Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs

Biochemistry

Volumn 36, Issue 41, 1997, Pages 12542-12553

  Pilch, Daniel S ^a   Yu, Chiang ^a   Makhey, Darshan ^b   LaVoie, Edmond J ^b   Srinivasan, A R ^b   Olson, Wilma K ^b   Sauers, Ronald R ^b   Breslauer, Kenneth J ^b   Geacintov, Nicholas E ^c   Liu, Leroy F ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DIHYDRO 8 DESMETHYLCORALYNE; 8 DESMETHYLCORALYNE; DNA; DNA TOPOISOMERASE; LIGAND; PALMATINE; PROTOBERBERINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; DNA BINDING; DNA CLEAVAGE; HUMAN; INTERCALATION COMPLEX; LIGAND BINDING; LINEAR DICHROISM; PRIORITY JOURNAL;

BERBERINE ALKALOIDS; CALORIMETRY; DNA; DNA TOPOISOMERASES, TYPE I; HUMANS; LIGANDS;

MAMMALIA;

EID: 0030753506     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971272q     Document Type: Article

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