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Volumn 30, Issue 5, 2009, Pages 967-973

Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay

Author keywords

Bone remodeling; Glucose insulin homeostasis; Hypothalamus; Leptin; Osteoblast; Osteocalcin

Indexed keywords

GREEN FLUORESCENT PROTEIN; HYPOTHALAMUS HORMONE; INSULIN; LEPTIN; OSTEOCALCIN;

EID: 67349253844     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2009.01.020     Document Type: Article
Times cited : (38)

References (66)
  • 1
    • 0036827697 scopus 로고    scopus 로고
    • Evidence for the existence of distinct central appetite and energy expenditure pathways and stimulation of ghrelin as revealed by hypothalamic site-specific leptin gene therapy
    • Bagnasco M., Dube M.G., Kalra P.S., and Kalra S.P. Evidence for the existence of distinct central appetite and energy expenditure pathways and stimulation of ghrelin as revealed by hypothalamic site-specific leptin gene therapy. Endocrinology 143 (2002) 4409-4421
    • (2002) Endocrinology , vol.143 , pp. 4409-4421
    • Bagnasco, M.1    Dube, M.G.2    Kalra, P.S.3    Kalra, S.P.4
  • 2
    • 2142687620 scopus 로고    scopus 로고
    • Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin
    • Bagnasco M., Dube M.G., Katz A., Kalra P.S., and Kalra S.P. Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin. Obes Res 11 (2003) 1463-1470
    • (2003) Obes Res , vol.11 , pp. 1463-1470
    • Bagnasco, M.1    Dube, M.G.2    Katz, A.3    Kalra, P.S.4    Kalra, S.P.5
  • 3
    • 34547105098 scopus 로고    scopus 로고
    • Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis
    • Baldock P.A., Allison S.J., Lundberg P., Lee N.J., Slack K., Lin E.J., et al. Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis. J Biol Chem 282 (2007) 19092-19102
    • (2007) J Biol Chem , vol.282 , pp. 19092-19102
    • Baldock, P.A.1    Allison, S.J.2    Lundberg, P.3    Lee, N.J.4    Slack, K.5    Lin, E.J.6
  • 6
    • 0033036199 scopus 로고    scopus 로고
    • CNS origins of the sympathetic nervous system outflow to brown adipose tissue
    • Bamshad M., Song C.K., and Bartness T.J. CNS origins of the sympathetic nervous system outflow to brown adipose tissue. Am J Physiol 276 (1999) R1569-R1578
    • (1999) Am J Physiol , vol.276
    • Bamshad, M.1    Song, C.K.2    Bartness, T.J.3
  • 7
    • 0029864416 scopus 로고    scopus 로고
    • Leptin enters the brain by a saturable system independent of insulin
    • Banks W.A., Kastin A.J., Huang W., Jaspan J.B., and Maness L.M. Leptin enters the brain by a saturable system independent of insulin. Peptides 17 (1996) 305-311
    • (1996) Peptides , vol.17 , pp. 305-311
    • Banks, W.A.1    Kastin, A.J.2    Huang, W.3    Jaspan, J.B.4    Maness, L.M.5
  • 8
    • 0036963628 scopus 로고    scopus 로고
    • Leptin-from a signal of adiposity to a hormonal mediator in peripheral tissues
    • Baratta M. Leptin-from a signal of adiposity to a hormonal mediator in peripheral tissues. Med Sci Monit 8 (2002) RA282-RA292
    • (2002) Med Sci Monit , vol.8
    • Baratta, M.1
  • 10
    • 33750948987 scopus 로고    scopus 로고
    • Hypothalamic clamp on insulin release by leptin-transgene expression
    • Boghossian S., Dube M.G., Torto R., Kalra P.S., and Kalra S.P. Hypothalamic clamp on insulin release by leptin-transgene expression. Peptides 27 (2006) 3245-3254
    • (2006) Peptides , vol.27 , pp. 3245-3254
    • Boghossian, S.1    Dube, M.G.2    Torto, R.3    Kalra, P.S.4    Kalra, S.P.5
  • 11
    • 22544464405 scopus 로고    scopus 로고
    • Suppression of fat deposition for the life time of rodents with gene therapy
    • Boghossian S., Lecklin A.H., Torto R., Kalra P.S., and Kalra S.P. Suppression of fat deposition for the life time of rodents with gene therapy. Peptides 26 (2005) 1512-1519
