VIRUS; ANIMALIA;

EID: 0031471130     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.25.13921     Document Type: Article

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