Correlation of the cytotoxic activity of four different alkaloids, from Chelidonium majus (greater celandine), with their DNA intercalating properties and ability to induce breaks in the DNA of NK/Ly murine lymphoma cells

Central European Journal of Biology

Volumn 1, Issue 1, 2006, Pages 2-15

  Kaminskyy, Vitaliy O ^a,b   Lootsik, Maxim D ^b   Stoika, Rostyslav S ^a,b  

^a IVAN FRANKO NATIONAL UNIVERSITY OF LVIV   (Ukraine)

^b INSTITUTE OF CELL BIOLOGY   (Ukraine)

Author keywords

Chelidonium majus L alkaloids; Comet assay; Cytotoxicity; DNA intercalation; Methyl green displacement test; NK Ly lymphoma

Indexed keywords

CHELIDONIUM; CHELIDONIUM MAJUS; MURINAE;

EID: 33748308871     PISSN: 1895104X     EISSN: 16443632     Source Type: Journal    
DOI: 10.2478/s11535-006-0001-y     Document Type: Article

References (29)

1. V.M. Adhami, M.H. Aziz, H. Mukhtar and N. Ahmad: "Activation of prodeath bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes", Clin. Cancer Res., Vol. 9, (2003), pp. 3176-3182.
2. M.C. Barreto, R.E. Pinto, J.D. Arrabaca and ML Pavao: "Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids", Toxicol. Lett., Vol. 146, (2003), pp. 37-47.
3. N.S. Burres, A. Frigo, R.R. Rasmussen and J.B. McAlpine: "A colorimetric microassay for the detection of agents that interact with DNA", J. Nat. Prod., Vol. 55, (1992), pp. 1582-1587.
4. M. Chaturvedi, A. Kumar, B. Darnay, G. Chainy, S. Agarwal and B. Agarwal: "Sanguinarine (Pseudochelerythrine) is a potent inhibitor of NF-kB Activation, IkBα Phosphorylation, and Degradation", J. Biol. Chem., Vol. 272, (1997), pp. 30129-30134.
5. A.R. Collins, M. Dusinska, M. Franklin, M. Somorovska, M. Petrovska, S. Duthie, L. Fillion, M. Panayiotidis, K. Raslova and N. Vaughan: "Comet assay in human biomonitoring studies: reliability, validation and applications", Environ. Mol. Mutagen., Vol. 30, (1997), pp. 139-146.
6. M.L. Colombo and E. Bosisio: "Pharmacological activities of Chelidonium majus L. (papaveraceae)", Pharmacol. Res., Vol. 33, (1996), pp. 127-134.
7. C. Dumontet and B.I. Sikic: "Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death", J. Clin. Oncol., Vol.17, (1999), pp. 1061-1070.
8. M.D. Faddeeva and T.N. Beliaeva: "Sanguinarine and ellipticine cytotoxic alkaloids isolated from well-known antitumor plants. Intracellular targets of their action", Tsitologiia, Vol. 39, (1997), pp. 181-208.
9. M. Gulston, C. de Lara, T. Jenner, E. Davis and P. O'Neill: "Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells postirradiation", Nucleic Acids Res., Vol. 32, (2004), pp. 1602-1609.
10. P.R. Heaton, R. Ransley, C.J. Charlton, S.J. Mann, J. Stevenson, B.H. Smith, J.M. Rawlings and E.J. Harper: "Application of Single-Cell Gel Electrophoresis (Comet) Assay for Assessing Levels of DNA Damage in Canine and Feline Leukocytes", J. Nutr., Vol. 132, (2002), pp. 1598S-1603S.
11. A. Kery, J. Horvath, I. Nasz, G. Verzar-Petri, G. Kulcsar and P. Dan: "Antiviral alkaloids in Chelidoniurn majus L", Acta Pharm. Hung., Vol. 57, (1987), pp. 19-25.