    • (2005) Peptides , vol.26 , pp. 1512-1519
    • Boghossian, S.1    Lecklin, A.H.2    Torto, R.3    Kalra, P.S.4    Kalra, S.P.5
  • 12
    • 34547770365 scopus 로고    scopus 로고
    • Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin
    • Boghossian S., Ueno N., Dube M.G., Kalra P.S., and Kalra S.P. Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin. Neurobiol Aging 28 (2007) 1594-1604
    • (2007) Neurobiol Aging , vol.28 , pp. 1594-1604
    • Boghossian, S.1    Ueno, N.2    Dube, M.G.3    Kalra, P.S.4    Kalra, S.P.5
  • 13
    • 0035911803 scopus 로고    scopus 로고
    • Parasympathetic and sympathetic control of the pancreas: a role for the suprachiasmatic nucleus and other hypothalamic centers that are involved in the regulation of food intake
    • Buijs R.M., Chun S.J., Niijima A., Romijn H.J., and Nagai K. Parasympathetic and sympathetic control of the pancreas: a role for the suprachiasmatic nucleus and other hypothalamic centers that are involved in the regulation of food intake. J Comp Neurol 431 (2001) 405-423
    • (2001) J Comp Neurol , vol.431 , pp. 405-423
    • Buijs, R.M.1    Chun, S.J.2    Niijima, A.3    Romijn, H.J.4    Nagai, K.5
  • 14
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks [see comments]
    • Campfield L.A., Smith F.J., Guisez Y., Devos R., and Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks [see comments]. Science 269 (1995) 546-549
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 15
    • 0034848003 scopus 로고    scopus 로고
    • Simvastatin increases serum osteocalcin concentration in patients treated for hypercholesterolaemia
    • Chan M.H., Mak T.W., Chiu R.W., Chow C.C., Chan I.H., and Lam C.W. Simvastatin increases serum osteocalcin concentration in patients treated for hypercholesterolaemia. J Clin Endocrinol Metab 86 (2001) 4556-4559
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4556-4559
    • Chan, M.H.1    Mak, T.W.2    Chiu, R.W.3    Chow, C.C.4    Chan, I.H.5    Lam, C.W.6
  • 16
    • 0034714038 scopus 로고    scopus 로고
    • Chronic leptin administration promotes lipid utilization until fat mass is greatly reduced and preserves lean mass of normal female rats
    • Chen Y., and Heiman M.L. Chronic leptin administration promotes lipid utilization until fat mass is greatly reduced and preserves lean mass of normal female rats. Regul Pept 92 (2000) 113-119
    • (2000) Regul Pept , vol.92 , pp. 113-119
    • Chen, Y.1    Heiman, M.L.2
  • 17
    • 0033037727 scopus 로고    scopus 로고
    • Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat
    • Chinookoswong N., Wang J.L., and Shi Z.Q. Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat. Diabetes 48 (1999) 1487-1492
    • (1999) Diabetes , vol.48 , pp. 1487-1492
    • Chinookoswong, N.1    Wang, J.L.2    Shi, Z.Q.3
  • 18
    • 45849141928 scopus 로고    scopus 로고
    • The effect of leptin on bone-an evolving concept of action
    • Cirmanova V., Bayer M., Starka L., and Zajickova K. The effect of leptin on bone-an evolving concept of action. Physiol Res 57 (2008) S143-S151
    • (2008) Physiol Res , vol.57
    • Cirmanova, V.1    Bayer, M.2    Starka, L.3    Zajickova, K.4
  • 20
    • 0034714042 scopus 로고    scopus 로고
    • Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change
    • Dhillon H., Ge Y., Minter R.M., Prima V., Moldawer L.L., Muzyczka N., et al. Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change. Regul Pept 92 (2000) 97-105
    • (2000) Regul Pept , vol.92 , pp. 97-105
    • Dhillon, H.1    Ge, Y.2    Minter, R.M.3    Prima, V.4    Moldawer, L.L.5    Muzyczka, N.6
  • 21
    • 0035876708 scopus 로고    scopus 로고
    • Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study
