메뉴 건너뛰기




Volumn 29, Issue 4, 2008, Pages 593-598

Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice

Author keywords

C reactive protein; Gene therapy; Inflammation; Interleukin 6; Obesity

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; GLUCOSE; GREEN FLUORESCENT PROTEIN; INSULIN; INTERLEUKIN 6; LEPTIN; RECOMBINANT PROTEIN; VIRUS VECTOR;

EID: 40249091255     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2008.01.001     Document Type: Article
Times cited : (24)

References (49)
  • 1
    • 33746152372 scopus 로고    scopus 로고
    • Adipose tissue as a secretory organ: from adipogenesis to the metabolic syndrome
    • [discussion 653-575]
    • Ailhaud G. Adipose tissue as a secretory organ: from adipogenesis to the metabolic syndrome. C R Biol 329 (2006) 570-577 [discussion 653-575]
    • (2006) C R Biol , vol.329 , pp. 570-577
    • Ailhaud, G.1
  • 2
    • 33645280927 scopus 로고    scopus 로고
    • Childhood obesity: trends and potential causes
    • Anderson P.M., and Butcher K.E. Childhood obesity: trends and potential causes. Future Child 16 (2006) 19-45
    • (2006) Future Child , vol.16 , pp. 19-45
    • Anderson, P.M.1    Butcher, K.E.2
  • 3
    • 0036827697 scopus 로고    scopus 로고
    • Evidence for the existence of distinct central appetite and energy expenditure pathways and stimulation of ghrelin as revealed by hypothalamic site-specific leptin gene therapy
    • Bagnasco M., Dube M.G., Kalra P.S., and Kalra S.P. Evidence for the existence of distinct central appetite and energy expenditure pathways and stimulation of ghrelin as revealed by hypothalamic site-specific leptin gene therapy. Endocrinology 143 (2002) 4409-4421
    • (2002) Endocrinology , vol.143 , pp. 4409-4421
    • Bagnasco, M.1    Dube, M.G.2    Kalra, P.S.3    Kalra, S.P.4
  • 4
    • 2142687620 scopus 로고    scopus 로고
    • Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin
    • Bagnasco M., Dube M.G., Katz A., Kalra P.S., and Kalra S.P. Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin. Obes Res. 11 (2003) 1463-1470
    • (2003) Obes Res. , vol.11 , pp. 1463-1470
    • Bagnasco, M.1    Dube, M.G.2    Katz, A.3    Kalra, P.S.4    Kalra, S.P.5
  • 5
    • 0036963628 scopus 로고    scopus 로고
    • Leptin-from a signal of adiposity to a hormonal mediator in peripheral tissues
    • Baratta M. Leptin-from a signal of adiposity to a hormonal mediator in peripheral tissues. Med Sci Monit 8 (2002) RA282-RA292
    • (2002) Med Sci Monit , vol.8
    • Baratta, M.1
  • 6
    • 85047681825 scopus 로고    scopus 로고
    • Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: effects on serum ghrelin and appetite-regulating genes
    • Beretta E., Dube M.G., Kalra P.S., and Kalra S.P. Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: effects on serum ghrelin and appetite-regulating genes. Pediatr Res 52 (2002) 189-198
    • (2002) Pediatr Res , vol.52 , pp. 189-198
    • Beretta, E.1    Dube, M.G.2    Kalra, P.S.3    Kalra, S.P.4
  • 7
    • 33750948987 scopus 로고    scopus 로고
    • Hypothalamic clamp on insulin release by leptin-transgene expression
    • Boghossian S., Dube M.G., Torto R., Kalra P.S., and Kalra S.P. Hypothalamic clamp on insulin release by leptin-transgene expression. Peptides 27 (2006) 3245-3254
    • (2006) Peptides , vol.27 , pp. 3245-3254
    • Boghossian, S.1    Dube, M.G.2    Torto, R.3    Kalra, P.S.4    Kalra, S.P.5
  • 8
    • 22544464405 scopus 로고    scopus 로고
    • Suppression of fat deposition for the life time of rodents with gene therapy
