Pro- and anti-apoptotic CD95 signaling in T cells

Cell Communication and Signaling

Volumn 9, Issue , 2011, Pages

  Paulsen, Maren ^a   Janssen, Ottmar ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; FAS ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; INTERNALIZATION; LYMPHOCYTE ACTIVATION; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 79953742967     PISSN: None     EISSN: 1478811X     Source Type: Journal    
DOI: 10.1186/1478-811X-9-7     Document Type: Article

References (90)

1. TNF/TNFR family members in costimulation of T cell responses. TH Watts, Annu Rev Immunol 2005 23 23 68 10.1146/annurev.immunol.23.021704.115839 15771565 (Pubitemid 40563164)
2. A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. FK Chan, J Shisler, JG Bixby, M Felices, L Zheng, M Appel, J Orenstein, B Moss, MJ Lenardo, J Biol Chem 2003 278 51613 51621 10.1074/jbc.M305633200 14532286 (Pubitemid 38020406)
3. Fas engagement accelerates liver regeneration after partial hepatectomy. J Desbarats, MK Newell, Nat Med 2000 6 920 923 10.1038/78688 10932231 (Pubitemid 30644752)
4. Regulation of TNFR1 and CD95 signalling by receptor compartmentalization. S Schütze, V Tchikov, W Schneider-Brachert, Nat Rev Mol Cell Biol 2008 9 655 662 18545270 (Pubitemid 352032925)
5. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. FC Kischkel, S Hellbardt, I Behrmann, M Germer, M Pawlita, PH Krammer, ME Peter, EMBO J 1995 14 5579 5588 8521815
6. CD95's deadly mission in the immune system. PH Krammer, Nature 2000 407 789 795 10.1038/35037728 11048730
7. Life and death in peripheral T cells. PH Krammer, R Arnold, IN Lavrik, Nat Rev Immunol 2007 7 532 542 10.1038/nri2115 17589543 (Pubitemid 46987784)
8. The many roles of FAS receptor signaling in the immune system. A Strasser, PJ Jost, S Nagata, Immunity 2009 30 180 192 10.1016/j.immuni.2009.01. 001 19239902
9. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. T Takahashi, M Tanaka, CI Brannan, NA Jenkins, NG Copeland, T Suda, S Nagata, Cell 1994 76 969 976 10.1016/0092-8674(94)90375-1 7511063 (Pubitemid 24106378)
10. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. R Watanabe-Fukunaga, CI Brannan, NG Copeland, NA Jenkins, S Nagata, Nature 1992 356 314 317 10.1038/356314a0 1372394
11. Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways. F Rieux-Laucat, F Le Deist, A Fischer, Cell Death Differ 2003 10 124 133 10.1038/sj.cdd.4401190 12655301 (Pubitemid 36511838)
12. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. GH Fisher, FJ Rosenberg, SE Straus, JK Dale, LA Middleton, AY Lin, W Strober, MJ Lenardo, JM Puck, Cell 1995 81 935 946 10.1016/0092-8674(95)90013-6 7540117
13. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. F Rieux-Laucat, F Le Deist, C Hivroz, IA Roberts, KM Debatin, A Fischer, JP de Villartay, Science 1995 268 1347 1349 10.1126/science.7539157 7539157
14. Induction of apoptosis in mature T cells by tumour necrosis factor. L Zheng, G Fisher, RE Miller, J Peschon, DH Lynch, MJ Lenardo, Nature 1995 377 348 351 10.1038/377348a0 7566090
15. Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system. M Li-Weber, PH Krammer, Semin Immunol 2003 15 145 157 10.1016/S1044-5323(03)00030-7 14563113 (Pubitemid 38155821)