    • Dhillon H., Kalra S.P., Prima V., Zolotukhin S., Scarpace P.J., Moldawer L.L., et al. Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study. Regul Pept 99 (2001) 69-77
    • (2001) Regul Pept , vol.99 , pp. 69-77
    • Dhillon, H.1    Kalra, S.P.2    Prima, V.3    Zolotukhin, S.4    Scarpace, P.J.5    Moldawer, L.L.6
  • 22
    • 40249091255 scopus 로고    scopus 로고
    • Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice
    • Dube M.G., Torto R., and Kalra S.P. Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice. Peptides 29 (2008) 593-598
    • (2008) Peptides , vol.29 , pp. 593-598
    • Dube, M.G.1    Torto, R.2    Kalra, S.P.3
  • 23
    • 0141737573 scopus 로고    scopus 로고
    • Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass
    • Ducy P., Amling M., Takeda S., Priemel M., Schilling A.F., Beil F.T., et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100 (2000) 197-207
    • (2000) Cell , vol.100 , pp. 197-207
    • Ducy, P.1    Amling, M.2    Takeda, S.3    Priemel, M.4    Schilling, A.F.5    Beil, F.T.6
  • 24
    • 15844412402 scopus 로고    scopus 로고
    • Increased bone formation in osteocalcin-deficient mice
    • Ducy P., Desbois C., Boyce B., Pinero G., Story B., Dunstan C., et al. Increased bone formation in osteocalcin-deficient mice. Nature 382 (1996) 448-452
    • (1996) Nature , vol.382 , pp. 448-452
    • Ducy, P.1    Desbois, C.2    Boyce, B.3    Pinero, G.4    Story, B.5    Dunstan, C.6
  • 25
    • 33747351246 scopus 로고    scopus 로고
    • Bone abnormalities in adolescent leptin-deficient mice
    • Ealey K.N., Fonseca D., Archer M.C., and Ward W.E. Bone abnormalities in adolescent leptin-deficient mice. Regul Pept 136 (2006) 9-13
    • (2006) Regul Pept , vol.136 , pp. 9-13
    • Ealey, K.N.1    Fonseca, D.2    Archer, M.C.3    Ward, W.E.4
  • 27
    • 67349190133 scopus 로고    scopus 로고
    • Three perspectives on thiazolidine and bone health
    • Evans R.M., Grey A., and Clarke B.L. Three perspectives on thiazolidine and bone health. Endocrine News (2008) 14-21
    • (2008) Endocrine News , pp. 14-21
    • Evans, R.M.1    Grey, A.2    Clarke, B.L.3
  • 28
    • 42449096306 scopus 로고    scopus 로고
    • Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice
    • Ferron M., Hinoi E., Karsenty G., and Ducy P. Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. PNAS 105 (2008) 5266-5270
    • (2008) PNAS , vol.105 , pp. 5266-5270
    • Ferron, M.1    Hinoi, E.2    Karsenty, G.3    Ducy, P.4
  • 29
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 30
    • 33646809677 scopus 로고    scopus 로고
    • Different skeletal regional response to continuous brain infusion of leptin in the rat
    • Guidobono F., Pagani F., Sibilia V., Netti C., Lattuada N., Rapetti D., et al. Different skeletal regional response to continuous brain infusion of leptin in the rat. Peptides 27 (2006) 1426-1433
    • (2006) Peptides , vol.27 , pp. 1426-1433
    • Guidobono, F.1    Pagani, F.2    Sibilia, V.3    Netti, C.4    Lattuada, N.5    Rapetti, D.6
  • 31
    • 19044381754 scopus 로고    scopus 로고
    • Leptin treatment induces loss of bone marrow adipocytes and increases bone formation in leptin-deficient ob/ob mice
    • Hamrick M.W., Della-Fera M.A., Choi Y.H., Pennington C., Hartzell D., and Baile C.A. Leptin treatment induces loss of bone marrow adipocytes and increases bone formation in leptin-deficient ob/ob mice. J Bone Miner Res 20 (2005) 994-1001
    • (2005) J Bone Miner Res , vol.20 , pp. 994-1001
    • Hamrick, M.W.1    Della-Fera, M.A.2    Choi, Y.H.3    Pennington, C.4    Hartzell, D.5    Baile, C.A.6
  • 32
    • 0037673933 scopus 로고    scopus 로고
    • Control of osteoblast function and regulation of bone mass