    • Boghossian S., Lecklin A.H., Torto R., Kalra P.S., and Kalra S.P. Suppression of fat deposition for the life time of rodents with gene therapy. Peptides 26 (2005) 1512-1519
    • (2005) Peptides , vol.26 , pp. 1512-1519
    • Boghossian, S.1    Lecklin, A.H.2    Torto, R.3    Kalra, P.S.4    Kalra, S.P.5
  • 9
    • 34547770365 scopus 로고    scopus 로고
    • Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin
    • Boghossian S., Ueno N., Dube M.G., Kalra P., and Kalra S. Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin. Neurobiol Aging 28 (2007) 1594-1604
    • (2007) Neurobiol Aging , vol.28 , pp. 1594-1604
    • Boghossian, S.1    Ueno, N.2    Dube, M.G.3    Kalra, P.4    Kalra, S.5
  • 10
    • 2942683422 scopus 로고    scopus 로고
    • Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk
    • Carr M.C., and Brunzell J.D. Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk. J Clin Endocrinol Metab 89 (2004) 2601-2607
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2601-2607
    • Carr, M.C.1    Brunzell, J.D.2
  • 11
    • 33645746168 scopus 로고    scopus 로고
    • Induction of leptin resistance through direct interaction of C-reactive protein with leptin
    • Chen K., Li F., Li J., Cai H., Strom S., Bisello A., et al. Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med 12 (2006) 425-432
    • (2006) Nat Med , vol.12 , pp. 425-432
    • Chen, K.1    Li, F.2    Li, J.3    Cai, H.4    Strom, S.5    Bisello, A.6
  • 12
    • 0034714042 scopus 로고    scopus 로고
    • Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change
    • Dhillon H., Ge Y., Minter R.M., Prima V., Moldawer L.L., Muzyczka N., et al. Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change. Regul Pept 92 (2000) 97-105
    • (2000) Regul Pept , vol.92 , pp. 97-105
    • Dhillon, H.1    Ge, Y.2    Minter, R.M.3    Prima, V.4    Moldawer, L.L.5    Muzyczka, N.6
  • 13
    • 0034882656 scopus 로고    scopus 로고
    • Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus
    • Dhillon H., Kalra S.P., and Kalra P.S. Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus. Mol Ther 4 (2001) 139-145
    • (2001) Mol Ther , vol.4 , pp. 139-145
    • Dhillon, H.1    Kalra, S.P.2    Kalra, P.S.3
  • 14
    • 0035876708 scopus 로고    scopus 로고
    • Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study
    • Dhillon H., Kalra S.P., Prima V., Zolotukhin S., Scarpace P.J., Moldawer L.L., et al. Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study. Regul Pept 99 (2001) 69-77
    • (2001) Regul Pept , vol.99 , pp. 69-77
    • Dhillon, H.1    Kalra, S.P.2    Prima, V.3    Zolotukhin, S.4    Scarpace, P.J.5    Moldawer, L.L.6
  • 15
    • 0036263327 scopus 로고    scopus 로고
    • Central leptin gene therapy blocks high fat diet-induced weight gain, hyperleptinemia and hyperinsulinemia: effects on serum ghrelin levels
    • Dube M.G., Beretta E., Dhillon H., Ueno N., Kalra P.S., and Kalra S.P. Central leptin gene therapy blocks high fat diet-induced weight gain, hyperleptinemia and hyperinsulinemia: effects on serum ghrelin levels. Diabetes 51 (2002) 1729-1736
    • (2002) Diabetes , vol.51 , pp. 1729-1736
    • Dube, M.G.1    Beretta, E.2    Dhillon, H.3    Ueno, N.4    Kalra, P.S.5    Kalra, S.P.6
  • 16
    • 18144408371 scopus 로고    scopus 로고
    • Adipose tissue, adipokines, and inflammation
    • Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 115 (2005) 911-919
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 911-919
