Sanguinarine induces apoptosis in A549 human lung cancer cells primarily via cellular glutathione depletion

Toxicology in Vitro

Volumn 23, Issue 2, 2009, Pages 281-287

  Jang, Byeong Churl ^a   Park, Jong Gu ^a   Song, Dae Kyu ^a   Baek, Won Ki ^a   Yoo, Sun Kyun ^b   Jung, Kyung Hwan ^c   Park, Gy Young ^d   Lee, Tae Yun ^e   Suh, Seong Il ^a  

^a Keimyung University School of Medicine   (South Korea)

^b Joongbu University   (South Korea)

^c Chungju National University   (South Korea)

^d Catholic University of Daegu   (South Korea)

^e Yeungnam University College of Medicine   (South Korea)

Author keywords

A549 cells; Apoptosis; Caspases; Glutathione depletion; Sanguinarine

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; CASPASE INHIBITOR; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; N BENZYLOXYCARBONYL VAL ALA ASP FLUOROMETHYLKETONE; SANGUINARINE; SMALL INTERFERING RNA; THIOL GROUP; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROTECTION; CYTOTOXICITY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; LUNG CANCER; LUNG NON SMALL CELL CANCER; PROTEIN DEPLETION; PROTEIN EXPRESSION;

AMINO ACID CHLOROMETHYL KETONES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BENZOPHENANTHRIDINES; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; DUAL SPECIFICITY PHOSPHATASE 1; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE SILENCING; GLUTATHIONE; HUMANS; ISOQUINOLINES; LUNG NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NEUROPROTECTIVE AGENTS; RNA, SMALL INTERFERING;

EID: 59449083445     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.12.013     Document Type: Article

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