    • Harada S.-i., and Rodan G.A. Control of osteoblast function and regulation of bone mass. Nature 423 (2003) 349-355
    • (2003) Nature , vol.423 , pp. 349-355
    • Harada, S.-i.1    Rodan, G.A.2
  • 33
    • 18344374382 scopus 로고    scopus 로고
    • Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats
    • Hidaka S., Yoshimatsu H., Kondou S., Tsuruta Y., Oka K., Noguchi H., et al. Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats. FASEB J 16 (2002) 509-518
    • (2002) FASEB J , vol.16 , pp. 509-518
    • Hidaka, S.1    Yoshimatsu, H.2    Kondou, S.3    Tsuruta, Y.4    Oka, K.5    Noguchi, H.6
  • 34
    • 59449093033 scopus 로고    scopus 로고
    • The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity
    • Hinoi E., Gao N., Jung D.Y., Yadav V., Yoshizawa T., Myers Jr. M.G., et al. The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol 183 (2008) 1235-1242
    • (2008) J Cell Biol , vol.183 , pp. 1235-1242
    • Hinoi, E.1    Gao, N.2    Jung, D.Y.3    Yadav, V.4    Yoshizawa, T.5    Myers Jr., M.G.6
  • 35
    • 34247546688 scopus 로고    scopus 로고
    • Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice
    • Iwaniec U.T., Boghossian S., Lapke P.D., Turner R.T., and Kalra S.P. Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice. Peptides 28 (2007) 1012-1019
    • (2007) Peptides , vol.28 , pp. 1012-1019
    • Iwaniec, U.T.1    Boghossian, S.2    Lapke, P.D.3    Turner, R.T.4    Kalra, S.P.5
  • 37
    • 37249046860 scopus 로고    scopus 로고
    • Central leptin insufficiency syndrome: an interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions
    • Kalra S.P. Central leptin insufficiency syndrome: an interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions. Peptides 29 (2008) 127-138
    • (2008) Peptides , vol.29 , pp. 127-138
    • Kalra, S.P.1
  • 38
    • 49749107875 scopus 로고    scopus 로고
    • Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic syndrome: new therapeutic approaches
    • Kalra S.P. Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic syndrome: new therapeutic approaches. Nutrition 24 (2008) 820-826
    • (2008) Nutrition , vol.24 , pp. 820-826
    • Kalra, S.P.1
  • 39
    • 0033038418 scopus 로고    scopus 로고
    • Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
    • Kalra S.P., Dube M.G., Pu S., Xu B., Horvath T.L., and Kalra P.S. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 20 (1999) 68-100
    • (1999) Endocr Rev , vol.20 , pp. 68-100
    • Kalra, S.P.1    Dube, M.G.2    Pu, S.3    Xu, B.4    Horvath, T.L.5    Kalra, P.S.6
  • 40
    • 25144507707 scopus 로고    scopus 로고
    • Gene transfer technology: a preventive neurotherapy to curb obesity, ameliorate metabolic syndrome and extend life-expectancy
    • Kalra S.P., and Kalra P.S. Gene transfer technology: a preventive neurotherapy to curb obesity, ameliorate metabolic syndrome and extend life-expectancy. Trends Pharmacol Sci 26 (2005) 488-495
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 488-495
    • Kalra, S.P.1    Kalra, P.S.2
  • 41
    • 4344595580 scopus 로고    scopus 로고
    • NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy
    • Kalra S.P., and Kalra P.S. NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy. Neuropeptides 38 (2004) 201-211
    • (2004) Neuropeptides , vol.38 , pp. 201-211
    • Kalra, S.P.1    Kalra, P.S.2
  • 42
    • 0034714036 scopus 로고    scopus 로고
    • Dynamic regulation of leptin entry into brain by the blood-brain barrier
    • Kastin A.J., and Pan W. Dynamic regulation of leptin entry into brain by the blood-brain barrier. Regul Pept 92 (2000) 37-43
    • (2000) Regul Pept , vol.92 , pp. 37-43
    • Kastin, A.J.1    Pan, W.2
  • 43
    • 33645851989 scopus 로고    scopus 로고
    • Intranasal leptin: blood-brain barrier bypass (BBBB) for obesity?