    • Fantuzzi, G.1
  • 17
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 18
    • 10044289719 scopus 로고    scopus 로고
    • Role of adipocytokines in metabolism and disease
    • Fruhbeck G., and Salvador J. Role of adipocytokines in metabolism and disease. Nutr Res 24 (2004) 803-826
    • (2004) Nutr Res , vol.24 , pp. 803-826
    • Fruhbeck, G.1    Salvador, J.2
  • 19
    • 2942675088 scopus 로고    scopus 로고
    • Obesity, metabolic syndrome, and cardiovascular disease
    • Grundy S.M. Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 89 (2004) 2595-2600
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2595-2600
    • Grundy, S.M.1
  • 20
    • 0032577404 scopus 로고    scopus 로고
    • Environmental contributions to the obesity epidemic
    • Hill J.O., and Peters J.C. Environmental contributions to the obesity epidemic. Science 280 (1998) 1371-1374
    • (1998) Science , vol.280 , pp. 1371-1374
    • Hill, J.O.1    Peters, J.C.2
  • 22
    • 34247546688 scopus 로고    scopus 로고
    • Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice
    • Iwaniec U.T., Boghossian S., Lapke P.D., Turner R.T., and Kalra S.P. Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice. Peptides 28 (2007) 1012-1019
    • (2007) Peptides , vol.28 , pp. 1012-1019
    • Iwaniec, U.T.1    Boghossian, S.2    Lapke, P.D.3    Turner, R.T.4    Kalra, S.P.5
  • 23
    • 37249046860 scopus 로고    scopus 로고
    • Central leptin insufficiency syndrome: An interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions
    • Kalra S.P. Central leptin insufficiency syndrome: An interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions. Peptides 29 (2008) 127-138
    • (2008) Peptides , vol.29 , pp. 127-138
    • Kalra, S.P.1
  • 24
    • 0033038418 scopus 로고    scopus 로고
    • Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
    • Kalra S.P., Dube M.G., Pu S., Xu B., Horvath T.L., and Kalra P.S. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 20 (1999) 68-100
    • (1999) Endocr Rev , vol.20 , pp. 68-100
    • Kalra, S.P.1    Dube, M.G.2    Pu, S.3    Xu, B.4    Horvath, T.L.5    Kalra, P.S.6
  • 25
    • 25144507707 scopus 로고    scopus 로고
    • Gene transfer technology: a preventive neurotherapy to curb obesity, ameliorate metabolic syndrome and extend life-expectancy
    • Kalra S.P., and Kalra P.S. Gene transfer technology: a preventive neurotherapy to curb obesity, ameliorate metabolic syndrome and extend life-expectancy. Trends Pharmacol Sci 26 (2005) 488-495
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 488-495
    • Kalra, S.P.1    Kalra, P.S.2
  • 26
    • 0041733148 scopus 로고    scopus 로고
    • Keeping obesity and metabolic syndrome at bay with central leptin and cytokine gene therapy
    • Hamilton I. (Ed), Bentham Science Publishers Ltd., San Francisco, CA
    • Kalra S.P., and Kalra P.S. Keeping obesity and metabolic syndrome at bay with central leptin and cytokine gene therapy. In: Hamilton I. (Ed). Current medicinal chemistry-central nervous system agent (2003), Bentham Science Publishers Ltd., San Francisco, CA 189-199
    • (2003) Current medicinal chemistry-central nervous system agent , pp. 189-199
    • Kalra, S.P.1    Kalra, P.S.2
  • 27
    • 33646529141 scopus 로고    scopus 로고
    • Serum C-reactive protein as a marker for wellness assessment
    • Kao P.C., Shiesh S.C., and Wu T.J. Serum C-reactive protein as a marker for wellness assessment. Ann Clin Lab Sci 36 (2006) 163-169
