The tolerogenic molecule CD95-L is expressed on the plasma membrane of human activated, but not resting, Langerhans' cells.

Experimental Dermatology

Volumn 12, Issue 5, 2003, Pages 692-699

  De Panfilis, Giuseppe ^a   Venturini, M ^b   Lavazza, A ^c   Mommaas, M A ^d   Semenza, D ^b   Torresani, C ^a   Pasolini, G ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

^c Zooprophylactic Institute   (Italy)

^d Electron Microscopy Laboratory   (Netherlands)

Author keywords

Apoptosis; Cryo ultramicrotomy; Dendritic cells; Immunoelectron microscopy; Langerhans' cells

Indexed keywords

FAS LIGAND; MONOCLONAL ANTIBODY; T LYMPHOCYTE ANTIGEN;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL ACTIVATION; CELL MEMBRANE; CELL ORGANELLE; CELL SUSPENSION; CONTROLLED STUDY; CYTOPLASM; DENDRITIC CELL; EPIDERMIS CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOGENICITY; INFLAMMATION; LANGERHANS CELL; MOLECULE; NONHUMAN; REST; SKIN BIOPSY; SKIN DISEASE; T LYMPHOCYTE; ULTRAMICROTOMY;

ANTIBODIES, MONOCLONAL; CELL MEMBRANE; CYTOPLASM; FAS LIGAND PROTEIN; HUMANS; IMMUNE TOLERANCE; LANGERHANS CELLS; MEMBRANE GLYCOPROTEINS; MICROSCOPY, IMMUNOELECTRON;

EID: 0142106499     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0625.2003.00079.x     Document Type: Article

References (58)