16. Activation or suppression of NFkappaB by HPK1 determines sensitivity to activation-induced cell death. D Brenner, A Golks, F Kiefer, PH Krammer, R Arnold, EMBO J 2005 24 4279 4290 10.1038/sj.emboj.7600894 16341093 (Pubitemid 41828903)
17. Concepts of activated T cell death. D Brenner, PH Krammer, R Arnold, Crit Rev Oncol Hematol 2008 66 52 64 10.1016/j.critrevonc.2008.01.002 18289867
18. Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity. PD Hughes, GT Belz, KA Fortner, RC Budd, A Strasser, P Bouillet, Immunity 2008 28 197 205 10.1016/j.immuni.2007.12. 017 18275830 (Pubitemid 351215234)
19. Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity. J Hutcheson, JC Scatizzi, AM Siddiqui, GK Haines, T Wu, QZ Li, LS Davis, C Mohan, H Perlman, Immunity 2008 28 206 217 10.1016/j.immuni.2007.12.015 18275831 (Pubitemid 351215233)
20. Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction. AE Weant, RD Michalek, IU Khan, BC Holbrook, MC Willingham, JM Grayson, Immunity 2008 28 218 230 10.1016/j.immuni.2007.12.014 18275832 (Pubitemid 351215232)
21. Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. DA Hildeman, Y Zhu, TC Mitchell, P Bouillet, A Strasser, J Kappler, P Marrack, Immunity 2002 16 759 767 10.1016/S1074-7613(02)00322-9 12121658 (Pubitemid 34786475)
22. CD95, BIM and T cell homeostasis. P Bouillet, LA O'Reilly, Nat Rev Immunol 2009 9 514 519 10.1038/nri2570 19543226
23. Posttranslational regulation of Fas ligand function. M Voss, M Lettau, M Paulsen, O Janssen, Cell Commun Signal 2008 6 11 10.1186/1478-811X-6-11 19114018
24. Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. LA O'Reilly, L Tai, L Lee, EA Kruse, S Grabow, WD Fairlie, NM Haynes, DM Tarlinton, JG Zhang, GT Belz, et al. Nature 2009 461 659 663 19794494
25. Soluble Fas ligand is chemotactic for human neutrophilic polymorphonuclear leukocytes. L Ottonello, G Tortolina, M Amelotti, F Dallegri, J Immunol 1999 162 3601 3606 10092820 (Pubitemid 29313614)
26. The cytoplasmic domain of Fas ligand costimulates TCR signals. M Sun, KT Ames, I Suzuki, PJ Fink, J Immunol 2006 177 1481 1491 16849454 (Pubitemid 44092481)
27. FasL cross-linking inhibits activation of human peripheral T cells. M Paulsen, B Mathew, J Qian, M Lettau, D Kabelitz, O Janssen, Int Immunol 2009 21 587 598 10.1093/intimm/dxp028 19332441
28. A new class of reverse signaling costimulators belongs to the TNF family. M Sun, PJ Fink, J Immunol 2007 179 4307 4312 17878324
29. Fas ligand costimulates the in vivo proliferation of CD8+ T cells. I Suzuki, S Martin, TE Boursalian, C Beers, PJ Fink, J Immunol 2000 165 5537 5543 11067907
30. Newly discovered role for Fas ligand in the cell-cycle arrest of CD4+ T cells. J Desbarats, RC Duke, MK Newell, Nat Med 1998 4 1377 1382 10.1038/3965 9846574 (Pubitemid 28553459)
31. The CD95 receptor: apoptosis revisited. ME Peter, RC Budd, J Desbarats, SM Hedrick, AO Hueber, MK Newell, LB Owen, RM Pope, J Tschopp, H Wajant, et al. Cell 2007 129 447 450 10.1016/j.cell.2007.04.031 17482535 (Pubitemid 46660984)
32. Fas transduces activation signals in normal human T lymphocytes. MR Alderson, RJ Armitage, E Maraskovsky, TW Tough, E Roux, K Schooley, F Ramsdell, DH Lynch, J Exp Med 1993 178 2231 2235 10.1084/jem.178.6.2231 7504062 (Pubitemid 23344883)