    • (2006) Ann Clin Lab Sci , vol.36 , pp. 163-169
    • Kao, P.C.1    Shiesh, S.C.2    Wu, T.J.3
  • 28
    • 0141459376 scopus 로고    scopus 로고
    • C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol
    • Kazumi T., Kawaguchi A., Hirano T., and Yoshino G. C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol. Metabolism 52 (2003) 1113-1116
    • (2003) Metabolism , vol.52 , pp. 1113-1116
    • Kazumi, T.1    Kawaguchi, A.2    Hirano, T.3    Yoshino, G.4
  • 29
    • 2942650969 scopus 로고    scopus 로고
    • Adipose tissue as an endocrine organ
    • Kershaw E.E., and Flier J.S. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89 (2004) 2548-2556
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2548-2556
    • Kershaw, E.E.1    Flier, J.S.2
  • 30
    • 33748420067 scopus 로고    scopus 로고
    • Biomarkers of outcome from cardiovascular disease
    • Khuseyinova N., and Koenig W. Biomarkers of outcome from cardiovascular disease. Curr Opin Crit Care 12 (2006) 412-419
    • (2006) Curr Opin Crit Care , vol.12 , pp. 412-419
    • Khuseyinova, N.1    Koenig, W.2
  • 31
    • 32644451260 scopus 로고    scopus 로고
    • Tracing from fat tissue, liver, and pancreas: a neuroanatomical framework for the role of the brain in type 2 diabetes
    • Kreier F., Kap Y.S., Mettenleiter T.C., van Heijningen C., van der Vliet J., Kalsbeek A., et al. Tracing from fat tissue, liver, and pancreas: a neuroanatomical framework for the role of the brain in type 2 diabetes. Endocrinology 147 (2006) 1140-1147
    • (2006) Endocrinology , vol.147 , pp. 1140-1147
    • Kreier, F.1    Kap, Y.S.2    Mettenleiter, T.C.3    van Heijningen, C.4    van der Vliet, J.5    Kalsbeek, A.6
  • 32
    • 20444421276 scopus 로고    scopus 로고
    • Perigestational suppression of weight gain with central leptin gene therapy results in lower weight F1 generation
    • Lecklin A.H., Dube M.G., Torto R., Kalra P.S., and Kalra S.P. Perigestational suppression of weight gain with central leptin gene therapy results in lower weight F1 generation. Peptides 26 (2005) 1176-1187
    • (2005) Peptides , vol.26 , pp. 1176-1187
    • Lecklin, A.H.1    Dube, M.G.2    Torto, R.3    Kalra, P.S.4    Kalra, S.P.5
  • 33
    • 0038577223 scopus 로고    scopus 로고
    • Minireview: adiposity, inflammation, and atherogenesis
    • Lyon C.J., Law R.E., and Hsueh W.A. Minireview: adiposity, inflammation, and atherogenesis. Endocrinology 144 (2003) 2195-2200
    • (2003) Endocrinology , vol.144 , pp. 2195-2200
    • Lyon, C.J.1    Law, R.E.2    Hsueh, W.A.3
  • 34
    • 0035431169 scopus 로고    scopus 로고
    • The effects of leptin administration in non-obese human subjects
    • Mackintosh R.M., and Hirsch J. The effects of leptin administration in non-obese human subjects. Obes Res 9 (2001) 462-469
    • (2001) Obes Res , vol.9 , pp. 462-469
    • Mackintosh, R.M.1    Hirsch, J.2
  • 35
  • 36
    • 34247622463 scopus 로고    scopus 로고
    • Role of novel biomarkers of inflammation in patients with stable coronary heart disease
    • Oren H., Erbay A.R., Balci M., and Cehreli S. Role of novel biomarkers of inflammation in patients with stable coronary heart disease. Angiology 58 (2007) 148-155
    • (2007) Angiology , vol.58 , pp. 148-155
    • Oren, H.1    Erbay, A.R.2    Balci, M.3    Cehreli, S.4
  • 37
    • 27944502118 scopus 로고    scopus 로고
    • Central leptin differentially modulates ultradian secretory patterns of insulin, leptin and ghrelin independent of effects on food intake and body weight
