Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: Binding aspects and implications for drug design

Medicinal Research Reviews

Volumn 31, Issue 6, 2011, Pages 821-862

  Bhadra, Kakali ^a   Kumar, Gopinatha Suresh ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

Alkaloids nucleic acid interaction; Calorimetry; Drug design; Isoquinoline alkaloids; Spectroscopy; Therapeutic implications

Indexed keywords

5,6 DIHYDRO 8 DESMETHYLCORALYNE; 8 DESMETHYLCORALYNE; ALKALOID DERIVATIVE; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTILEISHMANIAL AGENT; ANTILEUKEMIC AGENT; ANTINEOPLASTIC AGENT; BERBERINE; BEROLINE; CHELERYTHRINE; CORALYNE; CORALYNE DERIVATIVE; HYPOCHOLESTEROLEMIC AGENT; ISOQUINOLINE ALKALOID; JATRORRHIZINE; JATRORUBIN; NITIDINE; PALMATINE; PALMATRUBINE; PROTOBERBERINE; SANGUINARINE; UNCLASSIFIED DRUG;

AMMONOLYSIS; ANTIARRHYTHMIC ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; BERBERIDACEAE; BINDING AFFINITY; COMPLEX FORMATION; DEMETHYLATION; DIFFERENTIAL SCANNING CALORIMETRY; DNA BINDING; DNA DAMAGE; DNA HELIX; DNA SYNTHESIS; DRUG BINDING; DRUG DESIGN; DRUG DNA INTERACTION; DRUG STABILITY; DRUG STRUCTURE; DYSENTERY; ENTHALPY; ENTROPY; FUMARACEAE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HYPERTENSION; IC 50; INFLAMMATION; JAUNDICE; LIVER DISEASE; MEMBRANE PERMEABILITY; MENISPERMACEAE; MICROTUBULE ASSEMBLY; MITOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; PAPAVERACEAE; PLASMODIUM FALCIPARUM; PROTEIN DENATURATION; PROTEIN SYNTHESIS; REVIEW; RNA TRANSCRIPTION; SKIN LEISHMANIASIS; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION; TEMPERATURE; THERMODYNAMICS; VISCOMETRY;

ALKALOIDS; ANIMALS; BENZOPHENANTHRIDINES; BERBERINE; BERBERINE ALKALOIDS; CALORIMETRY; CHEMISTRY, PHARMACEUTICAL; DNA; DRUG DESIGN; HUMANS; ISOQUINOLINES; MICE; MODELS, CHEMICAL; NUCLEIC ACIDS; RNA; SPECTROPHOTOMETRY; TEMPERATURE;

EID: 79953751999     PISSN: 01986325     EISSN: 10981128     Source Type: Journal    
DOI: 10.1002/med.20202     Document Type: Review

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