12. J. Lenfeld, M. Kroutil, E. Marsalek, J. Slavick, V. Preininger and V. Simanek: "Antiinflammatory activity of quaternary benzophenanthridine alkaloids from Chelidonium majus", Planta Med., Vol. 43, (1981), pp. 161-165.
13. B.S. Nadin, L.M. Vargas-Roig and D.R. Ciocca: "A Silver Staining Method for Single-cell Gel Assay", J. Histochem. Cytochem., Vol. 49, (2001), pp. 1183-1186.
14. R. Nandi and M. Maiti: "Binding of sanguinarine to deoxyribonucleic acids of differing base composition", Biochem. Pharmacol., Vol. 34, (1985), pp. 321-324.
15. P.L. Olive: "The Comet Assay. An Overview of Techniques", Methods Mol. Biol., Vol. 203, (2001), pp. 179-194.
16. P.I. Oliynichenko, Z.P. Bulkina and T.I. Siniborova: Handbook of cancer polychemotherapy, Zdorov'ia, Kyiv, 2000 (in Ukrainian).
17. A. Panzer, E. Hamel, A. Joubert, P. Bianchi and J. Seegers: "Ukraine, a semisyntetic Chelidonium majus alkaloid derivative, acts by inhibition of tubuline polymeization in normal and malignant cell lines", Cancer Lett., Vol. 16, (2000), pp. 149-157.
18. A. Panzer, A. Joubert, P. Bianchi, E. Hamel and J. Seegers: "The effects of chelidonine on tubuline polymerization, cell cycle progression and selected signal transmission pathways", Eur. J. Cell Biol., Vol. 80, (2001), pp. 111-118.
19. A. Peeples and R.R. Dalvi: "Toxic alkaloids and their interaction with microsomal cytochrome P-450 in vitro", J. Appl. Toxicol., Vol. 2, (1982), pp. 300-302.
20. J. Sambrook, E.F. Fritsch and T. Maniatis: Molecular cloning: a laboratory manual, 2nd ed., Cold Spring Harbor Laboratory Press, New York, 1989.
21. T. Schmeller, B. Latz-Bruning and M. Wink: "Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores", Photochemistry, Vol. 44, (1997), pp. 257-266.
22. J. Slavik and L. Slavikova: "Minor alkaloids from Chelidonium majus L", Collection Czechoslov. Chem. Commun., Vol. 42, (1977), pp. 2686-2693.
23. J. Slavik, L. Slavikova and J. Brabenec: "Alkaloide der mohnegewachse (Papaveracea) XXX. Uber wurzelvon Chelidoniurn, majus L", Collection Czechoslov. Chem. Commun., Vol. 30, (1965), pp. 3697-3702
24. 32P-postlabeling technique", Chem. Biol. Interact., Vol. 140, (2002), pp. 231-242.
25. P. Syntichaki and N. Tavernarakis: "Death by necrosis", EMBO Rep., Vol. 3, (2002), pp. 604-609.
26. J. Vrba, P. Kosina, J. Ulrichova and M. Modriansky: "Involvement of cytochrome P450 1A in sanguinarine detoxication", Toxicol. Lett, Vol. 151, (2004), pp. 375-387.
27. B.H. Wang, Z.X. Lu and G.M. Polya: "Inhibition of eukaryote protein kinases by isoquinoline and oxazine alkaloids", Planta Med., Vol. 63, (1997), pp. 494-498.
28. P. Weerasinghe, S. Hallock and A. Liepins: "Bax, Bcl-2 and NF- kB expression in sanguinarine induced bimodal cell death", Exp. Mol Pathol., Vol. 71, (2001), pp. 89-98.
29. P. Weerasinghe, S. Hallock, S. Tang and A. Liepins: "Role of Bcl-2 family proteins and caspase-3 in sanguinarine-induced bimodal cell death", Cell Biol. Toxicol., Vol. 17, (2001), pp. 371-378.