    • Kastin A.J., and Pan W. Intranasal leptin: blood-brain barrier bypass (BBBB) for obesity?. Endocrinology 147 (2006) 2086-2087
    • (2006) Endocrinology , vol.147 , pp. 2086-2087
    • Kastin, A.J.1    Pan, W.2
  • 44
    • 32644451260 scopus 로고    scopus 로고
    • Tracing from fat tissue, liver, and pancreas: a neuroanatomical framework for the role of the brain in type 2 diabetes
    • Kreier F., Kap Y.S., Mettenleiter T.C., van Heijningen C., van der Vliet J., Kalsbeek A., et al. Tracing from fat tissue, liver, and pancreas: a neuroanatomical framework for the role of the brain in type 2 diabetes. Endocrinology 147 (2006) 1140-1147
    • (2006) Endocrinology , vol.147 , pp. 1140-1147
    • Kreier, F.1    Kap, Y.S.2    Mettenleiter, T.C.3    van Heijningen, C.4    van der Vliet, J.5    Kalsbeek, A.6
  • 45
    • 20444421276 scopus 로고    scopus 로고
    • Perigestational suppression of weight gain with central leptin gene therapy results in lower weight F1 generation
    • Lecklin A.H., Dube M.G., Torto R., Kalra P.S., and Kalra S.P. Perigestational suppression of weight gain with central leptin gene therapy results in lower weight F1 generation. Peptides 26 (2005) 1176-1187
    • (2005) Peptides , vol.26 , pp. 1176-1187
    • Lecklin, A.H.1    Dube, M.G.2    Torto, R.3    Kalra, P.S.4    Kalra, S.P.5
  • 46
    • 45349084061 scopus 로고    scopus 로고
    • Reciprocal regulation of bone and energy metabolism
    • Lee N.K., and Karsenty G. Reciprocal regulation of bone and energy metabolism. Trends Endocrinol Metab 19 (2008) 161-166
    • (2008) Trends Endocrinol Metab , vol.19 , pp. 161-166
    • Lee, N.K.1    Karsenty, G.2
  • 47
    • 0036790386 scopus 로고    scopus 로고
    • Role of leptin in immunology
    • S35-38, S68-87
    • Lord G. Role of leptin in immunology. Nutr Rev 60 (2002) S35-38, S68-87
    • (2002) Nutr Rev , vol.60
    • Lord, G.1
  • 48
    • 34547107887 scopus 로고    scopus 로고
    • Greater bone formation of Y2 knockout mice is associated with increased osteoprogenitor numbers and altered Y1 receptor expression
    • Lundberg P., Allison S.J., Lee N.J., Baldock P.A., Brouard N., Rost S., et al. Greater bone formation of Y2 knockout mice is associated with increased osteoprogenitor numbers and altered Y1 receptor expression. J Biol Chem 282 (2007) 19082-19091
    • (2007) J Biol Chem , vol.282 , pp. 19082-19091
    • Lundberg, P.1    Allison, S.J.2    Lee, N.J.3    Baldock, P.A.4    Brouard, N.5    Rost, S.6
  • 49
    • 0031766974 scopus 로고    scopus 로고
    • Fate of leptin after intracerebroventricular injection into the mouse brain
    • Maness L.M., Kastin A.J., Farrell C.L., and Banks W.A. Fate of leptin after intracerebroventricular injection into the mouse brain. Endocrinology 139 (1998) 4556-4562
    • (1998) Endocrinology , vol.139 , pp. 4556-4562
    • Maness, L.M.1    Kastin, A.J.2    Farrell, C.L.3    Banks, W.A.4
  • 50
    • 27944502118 scopus 로고    scopus 로고
    • Central leptin differentially modulates ultradian secretory patterns of insulin, leptin and ghrelin independent of effects on food intake and body weight
    • Otukonyong E.E., Dube M.G., Torto R., Kalra P.S., and Kalra S.P. Central leptin differentially modulates ultradian secretory patterns of insulin, leptin and ghrelin independent of effects on food intake and body weight. Peptides 26 (2005) 2559-2566
    • (2005) Peptides , vol.26 , pp. 2559-2566
    • Otukonyong, E.E.1    Dube, M.G.2    Torto, R.3    Kalra, P.S.4    Kalra, S.P.5
  • 51
    • 34250200434 scopus 로고    scopus 로고
    • The new field of neuroskeletal biology
    • Patel M.S., and Elefteriou F. The new field of neuroskeletal biology. Calc Tissue Int 80 (2007) 337-347
    • (2007) Calc Tissue Int , vol.80 , pp. 337-347
    • Patel, M.S.1    Elefteriou, F.2
  • 52
    • 34547808130 scopus 로고    scopus 로고
    • Simvastatin and atorvastatin enhance gene expression of collagen type 1 and osteocalcin in primary human osteoblasts and MG-63 cultures
    • Ruiz-Gaspa S., Nogues X., Enjuanes A., Monllau J.C., Blanch J., Carreras R., et al. Simvastatin and atorvastatin enhance gene expression of collagen type 1 and osteocalcin in primary human osteoblasts and MG-63 cultures. J Cell Biochem 101 (2007) 1430-1438