1. Banchereau J, Steinman R M. Dendritic cells and the control of immunity. Nature 1998: 392: 245-252.
2. Finkelman F D, Lees A, Birnbaum R, Gause W C, Morris S C. Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. J Immunol 1996: 157: 1406-1414.
3. -) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes. Transplantation 1995: 60: 1539-1545.
4. -) prolong cardiac allograft survival in non-immunosuppressed recipients. Transplantation 1996: 60: 659-665.
5. Chambers C A, Allison J P. Co-stimulation in T cell responses. Curr Opin Immunol 1997: 19: 396-404.
6. Steinbrink K, Wolfl M, Jonuleit H, Knop J, Enk A H. Induction of tolerance by IL-10-treated dendritic cells. J Immunol 1997: 159: 4772-4780.
7. Sauter B, Albert M L, Francisco L, Larsson M, Somersan S, Bhardwaj N. Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immuno-stimulatory dendritic cells. J Exp Med 2000: 191: 423-433.
8. Huang F P, Platt N, Wykes M et al. A discrete population of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J Exp Med 2000: 191: 435-444.
9. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 2000: 192: 1213-1222.
10. De Panfilis G, Caruso A, Sansoni P, Pasolini G, Semenza D, Torresani C. Identification of Fas-L-expressing apoptotic T lymphocytes in normal human peripheral blood: 'In vivo' suicide. Am J Pathol 2001: 158: 387-391.
11. Süss G, Shortman K. A subclass of dendritic cells kill CD4 T cells via Fas/Fas ligand-induced apoptosis. J Exp Dermatol 1996: 183: 1789-1796.
12. Kronin V, Winkel K, Suss G et al. A subclass of dendritic cells regulates the response of naïve CD8 T cells by limiting their IL-2 production. J Immunol 1996: 157: 3819-3827.
13. Lu L, Qian S, Hershberger P A, Rudert W A, Lynch D H, Thomson A W. Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation. J Immunol 1997: 158: 5676-5684.
14. Matsue H, Matsue K, Walters M, Okumura K, Yagita H, Takashima A. Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells. Nature Med 1999: 5: 930-937.
15. Mommaas A M, Mulder A A, Out C J et al. Distribution of HLA class II molecules in epidermal Langerhans cells in situ. Eur J Immunol 1995: 25: 520-525.
16. Austyn J M. Death, destruction, danger and dendritic cells. Nature Med 1999: 5: 1232-1233.
17. Austyn J M. Dendritic cells. Curr Opin Hematol 1998: 5: 3-15.
18. Sousa C R, Sher A, Kaye P. The role of dendritic cells in the induction and regulation of immunity to microbial infection. Curr Opin Immunol 1999: 11: 392-399.
19. Dezutter-Dambuyant C, Cordier G, Schmitt D, Faure M, Laquoi C, Thivolet J. Quantitative evaluation of two distinct cell populations expressing HLA-DR antigens in normal human epidermis. Br J Dermatol 1984: 111: 1-11.
20. De Panfilis G, Manara G C, Ferrari C, Torresani C. Simultaneous colloidal gold immunoelectronmicroscopy labeling of CD1a, HLA-DR and CD4 surface antigens of human epidermal Langerhans cells. J Invest Dermatol 1988a: 91: 547-552.
21. De Panfilis G, Manara G C, Ferrari C, Torresani C. Adhesion molecules on the plasma membrane of epidermal cells. II. The intercellular adhesion molecule-1 (ICAM-1) is constitutively present on the cell surface of human resting Langerhans cells. J Invest Dermatol 1990: 94: 317-321.
22. De Panfilis G, Manara G C, Ferrari C, Torresani C. Adhesion molecules on the plasma membrane of epidermal cells. III. Keratinocytes and Langerhans cells constitutively express the lymphocyte function-associated antigen 3. J Invest Dermatol 1991: 96: 512-517.
23. Symington F W, Braby W, Linsley P S. Expression and function of B7 on human epidermal Langerhans cells. J Immunol 1993: 150: 1286-1295.
24. Girolomoni G, Zambruno G, Manfredini R et al. Expression of B7 costimulatory molecules in cultured human epidermal Langerhans cells is regulated at the mRNA level. J Invest Dermatol 1994: 103: 54-59.
25. Yokozeki H, Katayama I, Ohki O et al. Functional CD86 (B7-2/B70) on cultured human Langerhans cells. J Invest Dermatol 1996: 106: 147-153.
26. Torresani C, Manara G C, Ferrari C, Devoto R M, De Panfilis G. Demonstration of CDw40 antigen on the plasma membrane of Langerhans cells of normal human skin. Italian General Rev Dermatol 1989: 26: 161-168.
27. Rovere P, Vallinoto C, Bondanza A et al. Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function. J Immunol 1998: 161: 4467-4471.
28. Gallucci S, Lolkema M, Matzinger P. Natural adjuvants: Endogenous activators of dendritic cells. Nature Med 1999: 5: 1249-1255.
29. Nakajima M, Nakajima A, Kayagaki N, Honda M, Yagita H, Okumura K. Expression of Fas ligand and its receptor in cutaneous lupus: Implication in tissue injury. Clin Immunol Immunopathol 1997: 83: 205-222.
30. Berthou C, Michel L, Souliè A et al. Acquisition of Granzyme B and Fas ligand proteins by human keratinocytes contributes to epidermal cell defense. J Immunol 1997: 159: 5293-5300.