33. Caspase activation is required for T cell proliferation. NJ Kennedy, T Kataoka, J Tschopp, RC Budd, J Exp Med 1999 190 1891 1896 10.1084/jem.190.12. 1891 10601363 (Pubitemid 30013854)
34. Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells. A Alam, LY Cohen, S Aouad, RP Sekaly, J Exp Med 1999 190 1879 1890 10.1084/jem.190.12.1879 10601362 (Pubitemid 30013853)
35. Caspase inhibition blocks human T cell proliferation by suppressing appropriate regulation of IL-2, CD25, and cell cycle-associated proteins. M Falk, S Ussat, N Reiling, D Wesch, D Kabelitz, S Adam-Klages, J Immunol 2004 173 5077 5085 15470051 (Pubitemid 39387790)
36. Fas costimulation of naive CD4 T cells is controlled by NF-kappaB signaling and caspase activity. M Maksimow, TS Soderstrom, S Jalkanen, JE Eriksson, A Hanninen, J Leukoc Biol 2006 79 369 377 10.1189/jlb.0505238 16330535 (Pubitemid 44831169)
37. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. HJ Chun, L Zheng, M Ahmad, J Wang, CK Speirs, RM Siegel, JK Dale, J Puck, J Davis, CG Hall, et al. Nature 2002 419 395 399 10.1038/nature01063 12353035
38. Interaction with XIAP prevents full caspase-3/-7 activation in proliferating human T lymphocytes. M Paulsen, S Ussat, M Jakob, G Scherer, I Lepenies, S Schütze, D Kabelitz, S Adam-Klages, Eur J Immunol 2008 38 1979 1987 10.1002/eji.200838211 18521960
39. Modulation of CD4(+) T-cell activation by CD95 co-stimulation. M Paulsen, S Valentin, B Mathew, S Adam-Klages, U Bertsch, I Lavrik, PH Krammer, D Kabelitz, O Janssen, Cell Death Differ 2010 21052094
40. Antiapoptotic signaling generated by caspase-induced cleavage of RasGAP. JY Yang, C Widmann, Mol Cell Biol 2001 21 5346 5358 10.1128/MCB.21.16.5346-5358. 2001 11463818 (Pubitemid 32702440)
41. Caspase-mediated cleavage of hematopoietic progenitor kinase 1 (HPK1) converts an activator of NFkappaB into an inhibitor of NFkappaB. R Arnold, J Liou, HC Drexler, A Weiss, F Kiefer, J Biol Chem 2001 276 14675 14684 10.1074/jbc.M008343200 11278403
42. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. R Arnold, CR Frey, W Muller, D Brenner, PH Krammer, F Kiefer, Cell Death Differ 2007 14 568 575 10.1038/sj.cdd.4402042 17024227
43. Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes. D Brenner, A Golks, M Becker, W Muller, CR Frey, R Novak, D Melamed, F Kiefer, PH Krammer, R Arnold, Blood 2007 110 3968 3977 10.1182/blood-2007-01-071167 17712048 (Pubitemid 350248452)
44. Cascleave: towards more accurate prediction of caspase substrate cleavage sites. J Song, H Tan, H Shen, K Mahmood, SE Boyd, GI Webb, T Akutsu, JC Whisstock, Bioinformatics 2010 26 752 760 10.1093/bioinformatics/btq043 20130033
45. Caspases and kinases in a death grip. M Kurokawa, S Kornbluth, Cell 2009 138 838 854 10.1016/j.cell.2009.08.021 19737514
46. DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance. M Shi, CJ Vivian, KJ Lee, C Ge, K Morotomi-Yano, C Manzl, F Bock, S Sato, C Tomomori-Sato, R Zhu, et al. Cell 2009 136 508 520 10.1016/j.cell.2008.12.021 19203584
47. TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1. M Thome, J Tschopp, Trends Immunol 2003 24 419 424 10.1016/S1471-4906(03) 00177-7 12909454 (Pubitemid 36928098)
