Bax, Bcl-2, and NF-κB expression in sanguinarine induced bimodal cell death

Experimental and Molecular Pathology

Volumn 71, Issue 1, 2001, Pages 89-98

  Weerasinghe, Priya ^a   Hallock, Sarathi ^a   Liepins, Andrejs ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

Alkaloid; Apoptosis; Bax; Bcl 2; Blebbing; Blister cell death; Chemoresistance; NF B; Programmed cell death; Sanguinarine

Indexed keywords

ANTINEOPLASTIC ALKALOID; ENZYME INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE C INHIBITOR; SANGUINARINE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN K 562; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ERYTHROLEUKEMIA CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

EID: 0034867935     PISSN: 00144800     EISSN: None     Source Type: Journal    
DOI: 10.1006/exmp.2001.2355     Document Type: Article

References (45)

1. Apoptosis: The role of endonuclease
2. Cytotoxicity of sanguinarine chloride to cultured human cells from oral tissue
3. Ikappa B-NF-kappa B structures: At the interface of inflammation control
4. Sequence selective, pH-dependent binding to DNA of benzophenanthridine alkaloids
5. Cloning the chromosomal break-point of t(14:18) human lymphomas: Clustering around JH on chromosome 14 and near a transcriptional unit on 18
6. Sanguinarine (pseudochelerythrine) is a potent inhibitor of NFkB activation, IkB phosphorylation and degradation
7. A biological hallmark of apoptosis: Internucleosomal degradation of the genome
8. Cytometry in cell necrobiology: Analysis of apoptosis and accidental cell death (necrosis)
9. Apoptosis control in syncytia induced by the HIV Type 1-Envelope glycoprotein complex: Role of mitochondria and caspases
10. Modifications of cystein-rich regions in protein kinase C induced by oxidant tumor promoters and enzyne specific inhibitors
11. Apoptosis and drug response
12. DNA topoisomerase ml-mediated DNA cleavage and cytoxocity of camptothesin analogues
13. Induction of apoptotic DNA fragmentation and cell death in HL-60 human pro myelocytic leukemia cells by pharmacological inhibitors of PKC
14. Evidence that de novo protein synthesis is dispensable for anti-apoptotic effects of NF-κB
15. Overexpression of Bax gene sensitizes K562 erythroleukemia cells to apoptosis induced by selective chemotherapeutic agents
16. Bcl2 gene family and the regulation of programmed cell death
17. Bcl-2/Bax: A rheostat that regulates an anti-oxidant pathway and cell death
18. Reduced expression of proapoptotic gene Bax is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma
19. ++ and mitochondrial membrane potential preceding cell death in hepatocytes
20. Morphological, physiological and biochemical parameters associated with cell injury
21. Cell injury and apoptosis
22. Induction of bimodal programmed cell death in malignant cells by the derivative Ukrain
23. Apoptosis, oncosis and necrosis. An overview of cell death
24. NF-κB as a primary regulator of the stress response
25. Discrimination of late apoptotic/necrotic cells (Type III) by flow cytometry in solid tumors
26. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
27. Cytosolic ionized calcium and bleb formation after acute cell injury of cultured rabbit renal tubule cells
28. High levels of HIV-1 replication show a clear correlation with downmodulation of Bcl-2 protein in peripheral blood lymphocytes of HIV-1-seropositive subjects
29. Regulation of chemoresistance by the Bcl-2 oncoprotein in non-Hodgkin lymphoma and lymphocytic leukemia cell lines
30. Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor
31. Sanguinarine: A positive inotropic alkaloid which inhibits cardiac Na+ K+ ATPase
32. Interaction of sanguinarine iminium and alkalolamine form with calf thymus DNA
33. Aberrant nuclear factor kappa B/Rel expression and the pathogenesis of breast cancer
34. Mechanisms of apoptosis: Integration of genetic, biochemical and cellular indicators
35. Sanguinarine, inhibitor of Na- K dependent ATPase
36. ++ in cell injury, necrosis and apoptosis
37. The pathways of cell death: Oncosis, apoptosis and necrosis
38. Analysis of the structure, transcripts and protein products of Bcl-2, the gene involved in human follicular lymphoma
39. Involvement of the bcl-2 gene in human follicular lymphoma
40. Inhibition of liver alanine aminotransferase activity by benzophenanthridine alkaloids
41. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB
42. Antimicrotubule properties of benzophenanthredine alkaloids
43. Molecular thanatopsis: A discourse on the Bcl-2 family and cell death
44. BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
45. A model for tumor cell killing by topoisomerase poisons