    • (2007) J Cell Biochem , vol.101 , pp. 1430-1438
    • Ruiz-Gaspa, S.1    Nogues, X.2    Enjuanes, A.3    Monllau, J.C.4    Blanch, J.5    Carreras, R.6
  • 53
    • 0036798083 scopus 로고    scopus 로고
    • Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide Y neurones
    • Sahu A. Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide Y neurones. J Neuroendocrinol 14 (2002) 796-804
    • (2002) J Neuroendocrinol , vol.14 , pp. 796-804
    • Sahu, A.1
  • 54
    • 45749112558 scopus 로고    scopus 로고
    • Structural basis of growth-related gain and age-related loss of bone strength
    • iv2-iv8
    • Seeman E. Structural basis of growth-related gain and age-related loss of bone strength. Rheumatology 47 (2008) iv2-iv8
    • (2008) Rheumatology , vol.47
    • Seeman, E.1
  • 55
    • 0008466784 scopus 로고    scopus 로고
    • Intracerebroventricular administration of leptin markedly enhances insulin sensitivity and systemic glucose utilization in conscious rats
    • Shi Z.Q., Nelson A., Whitcomb L., Wang J., and Cohen A.M. Intracerebroventricular administration of leptin markedly enhances insulin sensitivity and systemic glucose utilization in conscious rats. Metabolism 47 (1998) 1274-1280
    • (1998) Metabolism , vol.47 , pp. 1274-1280
    • Shi, Z.Q.1    Nelson, A.2    Whitcomb, L.3    Wang, J.4    Cohen, A.M.5
  • 57
    • 0036847619 scopus 로고    scopus 로고
    • Leptin regulates bone formation via the sympathetic nervous system
    • Takeda S., Elefteriou F., Levasseur R., Liu X., Zhao L., Parker K.L., et al. Leptin regulates bone formation via the sympathetic nervous system. Cell 111 (2002) 305-317
    • (2002) Cell , vol.111 , pp. 305-317
    • Takeda, S.1    Elefteriou, F.2    Levasseur, R.3    Liu, X.4    Zhao, L.5    Parker, K.L.6
  • 58
    • 2342518168 scopus 로고    scopus 로고
    • The complex effects of leptin on bone metabolism through multiple pathways
    • Thomas T. The complex effects of leptin on bone metabolism through multiple pathways. Curr Opin Pharmacol 4 (2004) 295-300
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 295-300
    • Thomas, T.1
  • 59
    • 4344675633 scopus 로고    scopus 로고
    • Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy
    • Ueno N., Dube M.G., Inui A., Kalra P.S., and Kalra S.P. Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy. Endocrinology 145 (2004) 4176-4184
    • (2004) Endocrinology , vol.145 , pp. 4176-4184
    • Ueno, N.1    Dube, M.G.2    Inui, A.3    Kalra, P.S.4    Kalra, S.P.5
  • 60
    • 33746886648 scopus 로고    scopus 로고
    • Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice
    • Ueno N., Inui A., Kalra S.P., and Kalra P.S. Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice. Peptides 27 (2006) 2332-2342
    • (2006) Peptides , vol.27 , pp. 2332-2342
    • Ueno, N.1    Inui, A.2    Kalra, S.P.3    Kalra, P.S.4
  • 62
    • 0032918044 scopus 로고    scopus 로고
    • A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse
    • Wang J., Takeuchi T., Tanaka S., Kubo S.K., Kayo T., Lu D., et al. A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse. J Clin Invest 103 (1999) 27-37
    • (1999) J Clin Invest , vol.103 , pp. 27-37
    • Wang, J.1    Takeuchi, T.2    Tanaka, S.3    Kubo, S.K.4    Kayo, T.5    Lu, D.6
  • 63
    • 67349095922 scopus 로고    scopus 로고
    • Whitfield JF. PTH and leptin: two bone builders at the Alamo. Part 2: leptin; 2002. medscape.com.
    • Whitfield JF. PTH and leptin: two bone builders at the Alamo. Part 2: leptin; 2002. medscape.com.
  • 64
    • 43449084959 scopus 로고    scopus 로고
    • Energy regulation by the skeleton
    • Wolf G. Energy regulation by the skeleton. Nutr Rev 66 (2008) 229-233
    • (2008) Nutr Rev , vol.66 , pp. 229-233
    • Wolf, G.1
  • 66
    • 0030907296 scopus 로고    scopus 로고
    • A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
    • Yoshioka M., Kayo T., Ikeda T., and Koizumi A. A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46 (1997) 887-894
    • (1997) Diabetes , vol.46 , pp. 887-894
    • Yoshioka, M.1    Kayo, T.2    Ikeda, T.3    Koizumi, A.4


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