48. N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway. T Kataoka, J Tschopp, Mol Cell Biol 2004 24 2627 2636 10.1128/MCB.24.7.2627- 2636.2004 15024054 (Pubitemid 38381257)
49. The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation. A Golks, D Brenner, PH Krammer, IN Lavrik, J Exp Med 2006 203 1295 1305 10.1084/jem.20051556 16682493 (Pubitemid 43736598)
50. The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways. T Kataoka, RC Budd, N Holler, M Thome, F Martinon, M Irmler, K Burns, M Hahne, N Kennedy, M Kovacsovics, J Tschopp, Curr Biol 2000 10 640 648 10.1016/S0960-9822(00)00512-1 10837247 (Pubitemid 30354699)
51. cFLIP regulation of lymphocyte activation and development. RC Budd, WC Yeh, J Tschopp, Nat Rev Immunol 2006 6 196 204 10.1038/nri1787 16498450 (Pubitemid 43290989)
52. The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway. N Zhang, K Hopkins, YW He, J Immunol 2008 180 5506 5511 18390734
53. cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes. T Wachter, M Sprick, D Hausmann, A Kerstan, K McPherson, G Stassi, EB Brocker, H Walczak, M Leverkus, J Biol Chem 2004 279 52824 52834 10.1074/jbc.M409554200 15459191 (Pubitemid 40051782)
54. NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP. S Kreuz, D Siegmund, JJ Rumpf, D Samel, M Leverkus, O Janssen, G Hacker, O Dittrich-Breiholz, M Kracht, P Scheurich, H Wajant, J Cell Biol 2004 166 369 380 10.1083/jcb.200401036 15289496 (Pubitemid 39031240)
55. Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha. R Imamura, K Konaka, N Matsumoto, M Hasegawa, M Fukui, N Mukaida, T Kinoshita, T Suda, J Biol Chem 2004 279 46415 46423 10.1074/jbc.M403226200 15337758 (Pubitemid 39518283)
56. Bcl-2 prevents CD95 (Fas/APO-1)-induced degradation of lamin B and poly(ADP-ribose) polymerase and restores the NF-kappaB signaling pathway. M Mandal, SB Maggirwar, N Sharma, SH Kaufmann, SC Sun, R Kumar, J Biol Chem 1996 271 30354 30359 10.1074/jbc.271.48.30354 8939996 (Pubitemid 26404036)
57. Non-apoptotic Fas signaling. H Wajant, K Pfizenmaier, P Scheurich, Cytokine Growth Factor Rev 2003 14 53 66 10.1016/S1359-6101(02)00072-2 12485619 (Pubitemid 36098431)
58. Quantitative interplay between activating and pro-apoptotic signals dictates T cell responses. A Chen, G Zheng, ML Tykocinski, Cell Immunol 2003 221 128 137 10.1016/S0008-8749(03)00069-8 12747954 (Pubitemid 36549088)
59. CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling. G Strauss, JA Lindquist, N Arhel, E Felder, S Karl, TL Haas, S Fulda, H Walczak, F Kirchhoff, KM Debatin, J Exp Med 2009 206 1379 1393 10.1084/jem.20082363 19487421
60. Murine models of autoimmunity: T-cell and B-cell defects. JD Mountz, CK Edwards, Curr Opin Rheumatol 1992 4 612 620 1419495
61. Induction of specific T-cell tolerance by adenovirus-transfected, Fas ligand-producing antigen presenting cells. HG Zhang, D Liu, Y Heike, P Yang, Z Wang, X Wang, DT Curiel, T Zhou, JD Mountz, Nat Biotechnol 1998 16 1045 1049 10.1038/3488 9831033 (Pubitemid 28515897)
62. Specific T-cell deletion by transfected human monocytes expressing Fas ligand and antigen. C Cancedda, J LeMaoult, PE Harris, N Suciu-Foca, R Cortesini, Transplant Proc 2001 33 165 166 10.1016/S0041-1345(00)01957-6 11266761 (Pubitemid 32237317)
