The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding: A possible mechanism for its antiproliferative activity

FEBS Journal

Volumn 273, Issue 10, 2006, Pages 2139-2150

  Lopus, Manu ^a   Panda, Dulal ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

Author keywords

Cancer chemotherapy; Microtubules; Mitosis; Sanguinarine; Tubulin

Indexed keywords

2 AMINO 4 (3 PYRIDYL) 4H NAPHTHO[1,2 B]PYRAN 3 CARBONITRILE; ALKALOID; BENOMYL; BENZOPHENANTHRIDINE DERIVATIVE; CRYPTOPHYCIN 52; GRISEOFULVIN; NOCODAZOLE; PACLITAXEL; SANGUINARINE; TUBULIN; UNCLASSIFIED DRUG; VINBLASTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEPOLYMERIZATION; DRUG PROTEIN BINDING; HELA CELL; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MITOSIS; MOLECULAR DYNAMICS; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

ALKALOIDS; ANILINO NAPHTHALENESULFONATES; BENZOPHENANTHRIDINES; CELL LINE; CELL PROLIFERATION; FLUORESCENT DYES; HELA CELLS; HUMANS; ISOQUINOLINES; MICROTUBULES; PHENANTHRIDINES; POLYMERS; PROTEIN STRUCTURE, SECONDARY; TUBULIN;

EID: 33646241080     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2006.05227.x     Document Type: Article

References (35)

1. Lodish H Berk A Zipursky SL Matsudaira P Baltimore D Darnell J 2000 Molecular Cell Biology 4th edn W.H. Freeman
2. Desai A Mitchison TJ 1997 Microtubule polymerization dynamics Annu Rev Cell Dev Biol 13 83 117
3. McIntosh JR Grishchuk E West RR 2002 Chromosome-microtubule interactions during mitosis Annu Rev Cell Dev Biol 18 193 219
4. Gunderson GG Cook TA 1999 Microtubules and signal transduction Curr Opin Cell Biol 11 81 94
5. Wilson L Panda D Jordan MA 1999 Modulation of microtubule dynamics by drugs: a paradigm for the actions of cellular regulators Cell Struct Funct 24 329 335
6. Downing KH 2000 Structural basis for the interaction of tubulin with proteins and drugs that affects microtubule dynamics Annu Rev Cell Dev Biol 16 89 111
7. Jordan MA 2002 Mechanism of action of antitumor drugs that interacts with microtubules and tubulin Curr Med Chem AntiCancer Agents 2 1 17
8. Jordan MA Wilson L 2004 Microtubules as a target for anticancer drugs Nat Rev Cancer 4 253 265
9. Hamel E 1996 Antimitotic natural products and their interactions with tubulin Med Res Rev 16 207 231
10. Panda D Jordan MA Chu KC Wilson L 1996 Differential effects of vinblastine on polymerization and dynamics at opposite microtubule ends J Biol Chem 271 29807 29812
11. Panda D Singh JP Wilson L 1997 Suppression of microtubule dynamics by LY290181. A potential mechanism for its antiproliferative action J Biol Chem 272 7681 7687
12. Panda D DeLuca K Williams D Jordan MA Wilson L 1998 Antiproliferative mechanism of action of cryptophycin-52: kinetic stabilization of microtubule dynamics by high-affinity binding to microtubule ends Proc Natl Acad Sci USA 95 9313 9318
13. Jordan MA Thrower D Wilson L 1991 Mechanism of inhibition of cell proliferation by Vinca alkaloids Cancer Res 51 2212 2222
14. Gupta K Bishop J Peck A Brown J Wilson L Panda D 2004 Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin Biochemistry 43 6645 6655
15. Panda D Rathinasamy K Santra MK Wilson L 2005 Kinetic suppression of microtubule dynamic instability by griseofulvin: implications for its possible use in the treatment of cancer Proc Natl Acad Sci USA 102 9878 9883
16. Davis A Jiang JD Middleton KM Wang Y Weisz I Ling YH Bekesi JG 1999 Novel suicide ligands of tubulin arrest cancer cells in S-phase Neoplasia 1 498 507
17. Leoni LM Hamel E Genini D Shih H Carrera CJ Cottam HB Carson DA 2000 Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells J Natl Cancer Inst 92 217 224
18. Godowski KC 1989 Antimicrobial action of sanguinarine J Clin Dent 1 96 101
19. Beuria TK Santra MK Panda D 2005 Sanguinarine blocks cytokinesis in bacteria by inhibiting FtsZ assembly and bundling Biochemistry 44 16584 16593
20. Ahmad N Gupta S Husain MM Heiskanen KM Mukhtar H 2000 Differential anti-proliferative and apoptotic response of sanguinarine for cancer cells versus normal cells Clin Cancer Res 6 1424 1428
21. Slaninova J Taborska E Bochorakoa & Slanina J 2001 Interaction of benzophenanthridine and protoberberine alkaloids with animal and yeast cells Cell Biol Toxicol 17 51 63
22. Weerasinghe P Hallock S Liepins A 2001 Bax, Bcl-2, and NF-kappaB expression in sanguinarine induced bimodal cell death Exp Mol Pathol 71 89 98
23. Ding Z Tang SC Weerasinghe P Yang X Pater A Liepins A 2002 The alkaloid sanguinarine is effective against multidrug resistance in human cervical cells via bimodal cell death Biochem Pharmacol 63 1415 1421
24. Adhami VM Aziz MH Mukhtar H Ahmad N 2003 Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes Clin Cancer Res 9 3176 3182
25. Adhami VM Aziz MH Reagan-Shaw SR Nihal M Mukhtar H Ahmad N 2004 Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery Mol Cancer Ther 3 933 940
26. Vogt A Tamewitz A Skoko J Sikorski RP Giuliano KA Lazo JS 2005 The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1 J Biol Chem 280 19078 19086
27. Eun JP Koh GY 2004 Suppression of angiogenesis by the plant alkaloid, sanguinarine Biochem Biophys Res Commun 317 618 624
28. Dvorak Z Vrzal R Maurel P Ulrichova J 2006 Differential effects of selected natural compounds with anti-inflammatory activity on the glucocorticoid receptor and NF-kappaB in HeLa cells Chem Biol Interact 159 117 128
29. Wolff J Knipling L 1993 Anti-microtubule properties of Benzophenanthridine alkaloids Biochemistry 32 1334 1339
30. Legrand O Simonin G Perrot JY Zittoun R Marie JP 1998 Pgp and MRP activities using calcein-AM are prognostic factors in adult acute myeloid leukemia patients Blood 91 4480 4488
31. McKeague AL Wilson J Nelson J 2003 Staurosporine-induced apoptosis and hydrogen peroxide-induced necrosis in two human breast cell lines Br J Cancer 8 125 131
32. Panda D Bhattacharyya B 1992 Excimer fluorescence of pyrene-maleimide-labeled tubulin Eur J Biochem 204 783 787
33. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle of protein-dye binding Anal Biochem 72 248 254
34. Gupta K Panda D 2002 Perturbation of microtubule polymerization by quercetin through tubulin binding: a novel mechanism of its antiproliferative activity Biochemistry 41 13029 13038
35. Gaskin F Cantor CR Shelanski ML 1974 Turbidimetric studies of the in vitro assembly and disassembly of porcine neurotubules J Mol Biol 89 737 755