    • Otukonyong E.E., Dube M.G., Torto R., Kalra P.S., and Kalra S.P. Central leptin differentially modulates ultradian secretory patterns of insulin, leptin and ghrelin independent of effects on food intake and body weight. Peptides 26 (2005) 2559-2566
    • (2005) Peptides , vol.26 , pp. 2559-2566
    • Otukonyong, E.E.1    Dube, M.G.2    Torto, R.3    Kalra, P.S.4    Kalra, S.P.5
  • 38
    • 20444480549 scopus 로고    scopus 로고
    • Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6
    • Park H.S., Park J.Y., and Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract 69 (2005) 29-35
    • (2005) Diabetes Res Clin Pract , vol.69 , pp. 29-35
    • Park, H.S.1    Park, J.Y.2    Yu, R.3
  • 39
    • 0037469232 scopus 로고    scopus 로고
    • Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association
    • Pearson T.A., Mensah G.A., Alexander R.W., Anderson J.L., Cannon III R.O., Criqui M., et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 107 (2003) 499-511
    • (2003) Circulation , vol.107 , pp. 499-511
    • Pearson, T.A.1    Mensah, G.A.2    Alexander, R.W.3    Anderson, J.L.4    Cannon III, R.O.5    Criqui, M.6
  • 41
    • 0041374029 scopus 로고    scopus 로고
    • Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha
    • Ruan H., and Lodish H.F. Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha. Cytokine Growth Factor Rev 14 (2003) 447-455
    • (2003) Cytokine Growth Factor Rev , vol.14 , pp. 447-455
    • Ruan, H.1    Lodish, H.F.2
  • 44
    • 0035161705 scopus 로고    scopus 로고
    • Neuroanatomical specificity of the circuits controlling sympathetic outflow to different targets
    • Sved A.F., Cano G., and Card J.P. Neuroanatomical specificity of the circuits controlling sympathetic outflow to different targets. Clin Exp Pharmacol Physiol 28 (2001) 115-119
    • (2001) Clin Exp Pharmacol Physiol , vol.28 , pp. 115-119
    • Sved, A.F.1    Cano, G.2    Card, J.P.3
  • 45
    • 27844545767 scopus 로고    scopus 로고
    • Signalling role of adipose tissue: adipokines and inflammation in obesity
    • Trayhurn P., and Wood I.S. Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans 33 (2005) 1078-1081
    • (2005) Biochem Soc Trans , vol.33 , pp. 1078-1081
    • Trayhurn, P.1    Wood, I.S.2
  • 46
    • 4344675633 scopus 로고    scopus 로고
    • Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy
    • Ueno N., Dube M.G., Inui A., Kalra P.S., and Kalra S.P. Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy. Endocrinology 145 (2004) 4176-4184
    • (2004) Endocrinology , vol.145 , pp. 4176-4184
    • Ueno, N.1    Dube, M.G.2    Inui, A.3    Kalra, P.S.4    Kalra, S.P.5
  • 47
    • 33746886648 scopus 로고    scopus 로고
    • Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice
    • Ueno N., Inui A., Kalra S.P., and Kalra P.S. Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice. Peptides 27 (2006) 2332-2342
    • (2006) Peptides , vol.27 , pp. 2332-2342
    • Ueno, N.1    Inui, A.2    Kalra, S.P.3    Kalra, P.S.4
  • 49
    • 0037133285 scopus 로고    scopus 로고
    • Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year
    • Ziccardi P., Nappo F., Giugliano G., Esposito K., Marfella R., Cioffi M., et al. Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation 105 (2002) 804-809
    • (2002) Circulation , vol.105 , pp. 804-809
    • Ziccardi, P.1    Nappo, F.2    Giugliano, G.3    Esposito, K.4    Marfella, R.5    Cioffi, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.