63. Membrane-bound CD95 ligand expressed on human antigen-presenting cells prevents alloantigen-specific T cell response without impairment of viral and third-party T cell immunity. G Strauss, W Osen, I Knape, EM Jacobsen, SM Muller, KM Debatin, Cell Death Differ 2007 14 480 488 10.1038/sj.cdd.4402019 16902496
64. Regulation of lymphocyte proliferation and death by FLIP. M Thome, J Tschopp, Nat Rev Immunol 2001 1 50 58 10.1038/35095508 11905814 (Pubitemid 33741975)
65. Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis. M Bentele, I Lavrik, M Ulrich, S Stosser, DW Heermann, H Kalthoff, PH Krammer, R Eils, J Cell Biol 2004 166 839 851 10.1083/jcb.200404158 15364960 (Pubitemid 39249835)
66. c-FLIP protects mature T lymphocytes from TCR-mediated killing. N Zhang, K Hopkins, YW He, J Immunol 2008 181 5368 5373 18832693
67. Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling. IN Lavrik, A Golks, D Riess, M Bentele, R Eils, PH Krammer, J Biol Chem 2007 282 13664 13671 10.1074/jbc.M700434200 17347143 (Pubitemid 47100557)
68. Dynamics within the CD95 death-inducing signaling complex decide life and death of cells. L Neumann, C Pforr, J Beaudouin, A Pappa, N Fricker, PH Krammer, IN Lavrik, R Eils, Mol Syst Biol 2010 6 352 10.1038/msb.2010.6 20212524
69. Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL. N Fricker, J Beaudouin, P Richter, R Eils, PH Krammer, IN Lavrik, J Cell Biol 2010 190 377 389 10.1083/jcb.201002060 20696707
70. The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers. S Schüngel, LE Buitrago-Molina, P Nalapareddy, M Lebofsky, MP Manns, H Jaeschke, A Gross, A Vogel, Hepatology 2009 50 1558 1566 19711425
71. Fas modulation of apoptosis during negative selection of thymocytes. JE Castro, JA Listman, BA Jacobson, Y Wang, PA Lopez, S Ju, PW Finn, DL Perkins, Immunity 1996 5 617 627 10.1016/S1074-7613(00)80275-7 8986720 (Pubitemid 27062070)
72. Negative selection in the thymus includes semimature T cells. H Kishimoto, J Sprent, J Exp Med 1997 185 263 271 10.1084/jem.185.2.263 9016875 (Pubitemid 27078283)
73. Mutation in fas ligand impairs maturation of thymocytes bearing moderate affinity T cell receptors. TE Boursalian, PJ Fink, J Exp Med 2003 198 349 360 10.1084/jem.20030220 12860933 (Pubitemid 36987860)
74. Activated B cells express functional Fas ligand. M Hahne, T Renno, M Schroeter, M Irmler, L French, T Bornard, HR MacDonald, J Tschopp, Eur J Immunol 1996 26 721 724 10.1002/eji.1830260332 8605944 (Pubitemid 26091406)
75. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand- induced apoptosis. G Suss, K Shortman, J Exp Med 1996 183 1789 1796 10.1084/jem.183.4.1789 8666935 (Pubitemid 26134319)
76. Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation. L Lu, S Qian, PA Hershberger, WA Rudert, DH Lynch, AW Thomson, J Immunol 1997 158 5676 5684 9190916 (Pubitemid 127483971)
77. The tolerogenic molecule CD95-L is expressed on the plasma membrane of human activated, but not resting, Langerhans' cells. G De Panfilis, M Venturini, A Lavazza, MA Mommaas, D Semenza, C Torresani, G Pasolini, Exp Dermatol 2003 12 692 699 10.1034/j.1600-0625.2003.00079.x 14705811 (Pubitemid 37279084)