31. Gutierrez-Steil C, Wrone-Smith T, Sun X, Krueger J G, Coven T, Nickoloff B J. Sunlight-induced basal cell carcinoma tumor cells and ultraviolet-B-irradiated psoriatic plaques express Fas ligand (CD95L). J Clin Invest 1998: 101: 33-39.
32. Viard I, Wehrli P, Bullani R et al. Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin. Science 1998: 282: 490-493.
33. Lonati A, Mommaas A M, Pasolini G, Lavazza A, Rowden G, De Panfilis G. Macrophages, but not Langerhans cell-like cells of dendritic lineage, express the CD36 molecule in normal human dermis: Relevance to downregulatory cutaneous immune responses? J Invest Dermatol 1996: 106: 96-101.
34. Groh V, Tani M, Harrer A, Wolff K, Stingl G. Leu-3/T4 expression on epidermal Langerhans cells in normal and diseased skin. J Invest Dermatol 1986: 86: 115-120.
35. De Panfilis G, Soligo D, Manara G C, Ferrari C, Torresani C. Adhesion molecules on the plasma membrane of epidermal cells. I. Human resting Langerhans cells express two members of the adherence-promoting CD11/CD18 family, namely, H-Mac-1 (CD11b/CD18) and gp150, 95 (CD11c/CD18). J Invest Dermatol 1989: 93: 60-69.
36. Nagata S, Suda T. Fas and Fas ligand: lpr and gld mutations. Immunol Today 1995: 16: 39-43.
37. De Panfilis G, Rowden G, Manara G C, Ferrari C, Torresani C, Sansoni P. The S-100beta protein in normal human peripheral blood is uniquely present within a discrete suppressor-T-cell compartment. Cell Immunol 1988: 114: 398-404.
38. Breathnach A S. An Atlas of the Ultrastructure of Human Skin. London: Churchill Livingston, 1971.
39. Mommaas A M, Wijsman M C, Mulder A A, Van Praag M C, Vermeer B J, Koning F. HLA class II expression on human epidermal Langerhans cells in situ: Upregulation during the elicitation of allergic contact dermatitis. Hum Immunol 1992: 34: 99-106.
40. De Panfilis G, Semenza D, Lavazza A, Mulder A A, Mommaas A M, Pasolini G. Keratinocytes constitutively express the CD95-ligand molecule on the plasma membrane: An 'in situ' immunoelectronmicroscopy study on ultracryosections of normal human skin. Br J Dermatol 2002: 147: 7-12.
41. Matutes E, Catovski D. The fine structure of normal lymphocyte subpopulations. A study with monoclonal antibodies and the immunogold technique. Clin Exp Immunol 1982: 50: 416-425.
42. De Panfilis G, Marcelli M, Pasolini G, Torresani C. CD95-ligand (Fas-L)-expressing epidermal lymphocytes. Br J Dermatol 2000: 143: 892-893.
43. Shibaki A, Katz S I. Activation through CD40 ligation induces functional Fas ligand expression by Langerhans cells. Eur J Immunol 2001: 31: 3006-3015.
44. Geuze H J. The role of endosomes and lysosomes in MHC class II functioning. Immunol Today 1998: 19: 282-287.
45. Oberg H, Lengl-Janssen B, Kabelitz D, Janssen O. Activation-induced T cell death. Resistance or susceptibility correlate with cell surface Fas ligand expression and T helper phenotype. Cell Immunol 1997: 181: 93-100.
46. Nagata S. Apoptosis by death factor. Cell 1997: 88: 355-365.
47. Rosenberg J S, Weiss E, Wilding P. Immunogold staining: Adaptation of a cell-labeling system for analysis of human leukocyte subsets. Clin Chem 1984: 30: 1462-1466.
48. Anel A, Buferne , M, Boyer C, Schmitt-Verhulst A M, Golstein P. T cell receptor-induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A. Eur J Immunol 1994: 24: 2469-2476.
49. Vignaux F, Vivier E, Malissen B, Depraetere V, Nagata S, Golstein P. TCR/CD3 coupling to Fas-based cytotoxicity. J Exp Med 1995: 181: 781-786.
50. Kawakami A, Eguchi K, Matsuoka N. Expression and function of Fas and Fas ligand on peripheral blood lymphocytes in normal subjects. J Lab Clin Med 1998: 132: 404-413.
51. Suda T, Takahashi T, Golstein P, Nagata S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993: 75: 1169-1178.
52. Saitoh A, Kawanabe T, Weidong H et al. Selective upregulation of fibroblast Fas ligand expression, and prolongation of Fas/Fas ligand-mediated skin allograft survival, by retinoic acid: The skin as a retinoide-inducible immune privilege site. J Invest Dermatol 2000: 115: 154-161.
53. Oishi M, Maeda K, Sugiyama S. Distribution of apoptosis-mediating Fas antigen in human skin and effects of anti-Fas monoclonal antibody on human epidermal keratinocytes and squamous cell carcinoma cell line. Arch Dermatol Res 1994: 286: 396-407.
54. Sayama K, Yonehara S, Watanabe Y, Miki Y. Expression of Fas antigen on keratinocytes in vivo and induction of apoptosis in cultured keratinocytes. J Invest Dermatol 1994: 103: 330-334.
55. Leverkus M, Yaar M, Gilchrest B A. Fas/Fas ligand contributes to UV-induced apoptosis in human keratinocytes. Exp Cell Res 1997: 232: 255-262.
56. Nagata S, Golstein P. The Fas death factor. Science 1995: 267: 1449-1456.
57. Peng C T, Chow K C, Chang W C. Expression of Fas ligand in Langerhans' cell histiocytosis: A case report of a boy with multisystem involvement. Am J Hematol 1999: 61: 256-261.
58. Stingl G, Katz S I, Clement L, Green I, Shevac E M. Immunologic function of Ia-bearing epidermal Langerhans cells. J Immunol 1978: 121: 2005-2013.