78. Immune escape of tumors: apoptosis resistance and tumor counterattack. FH Igney, PH Krammer, J Leukoc Biol 2002 71 907 920 12050175
79. Activation-induced CD4+ T cell death in HIV-positive individuals correlates with Fas susceptibility, CD4+ T cell count, and HIV plasma viral copy number. DH Dockrell, AD Badley, A Algeciras-Schimnich, M Simpson, R Schut, DH Lynch, CV Paya, AIDS Res Hum Retroviruses 1999 15 1509 1518 10.1089/ 088922299309793 10580401
80. Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand. G Lu, BM Janjic, J Janjic, TL Whiteside, WJ Storkus, NL Vujanovic, J Immunol 2002 168 1831 1839 11823516 (Pubitemid 34135783)
81. Dynamic correlation of apoptosis and immune activation during treatment of HIV infection. AD Badley, K Parato, DW Cameron, S Kravcik, BN Phenix, D Ashby, A Kumar, DH Lynch, J Tschopp, JB Angel, Cell Death Differ 1999 6 420 432 10.1038/sj.cdd.4400509 10381636 (Pubitemid 29245956)
82. Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain. XN Xu, B Laffert, GR Screaton, M Kraft, D Wolf, W Kolanus, J Mongkolsapay, AJ McMichael, AS Baur, J Exp Med 1999 189 1489 1496 10.1084/jem.189.9.1489 10224289 (Pubitemid 29227535)
83. Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells. YM Mueller, SC De Rosa, JA Hutton, J Witek, M Roederer, JD Altman, PD Katsikis, Immunity 2001 15 871 882 10.1016/S1074-7613(01)00246-1 11754810 (Pubitemid 34075369)
84. HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell. R Geleziunas, W Xu, K Takeda, H Ichijo, WC Greene, Nature 2001 410 834 838 10.1038/35071111 11298454 (Pubitemid 32303784)
85. Cryptococcus neoformans capsular glucuronoxylomannan induces expression of fas ligand in macrophages. C Monari, E Pericolini, G Bistoni, A Casadevall, TR Kozel, A Vecchiarelli, J Immunol 2005 174 3461 3468 15749881 (Pubitemid 40354053)
86. Elimination of activated but not resting primary human CD4+ and CD8+ T cells by Fas ligand (FasL/CD95L)-expressing Killer-dendritic cells. S Hoves, SW Krause, H Herfarth, D Halbritter, HG Zhang, JD Mountz, J Scholmerich, M Fleck, Immunobiology 2004 208 463 475 10.1078/0171-2985-00293 15124861 (Pubitemid 38515030)
87. Targeting the function of mature dendritic cells by human cytomegalovirus: a multilayered viral defense strategy. MJ Raftery, M Schwab, SM Eibert, Y Samstag, H Walczak, G Schonrich, Immunity 2001 15 997 1009 10.1016/S1074-7613(01)00239-4 11754820 (Pubitemid 34075379)
88. Measles virus induces apoptosis in uninfected bystander T cells and leads to granzyme B and caspase activation in peripheral blood mononuclear cell cultures. T Vuorinen, P Peri, R Vainionpaa, Eur J Clin Invest 2003 33 434 442 10.1046/j.1365-2362.2003.01164.x 12713458 (Pubitemid 36583713)
89. Decreased T cell stimulatory capacity of monocyte-derived human macrophages following herpes simplex virus type 1 infection. S Hoves, HH Niller, SW Krause, R Straub, T Gluck, JD Mountz, J Scholmerich, M Fleck, Scand J Immunol 2001 54 93 99 10.1046/j.1365-3083.2001.00956.x 11439154 (Pubitemid 32592334)
90. Fas expression on antigen-specific T cells has costimulatory, helper, and down-regulatory functions in vivo for cytotoxic T cell responses but not for T cell-dependent B cell responses. I Puliaeva, R Puliaev, A Shustov, M Haas, CS Via, J Immunol 2008 181 5912 5929 18941180